Patents by Inventor Werner Skuballa

Werner Skuballa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TETRAHYDRONAPHTHALENYLAMIDES, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20080200519
    Abstract: The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
    Type: Application
    Filed: February 15, 2008
    Publication date: August 21, 2008
    Inventors: Markus BERGER, Hartmut Rehwinkel, Heike Schacke, Ekkehard May, Werner Skuballa, Hermann Kunzer
  • Epothilone derivatives, method for producing same and their pharmaceutical use
    Patent number: 7407975
    Abstract: This invention relates to the new epothilone derivatives of general formula I, in which substituents Y, Z, R2a, R2b, R3, R4a, R4b, D-E, R5, R6, R7, R8 and X have the meanings that are indicated in more detail in the description. The new compounds interact with tubulin by stabilizing microtubuli that are formed. They are able to influence the cell-splitting in a phase-specific manner and are suitable for treating malignant tumors, for example, ovarian, stomach, colon, adeno-, breast, lung, head and neck carcinomas, malignant melanomas, acute lymphocytic and myelocytic leukemia. In addition, they are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases (psoriasis, arthritis). To avoid uncontrolled proliferation of cells and for better compatibility of medical implants, they can be applied or introduced into polymer materials.
    Type: Grant
    Filed: August 10, 1998
    Date of Patent: August 5, 2008
    Assignee: Bayer Schering Pharma AG
    Inventors: Ulrich Klar, Wolfgang Schwede, Werner Skuballa, Bernd Buchmann
  • MULTIPLY-SUBSTITUTED TETRAHYDRONAPHTHALENE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS
    Publication number: 20080153859
    Abstract: The invention relates to multiply-substituted tetrahydronaphthalene derivatives of formula (I) process for their production and their use as anti-inflammatory agents.
    Type: Application
    Filed: February 25, 2008
    Publication date: June 26, 2008
    Inventors: Hartmut Rehwinkel, Stefan Baeurle, Markus Berger, Norbert Schmees, Heike Schaecke, Konrad Krolikiewicz, Anne Mengel, Duy Nguyen, Stefan Jaroch, Werner Skuballa
  • NOVEL CHIRAL HEPTYNE DERIVATIVES FOR THE PREPARATION OF EPOTHILONES AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20080108838
    Abstract: The invention relates to a new synthetic process for the production of key intermediates useful in the synthesis of epothilones or epothilone derivatives, to certain compounds used to produce these key intermediates and to a process to produce said compounds.
    Type: Application
    Filed: December 12, 2007
    Publication date: May 8, 2008
    Inventors: Johannes Platzek, Orlin Petrov, Marc Willuhn, Klaus Graske, Werner Skuballa
  • Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
    Patent number: 7329753
    Abstract: The invention relates to quinoline and isoquinoline derivatives of general formula I and a process for their production, and their use as inflammation inhibitors.
    Type: Grant
    Filed: June 13, 2006
    Date of Patent: February 12, 2008
    Assignee: Schering AG
    Inventors: Stefan Jaroch, Manfred Lehmann, Norbert Schmees, Markus Berger, Hartmut Rehwinkel, Konrad Krolikiewicz, Werner Skuballa, Heike Schaecke, Arndt J. G. Schottelius
  • Chiral heptyne derivatives for the preparation of epothilones and processes for their preparation
    Patent number: 7326798
    Abstract: The invention relates to a new synthetic process for the production of key intermediates useful in the synthesis of epothilones or epothilone derivatives, to certain compounds used to produce these key intermediates and to a process to produce said compounds.
    Type: Grant
    Filed: April 21, 2005
    Date of Patent: February 5, 2008
    Assignee: Schering AG
    Inventors: Johannes Platzek, Orlin Petrov, Marc Willuhn, Klaus Dieter Graske, Werner Skuballa
  • 9-Chloro-15-deoxyprostaglandin derivatives, process for their preparation and their use as medicaments
    Publication number: 20070203096
    Abstract: The present invention relates to 9-chloroprostaglandin derivatives of the general formula I which may be advantageous for the treatment of fertility problems.
    Type: Application
    Filed: November 20, 2006
    Publication date: August 30, 2007
    Applicant: Schering Aktiengesellschaft
    Inventors: Bernd Buchmann, Daryl Faulds, William Guilford, Gernot Langer, Judy Li, Bernhard Lindenthal, Werner Skuballa, Luisella Toschi
  • Substituted pentanols, a process for their production and their use as anti-inflammatory agents
    Patent number: 7238707
    Abstract: The invention relates to substituted pentanols, a process for their production and their use as anti-inflammatory agents.
    Type: Grant
    Filed: October 5, 2004
    Date of Patent: July 3, 2007
    Assignee: Schering AG
    Inventors: Stefan Jaroch, Stefan Baeurle, Markus Berger, Konrad Krolikiewicz, Duy Nguyen, Hartmut Rehwinkel, Norbert Schmees, Werner Skuballa, Heike Schaecke
  • Method for producing c1-c15 fragments of epothilones and the derivatives thereof
    Publication number: 20070142675
    Abstract: This invention describes a process for the production of C1-C15-fragments of epothilones and derivatives thereof, in which a C1-C6-fragment is linked with a C7-C12-fragment to a C1-C12-fragment, and the latter then is reacted with a C13-15-fragment to form the C1-C15 initial epothilone product that is to be produced. The thus obtained C1-C15 initial epothilone products can be reacted according to known methods to form the actual active ingredients. In addition, the invention relates to the corresponding C1-C12-fragments.
