Abstract: A method of manufacturing a sensor assembly for an analyte sensor includes, forming a substrate, forming at least one electrode on the substrate, forming an enzymatic layer on the substrate and the at least one electrode, and disabling functionality of at least part of the enzymatic layer while a portion of the enzymatic layer over at least part of the at least one electrode remains active.

Abstract: A safety assembly for use with a laser-directed energy weapon is disclosed. The assembly comprises a control system comprising a photodetector and a processing unit; and an optical device configured to attach to a target such that, when attached, the optical device provides a light beam to the photodetector. The processing unit is arranged to compare the received light beam against one or more predetermined attributes, and to permit the laser-directed energy weapon to fire only when the received light beam is determined to have the one or more attributes.

Abstract: A sensor assembly includes a body having a first end, a second end, and a longitudinal axis extending between the first and second ends, wherein at least part of the body is tubular and defines a cavity that extends along the longitudinal axis to facilitate delivery of medication therethrough, and a plurality of electrodes formed on a surface of the body, wherein each of the electrodes extends at least partially longitudinally along the body, with an electrical contact closer to the first end and a sensing region closer to the second end.

Abstract: A processing unit includes a plurality of processing cores and is configured to arrange a sparse matrix for parallel performance by the cores on different rows of the matrix at least in part by calculating a respective quantity of non-zero elements in each row, assigning each row to a respective collection according to the respective quantity of non-zero elements for the row, wherein the processing unit is configured to assign at least one first row of the sparse matrix to respective collections of in parallel with assigning at least one second row of the sparse matrix to respective collections, and performing at least one mathematical operation on at least a first collection of the plurality of collections in parallel with performing the at least one mathematical operation on at least a second collection of the plurality of collections.

Abstract: A method of detecting a leak in an evaporative emissions system includes sealing an evaporative emissions system, achieving a first target pressure in the evaporative emissions system, achieving a second target pressure in the evaporative emissions system after achieving the first target pressure, and monitoring a system pressure subsequent to the second target pressure achieving step to determine a leak condition of the evaporative emissions system.

Abstract: A computer-implemented method includes supplying a large language model with company data. The large language model is supplied with sales guidelines. A trained model is derived from the large language model. The trained model is utilized for automated user interactions.

Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).

Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.

Abstract: A computer-implemented method for dynamic resource management can include evaluating, by at least one processor, whether a priority of one or more processes associated with a request for one or more shared resources meets a threshold condition. The method can additionally include determining, by the at least one processor and in response to an evaluation that the priority meets the threshold condition, whether the one or more shared resources is available to meet the request. The method can further include completing, by the at least one processor and in response to a determination that the one or more shared resources is available, execution of the one or more processes. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A system for enhancing personnel safety on a railroad track is presented. The system can receive data from sensors and/or a PTC system to determine positions of clients/worker and/or vehicles, and further utilize such data to determine if a vehicle is within a certain proximity of the client/worker location. The system can further generate geofences around clients/vehicles to and determine when such geofences intersect one another. Additionally, the present disclosure can assign severity levels and generate alerts with the assigned severity levels, and such severity levels can indicate how close a vehicle is to a particular location. It is an object of the invention to provide a system for generating alerts to notify personnel when they much retreat to a place of safety.

Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

Abstract: A method for compensating for a visual impairment in a virtual reality environment, by multiple computer systems associated with a head mounted display, including, rendering an initial image for display in a virtual reality environment, determining a first visual adjustment to the HMD based on an input received by the HMD, the input being associated with a visual impairment of a user of the HMD, determining that the first visual adjustment does not satisfy a threshold measure of compensation for the visual impairment of the user, determining a second visual adjustment to the HMD, and rendering an adjusted image for display in the virtual reality environment based on the first visual adjustment and the second visual adjustment.

Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).

Abstract: The present invention relates to an apparatus for supplying a liquid target material to a radiation source, comprising a first reservoir, a pressurizing system configured to pressurize a hydraulic fluid, and a separating device configured to separate the hydraulic fluid from the liquid target material in the first reservoir and to transfer a pressure from the hydraulic fluid to the liquid target material. The invention also relates to an associated method of supplying liquid target material to a radiation source.

Abstract: A bottle assembly has a bottle and a removable cap. The cap includes a nozzle and a vent arrangement. The vent arrangement can include a vent conduit that extends into an air cavity present at the bottom of the bottle assembly when the bottle assembly is inverted. The vent arrangement allows for pressure equalization within the bottom assembly in response to liquid being dispensed from the bottle assembly to permit high flow rates of the dispensed liquid without squeezing of the bottle.

Abstract: A semiconductor device, referred to herein as a Globally Interconnected Operations (GIO) layer, provides global operations in the form of global data reduction for one or more PE arrays. The GIO layer includes processing elements that perform global data reduction on processing results from one or more PE arrays. The GIO layer includes connectors that allow it to be arranged in a 3D stack with one or more PE arrays, for example, on top of or beneath a PE array. This allows reduction operations to be implemented across PE arrays using an efficient topology with superior flexibility, scalability, latency and/or power characteristics that is customizable for particular use cases at assembly time, without requiring costly and time-consuming redesign of PE arrays, and without being constrained by particular PE array designs.

Abstract: An applicator assembly for applying at least a portion of an analyte monitor includes a frame having a longitudinal axis and an opening, a resilient member having at least a first portion fixed relative to the frame and a second portion movable axially relative to the frame, a needle, and a cap engageable with the frame to cover at least part of the opening. The cap is adjustable to increase a bias on the resilient member and to move the second portion of the resilient member away from the opening. When the cap is separated from the frame, the second portion of the resilient member is configured to be held relative to the frame. The hold on the second portion of the resilient member is releasable, such that the bias on the resilient member advances the second portion of the resilient member and the needle towards the opening.