Patents by Inventor William A. Holmes

William A. Holmes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10485829
    Abstract: The present invention provides improved methods for producing retinal pigmented epithelial (RPE) cells from human embryonic stem cells, human induced pluripotent stem (iPS), human adult stem cells, human hematopoietic stem cells, human fetal stem cells, human mesenchymal stem cells, human postpartum stem cells, human multipotent stem cells, or human embryonic germ cells. The RPE cells derived from embryonic stem cells are molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The RPE cells described herein are useful for treating retinal degenerative conditions including retinal detachment and macular degeneration.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: November 26, 2019
    Assignee: Astellas Institute for Regenerative Medicine
    Inventors: Christopher Malcuit, Linda Lemieux, William Holmes, Pedro Huertas, Lucy Vilner
  • Patent number: 10467721
    Abstract: Methods of manufacturing security documents and security devices, and corresponding products, provide a lenticular device effect in a first registration zone. Viewing its appearance from two different angles in this way, the relative positioning of the focussing element array and the image array can be judged to a high degree of accuracy. If the two arrays do not have the desired relative position, this will be clearly apparent since the different first and second images will not be captured at the first and second test viewing angles.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: November 5, 2019
    Assignee: DE LA RUE INTERNATIONAL LIMITED
    Inventors: Brian William Holmes, Robert Whiteman, Lawrence George Commander
  • Patent number: 10438309
    Abstract: A method of making a security device including: (a) forming an array of focussing elements on at least a first region of a focussing element support layer, by: (a)(i) applying a first transparent curable material either to the focussing element support layer or to a casting tool carrying a surface relief corresponding to the focussing elements, over an first sub-region of the first region and applying a second transparent curable material to a second sub-region of the first region laterally offset from the first sub-region, the first and second transparent curable materials having different optical detection characteristics from one another; (a)(ii) forming the first and second transparent curable materials with the casting tool; and (a)(iii) curing the first and second transparent curable materials in the first region, so as to retain the surface relief.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: October 8, 2019
    Assignee: DE LA RUE INTERNATIONAL LIMITED
    Inventors: Brian William Holmes, John Godfrey
  • Publication number: 20190287657
    Abstract: Bodily fluid sample collection systems, devices, and method are provided. The device may comprise a first portion comprising at least a sample collection channel configured to draw the fluid sample into the sample collection channel via a first type of motive force. The sample collection device may include a second portion comprising a sample vessel for receiving the bodily fluid sample collected in the sample collection channel, the sample vessel operably engagable to be in fluid communication with the collection channel, whereupon when fluid communication is established, the vessel and/or another source provides a second motive force different from the first motive force to move a majority of the bodily fluid sample from the channel into the vessel.
    Type: Application
    Filed: February 13, 2019
    Publication date: September 19, 2019
    Inventors: Elizabeth A. Holmes, Clarissa Lui, Michael Chen, Daniel Young, Adrit Lath, Zachary Morrison, Brian Argyres, William Westrick
  • Patent number: 10414005
    Abstract: An apparatus and method for servicing a combustion liner in a combustion case of a turbine is provided. The apparatus includes an elongated bar having a handle at one end and a force applying member at an opposing end of the elongated bar. An attachment member is configured for attachment to a flange of the combustion case. The attachment member is also configured for pivotal attachment to the elongated bar. The apparatus is configured to apply a radially outward force on a downstream portion of the combustion liner when a radially inward force is applied to the handle.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: September 17, 2019
    Assignee: General Electric Company
    Inventors: Adrian Adam Klejc, Stuart Craig Hanson, John William Herbold, James Bradford Holmes, Sandra Beverly Kolvick, Thomas Alan Mogle, II, Robert Edward Huth, Lukasz Sajdak
  • Patent number: 10400475
    Abstract: A lock device including a keyway sized and configured to receive a key, a sensor assembly including an optical source and a key height sensor, and a controller in communication with the sensor assembly. The optical source is configured to generate an optical signal, and the key height sensor is configured to generate a key height signal in response to receiving the optical signal. The key is configured to interact with the optical signal such that the key height signal varies based upon the height of the key. The controller is configured to generate a key profile based at least in part upon the key height signal, to compare the key profile to authorization data, to select an action based upon the comparing, and to perform the action.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: September 3, 2019
    Assignee: Schlage Lock Company LLC
    Inventors: Peter Klammer, William P. Dye, Michael P. Hogan, Samir Moustaffa Tamer, Donald D. Baker, Douglas A. Holmes
  • Publication number: 20190263169
    Abstract: A method of manufacturing a security device is provided. The method comprises providing a substrate, the substrate having opposing first and second surfaces and a relief structure formed in the first surface of the substrate. A reflection enhancing layer is applied over the first surface of the substrate such that the reflection enhancing layer at least partially overlaps the relief structure and such that a first region of the first surface of the substrate does not have the reflection enhancing layer. An absorber layer is applied over the reflection enhancing layer such that the absorber layer at least partially overlaps the reflection enhancing layer and the relief structure where the reflection enhancing layer and the relief structure overlap each other, and such that the absorber layer at least partially overlaps the first region of the first surface of the substrate.
