Abstract: A method of reducing restenosis comprises administering to a patient a stent and reducing, shutting down or modifying functioning of the immune system in a controlled manner. In a preferred embodiment T-cell depletion or T-cell modification is used for controlling the immune system. The T-cell depletor or T-cell modifier is administered either separately or as part of the stent. Alternatively, an ex-vivo procedure may be used.

Abstract: The invention relates to a styrene-hypophosphite adduct of the formula (I) {R9[C(Ph(R1, R2, R3, R4, R5))R6—CR7R8]n}mP(O)(O 1/x Mx+)(R10)2-m where R1, R2, R3, R4, R5, R6, R7 and R8 are identical or different and are hydrogen, alkyl, linear or branched, aryl, aralkyl, oxoalkyl, oxoaryl, aminoalkyl, and/or aminoaryl, R9 is H or a free-radical-initiator radical, R10 is H, Mx+ is Li, Na, K, Mg, Ca, Sr, Ba, Al, Ge, Sn, Bi, Sb, Pb, Ti, TiO, Zr, ZrO, Zn, Fe, Ce, Mn, and/or a protonated nitrogen base having the valency x, m=1 or 2, and n=from 1 to 100, and is the number of styrene units C(Ph(R1, R2, R3, R4, R5))R6—CR7R8 inserted into the P—H bond.

Abstract: The invention relates to polymeric phosphinic acids and their salts of the formula (I) where X is hydrogen or 1/m of a metal of valency m, or is a protonated nitrogen base, R1 and R2 are identical or different and are hydrogen, a carboxy group, a carboxylic acid derivative, an unsubstituted or substituted alkyl group having from 1 to 10 carbon atoms, phenyl, benzyl, or alkyl-substituted aromatic systems, R3 and R4 may be identical or different and are an unsubstituted or substituted alkyl group having from 2 to 20 carbon atoms, or are OX, with the above meaning for X, and u is the average number of monomer units. The invention further relates to a process for preparing the abovementioned compounds, and to their use.

Abstract: The invention relates to a nanoparticulate phosphorus-containing flame retardant system, which comprises a phosphinic salt of the formula (I) and/or a diphosphinic salt of the formula (II) and/or their polymers, where R1 and R2 are identical or different and are C1-C6-alkyl, linear or branched, and/or aryl; R3 is C1-C10-alkylene, linear or branched, C6-C10-arylene, -alkylarylene, or -arylalkylene; M is Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Li, Na, K, and/or a protonated nitrogen base; m is from 1 to 4; n is from 1 to 4; x is from 1 to 4; and to a process for the preparation of these flame retardant systems, and to their use.

Abstract: The invention relates to a flame retardant combination comprising, as component A, a phosphinate of the formula (I) and/or a diphosphinate of the formula (II) and/or polymers of these where R1 and R2 are identical or different and are C1–C6-alkyl, linear or branched, and/or aryl; R3 is C1–C10-alkylene, linear or branched, C6–C10-arylene, -alkylarylene or -arylalkylene; M is calcium ions, magnesium ions, aluminum ions and/or zinc ions, m is 2 or 3; n is 1 or 3; x is 1 or 2; and comprising a component B1, B2 and/or B3 wherein B1 is a salt of 1,3,5-triazine compound with polyphosphoric acid, and wherein B2 is a melamine polymetaphosphate, and wherein B3 is a composite salt of polyphosphoric acid with melamine, melam and/or melem.

Abstract: The invention relates to polymeric phosphinic acids and their salts of the formula (I) where X is hydrogen or 1/m of a metal of valency m, or is a protonated nitrogen base, R1 and R2 are identical or different and are hydrogen, a carboxy group, a carboxylic acid derivative, an unsubstituted or substituted alkyl group having from 1 to 10 carbon atoms, phenyl, benzyl, or alkyl-substituted aromatic systems, R3 and R4 may be identical or different and are an unsubstituted or substituted alkyl group having from 2 to 20 carbon atoms, or are OX, with the above meaning for X, and ? is the average number of monomer units. The invention further relates to a process for preparing the above-mentioned compounds, and to their use.

Abstract: The invention relates to a stabilized flame retardant comprising a) from 99 to 1% by weight of melamine polyphosphate b) from 1 to 99% by weight of additive with latent alkalinity.

Abstract: The invention relates to phosphorus-containing thermally stabilized flame retardant agglomerates, comprising as component A from 6 to 99.99% by weight of aggregates and/or primary particles composed of a phosphinic salt of the formula (I) and/or of a diphosphinic salt of the formula (II), and/or of their polymers, where R1 and R2 are identical or different and are C1-C6-alkyl, linear or branched, and/or aryl; R3 is C1-C10-alkylene, linear or branched, C6-C10-arylene, -alkylarylene, or -arylalkylene; M is Mg, Ca, Al, Sb, Sn, Ge, Zn, Ti, Fe, Zr, Ce, Bi, Sr, Mn, Li, Na, K, and/or a protonated nitrogen base; m is from 1 to 4; n is from 1 to 4; and x is from 1 to 4; as component B from 0 to 90% by weight of a synergist which comprises a nitrogen compound or which comprises a phosphorus compound, or which comprises a phosphorus-nitrogen compound; as component C from 0 to 20% by weight of compounds of the elements of the second main and transition group; and as component D from 0.

