Patents by Inventor Wha Bin Im

Wha Bin Im has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ester prodrugs of gamma-lactams and their use
    Patent number: 10329284
    Abstract: Described herein are ester prodrugs of gamma-lactam compounds of Formula (I): or pharmaceutically acceptable salt thereof, and methods of use of such compounds for the treatment of ocular diseases including, among other things, glaucoma and macular degeneration.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: June 25, 2019
    Assignee: ALLERGAN, INC.
    Inventors: Robert M. Burk, Wha Bin Im
  • Quaternary ammonium alkyl esters as stable prodrugs
    Patent number: 9981938
    Abstract: Disclosed herein are compounds according to Formulas 1-12, compositions comprising these compounds, and methods of lowering intraocular pressure (IOP) or causing hair growth, and methods of using the same.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: May 29, 2018
    Assignee: ALLERGAN, INC.
    Inventors: Robert M. Burk, David W. Old, Wha Bin Im, Richard S. Graham, Mu-Lan Lee
  • ESTER PRODRUGS OF GAMMA-LACTAMS AND THEIR USE
    Publication number: 20170298050
    Abstract: Described herein are ester prodrugs of gamma-lactam compounds of Formula (I): or pharmaceutically acceptable salt thereof, and methods of use of such compounds for the treatment of ocular diseases including, among other things, glaucoma and macular degeneration.
    Type: Application
    Filed: October 2, 2015
    Publication date: October 19, 2017
    Inventors: Robert M. Burk, Wha Bin Im
  • QUATERNARY AMMONIUM ALKYL ESTERS AS STABLE PRODRUGS
    Publication number: 20170081304
    Abstract: Disclosed herein are compounds according to Formulas 1-12, compositions comprising these compounds, and methods of lowering intraocular pressure (IOP) or causing hair growth, and methods of using the same.
    Type: Application
    Filed: May 12, 2015
    Publication date: March 23, 2017
    Inventors: Robert M. Burk, David W. Old, Wha Bin Im, Richard S. Graham, Mu-Lan Lee
  • Bicyclic 1,3,4-oxadiazole derivatives as sphingosine-1-phosphate receptors' modulators
    Patent number: 9371296
    Abstract: The present invention relates to bicyclic 1,3,4-oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: June 21, 2016
    Assignee: Allergan, Inc.
    Inventors: Ling Li, Janet A. Takeuchi, Ken Chow, Wha Bin Im, Michael E. Garst
  • BICYCLIC 1,3,4-OXADIAZOLE DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE RECEPTORS' MODULATORS
    Publication number: 20160137616
    Abstract: The present invention relates to bicyclic 1,3,4-oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
    Type: Application
    Filed: November 10, 2015
    Publication date: May 19, 2016
    Inventors: Ling Li, Janet A. Takeuchi, Ken Chow, Wha Bin Im, Michael E. Garst
  • Methods of treating soft tissue defects
    Patent number: 9334262
    Abstract: The specification discloses compositions and methods for treating a soft tissue defect of an individual.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: May 10, 2016
    Assignee: Allergan, Inc.
    Inventors: Dennis E. Van Epps, Guan-Liang Jiang, Wha Bin Im
  • Pyrazole derivatives as sphingosine 1-phosphate (S1P) receptor modulators
    Patent number: 9108993
    Abstract: The present invention relates to pyrazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: August 18, 2015
    Assignee: Allergan, Inc.
    Inventors: Janet A. Takeuchi, Ling Li, Wha Bin Im, Ken Chow
  • Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes
    Patent number: 9090595
    Abstract: Compositions and methods for treating glaucoma are provided. In particular hydrophilic ester prodrugs and their use to reduce central corneal thickening is provided.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: July 28, 2015
    Assignee: Allergan, Inc.
    Inventors: Robert M. Burk, Wha Bin Im
  • Modulators of S1P receptors
    Patent number: 9079864
    Abstract: The present invention relates to novel diphenylethyne derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: July 14, 2015
    Assignee: Allergan, Inc.
    Inventors: Santosh C. Sinha, Smita S. Bhat, Ken Chow, Michael E. Garst, Wha Bin Im
  • Pyrazole azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators
    Patent number: 9062030
    Abstract: The present invention relates to pyrazole azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: June 23, 2015
    Assignee: Allergan, Inc.
    Inventors: Janet A. Takeuchi, Ling Li, Wha Bin Im, Ken Chow
  • Compositions and soft tissue replacement methods
    Patent number: 9005605
    Abstract: The specification discloses compositions and methods for treating a soft tissue defect of an individual.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: April 14, 2015
    Assignee: Allergan, Inc.
