Patents by Inventor Wilhelm Haas

Wilhelm Haas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220018847
    Abstract: In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.
    Type: Application
    Filed: July 28, 2021
    Publication date: January 20, 2022
    Applicants: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: Craig Braun, Wilhelm Haas, Steven P. Gygi, Gregory H. Bird, Loren D. Walensky, Martin Helmut Wuhr, Brian K. Erickson
  • Patent number: 11169155
    Abstract: In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: November 9, 2021
    Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: Craig Braun, Wilhelm Haas, Steven P. Gygi, Gregory H. Bird, Loren D. Walensky, Martin Helmut Wuhr, Brian K. Erickson
  • Patent number: 11105810
    Abstract: In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: August 31, 2021
    Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: Craig Braun, Wilhelm Haas, Steven P. Gygi, Gregory H. Bird, Loren D. Walensky, Martin Helmut Wuhr, Brian K. Erickson
  • Patent number: 10958264
    Abstract: A circuit system for controlling an electrical consumer, the circuit system including an up-down counter, and the circuit system being configured to generate a control signal for controlling the electrical consumer, in particular for shutting off the electrical consumer, as a function of a counter content of the up-down counter. The circuit system includes a controllable clock divider circuit, with the aid of which the circuit system is configured to predefine a counting direction and a counting speed of the up-down counter as a function of at least one variable characterizing an actual current and/or a nominal current of the electrical consumer.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: March 23, 2021
    Assignee: Robert Bosch GmbH
    Inventors: Yannick Chauvet, Federico Ignacio Sanchez Pinzon, Johannes Zondler, Michael Wilhelm Haas
  • Publication number: 20200225242
    Abstract: The disclosure features methods of identifying specific drug candidates for disease treatment, the methods including: for pairs of associated expressed proteins in a protein-protein interaction network for a plurality of biological samples, comparing relative concentration values of the associated proteins in each of the biological samples to identify outliers among a distribution of the relative concentration values, identifying a set of proteins involved in dysregulated protein-protein interactions in the network based on the outliers, and predicting an efficacy of one or more drug candidates from among a set of drug candidates for treating a disease based on the identified set of proteins and information about one or more of proteins, protein complexes, biological pathways, and functional modules targeted by the set of drug candidates.
    Type: Application
    Filed: August 23, 2018
    Publication date: July 16, 2020
    Inventors: Wilhelm Haas, Cyril Benes
  • Publication number: 20200174007
    Abstract: In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.
    Type: Application
    Filed: November 22, 2019
    Publication date: June 4, 2020
    Applicants: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: Craig Braun, Wilhelm Haas, Steven P. Gygi, Gregory H. Bird, Loren D. Walensky, Martin Helmut Wuhr, Brian K. Erickson
  • Patent number: 10642259
    Abstract: A method for operating a control unit of a motor vehicle including a function unit and a monitoring unit which have a communication connection to one another. In a first check, the function unit is checked for errors, an error of the function unit being inferred if an error counter reaches a threshold value, and the monitoring unit and the function unit exchange first data with one another. In the event of a correct exchange of the first data, a positive change of the error counter is carried out. Otherwise, a negative change of the error counter is carried out. In a second check, the monitoring unit and the function unit exchange second data with one another. In the event of an incorrect exchange of the second data, a negative change of the error counter and a negative change of the threshold value are carried out.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: May 5, 2020
    Assignee: Robert Bosch GmbH
    Inventors: Michael Wilhelm Haas, Jochen Huber, Wolfgang Haag
  • Publication number: 20190391187
    Abstract: A circuit for monitoring a supply voltage for an electronic device. The circuit includes a first reference voltage source, which generates a first reference voltage; a comparison device, which compares the first reference voltage with the supply voltage; a voltage regulator for regulating the supply voltage, the first reference voltage serving as a reference for the voltage regulator and the output voltage of the voltage regulator which supplies at least the comparison device a second reference voltage source, which generates a second reference voltage; and at least one comparator, which compares the output voltage of the voltage regulator with the second reference voltage.
