Abstract: The invention is directed to a much faster way of combining multiple colour channels in fluorescence microscopy for complex fast diagnostic and research purposes. The advantage is that the procedure and the microscope setting can be simplified and miniaturised to an extend that the construction of such automatic systems become much easier and by omitting the erasing step the speed of analysis is faster and moved to the processing of the images by image processing systems, nowadays working at almost real time.

Abstract: The invention is directed to a much faster way of combining multiple colour channels in fluorescence microscopy for complex fast diagnostic and research purposes. The advantage is that the procedure and the microscope setting can be simplified and miniaturised to an extend that the construction of such automatic systems become much easier and by omitting the erasing step the speed of analysis is faster and moved to the processing of the images by image processing systems, nowadays working at almost real time.

Abstract: The invention is directed to a much faster way of combining multiple colour channels in fluorescence microscopy for complex fast diagnostic and research purposes. The advantage is that the procedure and the microscope setting can be simplified and miniaturised to an extend that the construction of such automatic systems become much easier and by omitting the erasing step the speed of analysis is faster and moved to the processing of the images by image processing systems, nowadays working at almost real time.

Abstract: A pyrotechnical igniter (100) for an inflator of a vehicle safety system comprises at least two contact pins (102) physically separated from each other by an electrically insulating compound and a bridge wire (110) connected to both contact pins (102) in an electrically conducting manner. A fastening portion (112) in which the bridge wire (110) is welded to the contact pins (102) is provided at each of the contact pins (102).

Abstract: A pyrotechnical igniter (100) for an inflator of a vehicle safety system comprises at least two contact pins (102) physically separated from each other by an electrically insulating compound and a bridge wire (110) connected to both contact pins (102) in an electrically conducting manner. A fastening portion (112) in which the bridge wire (110) is welded to the contact pins (102) is provided at each of the contact pins (102).

Abstract: A pyrotechnical igniter (100) for an inflator of a vehicle safety system comprises at least two contact pins (102) physically separated from each other by an electrically insulating compound and a bridge wire (110) connected to both contact pins (102) in an electrically conducting manner. A fastening portion (112) in which the bridge wire (110) is welded to the contact pins (102) is provided at each of the contact pins (102).

Abstract: A gearbox arrangement (1), which is arranged in a drive train of a multi-axle land vehicle (2), in particular a commercial vehicle, or a similar means of transportation, wherein at least one of said axles is driven, wherein at least one planetary drive (8) is associated with each of the axle halves (5) of a driven axle. The gearbox arrangement comprises at least one sensor device (7) for detecting a steering manipulation on the vehicle (2) and a control device (6).

Abstract: The invention relates to a pyrotechnic actuator assembly (10) for release of a retaining means (12) in a vehicle safety system (14) comprising a housing (16) composed of a first housing part (18) and a second housing part (20) fixedly connected to the first housing part (18), the two housing parts (18, 20) forming a substantially tight housing chamber (22), a pyrotechnic charge (24) received in the housing chamber (22) as well as an electric ignition unit (26) for triggering of the pyrotechnic charge (24), wherein the electric ignition unit (26) extends from outside of the housing chamber (22) through the first housing part (18) into the housing chamber (22), and wherein the housing (16) includes a housing chamber portion (28) to which the pyrotechnic charge (24) is directly adjacent and includes a contact portion (30) for fastening the retaining means (12). Moreover the invention also comprises an airbag module of a vehicle safety system including such actuator assembly (10).

Abstract: The invention relates to a pyrotechnic actuator assembly (10) for release of a retaining means (12) in a vehicle safety system (14) comprising a housing (16) composed of a first housing part (18) and a second housing part (20) fixedly connected to the first housing part (18), the two housing parts (18, 20) forming a substantially tight housing chamber (22), a pyrotechnic charge (24) received in the housing chamber (22) as well as an electric ignition unit (26) for triggering of the pyrotechnic charge (24), wherein the electric ignition unit (26) extends from outside of the housing chamber (22) through the first housing part (18) into the housing chamber (22), and wherein the housing (16) includes a housing chamber portion (28) to which the pyrotechnic charge (24) is directly adjacent and includes a contact portion (30) for fastening the retaining means (12). Moreover the invention also comprises an airbag module of a vehicle safety system including such actuator assembly (10).

Abstract: A pyrotechnical igniter (100) for an inflator of a vehicle safety system comprises at least two contact pins (102) physically separated from each other by an electrically insulating compound and a bridge wire (110) connected to both contact pins (102) in an electrically conducting manner. A fastening portion (112) in which the bridge wire (110) is welded to the contact pins (102) is provided at each of the contact pins (102).

