Abstract: The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity.

Abstract: A solenoid valve and method has a simplified structure that integrates the fluid metering functions of the spool in the armature, thereby eliminating the need for a separate spool, bearings, and pin in the valve. The armature has a aperture that communicates with at least one port in a valve body. The position of the differential in the armature with respect to the ports in the valve body controls the pressure of fluid exiting the outputs of the valve body. In one embodiment, the same overall valve structure can be modified to form both inversely proportional valves and directly proportional valves. By integrating the fluid metering functions of the spool into a single ported armature, the inventive valve assembly reduces the number of parts in the valve, simplifying construction.

Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.

Abstract: Disclosed is a method, a computer system and a computer readable media product that contains a set of computer executable software instructions for directing the computer system to execute a process for determining a non-replicative behavior of a program that is suspected of containing an undesirable software entity. The process causes execution of the program in at least one known environment and automatically examines the at least one known environment to detect if a change has occurred in the environment as a result of the execution of the program. If a change is detected, the process automatically analyzes the detected change (i.e., the process performs a side effects analysis) to determine if the change resulted from execution of the program or from execution of the undesirable software entity. The process then uses the result of the analysis at least for undoing a detected change that results from execution of the undesirable software entity.

Abstract: A system and method are provided to establish trust between a user and a policy system that generates recommended actions in accordance with specified policies. Trust is introduced into the policy-based system by assigning a value to each execution of each policy with respect to the policy-based system, called the instantaneous trust index. The instantaneous trust indices for each one of the policies, for the each execution of a given policy or for both are combined into the overall trust index for a given policy or for a given policy-based system. The recommended actions are processed in accordance with the level or trust associated with a given policy as expressed by the trust indices. Manual user input is provided to monitor or change the recommended actions. In addition, reinforcement learning algorithms are used to further enhance the level of trust between the user and the policy-based system.

Abstract: Disclosed is a process to produce a purified carboxylic acid product. The process comprises removing impurities from a crude carboxylic acid slurry in a solid-liquid displacement zone to form a slurry product. The slurry product if further treated in a staged oxidation zone and a crystallization zone to from a crystallized product. The crystallized product is further cooled in a cooling zone and subsequently filtered and dried in a filtration and drying zone. The process produces purified carboxylic acid product having good color and low impurity levels without the use of purification steps like hydrogenation.

Abstract: A blister pack may include a first layer, a second layer and a third layer. The first layer may include a hole. The second layer may include an indentation substantially aligned through the hole when the first and second layers are aligned and a second area surrounding the indentation. The third layer, which is in contact with the second layer, may include a third area that is substantially aligned with the second area when the second and third layers are aligned. The indentation may contain a medicament. The blister pack may include adhesives that secure the second layer to the first layer and the third layer. The second and third areas may be scored, cut and/or perforated. When sufficient force is applied to the third area, a blister, including the second and third areas, may be displaced containing the medicament.

Abstract: The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.

Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.

Abstract: A child resistant product dispenser includes a blister card having compartments for holding a product, a housing, and a blister cover for use in covering the blister card compartments. The blister cover may include a dispensing area for each compartment of the blister card. To remove a product from the product dispenser the user presses a dispensing area against either a compartment thereby forcing the product through a frangible area on the blister card and through a frangible area in the housing or against a peelable area on the blister card and a frangible area in the housing. This creates an opening through which the product is removed.

Abstract: The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of AblKD and variants and subsets thereof, including binding pockets, methods of using the structure to identify and design affecters, including inhibitors and activator AblKD crystals and compounds and compositions that affect Abl activity.

Abstract: Apparatus for mixing liquid in a container, comprises a hollow sleeve member for location in the lower regions of the container, a plurality of circumferentially spaced outlets being provided in the upper regions of the sleeve member, pump means for creating a reciprocating flow of liquid applied to the lower regions of the sleeve member, and in the flow path of liquid from the pump means to the sleeve member, a transducer mechanism cooperating with the sleeve member and subjected to the reciprocating flow of liquid such as to rotate the sleeve member about its central longitudinal axis in dependence upon said reciprocating flow.

Abstract: A method for atomizing a fluid wherein a gas is heated with the heating facilitating the acceleration of the gas to a high velocity. The accelerated gas contacts the fluid transferring shear, pressure and inertial forces and heat to the fluid effecting efficient atomization of the fluid.

Abstract: A system for combusting difficult to combust fluid such as waste fluid wherein fuel and gaseous oxidant combust in a hot combustion gas chamber to form a hot combustion gas mixture which is accelerated to a high speed and at a steady, i.e. non-pulsing, flow is then used to atomize and then combust the fluid.

Abstract: A method for atomizing a fluid wherein a gas is heated with the heating facilitating the acceleration of the gas to a high velocity. The accelerated gas contacts the fluid transferring shear, pressure and inertial forces and heat to the fluid effecting efficient atomization of the fluid.

Abstract: A method for facilitating movement of a plurality of nested trollies (including a leading trolley and a trailing trolley), the method comprising the steps of connecting an adjustable ratchet-type tension mechanism between the leading and trailing trolleys, and actuating the tension mechanism so as to produce a preselected tension between the leading and trailing trolleys to thereby hold the nested trolleys tightly together. In the preferred embodiment, the preselected tension is sufficient to upwardly the leading and trailing trolleys off of the ground surface.

Abstract: A method for facilitating movement of a plurality of nested trollies (including a leading trolley and a trailing trolley), the method comprising the steps of connecting an adjustable ratchet-type tension mechanism between the leading and trailing trolleys, and actuating the tension mechanism so as to produce a preselected tension between the leading and trailing trolleys to thereby hold the nested trolleys tightly together. In the preferred embodiment, the preselected tension is sufficient to upwardly the leading and trailing trolleys off of the ground surface.

Abstract: A system for combusting difficult to combust fluid such as waste fluid wherein fuel and gaseous oxidant combust in a hot combustion gas chamber to form a hot combustion gas mixture which is accelerated to a high speed and at a steady, i.e. non-pulsing, flow is then used to atomize and then combust the fluid.

Abstract: A blister package is disclosed that comprises a blister layer having an article receiving blister formed therein for holding medicaments, and a base layer. The blister layer has one or more tearing blisters formed therein and the blister layer is joined to the base layer except in the areas of the article receiving blister and the tearing blisters. The base layer and the blister layer are joined such that opening the blister package to access the medicament requires tearing through one of the tearing blisters and the article receiving blister. The tearing blisters preferably extend from one or more outer edges, which may include the corners, of the blister layer toward said article receiving blister.

Abstract: A self propelled forklift vehicle having a frame formed by two spaced parallel longitudinal frame members and a rear transverse frame member. The fork carriage is movable forwardly and rearwardly on the longitudinal frame members, along the path of the machine, and carries a fork tower and forks. The forks can be forced below the vehicle to raise the vehicle up beneath the rear of a trailer for transport. The vehicle's rear wheels, which steer and drive the vehicle, are closely spaced and tiltable from side to side to allow for rough terrain, with the operator seat and motor on opposite sides thereof to balance each other. A manually operated split pulley drive allows creeping of the vehicle at a closely controlled low speed. The fork tines include erectable rollers to support part of the vehicle weight when the forks carry a forwardly extended load, to prevent tipping. A front gate causes discharge of the contents of a pallet onto the ground when the fork carriage is retracted.