Abstract: The present disclosure relates to compositions and methods for reducing expression of MYC gene in a cell. In some embodiments, an expression repressor comprises a targeting moiety that binds a MYC promoter, anchor sequence, or super-enhancer. In some embodiments, the expression repressor comprises an effector moiety that represses transcription or methylates DNA. Systems comprising two expression repressors are also disclosed. The compositions can be used, for example, to treat cancers such as HCC or NSCLC.

Abstract: A method of forming a glass sheet comprises: (a) forming a ribbon of glass from molten glass with a pair of forming rollers; (b) reducing horizontal temperature variability of the ribbon of glass to be 10° C. or less across 80 percent of an entire width of the ribbon of glass before the ribbon of glass cools to a glass transition temperature; (c) controlling a cooling rate of the ribbon of glass while the ribbon of glass moves vertically downward within a setting zone such that the ribbon of glass has a first average cooling rate before the ribbon of glass cools to the glass transition temperature and a second average cooling rate after the ribbon of glass cools to the glass transition temperature, the first average cooling rate being less than the second average cooling rate; and (d) separating a glass sheet from the ribbon of glass.

Abstract: A dedicated outdoor air system (DOAS) includes an outdoor unit providing a temperature at a set dry bulb temperature and dew point temperature in a wide variety of outdoor air conditions. The DOAS monitors and modulates suction pressure and head pressure in order to maintain a dew point temperature of 45° F. for supplied air. Furthermore, the DOAS includes a hot gas reheat coil, allowing the system to heat the air to 73° F. before supplying the air to a space, even where outdoor air temperature is lower than 73° F. In one embodiment, the DOAS includes an energy recovery ventilator (ERV) in order to precondition the air to decrease the amount of energy needed to operate the DOAS in some conditions.

Abstract: A method of manufacturing ceramic tape includes a step of directing a tape of partially-sintered ceramic into a furnace. The tape is partially-sintered such that grains of the ceramic are fused to one another yet the tape still includes at least 10% porosity by volume, where the porosity refers to volume of the tape unoccupied by the ceramic. The method further includes steps of conveying the tape through the furnace and further sintering the tape as the tape is conveyed through the furnace. The porosity of the tape decreases during the further sintering step.

Abstract: A process of forming a sintered article includes heating a green portion of a tape of polycrystalline ceramic and/or minerals in organic binder at a binder removal zone to a temperature sufficient to pyrolyze the binder; horizontally conveying the portion of tape with organic binder removed from the binder removal zone to a sintering zone; and sintering polycrystalline ceramic and/or minerals of the portion of tape at the sintering zone, wherein the tape simultaneously extends through the removal and sintering zones.

Abstract: A carousel ride system includes a first rotatable platform and multiple second rotatable platforms. Each second rotatable platform of the multiple second rotatable platforms is positioned within a respective opening in the first rotatable platform. A first drive system is configured to drive rotation of the first rotatable platform and multiple second drive assemblies are configured to drive rotation of the multiple second rotatable platforms. Multiple figures extend over the multiple second rotatable platforms and multiple figure drive assemblies are configured to independently lift and rotate the multiple figures relative to the multiple second rotatable platforms. One or more processors are configured to coordinate operation of the first drive system, the multiple second drive assemblies, and the multiple figure drive assemblies to maintain the multiple figures in a forward-facing orientation relative to a direction of travel of the first rotatable platform during operation of the carousel ride system.

Abstract: A ride vehicle includes a riding assembly configured to carry a rider, a base configured to couple to the riding assembly, and a control system configured to control the coordination of movements of the ride vehicle with movements of separate ride vehicles. The base includes a surface movement system configured to move the ride vehicle along a surface, a vertical movement system configured to move the riding assembly vertically relative to the base, and a roll system configured to move the riding assembly angularly relative to the base.

Abstract: A manufacturing system includes a tape advancing through the manufacturing system and a station of the manufacturing system. The tape includes a first portion having grains of an inorganic material bound by an organic binder. The station of the manufacturing system receives the first portion of the tape and prepares the tape for sintering by chemically changing the organic binder and/or removing the organic binder from the first portion of the tape, leaving the grains of the inorganic material, to form a second portion of the tape and, at least in part, prepare the tape for sintering.

Abstract: A workstation including a height-adjustable work surface is described. The workstation includes a frame, and the work surface is configured to translate relative to the frame to vary a height of the work surface. A lift assembly configured to assist translation of the work surface relative to the frame. The lift assembly includes a moveable component and translation of the moveable component results in a translation of the work surface relative to the frame. A translation sensor is coupled to one of the frame or the movable component, and it is configured to measure translation of the moveable component relative to the frame. A control circuit is in communication with the translation sensor to determine an amount of translation of the work surface relative to the frame.

Abstract: Techniques for distributing electrical power to a plurality of electrical loads can include coupling an existing group of electrical loads to a common power source through a load management system, measuring an aggregate group current drawn by at least the existing group of electrical loads and comparing the measured aggregate group current to an aggregate group current threshold value. When the measured aggregate group current exceeds the aggregate group current threshold value, increase a number of subgroups of the existing group, using subgroups that are formed without requiring information about individual current associated with the individual electrical loads, sequentially apply power to individual subgroups during non-overlapping time periods, sequentially measure at least a corresponding current drawn by the individual subgroups while power is applied to the subgroups, and sequentially comparing the measured current to a threshold value.