    Type: Application
    Filed: January 8, 2018
    Publication date: December 26, 2019
    Inventors: Alexander Barner, Federico Ignacio Sanchez Pinzon, Michael Wilhelm Haas, Uwe Lueders
  • Publication number: 20190190509
    Abstract: A circuit system for controlling an electrical consumer, the circuit system including an up-down counter, and the circuit system being configured to generate a control signal for controlling the electrical consumer, in particular for shutting off the electrical consumer, as a function of a counter content of the up-down counter. The circuit system includes a controllable clock divider circuit, with the aid of which the circuit system is configured to predefine a counting direction and a counting speed of the up-down counter as a function of at least one variable characterizing an actual current and/or a nominal current of the electrical consumer.
    Type: Application
    Filed: July 31, 2017
    Publication date: June 20, 2019
    Inventors: Yannick Chauvet, Federico Ignacio Sanchez Pinzon, Johannes Zondler, Michael Wilhelm Haas
  • Patent number: 10145818
    Abstract: Embodiments are directed to a method, a computer readable medium encoded with instructions that, when executed, perform a method, and a system for performing mass spectrometry analysis. Molecules of different samples may be labeled with a chemical tag, allowing a multiplexed analysis of multiple samples. The labeled molecules may be fragmented, each fragmented molecule creating at least two separate ions. The relative abundance of each of the heavier ions, which may comprise the original molecule from the sample, may be measured. A relative abundance of the labeled molecules in each of the samples may be determined from the measured relative abundances of the heavier ions.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: December 4, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Martin Helmut Wuhr, Steven P. Gygi, Wilhelm Haas, Graeme Conrad McAlister, Leonid Peshkin, Ramin Rad, Marc W. Kirschner
  • Publication number: 20180321669
    Abstract: A method for operating a control unit of a motor vehicle including a function unit and a monitoring unit which have a communication connection to one another. In a first check, the function unit is checked for errors, an error of the function unit being inferred if an error counter reaches a threshold value, and the monitoring unit and the function unit exchange first data with one another. In the event of a correct exchange of the first data, a positive change of the error counter is carried out. Otherwise, a negative change of the error counter is carried out. In a second check, the monitoring unit and the function unit exchange second data with one another. In the event of an incorrect exchange of the second data, a negative change of the error counter and a negative change of the threshold value are carried out.
    Type: Application
    Filed: November 7, 2016
    Publication date: November 8, 2018
    Inventors: Michael Wilhelm Haas, Jochen Huber, Wolfgang Haag
  • Publication number: 20180209985
    Abstract: In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.
    Type: Application
    Filed: June 3, 2016
    Publication date: July 26, 2018
    Applicants: President and Fellows of Harvard College, Dana-Faber Cancer Institute, Inc.
    Inventors: Craig Braun, Wilhelm Haas, Steven P. Gygi, Gregory H. Bird, Loren D. Walensky, Martin Helmut Wuhr, Brian K. Erickson
  • Publication number: 20170082634
    Abstract: The disclosure features methods of identifying protein-protein deregulation that include: generating a basal protein-protein interaction network for a plurality of biological samples, the network featuring a set of proteins expressed in the biological samples and concentrations of each member of the set of expressed proteins in each of the biological samples; identifying two associated expressed proteins in the network; for the two associated expressed proteins, comparing correlated relative concentration values of the two proteins in each of the biological samples to identify outliers among a distribution of the relative concentration values; and identifying members of the plurality of biological samples in which deregulation of the two associated expressed proteins occurs based on the outliers.
