Abstract: An inhaler comprising a housing to receive a strip having a plurality of blisters is disclosed. Each blister has a puncturable lid and contains a dose of medicament for inhalation by a user. A mouthpiece is pivotally mounted to the housing through which a dose of medicament is inhaled by a user. The inhaler also has an actuating mechanism including a lever operable to sequentially move each blister into alignment with a blister piercing member depending from the mouthpiece. The actuating lever is also operable to cause the mouthpiece to pivot so that the blister piercing member punctures the lid of an aligned blister so that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it, via the mouthpiece, into the user's airway.

Abstract: A high-temperature heat resistant elastic composite comprising a porous high molecular-weight silicon polymer and a reinforcing material wherein the silicon polymer comprises a silicon resin, silica and boron oxide catalyzed by the boron oxide to form a reaction mass that is polymerized in acetone and to which the silica and boron nitride are added and wherein pores of silicone polymer are filled with a densification resin blend.

Abstract: The present invention relates to domain antibodies which have modified framework regions such that the potency or level of binding of the domain antibody is improved. In particular the present invention relates to domain antibodies which bind TNFa in which changes have been made to framework sequences and to constructs including these domain antibodies.

Abstract: The present invention provides an antibody comprising an antigen binding domain which binds to human IL-12 and human IL-23. The antibody binds human IL-12p40 existing as a monomer (human IL-12p40) and as a homodimer (human IL-12p80) and the antibody inhibits the binding of human IL-12 to human IL-12R ?2 and human IL-23 to human IL-23R but does not inhibit the binding of human IL-12 or human IL-23 or human IL-12p40 or human IL-12p80 to human IL-12R?1.

Abstract: A process for selectively stripping a coating from a component of a turbomachine, and particularly a coating having a ceramic matrix that contains metallic particles dispersed therein that render the coating more difficult to remove from the component after the component has been subjected to elevated temperatures during operation of the turbomachine. The process generally includes immersing the component in an aqueous solution containing ferric chloride, nitric acid, and phosphoric acid, for a duration sufficient to attack the metallic particles in the coating. The component is then removed from the aqueous solution and its surface rinsed of the aqueous solution. The immersing and removing steps are then sequentially repeated a sufficient number of times to sufficiently attack the metallic particles to enable the coating to be mechanically removed from the component.

Abstract: A dispensing device comprising a housing having an upper loading chamber, a dispensing chamber located beneath the loading chamber and a gate movable between a first, open position and second, closed position to allow selective communication of the loading chamber and the dispensing chamber, entry to the lower chamber being by way of a door, the device further comprising a lock which prevents the door from opening when the gate is in the open position and which prevents opening of the gate, when the door is open.

Abstract: The present invention provides a method for preparing an electroless nickel coating composition that includes (a) coating a substrate with an electroless nickel coating to provide a coated substrate; and (b) subjecting the coated substrate to a heating protocol comprising heating to a temperature in a range from about 550° C. to about 700° C. for a period of from about 7 to about 30 hours. An article made from the method is also provided.

Abstract: A leading edge structure for use in an aerospace vehicle includes a body having a flowpath surface which defines a leading edge adapted to face an air flow during operation; and a metallic icephobic plating comprising nickel applied to at least a portion of the flowpath surface.

Abstract: An inhaler is disclosed. It comprises a housing to receive a strip of blisters each having a puncturable lid and containing a dose of medicament for inhalation by a user, a mouthpiece through which a dose of medicament is inhaled by a user and, an actuator operable to sequentially move each blister into alignment with a blister piercing member. The actuator is also operable to cause the blister piercing element to puncture the lid of a blister such that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it out of the blister and via the mouthpiece into the user's airway.

Abstract: An inhaler (1) is disclosed. It comprises a housing (2) to receive a strip (6) of blisters (6a) each having a puncturable lid (6c) and containing a dose of medicament for inhalation by a user, a mouthpiece through which a dose of medicament is inhaled by a user and, an actuator (3) operable to sequentially move each blister into alignment with a blister piercing member (7, 9). The actuator is also operable to cause the blister piercing element to puncture the lid of a blister such that, when a user inhales through the mouthpiece, an airflow through the blister is generated to entrain the dose contained therein and carry it but of the blister and via the mouthpiece into the user's airway.

Abstract: An Inhaler for delivering an aerosolised dose of a powdered drug for inhalation by a user is disclosed. The inhaler comprises a drug entreinment device to a receive a package having a piercable lid containing a dose to be delivered, the device including a drug outlet tube terminating with a primary piercing element to pierce an opening in said lid when a package is located in the inhaler, a secondary piercing member to pierce a plurality of peripheral openings in said lid and, an airflow path to enable the supply of a charge of gas into the package via said peripheral openings to scour the interior of a pierced package such that all or substantially all of the dose is entrained in the gas and flows out of the package via the drug outlet tube. A medicament pack is also disclosed.

Abstract: This invention describes how a blend of silicon polymers, mixed with the right combination of fillers applied to fiber reinforcement laminated with an embedded circuit and laser cut into vacuum formable preforms enables the production of “red heat” durable flexible ceramic multiple spark ignition devices which are vacuum formed into the head combustion chamber of IC engines for realizing fuel savings from up to 33% increased combustion efficiency. The MSI device also comprises a spark plug which is made with the steel adjustable grounding gap section removed. The spark plug electrode alignment for the fuel injectors is also used to align the spark plug electrode to insert during assembly into the MSI device (see FIG. 1) circuit port. This electrode insertion enables the electrode to arc within the 360° gap of the circuit port setting off the “in series” arcing of the two other electrodes within the surround combustion circuit completing the drop in potential at the ground attachment (see FIG. 1).

Abstract: This invention relates to composites for use in high temperature elastic composite applications. Most particularly, this invention relates to elastic composites formed with a silanol-silanol condensation reaction mixture of silsesquioxane silicone resins thermally stabilized by boron nitride, silica and boron oxide additives as their matrix. The polymer matrix composite comprise a matrix of cured high, intermediate and optionally low molecular weight silicone resins including boron nitride and silica additives and reinforcing material.

Abstract: This invention extends the elastic range of silicone composite gaskets from typically ?40 to 300° C. (Reference I) to temperatures within the “red heat”, Le, 600 to 1000° C.

Abstract: An inhaler (1) for the delivery of a dose of powdered medicament for inhalation by a user comprising a housing (2) containing a cylinder (5) defining a chamber (5a) and a piston (6) movably received in the cylinder to enable a user to generate a charge of compressed air in the chamber to entrain a dose when the charge is released, wherein the cylinder and the piston include co-operating means (8, 9) thereon operable to draw the piston into the cylinder to compress a charge of air in the chamber in response to rotation of the piston.