Abstract: The invention relates to the use of stabilizers in phosphorus-containing thermally stabilized flame retardant agglomerates.

Abstract: The invention relates to a compacted flame-retardant composition comprising an organophosphorus flame-retardant component, prepared by compacting an organophosphorus flame-retardant component with or without a compacting auxiliary, and to a process for preparing these flame-retardant compositions, and to polymer molding compositions which comprise these flame-retardant compositions.

Abstract: A method of preventing formation of multi-drug resistance (MDR) or of treating a patient that has developed or is subject to the development of MDR comprises administering a regimen comprising one or more active drugs together with one or more MDR inhibitors such that the pharmacokinetic (PK) profile of the MDR inhibitor(s) is/are matched to the PK profile of the active drug(s).

Abstract: Disclosed are radiolabeled drugs and methods to improve their efficacy by using a radiosensitizer such that the radiosensitizer is either part of the radiolabeled drug by directly attaching the radiosensitizer to the radiolabeled drug or by producing a mixture of the radiolabeled drug and an analogue of the drug with the radiosensitizer attached to the drug instead of the radiolabel.

Abstract: The invention relates to diorganylphosphinic salts of the formula (I) and/or diorganyidiphosphinic salts of the formula (II) and/or any of their polymers where R1 and R2 are identical or different and are C1-C6-alkyl, linear or branched, and/or aryl; R3 is C1-C10-alkylene, linear or branched, C6-C10-arylene, -alkylarylene, or -arylalkylene; M is Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Li, Na, K, and/or a protonated nitrogen base; m is from 1 to 4; n is from 1 to 4; x is from 1 to 4, wherein the total content of partially water-soluble, ionizable compounds and the water-soluble content of the partially water-soluble, ionizable compounds is from 8200 to 100 ppm, preferably from 7000 to 200 ppm.

Abstract: A method of treating HIV infection comprises administering to a patient a regimen that is able to shut down the immune system in a controlled manner by using T-cell depletion or T-cell modification such that T-cells no longer can be attacked by HIV cells. The T-cell depletor or T-cell modifiers are administered either alone or in combination with “conventional” anti-HIV drugs.

Abstract: A method of treating B-cell lymphoma comprises administering to a patient a chemotherapeutic regimen, followed by treatment with a radiolabeled anti-CD20 antibody, wherein at the time of said treatment with said radiolabeled antibody said patient is not refractory to said chemotherapeutic regimen and has not relapsed.

Abstract: The invention relates to a flame-retardant polymer molding composition which comprises a nanoparticulate phosphorus-containing flame retardant system which comprises at least one phosphinic salt of the formula (I) and/or diphosphinic salt of the formula (II) and/or their polymers, where R1 and R2 are identical or different and are C1-C6-alkyl, linear or branched, and/or aryl; R3 is C1-C10-alkylene, linear or branched, C6-C10-arylene, -alkylarylene, or -arylalkylene; M is Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Li, Na, K, and/or a protonated nitrogen base; m is from 1 to 4; n is from 1 to 4; x is from 1 to 4.

Abstract: The invention relates to a phosphorus-containing flame retardant formulation for cellulose-containing moldings, comprising from 0.1 to 99.9% by weight of a resin of an organic nitrogen compound and from 0.1 to 99.9% by weight of a phosphorus-containing flame retardant.

Abstract: The invention relates to phosphorus-containing flame retardant agglomerates comprising a) from 99.99 to 80% by weight of aggregates and/or primary particles composed of a phosphinic salt of the formula (I) and/or composed of a diphosphinic salt of the formula (II), and/or composed of polymers of these, where R1,R2 are identical or different and are C1-C6-alkyl, linear or branched, and/or aryl; R3 is C1-C10-alkylene, linear or branched, C6-C10-arylene, -alkylarylene or -arylalkylene; M is Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Ce, Bi, Sr, Mn, Li, Na, K and/or a protonated nitrogen base; m is from 1 to 4; n is from 1 to 4; x is from 1 to 4 and b) from 0.01 to 20% by weight of auxiliaries. The invention likewise relates to a process for the production of these phosphorus-containing flame retardant agglomerates, and also to polymeric compositions and moldings which comprise these phosphorus-containing flame retardant agglomerates.

Abstract: The invention relates to a process for preparation of salts of dialkylphosphinic acids, which comprises a) reacting hypophosphorous acid and/or its salts with olefins in the presence of a free-radical initiator to give dialkylphosphinic acids and/or their alkali metal salts, in a solvent system, and b) reacting the dialkylphosphinic acids and/or alkali metal dialkylphosphinates obtained in a) with compounds of the metals Mg, Ca, Al, Zn, Ti, Sn, Zr, and/or Fe to give the dialkylphosphinic salts of these metals. The invention also relates to the use of the metal dialkylphosphinic salts obtained by the inventive process, in particular for preparation of flame retardants.

Abstract: The invention relates to a flame retardant polymer compound comprising from 50-95 wt % polymer matrix related to the total amount of the flame retardant polymeric compound and 5-50 wt % of flame retardant additive system related to the total amount of the flame retardant polymeric compound.