Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.

Abstract: Activation of an automatic driving feature in a vehicle is detected by evaluating sequential vehicle operation data against subtractive and additive heuristic rules that define a likelihood of an automatic driving feature having been engaged as a function of vehicle performance. The sequential vehicle operation data, which does not include an explicit indication of whether the automatic driving feature was engaged, is provided for time intervals of a trip made by the vehicle. Automatic driving information is generated, which provides an indication of whether the automatic driving feature was engaged during a subset of the time intervals.

Abstract: Methods and compositions for modulating a target genome are disclosed.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating alpha-1 antitrypsin deficiency (AATD) are described.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating phenylketonuria (PKU) are described.

Abstract: The various implementations described herein include a video camera assembly that includes: (1) a housing; (2) an image sensor encased in the housing and configured to capture activity of the smart home environment; (3) a wireless radio configured to transmit video frames captured by the image sensor to an electronic device via a remote server; (4) at least one infrared transmitter configured to selectively illuminate the smart home environment; (5) one or more circuit boards encased in the housing, the one or more circuit boards including at least one processor mounted thereon; and (6) a heating component coupled to the image sensor, the heating component configured to continuously maintain the image sensor at a temperature above a threshold temperature while the image sensor is capturing the activity of the smart home environment.

Abstract: Methods and compositions for modulating a target genome are disclosed.

Abstract: The various implementations described herein include a video camera assembly that includes: (1) a housing; (2) an image sensor positioned within the housing and having a field of view corresponding to a scene in the smart home environment; and (3) a concave-shaped front face positioned in front of the image sensor such that light from the scene passes through the front face prior to entering the image sensor; where the front face includes: (a) an inner section corresponding to the image sensor; and (b) an outer section between the housing and the inner section, the outer section having a concave shape that extends from an outer periphery of the outer section to an inner periphery of the outer section; and where the concave shape extends around an entirety of the outer periphery.

Abstract: The present disclosure relates to a dose detection system for use with a medication delivery device in which a dose setting member rotates relative to an actuator during dose delivery. The dose detection system includes a module which is removably attached to the medication delivery device. The module includes a rotation sensor attached to the actuator during dose delivery. A sensed element is attached to the dose setting member and includes surface features detectable by the rotation sensor. The rotation sensor comprises a following member including a contact portion resting against and spring-biased in the direction of the surface features. The contact surface is positioned to move over the surface features during rotation of the sensed element, and the rotation sensor is responsive to the movement of the contact portion over the surface features to detect the rotation of the dose setting member.

Abstract: A manufacturing system includes a tape advancing through the manufacturing system and a station of the manufacturing system. The tape includes a first portion having grains of an inorganic material bound by an organic binder. The station of the manufacturing system receives the first portion of the tape and prepares the tape for sintering by chemically changing the organic binder and/or removing the organic binder from the first portion of the tape, leaving the grains of the inorganic material, to form a second portion of the tape and, at least in part, prepare the tape for sintering.

Abstract: A method for identifying damage in a component of a wind turbine includes placing a conductive element onto at least one surface of the component of the wind turbine. The method also includes electrically connecting the conductive element into an electrical circuit. Further, the method includes monitoring a status of the electrical circuit to identify the damage in the component. In particular, when the status of the electrical circuit is open, damage is likely present in the component, and when the status of the electrical circuit is closed, damage is unlikely present in the component. Moreover, the method includes transmitting the status of the electrical circuit to a user interface for display.

Abstract: A printed circuit board having an electrically insulative layer and a conductive solder pad. The conductive solder pad is disposed at least partially over the electrically insulative layer, and defines a solder contact area. The solder contact area is configured for making an electrical connection to an electrical component via laser soldering. The printed circuit board further includes a solder mask coating the conductive solder pad and defining an exposed area of the conductive solder pad. The conductive solder pad protects the electrically insulative layer from incident heat during the laser soldering by extending a length underneath the solder mask along a periphery of the exposed area.

Abstract: A method, system, and computer program product are configured to: initiate a transaction in response to receiving a readiness probe request from a requesting system; set a probe flag for the transaction to a first state; send the transaction to a user application for processing; based on the probe flag being set to the first state, keep updates to recoverable resources in-flight while the user application is processing the transaction; based on the probe flag being set to the first state, roll back the updates to the recoverable resources in response to the user application ending processing the transaction; and send a readiness probe response to the requesting system based on how the user application ended processing the transaction.

Abstract: An adaptive X-ray anti-scatter device for placement in a source-detector axis of an X-ray imager includes an anti-scatter filter having a source orientable surface and a detector orientable surface. The anti-scatter filter comprises a plurality of realignable slats that absorb incident X-rays and are separated by a plurality of interstitial portions. The device also includes a first actively deformable member comprising a first set of one or more actively deformable actuators disposed across a first region of the first actively deformable member. At least a portion of the first set is partially or fully recessed within the interstitial portions. At least one actuator of the first set is in contact with a corresponding realignable slat of the plurality of realignable slats and is configured to change the alignment of the corresponding realignable slat in relation to the source-detector axis.

Abstract: The invention provides, inter alia, systems and associated methods, for modifying DNA, such as the genome of a cell. The systems, in certain embodiments, encompass one or more tissue-specific expression-control sequences, such as promoters and microRNA binding sites in addition to a transposase (or a nucleic acid encoding the same) and a template nucleic acid comprising a sequence to be inserted into the genome of a cell, tissue, or subject.

Abstract: Methods and compositions for modulating a target genome are disclosed.

Abstract: A vertical axis turbine having a first rotor and at least one second rotor, the first rotor being configured to rotate around a first rotation axis that is vertical or more vertical than horizontal. The first rotor may be configured to be driven and/or rotated by wind or water flow. The at least one second rotor is provided on or coupled to the first rotor such that the first rotor is operable to move the second rotor upon rotation of the first rotor. The second rotor is operable to drive a power take off system. Each second rotor rotates around a respective second rotation axis that may be angled or perpendicular to the first rotation axis of the first rotor. The first and second rotors are configured so that the power take-off system can be driven without the need for a gearbox.

Abstract: Methods and apparatus for image processing of spherical content via hardware acceleration components. In one embodiment, an EAC image is subdivided into facets via existing software addressing and written into the memory buffers (normally used for rectilinear cubemaps) in a graphics processing unit (GPU). The EAC facets may be translated, rotated, and/or mirrored so as to align with the expected three-dimensional (3D) coordinate space. The GPU may use existing hardware accelerator logic, parallelization, and/or addressing logic to greatly improve 3D image processing effects (such as a multi-band blend using Gaussian blurs.

Abstract: Methods and compositions for modulating a target genome are disclosed.

Abstract: A downhole tool comprises a heater including a container enclosing a volume of compacted thermite. A volume of flowable alloy is provided above the heater. A fusible bulkhead may be provided between the heater and the alloy and provides for direct conduction of heat from the heater to the alloy. A housing containing the alloy may be separated from the heater by heating a fusible socket that anchors an end of a tensioned support member. The thermite may define an internal volume adapted to receive alloy. The heater may be activated to melt the alloy and the alloy may then solidify to form a bore-sealing plug.