Patents by Inventor Wilhelmus Franciscus Johannes Verhaegh

Wilhelmus Franciscus Johannes Verhaegh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240164718
    Abstract: A system includes a monitoring device including an accelerometer, an on-board electronic processor, and a wireless transmitter or transceiver. The monitoring device configured to be attached to a patient and the accelerometer configured to measure accelerometer data. The on-board electronic processor of the monitoring device performs a health status monitoring method including analyzing the accelerometer data to determine respiration rate data for the patient or an indication that respiration rate data cannot be determined from the accelerometer data; determining whether the monitoring device is attached to the patient based at least on the whether the analyzing determines that respiration rate data cannot be determined; and one of (i) displaying health status information for the patient generated from the accelerometer data and the determined respiration rate data; or (ii) displaying an indication that the monitoring device is not attached to the patient.
    Type: Application
    Filed: November 15, 2023
    Publication date: May 23, 2024
    Inventors: Wilhelmus Franciscus Johannes Verhaegh, Sjoerd Herman Garssen, Cartljin Andrea Vernooij
  • Publication number: 20240105333
    Abstract: The present invention relates to monitoring a patients response to therapy. In order to facilitate monitoring a patients response to therapy, a method is provided to identify groups of trends in each of genetic changes with similar genetic changes over time and to analyse these groups to determine the patients response to therapy.
    Type: Application
    Filed: October 13, 2020
    Publication date: March 28, 2024
    Inventors: Pieter Jan Van Der Zaag, Wilhelmus Franciscus Johannes Verhaegh
  • Patent number: 11908549
    Abstract: The invention relates to a computer-implemented Bayesian inference method for performing Bayesian inference in a Bayesian network, which includes a continuous child node (3) and its discrete parent node (2) having two states. Being provided with a calibrated continuous probability distribution of the observations of the child node (3) for each of the two states of the parent node (2), the inferring for a new observation of the child node (3) for which the state of the parent node (2) is not known of the probability of at least a first state of the parent node (2) makes use of masses of portions of the probability distributions that depend on a locational relationship of the probability distributions and the value of the new observation. This may ensure that the inferred probability of the first state of the parent node (2) monotonically changes with monotonically changing values of the new observation.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: February 20, 2024
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Martijn Theodorus Lambert Akse, Wilhelmus Franciscus Johannes Verhaegh
  • Publication number: 20240052415
    Abstract: The invention relates to a method for characterizing a cell or tissue culture sample based on multiple cellular signaling pathway activities. The cellular signaling pathway activities are preferably determined based on expression levels of target genes of the respective pathways. The invention further describes products useful for the method having primers for the detection of pathway target genes, and uses of the product.
    Type: Application
    Filed: January 27, 2022
    Publication date: February 15, 2024
    Applicant: InnoSIGN B.V.
    Inventors: Wilbert Hendrik BOUWMAN, Wilhelmus Franciscus Johannes VERHAEGH, Anja VAN DE STOLPE
  • Patent number: 11674185
    Abstract: The present application mainly relates to a method for determining a prognosis for a subject diagnosed with high-grade serous ovarian cancer. The method comprises determining the prognosis based on activities of at least two cellular signaling pathways including a phosphatidylinositide 3-kinase (PI3K) pathway and a nuclear factor-kappa B (NFkB or NF?B) pathway in a sample of the subject. The present application also relates to a method for identifying a subject diagnosed with high-grade serous ovarian cancer that will be suitable for a PI3K pathway targeting therapy or an NFkB pathway targeting therapy. The method comprises identifying the subject based on activities of at least two cellular signaling pathways including a PI3K pathway and an NFkB pathway in a sample of the subject. The present application further relates to corresponding apparatuses, non-transitory storage media, computer programs and kits.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: June 13, 2023
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Anja Van de Stolpe, Wilhelmus Franciscus Johannes Verhaegh
  • Patent number: 11649488
    Abstract: A bioinformatics process which provides an improved means to detect a JAK-STAT1/2 cellular signaling pathway in a subject, such as a human, based on the expression levels of at least three unique target genes of the JAK-STAT1/2 cellular signaling pathway measured in a sample. The invention includes an apparatus comprising a digital processor configured to perform such a method, a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and a computer program comprising program code means for causing a digital processing device to perform such a method. Kits are also provided for measuring expression levels of unique sets of JAK-STAT1/2 cellular signaling pathway target genes.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: May 16, 2023
    Assignee: InnoSIGN B.V.
