Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z?? (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z?? (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: W—X—Y—Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: A method for managing oilfield water. Oilfield water data is grouped into discrete and non-overlapping groups. Outliers are removed from the data. Features of the remaining data are analyzed to identify most discriminative feature. The data is separated into training data and testing data, and the training data is fit into a model that shows the best precision, accuracy and recall. The model is confirmed using the testing data. Upon confirmation of the accuracy of the model, the model is applied to data for a new proposed oilfield well, and a new proposed project is implemented or disapproved based on a result of the identified model that predicts water production of the new proposed oilfield well.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z??(I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: Techniques are disclosed relating to the execution of a set of program instructions in the background. A parent environment of an application executing on a computer system may receive a request from a first child environment within the parent environment to execute a set of program instructions. The first child environment does not permit the set of program instructions to be executed within the first child environment while the application is backgrounded. In response to the request, the parent environment may spawn a second child environment within the parent environment that permits the set of program instructions to be executed while the application is backgrounded. The parent environment may cause the set of program instructions to be executed within the second child environment and may return a result of the executing to the first child environment.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z5 (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity 10 is implicated.

Abstract: A method for managing oilfield water. Oilfield water data is grouped into discrete and non-overlapping groups. Outliers are removed from the data. Features of the remaining data are analyzed to identify most discriminative feature. The data is separated into training data and testing data, and the training data is fit into a model that shows the best precision, accuracy and recall. The model is confirmed using the testing data. Upon confirmation of the accuracy of the model, the model is applied to data for a new proposed oilfield well, and a new proposed project is implemented or disapproved based on a result of the identified model that predicts water production of the new proposed oilfield well.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z??(I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: The present invention relates to compounds that function as inhibitors and/or degraders of BCDIN3D activity. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCDIN3D activity is implicated.

Abstract: The present disclosure is directed to systems and methods for generating an API caching library using a shared resource file. For example, a method may include: receiving, at a first platform, a shared resource file comprising metadata for declaratively deriving an application programming interface (API) caching library for a native application operating on the first platform and a corresponding application related to the native application for a second platform; parsing the shared resource file to extract the metadata at run-time of the native application; declaratively deriving the API caching library based on the extracted metadata, the declaratively deriving the API caching library comprising creating a plurality of objects that represent respective API endpoints of the API caching library; and executing a function of the native application based on at least one of the API endpoints.

Abstract: The present disclosure is directed to systems and methods for generating an API caching library using a shared resource file. For example, a method may include: receiving, at a first platform, a shared resource file comprising metadata for declaratively deriving an application programming interface (API) caching library for a native application operating on the first platform and a corresponding application related to the native application for a second platform; parsing the shared resource file to extract the metadata at run-time of the native application; declaratively deriving the API caching library based on the extracted metadata, the declaratively deriving the API caching library comprising creating a plurality of objects that represent respective API endpoints of the API caching library; and executing a function of the native application based on at least one of the API endpoints.

Abstract: The present disclosure is directed to systems and methods for testing a hybrid application. For example a method may include: executing a plug-in on a computing device; in response to the executing the plug-in, generating an emulator for testing a hybrid application, the emulator simulating an operating system of a client device such that, during testing, the hybrid application replicates operations of a browser operating on the client device; installing the hybrid application in the emulator; notifying a server that the hybrid application is ready for testing; executing instructions received from the server for testing the hybrid application; and providing results from testing the hybrid application to the server.

Abstract: A method for managing oilfield water. Oilfield water data is grouped into discrete and non-overlapping groups. Outliers are removed from the data. Features of the remaining data are analyzed to identify most discriminative feature. The data is separated into training data and testing data, and the training data is fit into a model that shows the best precision, accuracy and recall. The model is confirmed using the testing data. Upon confirmation of the accuracy of the model, the model is applied to data for a new proposed oilfield well, and a new proposed project is implemented or disapproved based on a result of the identified model that predicts water production of the new proposed oilfield well.

Abstract: Techniques are disclosed relating to the execution of a set of program instructions in the background. A parent environment of an application executing on a computer system may receive a request from a first child environment within the parent environment to execute a set of program instructions. The first child environment does not permit the set of program instructions to be executed within the first child environment while the application is backgrounded. In response to the request, the parent environment may spawn a second child environment within the parent environment that permits the set of program instructions to be executed while the application is backgrounded. The parent environment may cause the set of program instructions to be executed within the second child environment and may return a result of the executing to the first child environment.

Abstract: Techniques are disclosed relating to the execution of a set of program instructions in the background. A parent environment of an application executing on a computer system may receive a request from a first child environment within the parent environment to execute a set of program instructions. The first child environment does not permit the set of program instructions to be executed within the first child environment while the application is backgrounded. In response to the request, the parent environment may spawn a second child environment within the parent environment that permits the set of program instructions to be executed while the application is backgrounded. The parent environment may cause the set of program instructions to be executed within the second child environment and may return a result of the executing to the first child environment.

Abstract: Techniques are disclosed relating to the execution of a set of program instructions in the background. A parent environment of an application executing on a computer system may receive a request from a first child environment within the parent environment to execute a set of program instructions. The first child environment does not permit the set of program instructions to be executed within the first child environment while the application is backgrounded. In response to the request, the parent environment may spawn a second child environment within the parent environment that permits the set of program instructions to be executed while the application is backgrounded. The parent environment may cause the set of program instructions to be executed within the second child environment and may return a result of the executing to the first child environment.

Abstract: Techniques are disclosed relating to providing a web application capable of executing within a particular web browser or a client application native to a client platform. The particular web browser and the client platform support differing sets of features. A server computer system hosts the web application for distributing to instances of the client application. The server computer system receives, from a particular instance of the client application that is executing on a client device that implements the client platform, a request for the web application. The server computer system sends the web application to the particular instance to cause the web application to be executed within the particular instance. Such execution of the web application permits the web application to use at least one feature not supported by the particular web browser.

Abstract: Techniques are disclosed relating to providing a web application capable of executing within a particular web browser or a client application native to a client platform. The particular web browser and the client platform support differing sets of features. A server computer system hosts the web application for distributing to instances of the client application. The server computer system receives, from a particular instance of the client application that is executing on a client device that implements the client platform, a request for the web application. The server computer system sends the web application to the particular instance to cause the web application to be executed within the particular instance. Such execution of the web application permits the web application to use at least one feature not supported by the particular web browser.