    Type: Application
    Filed: October 31, 2017
    Publication date: August 29, 2019
    Applicant: DE LA RUE INTERNATIONAL LIMITED
    Inventor: Brian William HOLMES
  • Publication number: 20190251518
    Abstract: Techniques of intelligent management of calendar items in computing systems are disclosed herein. In one embodiment, a calendar server can be configured to determine whether to accept a requested meeting utilizing a decision tree pre-configured at the server by a service provider. The decision tree contains one or more hierarchical decision nodes individually comparing one or more of parameters provided by a meeting requester to a corresponding criterion previously provided by the service provider. The calendar server can also be configured to invoke an application identified in the decision tree and provide results of the invoked application to the meeting requester in lieu of accepting the requested meeting.
    Type: Application
    Filed: February 9, 2018
    Publication date: August 15, 2019
    Inventors: Anant Trivedi, William Holmes, Chandresh Kumar Jain
  • Patent number: 10374254
    Abstract: Set forth herein are electrolyte compositions that include both organic and inorganic constituent components and which are suitable for use in rechargeable batteries. Also set forth herein are methods and systems for making and using these composite electrolytes.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: August 6, 2019
    Assignee: QuantumScape Corporation
    Inventors: Kim Van Berkel, Tim Holme, Mohit Singh, Amal Mehrotra, Zhebo Chen, Kian Kerman, Wes Hermann, William Hudson
  • Publication number: 20190232708
    Abstract: A security device is disclosed, comprising an array of focussing elements with regular periodicity in at least a first direction, each focusing element having an optical footprint of which different portions will be directed to the viewer in dependence on the viewing angle; and an array of image elements with regular periodicity in at least the first direction overlapping the array of focusing structures, the image elements representing portions of at least two respective images, and at least one image element from each respective image being located in the optical footprint of each focusing structure.
    Type: Application
    Filed: September 29, 2017
    Publication date: August 1, 2019
    Applicant: DE LA RUE INTERNATIONAL LIMITED
    Inventors: Brian William HOLMES, John GODFREY, Robert WHITEMAN
  • Patent number: 10347937
    Abstract: The instant disclosure sets forth multiphase lithium-stuffed garnet electrolytes having secondary phase inclusions, wherein these secondary phase inclusions are material(s) which is/are not a cubic phase lithium-stuffed garnet but which is/are entrapped or enclosed within a lithium-stuffed garnet. When the secondary phase inclusions described herein are included in a lithium-stuffed garnet at 30-0.1 volume %, the inclusions stabilize the multiphase matrix and allow for improved sintering of the lithium-stuffed garnet. The electrolytes described herein, which include lithium-stuffed garnet with secondary phase inclusions, have an improved sinterability and density compared to phase pure cubic lithium-stuffed garnet having the formula Li7La3Zr2O12.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: July 9, 2019
    Assignee: QuantumScape Corporation
    Inventors: Larry Beck, Cheng-Chieh Chao, Lei Cheng, Niall Donnelly, William H. Gardner, Tim Holme, Will Hudson, Sriram Iyer, Oleh Karpenko, Yang Li, Gengfu Xu
  • Patent number: 10343393
    Abstract: A method of manufacturing a pattern on a substrate web includes providing a production tool having a surface relief structure of elevations and depressions. The elevations correspond to a desired pattern. A curable material is applied to the elevations. The material is brought into contact with a substrate web at a first location. The substrate web and surface relief structure are transported together in contact from the first location to a second location spaced from one another along the transport direction of the substrate web. The substrate web is separated from the surface relief structure at the second location whereupon the material forming the pattern is affixed to and carried by the substrate web. The material is cured by exposure to a curing energy source, either between the first and second locations and/or after the substrate web has been separated from the surface relief structure at the second location.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: July 9, 2019
    Assignee: DE LA RUE INTERNATIONAL LIMITED
    Inventor: Brian William Holmes
  • Publication number: 20190193453
    Abstract: A method of producing a security device comprises providing a substrate having a relief structure in/on its surface, the structure provided in a first region of the substrate. The structure in the first region a first recess or a plurality of first recesses in/on the surface of the substrate, the first recess or recesses being recessed with respect to one or more corresponding first land areas of the first region in/on the surface of the substrate. Further comprises applying a colour-shifting coating structure to the relief structure that the colour-shifting coating structure received in the first recess or recesses of the first region and on one or more first land areas. The colour-shifting coating structure applied wherein a thickness of the colour-shifting coating structure in the first recess or recesses is greater than or less than a thickness of the colour-shifting coating structure on one or more first land areas.