    Inventors: Wilhelmus Franciscus Johannes Verhaegh, Meng Dou, Anja Van De Stolpe, Rick Velter
  • Patent number: 11640845
    Abstract: A bioinformatics method for determining a risk score that indicates a risk that a subject will experience a negative clinical event within a certain period of time. The risk score is based on a combination of activities of two or more cellular signaling pathways in a subject, such as a human, wherein the specific cellular signaling pathways are the PI3K pathway and one or more of a Wnt pathway, an ER pathway, and an HH pathway. The invention also includes an apparatus with a digital processor configured to perform such a method, to a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and to a computer program comprising program code means for causing a digital processing device to perform such a method. The invention achieves advanced prognosis of negative clinical events, for example, disease progression, recurrence, development of metastasis, or even death.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: May 2, 2023
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Hendrik Jan Van Ooijen, Wilhelmus Franciscus Johannes Verhaegh, Anne Godefrida Catharina Van Brussel, Janneke Wrobel, Robert Van Gog
  • Publication number: 20230105263
    Abstract: The present application mainly relates to specific methods for inferring activity of one or more cellular signaling pathway(s) in tissue of a medical subject based at least on the expression level(s) of one or more target gene(s) of the cellular signaling pathway(s) measured in an extracted sample of the tissue of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods.
    Type: Application
    Filed: August 24, 2022
    Publication date: April 6, 2023
    Applicant: InnoSIGN B.V.
    Inventors: WILHELMUS FRANCISCUS JOHANNES VERHAEGH, ANJA VAN DE STOLPE, HENDRIK JAN VAN OOIJEN, KALYANA CHAKRAVARTHI DULLA, MARCIA ALVES DE INDA, RALF HOFFMAN
  • Publication number: 20230030858
    Abstract: The present application mainly relates to specific methods for inferring activity of a cellular signaling pathway in tissue and/or cells of a medical subject based at least on expression levels of one or more target gene(s) of the cellular signaling pathway measured in an extracted sample of the tissue and/or cells of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods.
    Type: Application
    Filed: April 6, 2022
    Publication date: February 2, 2023
    Applicant: InnoSIGN B.V.
    Inventors: Hendrik Jan VAN OOIJEN, Wilhelmus Franciscus Johannes VERHAEGH, Paul Arnold VAN DE WIEL
  • Publication number: 20230028306
    Abstract: The present invention relates to an apparatus (10) for diagnostic image acquisition, comprising: an input unit (20); a processing unit (30); and an output unit (40). The input unit is configured to receive a data value relating to at least one biomarker in a measurement blood sample of a patient. The processing unit is configured to determine a time to acquire a diagnostic image of the patient, wherein the determination comprises utilization of the data value. The output unit is configured to output an indication of the time to acquire the diagnostic image of the patient.
    Type: Application
    Filed: November 17, 2020
    Publication date: January 26, 2023
    Inventors: Pieter Jan van der Zaag, Wilhelmus Franciscus Johannes Verhaegh, Jochen Keupp
  • Patent number: 11443831
    Abstract: The present application mainly relates to specific methods for inferring activity of one or more cellular signaling pathway(s) in tissue of a medical subject based at least on the expression level(s) of one or more target gene(s) of the cellular signaling pathway(s) measured in an extracted sample of the tissue of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: September 13, 2022
    Assignee: InnoSIGN B.V.
    Inventors: Wilhelmus Franciscus Johannes Verhaegh, Anja Van De Stolpe, Hendrik Jan Van Ooijen, Kalyana Chakravarthi Dulla, Marcia Alves De Inda, Ralf Hoffmann
  • Publication number: 20220259666
    Abstract: The present invention relates to a method comprising inferring activity of a PI3K cellular signaling pathway in a tissue and/or cells and/or a body fluid of a medical subject based at least on expression levels of one or more target gene(s) of the PI3K cellular signaling pathway measured in an extracted sample of the tissue and/or the cells and/or the body fluid of the medical subject. The present invention further relates to an apparatus comprising a digital processor configured to perform such a method, a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and a computer program comprising program code means for causing a digital processing device to perform such a method.
    Type: Application
    Filed: January 17, 2022
    Publication date: August 18, 2022
    Inventors: Hendrik Jan VAN OOIJEN, Wilhelmus Franciscus Johannes VERHAEGH, Anja VAN DE STOLPE
  • Patent number: 11306360
    Abstract: The present application mainly relates to specific methods for inferring activity of a cellular signaling pathway in tissue and/or cells of a medical subject based at least on expression levels of one or more target gene(s) of the cellular signaling pathway measured in an extracted sample of the tissue and/or cells of the medical subject, an apparatus comprising a digital compressor configured to perform such methods and a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such methods.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: April 19, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Hendrik Jan Van Ooijen, Wilhelmus Franciscus Johannes Verhaegh, Paul Arnold Van De Wiel
  • Patent number: 11309059
    Abstract: A method for determining a risk score that indicates a risk that a clinical event will occur within a certain period of time. The risk score is based at least in part on a combination of inferred activities of two or more cellular signaling pathways in a tissue and/or cells and/or a body fluid of a subject. The cellular signaling pathways comprise a Wnt pathway, an ER pathway, an HH pathway, and/or an AR pathway. The risk score is defined such that the indicated risk that the clinical event will occur within the certain period of time decreases with an increasing PER and increases with an increasing max(PWnt, PHH), wherein PER, PWnt, and PHH denote the inferred activity of the ER pathway, the Wnt pathway, and the HH pathway, respectively.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: April 19, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Wilhelmus Franciscus Johannes Verhaegh, Hendrik Jan Van Ooijen, Anja Van De Stolpe, Marcia Alves De Inda
  • Patent number: 11261495
    Abstract: The present invention relates to a method comprising inferring activity of a PI3K cellular signaling pathway in a tissue and/or cells and/or a body fluid of a medical subject based at least on expression levels of one or more target gene(s) of the PI3K cellular signaling pathway measured in an extracted sample of the tissue and/or the cells and/or the body fluid of the medical subject. The present invention further relates to an apparatus comprising a digital processor configured to perform such a method, a non-transitory storage medium storing instructions that are executable by a digital processing device to perform such a method, and a computer program comprising program code means for causing a digital processing device to perform such a method.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: March 1, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Jan Hendrik Van Ooijen, Wilhelmus Franciscus Johannes Verhaegh, Anja Van De Stolpe
  • Publication number: 20210158900
    Abstract: A method (100) comprising: (i) providing (104, 106) a reference data set for a first gene expression platform and a training data set for a second platform; (iii) computing (108) a boundary expression level that distinguishes between the subtypes; (iv) generating (1 10) a confusion matrix; (v) determining (112) an effectiveness of the gene markers to discriminate between the subtypes; (vi) filtering (114) any gene marker with an expression level below a threshold or with determined effectiveness below a threshold; (v) calculating (118) a mean and/or median expression level for each subtype, and comparing them to generate an expression level change; (vi) comparing (118) the expression level change to a reference expression level change; and (vii) selecting (120) the gene marker if the generated expression level change and the reference expression level change are changed in the same direction; and (viii) providing (124) the selected gene markers via a user interface.
