Patents by Inventor William A. Grissom

William A. Grissom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240180607
    Abstract: A system and method to analyze image data. The image data may be used to assist in determine the presence of a feature in the image. The feature may include a bubble.
    Type: Application
    Filed: February 9, 2024
    Publication date: June 6, 2024
    Inventors: Christine R. DROWN, Andrew WALD, Rebecca L. VINCELETTE, William A. GRISSOM
  • Patent number: 11957936
    Abstract: A system for transcranial magnetic resonance (MR)-guided focused ultrasound and method of using transcranial MR-guided focused ultrasound are disclosed. The system includes a transcranial ultrasound transducer configured to apply ultrasound radiation to a patient's head. The system also includes an antenna that reflects radio frequency (RF) waves. The antenna is configured to be positioned between the transducer and the patient's head. The antenna and at least a portion of the patient's head are surrounded by a fluid. Embodiments foster improved MR image quality scans of the patient's head when the transducer is filled with the fluid.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: April 16, 2024
    Assignee: Vanderbilt University
    Inventors: Xinqiang Yan, William A. Grissom
  • Publication number: 20240069134
    Abstract: A system and method is provided using a nuclear magnetic resonance (NMR) system. The method includes applying an off-resonance radio frequency (RF) pulse using a radio-frequency coil that is spatially inhomogeneous to induce a B1-dependent resonant frequency shift in spins in a subject and, in the presence of the off-resonance RF pulse, applying a frequency-modulated, frequency-selective RF excitation pulse to spatially encode the spins in the subject. The method also includes acquiring NMR data from the subject that is spatially encoded and reconstructing the NMR data to produce a report of internal materials forming the subject.
    Type: Application
    Filed: February 24, 2022
    Publication date: February 29, 2024
    Inventors: Jonathan B. Martin, William A. Grissom, Mark A. Griswold
  • Patent number: 11896288
    Abstract: A system and method to analyze image data. The image data may be used to assist in determine the presence of a feature in the image. The feature may include a bubble.
    Type: Grant
    Filed: August 3, 2022
    Date of Patent: February 13, 2024
    Assignee: Medtronic Navigation, Inc.
    Inventors: Christine R. Drown, Andrew Wald, Rebecca L. Vincelette, William A. Grissom
  • Publication number: 20240041345
    Abstract: A system and method of magnetic particle imaging (MPI) are disclosed. The system and method use ultrasound to drive magnetic particles (such as nanoparticles) through a magnetic field gradient to generate a signal and map the magnetic particles' distribution or concentration.
    Type: Application
    Filed: October 23, 2023
    Publication date: February 8, 2024
    Inventors: William A. Grissom, Charles F. Caskey
  • Patent number: 11874353
    Abstract: Described here are systems and methods for producing images with a magnetic resonance imaging (“MRI”) system using a high-resolution, motion-robust, artifact-free segmented echo planar imaging (“EPI”) technique. In particular, a fast low angle excitation echo planar imaging technique (“FLEET”) using variable flip angle (“VFA”) radio frequency (“RF”) excitation pulses that are recursively designed to have a flat magnitude and phase profile across a slice for a range of different flip angles by accounting for longitudinal magnetization remaining after each preceding RF pulse is applied.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: January 16, 2024
    Assignee: The General Hospital Corporation
    Inventors: Avery J. L. Berman, Jonathan R. Polimeni, William A. Grissom, Kawin Setsompop, Thomas Witzel
  • Publication number: 20230398380
    Abstract: A workflow has been developed that enables initially mapping of a focused ultrasound (FUS) beam using magnetic resonance (MR) thermometry or MR-acoustic radiation force imaging (MR-ARFI) while working within the MRI device. During this procedure, key measurements will be taken including the precise location of the transducer relative to the skull and the transducer parameters (such as amplitudes and phases) required to place the ultrasound focus at the desired focal size and location in the skull. The anatomical measurements will be used to build a patient-specific, device-specific stereotactic frame to hold the transducer in the position relative to the skull and the aberration corrects will be applied. FUS therapy can then be delivered to the patient outside of the MR environment.
    Type: Application
    Filed: October 8, 2021
    Publication date: December 14, 2023
    Inventors: Charles F. Caskey, Limin Chen, William A. Grissom, Peter E. Konrad, Benoit M. Dawant, Willliam J. Rodriguez
  • Patent number: 11839458
    Abstract: A system and method of magnetic particle imaging (MPI) are disclosed. The system and method use ultrasound to drive magnetic particles (such as nanoparticles) through a magnetic field gradient to generate a signal and map the magnetic particles' distribution or concentration.
    Type: Grant
    Filed: February 8, 2022
    Date of Patent: December 12, 2023
    Assignee: Vanberbilt University
    Inventors: William A. Grissom, Charles F. Caskey
  • Patent number: 11841413
    Abstract: The present application provides a system and method for using a nuclear magnetic resonance (NMR) system. The method includes performing a pulse sequence using the NMR system that spatially encodes NMR signal evolutions to be acquired from a subject using an aggregated radio-frequency (B1) field incoherence and resolving the NMR signal evolutions acquired from the subject using at least one of a dictionary of known magnetic resonance fingerprinting (MRF) signal evolutions to determine matches in the NMR signal evolutions to the known MRF signal evolutions or an optimization process. The method also includes generating at least two spatially-resolved measurements indicating quantitative tissue parameters of the subject in at least two locations.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: December 12, 2023
    Assignees: Case Western Reserve University, Vanderbilt University
    Inventors: Mark A. Griswold, William A. Grissom
  • Publication number: 20230039004
    Abstract: The present application provides a system and method for using a nuclear magnetic resonance (NMR) system. The method includes performing a pulse sequence using the NMR system that spatially encodes NMR signal evolutions to be acquired from a subject using an aggregated radio-frequency (B1) field incoherence and resolving the NMR signal evolutions acquired from the subject using at least one of a dictionary of known magnetic resonance fingerprinting (MRF) signal evolutions to determine matches in the NMR signal evolutions to the known MRF signal evolutions or an optimization process. The method also includes generating at least two spatially-resolved measurements indicating quantitative tissue parameters of the subject in at least two locations.