Abstract: A workstation including a height-adjustable work surface is described. The workstation includes a frame, and the work surface is configured to translate relative to the frame to vary a height of the work surface. A lift assembly configured to assist translation of the work surface relative to the frame. The lift assembly includes a moveable component and translation of the moveable component results in a translation of the work surface relative to the frame. A translation sensor is coupled to one of the frame or the movable component, and it is configured to measure translation of the moveable component relative to the frame. A control circuit is in communication with the translation sensor to determine an amount of translation of the work surface relative to the frame.

Abstract: Systems and methods for monitoring and management of an electronic device are discussed here. An authentication request is received from a user for access to an electronically secured compartment of an electronic device. Authentication data is obtained from the user. An authentication request that includes a device identifier for the electronically secured compartment and the authentication data is transmitted to a cloud-based authentication service. Access to the electronically secured compartment is provided upon receipt of an indication of an association between the user and the electronically secured compartment from the cloud-based service provider.

Abstract: An electric assisted height adjustable workstation featuring an integrated user interface for height adjustment and power control resulting in zero standby power consumption is described. Power is connected to the workstation via a physical movement of the integrated user interface causing an integrated connector to complete a circuit. Power is disconnected between the power source and the workstation via physical retraction of the integrated UI or an automatic retraction if the user interface remains inactive for a period of time.

Abstract: The present system incorporates mobile computing devices to play games, such as electronic pull-tabs, in a plurality of venues, each having a local wireless network. Each network communicates with a central system that generates decks of game outcomes and associated awards. All wagers and awards for each game are tracked on the central system, which also provides each game award and associated outcome from a deck stored on the central system.

Abstract: A dedicated outdoor air system (DOAS) includes an outdoor unit providing a temperature at a set dry bulb temperature and dew point temperature in a wide variety of outdoor air conditions. The DOAS monitors and modulates suction pressure and head pressure in order to maintain a dew point temperature of 45° F. for supplied air. Furthermore, the DOAS includes a hot gas reheat coil, allowing the system to heat the air to 73° F. before supplying the air to a space, even where outdoor air temperature is lower than 73° F. In one embodiment, the DOAS includes an energy recovery ventilator (ERV) in order to precondition the air to decrease the amount of energy needed to operate the DOAS in some conditions.

Abstract: Systems and methods for monitoring and management of an electronic device are discussed here. An authentication request is received from a user for access to an electronically secured compartment of an electronic device. Authentication data is obtained from the user. An authentication request that includes a device identifier for the electronically secured compartment and the authentication data is transmitted to a cloud-based authentication service. Access to the electronically secured compartment is provided upon receipt of an indication of an association between the user and the electronically secured compartment from the cloud-based service provider.

Abstract: Methods for determining parameter/s of a well completion design (WCD) for at least a portion of a drilled well based on drilling data corresponding to variables of mechanical specific energy (MSE) are provided. In some cases, MSE values may be acquired and the WCD parameter/s may be based on the MSE values. The MSE values may be obtained from a provider or may be acquired by calculating the MSE values via the drilling data. In some cases, the data may be amended prior to determining the WCD parameter/s to substantially neutralize distortions of the data. In some cases, the methods may include creating a geomechanical model of the drilled well from acquired MSE values, optionally amending the geomechanical model and determining the WCD parameter/s from the geomechanical model. Storage mediums having program instructions which are executable by a processor for performing any steps of the methods are also provided.

Abstract: Techniques for distributing electrical power to a plurality of electrical loads can include coupling an existing group of electrical loads to a common power source through a load management system, measuring an aggregate group current drawn by at least the existing group of electrical loads and comparing the measured aggregate group current to an aggregate group current threshold value. When the measured aggregate group current exceeds the aggregate group current threshold value, increase a number of subgroups of the existing group, using subgroups that are formed without requiring information about individual current associated with the individual electrical loads, sequentially apply power to individual subgroups during non-overlapping time periods, sequentially measure at least a corresponding current drawn by the individual subgroups while power is applied to the subgroups, and sequentially comparing the measured current to a threshold value.

Abstract: A carousel ride system includes a first rotatable platform and multiple second rotatable platforms. Each second rotatable platform of the multiple second rotatable platforms is positioned within a respective opening in the first rotatable platform. A first drive system is configured to drive rotation of the first rotatable platform and multiple second drive assemblies are configured to drive rotation of the multiple second rotatable platforms. Multiple figures extend over the multiple second rotatable platforms and multiple figure drive assemblies are configured to independently lift and rotate the multiple figures relative to the multiple second rotatable platforms. One or more processors are configured to coordinate operation of the first drive system, the multiple second drive assemblies, and the multiple figure drive assemblies to maintain the multiple figures in a forward-facing orientation relative to a direction of travel of the first rotatable platform during operation of the carousel ride system.

Abstract: The present system incorporates mobile computing devices to play games, such as electronic pull-tabs, in a plurality of venues, each having a local wireless network. Each network communicates with a central system that generates decks of game outcomes and associated awards. All wagers and awards for each game are tracked on the central system, which also provides each game award and associated outcome from a deck stored on the central system.