Abstract: A closure for a container has an upper part (1) that can be connected to the container. The upper part (1) has an opening (2) and an outer hollow body (3). An inner hollow body (4) is arranged coaxially in the outer hollow body (3) with an intermediate space therebetween. A lower part (7) in the form of a hollow body can be displaced longitudinally in the intermediate space. A plug (5) is held coaxially in the lower part (7) and opens or closes the opening as the lower part (7) is displaced longitudinally in the intermediate space.

Abstract: A stirrer for a bioreactor has first and second opposed mountings fastened to the inner surfaces of opposite walls of the bioreactor and disposed along a common rotational axis. A first arm has an end connected to the first mounting for rotation about the rotational axis and for pivoting about a first pivot axis that is transverse to the rotational axis. A second arm has an end connected to the second mounting for rotation about the rotational axis and for pivoting about a second pivot axis that is transverse to the rotational axis. Ends of the arms are coupled for pivoting about at least one additional pivot axis that is transverse to the rotational axis.

Abstract: A dosing system and a method for dosing a medium, having a dosing control unit (4), at least one exchangeable container (2) containing a medium to be dosed, and a dosing valve (3, 3?) that can be connected to the container (2), wherein at least one part of the dosing valve (3, 3?) that comes into contact with the medium is designed as an exchangeable system component (7, 10) and has a machine-readable code for identification purposes, wherein at least one container (2), as an exchangeable system component (2), has a machine-readable code for identification purposes, wherein the exchangeable parts (2, 7, 10, 19) that come into contact with the medium are designed as disposable parts, and wherein the dosing control unit (4) is connected with a communication unit (5) to read the codes, and wherein the communication unit (5) has a unique read connection (22) to each exchangeable system component (2, 7, 10, 19) or its code.

Abstract: A system for use in freezing, thawing, transporting or storing biopharmaceutical materials which includes a container, a holder and plurality of heat transfer members. The container is configured to hold biopharmaceutical materials therein. The holder has a cavity for receiving the container and includes an interior surface bounding the cavity. A plurality of pockets contact outer surfaces of the container and is received in the cavity. Each pocket of the plurality of pockets includes a pocket cavity. A heat transfer member actively controls the temperature of biopharmaceutical materials held in the container and is received in the pocket cavity.

Abstract: A system for use in freezing, thawing, transporting or storing biopharmaceutical materials which includes a container, a holder and plurality of heat transfer members. The container is configured to hold biopharmaceutical materials therein. The holder has a cavity for receiving the container and includes an interior surface bounding the cavity. A plurality of pockets contact outer surfaces of the container and is received in the cavity. Each pocket of the plurality of pockets includes a pocket cavity. A heat transfer member actively controls the temperature of biopharmaceutical materials held in the container and is received in the pocket cavity.

Abstract: Device for fastening a sensor on containers with a flexible container wall, in particular mixing bags, comprising a sensor support which is fitted with a sensor, bears against an inner wall of the container wall at least with a rear subsurface averted from the sensor, and is guided with a central piece through an opening in the container wall in which the sensor support is fixed on the container wall by a clamping part which can be connected to the central piece, in which the container wall is clamped between the rear subsurface of the sensor support and on a bearing surface, facing an outer wall of the container, of the clamping part, and in which the rear subsurface bears sealingly against the inner wall of the container wall. The sensor support can also have an electronic or optical transmit unit which is connected to the sensor, in which case the transmit unit communicates in a wireless fashion with a receive unit arranged outside the container.

Abstract: Bioreactor with a vessel having at least one gas dissipation duct for gas discharge, the orifice of the gas dissipation duct being connected to a hydrophobic sterile filter and to a condenser arranged between them and having condensation surfaces, a turbulence generator for generating a turbulent flow is arranged in the gas dissipation duct in the region of the condenser.

Abstract: A mixing system has a single-use container (1) with flexible walls and a mixing device. The mixing device has at least one encapsulated drive (5) and a mixer shaft (3). The drive (5) can be disposed of after use together with the mixer shaft (3) and the single-use container (1). The mixing system can be used in biotechnology and the pharmaceutical industry for mixing liquids, dissolving solids or cultivating cells and microorganisms.

Abstract: A mixing system has a container with flexible walls (1), a fluid-tight drive space (6) and a mixing device. The container with flexible walls (1) has at least one head plate (5). The fluid-tight drive space (6) is outside of the container interior (2), and is enclosed by the head plate (5) and a cap (7) attached to the head plate (5). The mixing device has a stirrer shaft (3), onto which stirrer elements (4, 4?) are attached. The stirrer shaft (3) is guided from the container interior (2) through an opening in the head plate (5) and the section of the stirrer shaft (3) in the drive space (6) is guided by bearings (9, 10). A seal (8) is fit into the opening of the head plate, and encloses the stirrer shaft (3) and seals the container interior (2) from the drive space (6).

Abstract: A mixing vessel includes a flexible container, elements for mixing its contents, aeration elements, a drain/lower bearing port having a rigid flange provided with a drain passage, attached in a tight manner to the lower portion of the container wall, supporting a lower bearing that is adjacent to the drain passage. The vessel includes an extended element for dispensing aeration gas and is spaced essentially radially from the drain/bearing port; at least one tubular element for dispensing aeration gas extends from the extended dispensing element, in the inside space, along the inside surface of the lower portion and the side portion of the wall of the container and extends on the outside of the container from the upper portion; at least one mixing element is spaced essentially from the lower portion of the container wall, from the lower bearing, and from at least one extended element for dispensing aeration gas.