    Type: Application
    Filed: June 19, 2004
    Publication date: June 21, 2007
    Inventors: Ulrich Klar, Bernd Buchmann, Wolfgang Schwede, Werner Skuballa
  • Tetrahydronaphthalene derivatives, processes for their preparation and their use as antiinflammatory agents
    Publication number: 20070129359
    Abstract: The invention relates to multiply substituted tetrahydronaphthalene derivatives of the formula (I) processes for their preparation and their use as anti-inflammatory agents.
    Type: Application
    Filed: May 1, 2006
    Publication date: June 7, 2007
    Inventors: Christoph Huwe, Werner Skuballa, Duy Nguyen, Heike Schaecke, Wheeseong Lee
  • Lipoxin Aanalogs
    Patent number: 7223798
    Abstract: This invention is directed to lipoxin A4 analogs of the following formula (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: May 29, 2007
    Assignee: Schering Aktiengesellschaft
    Inventors: John G Bauman, William J Guilford, John F Parkinson, Werner Skuballa, Babu Subramanyam
  • Intermediates for the preparation of lipoxin A4 analogs
    Publication number: 20070037864
    Abstract: This invention is directed to lipoxin A4 analogs of the following formula (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.
    Type: Application
    Filed: October 23, 2006
    Publication date: February 15, 2007
    Applicant: Schering Aktiengesellschaft
    Inventors: John Bauman, William Guilford, John Parkinson, Werner Skuballa, Babu Subramanyam
  • Nonsteroidal antiinflammatory agents
    Patent number: 7166592
    Abstract: Compounds of Formula 1 are useful in the treatment of inflammation.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: January 23, 2007
    Assignee: Schering Aktiengesellschaft
    Inventors: Stefan Jaroch, Manfred Lehmann, Norbert Schmees, Bernd Buchmann, Harmur Rehwinkel, Peter Droescher, Werner Skuballa, Konrad Krolikiewicz, Hartwig Hennekes, Heike Schaecke, Arndr Schottelius
  • Nonsteroidal antiinflammatory agents
    Patent number: 7129270
    Abstract: Compounds of Formula 1 are useful in the treatment of inflammation.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: October 31, 2006
    Assignee: Schėring AG
    Inventors: Stefan JaRoch, Manfred Lehmann, Norbert Schmees, Bernd Buchmann, Harmur Rehwinkel, Peter Droescher, Werner Skuballa, Konrad Krolikiewicz, Hartwig Hennekes, Heike Schaecke, Arndr Schottelius
  • 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
    Patent number: 7125893
    Abstract: This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula I in which R1a, R1b, R2a, R3a, R3b, R4, R5, R6, R7, A, Y, D, E, G, Y and Z are as defined in the specification. The compounds are useful in treating malignant tumours, for example, ovarian, stomach, colon, breast, adeno-, head and neck carcinomas, acute lymphocytic and myelocytic leukemia. In addition, these compounds are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases such as psoriasis and arthritis. Methods of use and preparation of the compounds are also described.
    Type: Grant
    Filed: May 1, 2000
    Date of Patent: October 24, 2006
    Assignee: Schering AG
    Inventors: Ulrich Klar, Wolfgang Schwede, Werner Skuballa, Bernd Buchmann, Jens Hoffmann, Rosemarie Lichtner
  • Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
    Publication number: 20060229333
    Abstract: The invention relates to quinoline and isoquinoline derivatives of general formula I and a process for their production, and their use as inflammation inhibitors.
    Type: Application
    Filed: June 13, 2006
    Publication date: October 12, 2006
    Inventors: Stefan Jaroch, Manfred Lehmann, Norbert Schmees, Markus Berger, Hartmut Rehwinkel, Konrad Krolikiewicz, Werner Skuballa, Heike Schaecke, Arndt. Schottelius
  • Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
    Patent number: 7109212
    Abstract: The invention relates to quinoline and isoquinoline derivatives of general formula I and a process for their production, and their use as inflammation inhibitors.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: September 19, 2006
    Assignee: Schering AG
    Inventors: Stefan Jaroch, Manfred Lehmann, Norbert Schmees, Markus Berger, Hartmut Rehwinkel, Konrad Krolikiewicz, Werner Skuballa, Heike Schaecke, Arndt. J. G. Schottelius
  • Novel optically active, heteroaromatic beta-hydroxy esters and processes for their preparation from beta-keto esters and processes for the preparation of these beta-keto esters
    Publication number: 20060148043
    Abstract: The present invention relates to new optically active heteroaromatic ?-hydroxy esters useful in the synthesis of epothilone derivatives, to certain compounds used to produce these intermediates, as well as to processes for their production.
    Type: Application
    Filed: January 3, 2005
    Publication date: July 6, 2006
    Inventors: Johannes Platzek, Ludwig Zorn, Bernd Buchmann, Werner Skuballa
  • 5-Substituted quinoline and isoquinoline derivatives, a process for their production and their use as anti-inflammatory agents
    Publication number: 20060116396
    Abstract: Compounds of general formula (IIa) or (IIb) and their use as pharmaceutical agents.
    Type: Application
    Filed: November 14, 2005
    Publication date: June 1, 2006
    Inventors: Stefan Jaroch, Hartmut Rehwinkel, Heike Schaecke, Norbert Schmees, Werner Skuballa, Jan Huebner, Orlin Petrov, Matthias Schneider, Christian Dinter
  • Novel chiral heptyne derivatives for the preparation of epothilones and processes for their preparation
    Publication number: 20060100442
    Abstract: The invention relates to a new synthetic process for the production of key intermediates useful in the synthesis of epothilones or epothilone derivatives, to certain compounds used to produce these key intermediates and to a process to produce said compounds.
    Type: Application
    Filed: April 21, 2005
    Publication date: May 11, 2006
    Inventors: Johannes Platzek, Orlin Petrov, Marc Willuhn, Klaus Graske, Werner Skuballa