    Type: Application
    Filed: July 21, 2016
    Publication date: March 23, 2017
    Inventor: Wilhelm Haas
  • Patent number: 9437407
    Abstract: A method of performing a mass spectrometry analysis includes labeling each of a plurality of samples with a corresponding chemical tag; forming a first plurality of ions from molecules in the samples; selecting a subset of the first plurality of ions, the subset being selected by isolating ions of the first plurality of ions in a plurality of ranges of mass-to-charge; forming a second plurality of ions by fragmenting ions in the subset; and measuring information indicative of a quantity of each of the plurality of chemical tags present in each of the plurality of samples.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: September 6, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: Graeme Conrad McAlister, Wilhelm Haas, Steven P. Gygi
  • Publication number: 20150293058
    Abstract: Embodiments are directed to a method, a computer readable medium encoded with instructions that, when executed, perform a method, and a system for performing mass spectrometry analysis. Molecules of different samples may be labeled with a chemical tag, allowing a multiplexed analysis of multiple samples. The labeled molecules may be fragmented, each fragmented molecule creating at least two separate ions. The relative abundance of each of the heavier ions, which may comprise the original molecule from the sample, may be measured. A relative abundance of the labeled molecules in each of the samples may be determined from the measured relative abundances of the heavier ions.
    Type: Application
    Filed: October 22, 2013
    Publication date: October 15, 2015
    Applicant: President and Fellows of Harvard College
    Inventors: Martin Helmut Wuhr, Steven P. Gygi, Wilhelm Haas, Graeme Conrad McAlister, Leonid Peshkin, Ramin Rad, Marc W. Kirschner
  • Publication number: 20130334414
    Abstract: A method of performing a mass spectrometry analysis includes labeling each of a plurality of samples with a corresponding chemical tag; forming a first plurality of ions from molecules in the samples; selecting a subset of the first plurality of ions, the subset being selected by isolating ions of the first plurality of ions in a plurality of ranges of mass-to-charge; forming a second plurality of ions by fragmenting ions in the subset; and measuring information indicative of a quantity of each of the plurality of chemical tags present in each of the plurality of samples.
    Type: Application
    Filed: May 23, 2013
    Publication date: December 19, 2013
    Inventors: Graeme Conrad McAlister, Wilhelm Haas, Steven P. Gygi
  • Patent number: 7012041
    Abstract: The invention relates to novel phenylpyridazinones of the general formula (I) in which R1, R2, R3, R4, R5 and R6 are each as defined in the description, to processes for their preparation, to their use as herbicides and to novel intermediates and processes for preparing them.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: March 14, 2006
    Assignee: Bayer AG
    Inventors: Karl-Heinz Linker, Kurt Findeisen, Wilhelm Haas, Markus Dollinger, Hans-Joachim Santel
  • Patent number: 6841517
    Abstract: The invention relates to novel herbicidal synergistic active compound combinations comprising on the one hand known N-aryl-triazolin(ethi)ones and on the other hand known herbicidally active compounds and/or compounds which improve crop plant compatibility and which can be used with particularly good results for the selective control of weeds in various crops of useful plants.
    Type: Grant
    Filed: September 18, 2000
    Date of Patent: January 11, 2005
    Assignee: Bayer Aktiengesellschaft
    Inventors: Dieter Feucht, Mark Wilhelm Drewes, Peter Dahmen, Birgit Krauskopf, Mathias Kremer, Rolf Pontzen, Arndt Wellmann, Wilhelm Haas
  • Publication number: 20030119673
    Abstract: The invention relates to novel phenylpyridazinones of the general formula (I) 1
    Type: Application
    Filed: September 30, 2002
    Publication date: June 26, 2003
    Inventors: Karl-Heinz Linker, Kurt Findeisen, Wilhelm Haas, Markus Dollinger, Hans-Joachim Santel
  • Patent number: RE39263
    Abstract: There is disclosed substituted thiocarboxamides of the general formula (I) useful as herbicides.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: September 5, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Karl-Heinz Linker, Kurt Findeisen, Roland Andree, Mark-Wilhelm Drewes, Andreas Lender, Otto Schallner, Wilhelm Haas, Hans-Joachim Santel, Markus Dollinger