Abstract: A method for producing a series of base lenses, which cover a predetermined power range, wherein each base lens of the series has a base power different from the base powers of the other base lenses of the series, and has at least one diffractive base grating, the method comprising: specifying the base powers of each base lens of the series; and calculating the base grating of each base lens of the series so as to minimize the color fringe of the respective base lens with the specified base power in a predetermined region of the spectacle lens.

Abstract: A computer-implemented method and a device for optimizing an optical element comprising at least one diffraction grating, wherein at least one refractive surface contributing to the refractive light deflection and/or the at least one diffraction grating of the optical element are/is optimized in such a way as to minimize the color fringe and at least a second-order aberration of the optical element. Also, a corresponding production method and a corresponding device for producing an optical element comprising at least one diffraction grating.

Abstract: A gearbox arrangement (1), which is arranged in a drive train of a multi-axle land vehicle (2), in particular a commercial vehicle, or a similar means of transportation, wherein at least one of said axles is driven, wherein at least one planetary drive (8) is associated with each of the axle halves (5) of a driven axle. The gearbox arrangement comprises at least one sensor device (7) for detecting a steering manipulation on the vehicle (2) and a control device (6).

Abstract: A module for a tester for the testing of circuit boards is described. Such testers have a basic grid on which an adapter and/or a translator may be arranged in order to connect contact points of the basic grid with circuit board test points of a circuit board to be tested. The module comprises a support plate and a contact board. The contact board is formed by a rigid circuit board section which is described as the basic grid element, and at least one flexible circuit board section. Provided on the basic grid element are contact points which each form part of the contact points of the basic grid. The basic grid element is mounted at an end face of the support plate, and the flexible circuit board section is bent in such a way that at least part of the other section of the contact board is parallel to the support plate.

Abstract: A method for automatic sleeve filling of a winding shaft on roll cutting and winding machines is provided in which, in an exemplified embodiment, in a first step at least two empty winding sleeves are slid onto a free end of a winding shaft so that the winding sleeves are adjacent to one another, in a second step the last winding sleeve slid on by a freely positionable fork piece of a freely programmable draw-off plate along the winding shaft is slid over the winding shaft until the last winding sleeve has reached a predetermined position, in a third step the next-to-last winding sleeve slid on is grasped by tongs freely positionable along the winding shaft and is slid over the winding shaft to the point where in a fourth step the fork piece can dip into the gap produced by the tongs so that the next-to-last winding sleeve is positionable along the winding shaft by the fork piece.

Abstract: The invention relates to a method for the production of a eukaryotic cell selectable by inactivation or reduction of an endogenous gene function, comprising the steps of (a) introduction of one or more vectors into the cell and (b) expression of a siRNA and preferably shRNA coded by the one or more vectors, directed against an endogenous selectable gene and inactivating same, said siRNA or shRNA being the transcription product of an RNAi selection cassette, the selection cassette comprising a section of at least 19 nucleotides of the transcribed region of the gene, said selection being operatively linked to a promoter and a transcription termination signal.

Abstract: The present invention relates to 1-aza-bicycloalkyl derivatives of Formula (I); wherein the substituents are as defined in the specification, to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them. Formula (I), wherein A represents O or N(R1); Y represents a group of formula, or wherein the left bond is attached to the A group and the right bond is attached to the R group; R represents a substituted or unsubstituted C5-C10aryl, substituted or unsubstituted hetero-C5-C10aryl, a group N(R1)(R4), or a group N(R2)(CHP3R4); R represent a hydrogen, C1-C4alkyl, or CF3; R2 represents hydrogen, C1-C4alkyl, or CF3; R3 represents hydrogen, C1-C4alkyl, or CF3; R4 represents a substituted or unsubstituted C5-C10 aryl or a substituted or unsubstituted C5-C10heteroaryl; in free base or acid addition salt form.

Abstract: Silicatein is an enzyme of silicate-forming organisms used for the synthesis of their silicate scaffold. The present invention relates to the use of highly-expressed and highly active recombinant silicatein, silicatein isolated from natural sources after gene induction as well as silicatein-fusion proteins for the synthesis of amorphous silicon dioxide (silicic acids and silicates), siloxanes as well as modification of these compounds and their technical use.

Abstract: The invention relates to compounds of formula (I) Wherein R1, R2, R3, R4 and n are as defined in the specification, to processes for their manufacture, to their use as pharmaceuticals, in diagnosis, as PET ligands and to pharmaceutical or diagnostic compositions comprising such compounds.

Abstract: A method of producing a progressive spectacle glass by defining an ordering value for the average use value in the far reference point of the progressive spectacle glass, calculating the progressive spectacle glass while taking into account a calculation value of the average use value in the far reference point, the calculation value having a negative desired refraction deviation between 0.03 dpt and 0.2 dpt with respect to the ordering value in the far reference point, and producing the calculated progressive spectacle glass.