    Type: Application
    Filed: December 30, 2020
    Publication date: February 9, 2023
    Inventors: Mark A. Griswold, William A. Grissom
  • Publication number: 20220378493
    Abstract: A system and method to analyze image data. The image data may be used to assist in determine the presence of a feature in the image. The feature may include a bubble.
    Type: Application
    Filed: August 3, 2022
    Publication date: December 1, 2022
    Inventors: Christine R. DROWN, Andrew WALD, Rebecca L. VINCELETTE, William A. GRISSOM
  • Patent number: 11426229
    Abstract: A system and method to analyze image data. The image data may be used to assist in determine the presence of a feature in the image. The feature may include a bubble.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: August 30, 2022
    Assignee: Medtronic Navigation, Inc.
    Inventors: Christine R. Drown, Andrew Wald, Rebecca L. Vincelette, William A. Grissom
  • Publication number: 20220248974
    Abstract: A system and method of magnetic particle imaging (MPI) are disclosed. The system and method use ultrasound to drive magnetic particles (such as nanoparticles) through a magnetic field gradient to generate a signal and map the magnetic particles' distribution or concentration.
    Type: Application
    Filed: February 8, 2022
    Publication date: August 11, 2022
    Inventors: William A. Grissom, Charles F. Caskey
  • Patent number: 11403760
    Abstract: A system and method to analyze image data. The image data may be used to assist in determine the presence of a feature in the image. The feature may include a bubble.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: August 2, 2022
    Assignee: Medtronic Navigation, Inc.
    Inventors: Christine R. Drown, Andrew Wald, Rebecca L. Vincelette, William A. Grissom
  • Publication number: 20220179024
    Abstract: Described here are systems and methods for producing images with a magnetic resonance imaging (“MRI”) system using a high-resolution, motion-robust, artifact-free segmented echo planar imaging (“EPI”) technique. In particular, a fast low angle excitation echo planar imaging technique (“FLEET”) using variable flip angle (“VFA”) radio frequency (“RF”) excitation pulses that are recursively designed to have a flat magnitude and phase profile across a slice for a range of different flip angles by accounting for longitudinal magnetization remaining after each preceding RF pulse is applied.
    Type: Application
    Filed: March 27, 2020
    Publication date: June 9, 2022
    Inventors: Avery J.L. Berman, Jonathan R. Polimeni, William A. Grissom, Kawin Setsompop, Thomas Witzel
  • Patent number: 11276174
    Abstract: A system and method to analyze image data. The image data may be used to assist in determine the presence of a feature in the image. The feature may include a bubble.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: March 15, 2022
    Assignee: Medtronic Navigation, Inc.
    Inventors: Christine R. Drown, Andrew Wald, Rebecca L. Vincelette, William A. Grissom
  • Patent number: 11237233
    Abstract: A self-decoupled RF coil and method for adjusting the same is disclosed. The RF coil is an array of elements including at least one loop. Electromagnetic coupling between elements in the array causes an induced current in the at least one loop. The induced current has two modes. A reactance inserted in the at least one loop balances the two modes. The balanced current modes cancel. This cancelation results in self-decoupling of at the least one loop from the other elements in the RF coil array.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: February 1, 2022
    Assignee: Vanderbilt University
    Inventors: Xinqiang Yan, John C. Gore, William A. Grissom
  • Publication number: 20210307769
    Abstract: Applications related to non-invasive magnetic resonance guided focused ultrasound (MRgFUS) in a patient's vasculature are described. For example, the applications can include an ablation procedure, an occlusion procedure, a cauterization procedure, and the like. Accordingly, one aspect of the present disclosure is directed to a method for performing an MRgFUS application that includes selecting a target area within a patient's vasculature, configuring multifocal acoustic waves, and applying the multifocal acoustic waves to the target area to heat sequential locations in the target area simultaneously to facilitate the MRgFUS application.
    Type: Application
    Filed: August 4, 2017
    Publication date: October 7, 2021
    Inventors: Sandeep S. ARORA, Charles F. CASKEY, William A. GRISSOM
  • Publication number: 20210190889
    Abstract: A self-decoupled RF coil and method for adjusting the same is disclosed. The RF coil is an array of elements including at least one loop. Electromagnetic coupling between elements in the array causes an induced current in the at least one loop. The induced current has two modes. A reactance inserted in the at least one loop balances the two modes. The balanced current modes cancel. This cancelation results in self-decoupling of at the least one loop from the other elements in the RF coil array.
    Type: Application
    Filed: March 21, 2018
    Publication date: June 24, 2021
    Inventors: Xinqiang YAN, John C. GORE, William A. GRISSOM
  • Publication number: 20200360733
    Abstract: A system for transcranial magnetic resonance (MR)-guided focused ultrasound and method of using transcranial MR-guided focused ultrasound are disclosed. The system includes a transcranial ultrasound transducer configured to apply ultrasound radiation to a patient's head. The system also includes an antenna that reflects radio frequency (RF) waves. The antenna is configured to be positioned between the transducer and the patient's head. The antenna and at least a portion of the patient's head are surrounded by a fluid. Embodiments foster improved MR image quality scans of the patient's head when the transducer is filled with the fluid.
    Type: Application
    Filed: May 13, 2020
    Publication date: November 19, 2020
    Inventors: Xinqiang Yan, William A. Grissom