    Type: Application
    Filed: June 25, 2018
    Publication date: May 27, 2021
    Inventors: Yee Him Cheung, Nevenka Dimitrova, Wilhelmus Franciscus Johannes Verhaegh
  • Publication number: 20200347460
    Abstract: The present application mainly relates to a method for determining a prognosis for a subject diagnosed with high-grade serous ovarian cancer. The method comprises determining the prognosis based on activities of at least two cellular signaling pathways including a phosphatidylinositide 3-kinase (PI3K) pathway and a nuclear factor-kappa B (NFkB or NF?B) pathway in a sample of the subject. The present application also relates to a method for identifying a subject diagnosed with high-grade serous ovarian cancer that will be suitable for a PI3K pathway targeting therapy or an NFkB pathway targeting therapy. The method comprises identifying the subject based on activities of at least two cellular signaling pathways including a PI3K pathway and an NFkB pathway in a sample of the subject. The present application further relates to corresponding apparatuses, non-transitory storage media, computer programs and kits.
    Type: Application
    Filed: May 1, 2020
    Publication date: November 5, 2020
    Inventors: ANJA VAN DE STOLPE, WILHELMUS FRANCISCUS JOHANNES VERHAEGH
  • Publication number: 20200273536
    Abstract: The invention relates to a computer-implemented Bayesian inference method for performing Bayesian inference in a Bayesian network, which includes a continuous child node (3) and its discrete parent node (2) having two states. Being provided with a calibrated continuous probability distribution of the observations of the child node (3) for each of the two states of the parent node (2), the inferring for a new observation of the child node (3) for which the state of the parent node (2) is not known of the probability of at least a first state of the parent node (2) makes use of masses of portions of the probability distributions that depend on a locational relationship of the probability distributions and the value of the new observation. This may ensure that the inferred probability of the first state of the parent node (2) monotonically changes with monotonically changing values of the new observation.
    Type: Application
    Filed: September 21, 2018
    Publication date: August 27, 2020
    Inventors: MARTIJN THEODORUS LAMBERT ASKE, WILHELMUS FRANCISCUS JOHANNES VERHAEGH
  • Publication number: 20200240979
    Abstract: A method for determining functional status of at least one immune cell type in at least one sample of a subject comprises determining the functional status of the at least one immune cell type based on activity of at least one signaling pathway in the at least one immune cell type in the at least one sample of the subject; and optionally providing the functional status of the at least one immune cell type in the at least one sample of the subject.
    Type: Application
    Filed: October 1, 2018
    Publication date: July 30, 2020
    Inventors: ANJA VAN DE STOLPE, ARIE ROMBERTUS VAN DOORN, WILHELMUS FRANCISCUS JOHANNES VERHAEGH, STEVEN PAULUS LAMBERTUS KUIJPERS, MICHAEL VAN HARTSKAMP, HUSSAM NACHABE
  • Publication number: 20190376142
    Abstract: The present invention relates to certain target genes of the FOXO transcription factor family, which are markers for an oxidative stress state and can be used for inferring an oxidative stress state of a FOXO transcription factor element in the body of a medical subject. The invention further relates to methods for inferring an oxidative stress state of a FOXO transcription element and for inferring the activity of the FOXO/PI3K cellular signalling pathway based on expression levels of the target genes as well as products to perform the methods.
    Type: Application
    Filed: November 24, 2017
    Publication date: December 12, 2019
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Anja VAN DE STOLPE, Rick VELTER, Wilhelmus Franciscus Johannes VERHAEGH, Hendrik Jan VAN OOIJEN, Martijn Theodorus Lambert AKSE