Abstract: A viewing direction may define an angle/visual portion of a spherical video at which a viewing window is directed. A trajectory of viewing direction may include changes in viewing directions for playback of spherical video. Abrupt changes in the viewing directions may result in jerky or shaky views of the spherical video. Changes in the viewing directions may be stabilized to provide stabilized views of the spherical video. Amount of stabilization may be limited by a margin constraint.

Abstract: In embodiments, a wearable cardiac defibrillation (WCD) system includes one or more flexible ECG electrodes. The WCD system may have a support structure that is dimensioned to be worn so as to press the electrodes towards the body of the patient. The electrodes may be made from appropriate material so as to flex in order to match a contour of the body of the patient. An advantage over the prior art is that the flexible electrode may make better electrical contact with the patient's skin, and therefore provide a better ECG signal for the WCD system to perform its diagnosis.

Abstract: Methods and compositions for modulating a target genome are disclosed.

Abstract: Systems and methods that generate data representing an analytic result relating to at least one of a state, a workflow, or an event in a digital token system, including a digital token system that cryptographically links a set of digital tokens to instances of a set of real-world entities. The systems and methods produce a trading analytic by processing a set of collected data, structuring and filtering the collected data to obtain a multi-dimensional structured data set, and querying the multi-dimensional structured data set. Systems and methods further leverage a set of data collection services configured to collect data from one or more interfaces, a set of workflows configured to produce event data, and a data store configured to store collected attribute data.

Abstract: Systems and methods for tokenizing real-world items for use in digital commerce are disclosed. In some embodiments, a recognized activity in a workflow of a customer relationship management system triggers a workflow for a set of digital tokens associated with the recognized activity in a digital token transaction system.

Abstract: Provided herein are methods of using a compound provided herein (e.g., Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6, or Compound 7, or a stereoisomer or mixture of stereoisomers, pharmaceutically acceptable salt, tautomer, prodrug, solvate, hydrate, co-crystal, clathrate, or polymorph thereof), in combination with a second) active agent for treating cancer. The second active agent is one or more of a PLK1 inhibitor, a BRD4 inhibitor, a BET inhibitor, an NEK2 inhibitor, an AURKB inhibitor, an MEK inhibitor, a PHF19 inhibitor, a BTK inhibitor, an mTOR inhibitor, a PIM inhibitor, an IGF-1R inhibitor, an XPO1 inhibitor, a DOT1L inhibitor, an EZH2 inhibitor, a JAK2 inhibitor, a BIRCS inhibitor, or a DNA methyltransferase inhibitor.

Abstract: A fuel additive bottle has a neck and thread pattern that allows insertion into a capless diesel fuel system so the bottle's contents can be poured by gravity into a fuel tank. The neck of the bottle is elongated and has a diameter of approximately 0.932 inches, and the novel thread pattern includes thread interruptions that form two or four threadless paths. In use, the spring loaded tabs of a capless fuel system are depressed by the threadless path portion of bottle, thereby triggering the self-sealing mechanism to open, so the fluid receiving aperture is exposed. The use of the threadless paths facilitates the safe and easy entry and removal of the bottle from the capless fuel system.

Abstract: Methods and compositions for modulating a target genome are disclosed.

Abstract: Systems and methods that generate data representing an analytic result relating to at least one of a state, a workflow, or an event in a digital token system, including a digital token system that cryptographically links a set of digital tokens to instances of a set of real-world entities. The systems and methods produce a cost analytic by processing a set of collected data, structuring and filtering the collected data to obtain a multi-dimensional structured data set, and querying the multi-dimensional structured data set. Systems and methods further leverage a set of data collection services configured to collect data from one or more interfaces, a set of workflows configured to produce event data, and a data store configured to store collected attribute data.

Abstract: An optical bonding machine is provided that includes a robotic placement machine having a Z axis actuator coupled to a first end of a base portion of the robotic placement machine, the Z axis actuator capable of moving up and down a Z axis, and a pick and place plate operably connected to the Z axis actuator, and a vertically oriented adhesive application valve configured to apply an amount of adhesive onto an underside of a substrate, the underside of the substrate facing down when the amount of adhesive is applied, wherein the pick-and-place plate of the robotic placement machine manipulates the substrate within the optical bonding machine such that the substrate receives the amount of adhesive prior to being optically bonded to an other substrate; wherein a movement of the robotic placement machine is controllable over at least 3 axes.

Abstract: Embodiments are for using adaptive fill techniques to avoid electromigration, thereby resulting in electromigration signoff. A wire segment failing to meet an electromigration current limit is determined on an integrated circuit (IC). Fill shapes are connected adjacent to the wire segment to cause the wire segment to meet the electromigration current limit. The fill shapes are non-functional shapes on the IC.

Abstract: The disclosure provides, e.g., compositions and methods for modulating a host response to a Gene Writer system. In some embodiments, modulation of the host response results in increased integration of a heterologous nucleic acid sequence of interest into a target genome. In some embodiments, modulation of the host response results in an increased stability, e.g., maintenance of an insertion or expression thereof. In some embodiments, modulation of the host response results in decreased cytotoxicity.