    Type: Application
    Filed: September 6, 2017
    Publication date: June 27, 2019
    Applicant: DE LA RUE INTERNATIONAL LIMITED
    Inventors: Frederic FOURNIER, Brian William HOLMES
  • Publication number: 20190105938
    Abstract: A security element includes a first layer, the first layer having opposing first and second surfaces, and being formed of a substantially transparent first material having a first refractive index, the first surface of the first layer having formed therein, in a first region, an array of focussing elements. An optically variable effect generating structure is located over the first layer in a second region at least partially overlapping the array of focussing elements in the first region. An array of image elements is arranged over the array of focussing elements such that a first image, formed from at least some of the image elements, is displayed to a viewer viewing the image elements via the array of focussing elements of the first layer. The optically variable effect generating structure is also configured to display, in the second region, a second image to the viewer.
    Type: Application
    Filed: April 26, 2017
    Publication date: April 11, 2019
    Applicant: DE LA RUE INTERNATIONAL LIMITED
    Inventors: Brian William HOLMES, Navin SUYAL
  • Publication number: 20190108270
    Abstract: Embodiment for identifying data convergence are presented. First and second sets of data each comprising heterogeneous data are each processed in accordance with a data clustering algorithm so as to obtain a plurality of primary and secondary data clusters, respectively, where each data cluster comprising homogeneous data. The primary and secondary data clusters are analyzed with respect to time to identify convergence of data of the first and second sets of data to first and second topics, respectively. The first and second topics are compared to determine a pattern of data convergence for the first and second data sets.
    Type: Application
    Filed: October 5, 2017
    Publication date: April 11, 2019
    Inventors: Jonathan Dunne, Karen Forde, William Holmes, Andrew Penrose
  • Patent number: 10252562
    Abstract: A security element including substrate on which is disposed: in first area, a first optically variable device including a diffractive or reflective relief structure and reflection enhancing material following contours of relief structure; and, in second area, a second optically variable device including an iridescent amplitude interference material. First optically variable device is constituted by a plurality of sub-areas arranged in cyclically repeating sequence along predetermined direction of the security element, the plurality of sub-areas collectively forming first area.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: April 9, 2019
    Assignee: DE LA RUE INTERNATIONAL LIMITED
    Inventor: Brian William Holmes
  • Publication number: 20190062703
    Abstract: The present invention provides improved methods For producing RPE cells from human embryonic stem cells or from other human pluripotent stem cells. The invention also relates to human retinal pigmented epithelial cells derived from human embryonic stem cells or other human multipotent or pluripotent stem cells. hRPE cells derived from embryonic stem cells are molecularly distinct from adult and fetal-derived RPE cells, and are also distinct from embryonic stem cells. The hRPE cells described herein are useful for treating retinal degenerative diseases.
    Type: Application
    Filed: August 27, 2018
    Publication date: February 28, 2019
    Applicant: Astellas Institute for Regenerative Medicine
    Inventors: Christopher Malcuit, Linda Lemieux, William Holmes, Pedro Huertas, Lucy Vilner
  • Publication number: 20190000246
    Abstract: A display stand for securement of a photograph to a surface. The display stand is provided having a base with a bottom surface with an adhesive thereon. The display stand includes a screw that selectively moves a middle panel along a rail from a clamped to an unclamped position. A gripping surface is provided on the middle panel and a front surface.
    Type: Application
    Filed: January 24, 2018
    Publication date: January 3, 2019
    Inventors: William Holmes, Lisa Holmes
  • Patent number: 10127755
    Abstract: A moiré magnification device including a transparent substrate carrying: an array of micro-focusing elements, the focusing elements defining a focal plane; a first array of microimage elements in a first colour and a second array of microimage elements in a second colour, the first and second arrays of microimage elements are located in a plane substantially coincident with the focal plane of the focusing elements, the second array of microimage elements being laterally offset from the first. The pitches of the micro-focusing elements, first and second arrays of microimage elements and their relative locations are such that the array of micro-focusing elements cooperates with each of the first and second arrays of microimage elements to generate respective magnified versions of the microimage elements due to the moiré effect. An interruption zone is perceived between the magnified versions of the first and second microimage arrays, respectively, and exhibits no magnified versions.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: November 13, 2018
    Assignee: DE LA RUE INTERNATIONAL LIMITED
    Inventor: Brian William Holmes
  • Publication number: 20180315151
    Abstract: Methods of manufacturing security documents and security devices, and corresponding products, provide a lenticular device effect in a first registration zone. Viewing its appearance from two different angles in this way, the relative positioning of the focussing element array and the image array can be judged to a high degree of accuracy. If the two arrays do not have the desired relative position, this will be clearly apparent since the different first and second images will not be captured at the first and second test viewing angles.
    Type: Application
    Filed: July 11, 2016
    Publication date: November 1, 2018
    Applicant: DE LA RUE INTERNATIONAL LIMITED
    Inventors: Brian William HOLMES, Robert WHITEMAN, Lawrence George COMMANDER