    Inventors: Dennis E. Van Epps, Guang-Liang Jiang, Wha Bin Im
  • Substituted pyrazole azetidines as sphingosine receptor modulators
    Patent number: 8987467
    Abstract: The present invention relates to substituted pyrazole azetidines, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
    Type: Grant
    Filed: February 13, 2014
    Date of Patent: March 24, 2015
    Assignee: Allergan, Inc.
    Inventors: Janet A. Takeuchi, Ling Li, Wha Bin Im, Ken Chow
  • Substituted dihydropyrazoles as sphingosine receptor modulators
    Patent number: 8987471
    Abstract: The present invention relates to substituted dihydropyrazoles, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
    Type: Grant
    Filed: February 13, 2014
    Date of Patent: March 24, 2015
    Assignee: Allergan, Inc.
    Inventors: Janet A. Takeuchi, Ling Li, Wha Bin Im, Ken Chow
  • Bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators
    Patent number: 8946195
    Abstract: The present invention relates to novel bicyclic methyl amine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: February 3, 2015
    Assignee: Allergan, Inc.
    Inventors: Janet A. Takeuchi, Ling Li, Wha Bin Im
  • Compositions and soft tissue replacement methods
    Patent number: 8926963
    Abstract: The specification discloses compositions and methods for treating a soft tissue defect of an individual.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: January 6, 2015
    Assignee: Allergan, Inc.
    Inventors: Dennis E. Van Epps, Guang-Liang Jiang, Adam L. Collette, Rebecca L. Horan, Jingsong Chen, Gregory H. Altman, Wha Bin Im
  • 2-THIO-1,3,4-OXADIAZOLES AZETIDINE DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS
    Publication number: 20140363457
    Abstract: The present invention relates to 2-thio-1,3,4-oxadiazoles azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
    Type: Application
    Filed: August 26, 2014
    Publication date: December 11, 2014
    Inventors: Janet A. Takeuchi, Ling Li, Wha Bin Im, Ken Chow
  • Compositions and soft tissue replacement methods
    Patent number: 8900571
    Abstract: The invention relates to compositions comprising a silk fibroin material, adipose tissue and a compound of the structure where X1 and X5 are independently CH or N; X7 is NH, O or S; X8 and X9 are independently CH or N; R13 is an optionally substituted aryl or optionally substituted heteroaryl and R14 is C1-6 alkyl, optionally substituted aryl or optionally substituted heteroaryl. The composition is administered to a site of a soft tissue condition including those of breast tissue. The silk fibroin material can be in the form of a silk hydrogel, a silk film, a silk scaffold, a silk sheet, a silk porous material or a silk fiber. The silk fibroin material can be substantially sericin free.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: December 2, 2014
    Assignee: Allergan, Inc.
    Inventors: Dennis E. Van Epps, Guang-Liang Jiang, Adam L. Collette, Rebecca L. Horan, Jingsong Chen, Gregory H. Altman, Wha Bin Im
  • Compositions and soft tissue replacement methods
    Patent number: 8894992
    Abstract: The invention relates to compositions comprising adipose tissue, a silk fibroin material and a compound of the structure The composition is administered to a site of a soft tissue condition including those of breast tissue. The silk fibroin material can be in the form of a silk hydrogel, a silk film, a silk scaffold, a silk sheet, a silk porous material, a silk fiber or a combination of those materials. The silk material may be substantially sericin free.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: November 25, 2014
    Assignee: Allergan, Inc.
    Inventors: Dennis E. Van Epps, Guang-Liang Jiang, Adam L. Collette, Rebecca L. Horan, Jingsong Chen, Gregory H. Altman, Wha Bin Im
  • Compositions and soft tissue replacement methods
    Patent number: 8889123
    Abstract: The invention relates to compositions comprising a hydrogel material that comprises a glycosaminoglycan polymer, adipose tissue and a compound of the structure where X1 and X5 are independently CH or N; X7 is NH, O or S; X8 and X9 are independently CH or N; R13 is an optionally substituted aryl or optionally substituted heteroaryl and R14 is C1-6 alkyl, optionally substituted aryl or optionally substituted heteroaryl. The composition is administered to a site of a soft tissue condition including those of breast tissue. The hydrogel material can be porous or of solid particles. The glycosaminoglycan polymer can be a hyaluronan polymer.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: November 18, 2014
    Assignee: Allergan, Inc.
    Inventors: Dennis E. Van Epps, Guang-Liang Jiang, Wha Bin Im