Abstract: An embedded component stack includes a first metal layer, a first dielectric layer disposed on the first metal layer, a second metal layer disposed on the first dielectric layer, a first component disposed and embedded entirely within the first dielectric layer and entirely between the first metal layer and the second metal layer, a second dielectric layer disposed on the second metal layer, and a second component disposed on or embedded entirely within the second dielectric layer. The first and second components can be bare, unpackaged dies disposed over the metal layers by micro-transfer printing. The metal layers can be patterned and can be electrically connected to the components. The first component can be rotated with respect to the second component. Multiple components can be embedded in one or more of the dielectric layers.

Abstract: A child-resistant storage case has a lid hinged to a base to define an interior storage space. Two side latches are spaced apart from one another on opposing side aspects of the storage case. A front latch mechanism includes a horizontal tab extending forward from the front aspect of the case. To open the storage case, the user must simultaneously press inward on the side latches, press downward on the horizontal tab, and lift the lid upward. The required downward actuation of the front latch mechanism is counter-intuitive for most people, and in combination with the side latches, is very difficult for most small children.

Abstract: A turbine for a turbo-machine is proposed in which, at a gas inlet for a turbine wheel, vanes extend from a nozzle ring though slots in a shroud. The nozzle ring and shroud are relatively rotatable about a rotational axis of the turbine by at least 0.1 degrees. In use, the nozzle ring and shroud are relatively rotated to bring one side of the vane into close contact with one surface of the slot, to inhibit leakage of gas between the vane and the slot surface. For this purpose the respective surfaces of the nozzle and slot can be configured to closely conform to each other. If there is differential thermal expansion of the shroud and nozzle ring, the nozzle ring and shroud can relatively rotate, to withdraw the vane from the edge of the slot to relieve the pressure between them.

Abstract: Embodiments include thermally coupled aware device placement in the schematic design stage of the development of an integrated circuit. Aspects of the invention include obtaining a schematic design of a macro, the schematic design including a plurality of devices disposed within the macro. Aspects also include determining an initial temperature for each of the plurality of devices, where the initial temperature due to self-heating. Aspects further include determining, iteratively for each of the plurality of devices, an uplift temperature, where the uplift temperature for a first device of the plurality of devices is determined based on the initial temperature of each of the other plurality of devices and a distance between the first device and each of the other plurality of devices as encoded in the schematic design. Aspects also include modifying the schematic design of the macro based on a determination that the uplift temperature of at least one of the plurality of devices is above a threshold value.

Abstract: A method of forming a glass sheet comprises: (a) forming a ribbon of glass from molten glass with a pair of forming rollers; (b) reducing horizontal temperature variability of the ribbon of glass to be 10° C. or less across 80 percent of an entire width of the ribbon of glass before the ribbon of glass cools to a glass transition temperature; (c) controlling a cooling rate of the ribbon of glass while the ribbon of glass moves vertically downward within a setting zone such that the ribbon of glass has a first average cooling rate before the ribbon of glass cools to the glass transition temperature and a second average cooling rate after the ribbon of glass cools to the glass transition temperature, the first average cooling rate being less than the second average cooling rate; and (d) separating a glass sheet from the ribbon of glass.

Abstract: An adhesive application valve comprising an applicator, a Z-axis actuator operably connected to the applicator, wherein the Z-axis actuator and the rotation device are each capable of moving independently of each other to position the applicator in a position to apply an amount of adhesive to a top substrate prior to bonding with a bottom substrate is provided. Furthermore, a machine comprising an end effector, and an adhesive application valve configured to apply an amount of adhesive onto the top substrate, the end effector configured to place the top substrate into a position of engagement with the adhesive application valve, and place the top substrate onto the bottom substrate to facilitate initial contact between the adhesive applied to the top substrate and a fill material applied to the bottom substrate is also provided. A method of optical bonding is further provided.

Abstract: Systems and methods for tokenizing real-world items for use in digital commerce are disclosed. In some embodiments, the tokenization platform is configured to generate digital tokens that are cryptographically linked with a basket of items. The basket of items is configurable to include a variety of items and is redeemable through a transaction of the set of digital tokens in a digital token transaction system.

Abstract: An imaging system for a moving vehicle aggregates pre-existing data with sensor data to provide an image of the surrounding environment in real-time. The pre-existing data are combined with data from one or more 3-D sensors, and 2-D information from a camera, to create a scene model that is rendered for display. The system accepts data from a 3-D sensor, transforms the data into a 3-D data structure, fuses the pre-existing scene data with the 3-D data structure and 2-D image data from a 2-D sensor to create a combined scene model, and renders the combined scene model for display. The system may also weight aspects of data from first and second sensors to select at least one aspect from the first sensor and another aspect from the second sensor; wherein fusing the pre-existing scene data with the sensor data uses the selected aspect from the first sensor and the selected aspect from the second sensor.