Abstract: A method of mixing including providing a flexible container which comprises at least two components, assembling the components from outside the flexible container to form a centrally disposed magnetic driven shaft with at least one impeller, whereby the integrity of the flexible container is maintained, filling the flexible container having the centrally disposed magnetic driven shaft with one or more ingredients of the contents to be mixed; engaging a magnetic element of the centrally disposed magnetic driven shaft with an external magnetic drive element; analyzing the contents of the flexible container using at least one sensor or a sampling line on the flexible container; and draining the contents of the flexible container through a drain port at the bottom of the flexible container.

Abstract: A disposable mixing vessel comprising a flexible container, a centrally disposed shaft having first and second ends with one or more impellers thereon and a magnetic element associated with a first shaft end, a first flange adapted to rotatably engage the first shaft end and a second flange adapted to rotatably engage the second shaft end.

Abstract: A hose system has a pump hose with a hose portion insertable into a pump head of a hose pump. The hose portion has at least a first stop element fixing the hose portion in the feed direction. The first stop element can subsequently be connected immovably to the pump hose at a predefinable position of the pump hose. Thus, the pump hose can be used more universally and can be adapted to different pump heads.

Abstract: A bioreactor (1) having a container (2), a shaft housing (3) for guiding a shaft (5) through a wall (7), a stirrer (6) connected to the shaft (5) in the interior (9) of the container (2), and a drive (4) arranged outside the container (2) and connectable to the shaft (5). The shaft (5) is mounted in the shaft housing (3) via at least one ball bearing (23) and is sealed in relation to the shaft housing (3) by at least one seal (11, 20). The seal (11, 20) is configured as a radial shaft seal (28) having two sealing lips (30, 31) that are arranged one behind the other in the longitudinal direction of the shaft (5) and are able to run on the shaft (5) without lubricant.

Abstract: The invention relates to a filtration system and method for carrying out a process for the filtration of fluids, comprising at least one filtration device with at least one filtration element comprising readable data and a check and/or test apparatus to which the filtration device may be connected, by means of data and testing means lines. The check and/or testing device is connected to a process controller, by data exchange means, for regulation and control of the filtration process and the process controller is connected to a filtration databank, by means of data exchange means, which comprises data sets for at least one filter element and/or for each filtration device and/or for the filtration process. The invention further relates to a computer program product for carrying out a filtration process on fluids whereby program components may be called up from a program memory which support the carrying out of the filtration process.

Abstract: The invention relates to a waste gas system for bioreactors having a hydrophobic sterile filter, arranged at the end, and a heat exchanger which protects the sterile filter against blocking by liquid media. The gas outflow duct for discharging waste gas from a bioreactor vessel is divided in a cooling zone of the heat exchanger into a multiplicity of subducts and is extended in a heating zone of the heat exchanger to a calming zone. Due to the multiplicity of subducts, a considerably larger surface area for the removal of heat from the waste gas is available, with the result that in the case of laminar flow of the waste gas through the subducts a high effectiveness of the separation of liquids from the waste gas can be achieved.

Abstract: A filter cartridge unit including a first end plate, at least one second end plate, and a filter cartridge that is arranged between the end plates. The filter cartridge is connected, in a form-fitting and fluid-tight manner, to its adjacent end plates in a circumferential subarea of contact surfaces thereof using an adhesive.

Abstract: A connector system (10) for producing a sterile connection includes a fluid conduit (32), an engagement device (14, 22) designed to engage with a complementary engagement device (16, 24) of a complementary connector (12), a displacement device (26) with a substantially plane displacement surface (30) and a fluid conduit aperture (60) which extends through the displacement surface (30) and is connected to the fluid conduit (32), with the displacement device (26) being designed to displace the connector (12) and the complementary connector (12) relative to one another in a displacement direction (40) after the engagement device (14, 22) has engaged with the complementary engagement device (16, 24), and with the displacement direction (40) being substantially parallel to the displacement surface (30), and a sterile cover device (20, 74) designed to cover at least the fluid conduit aperture (60) in a sterile manner.

Abstract: A connector (10) is provided for sterile connection to a complementary connector (12). The connector (10) has a housing (14) with an engagement device (16) to engage a complementary engagement device (18) of the complementary connector (12) along an engagement direction (44). The connector (10) is displaceable relative to the complementary connector (12) along the engagement direction (44) after the engagement device (16) engages the complementary engagement device (18). The housing (14) has a feed-through opening (24) for receiving a sensor (34) and a cover (22). The cover (22) is displaced relative to the connector (10) along the engagement direction (44) to close the feed-through opening (24) in a sterile manner. The connector (10) also has a sterile sensor (34) that is movable along a sensor displacement direction (52) that differs from the engagement direction (44).

Abstract: Device for fastening a sensor on containers with a flexible container wall, in particular mixing bags, comprising a sensor support which is fitted with a sensor, bears against an inner wall of the container wall at least with a rear subsurface averted from the sensor, and is guided with a central piece through an opening in the container wall in which the sensor support is fixed on the container wall by a clamping part which can be connected to the central piece, in which the container wall is clamped between the rear subsurface of the sensor support and on a bearing surface, facing an outer wall of the container, of the clamping part, and in which the rear subsurface bears sealingly against the inner wall of the container wall. The sensor support can also have an electronic or optical transmit unit which is connected to the sensor, in which case the transmit unit communicates in a wireless fashion with a receive unit arranged outside the container.