Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).

Abstract: A method of treating plasma with a pretreatment solution that has a physiologically compatible spray dry stable acidic substance (SDSAS) and an amino acid, prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.

Abstract: Embodiments include exerciser device placement in the development of an integrated circuit. Aspects of the invention include obtaining a design of an integrated circuit and creating a dynamic power blockage map for the integrated circuit. Aspects also include updating the integrated circuit design by placing one or more exercisers on the integrated circuit, wherein a location of the one or more exercisers on the integrated circuit is based on at least in part on the dynamic power blockage map. Based on a determination that the updated integrated circuit design complies with one or more design constraints, aspects further include outputting the updated integrated circuit design.

Abstract: Embodiments herein relate to hollow profiles and methods of preparing the same for joining operations. A method herein can include placing a dam within a channel defined by the hollow profile, fitting a die block over an end of the channel, and injecting a flowable composition through an injection port into the channel. Another method can include defining a volume within a first member using at least one flow control device, filling the defined volume with a flowable polymeric composition, allowing the flowable polymeric composition to solidify to form a solid portion in the first member, and mechanically modifying the solid portion to define a joining surface suitable for joining to the second member. Other embodiments are also included herein.

Abstract: A manufacturing system includes a tape advancing through the manufacturing system and a station of the manufacturing system. The tape includes a first portion having grains of an inorganic material bound by an organic binder. The station of the manufacturing system receives the first portion of the tape and prepares the tape for sintering by chemically changing the organic binder and/or removing the organic binder from the first portion of the tape, leaving the grains of the inorganic material, to form a second portion of the tape and, at least in part, prepare the tape for sintering.

Abstract: Apparatus including an optical signal generator, a data transmission path, and an optical signal receiver. Optical signal generator includes a coherent light source for generating a spectrum of carrier signals at different carrier frequencies, an optical demultiplexer that receives and separates the different carrier signals into separate optical paths, a pair of optical modulators located in each of the separate optical paths to modulate each different carrier signal with a data signal and produce an upper and lower sideband pair at each of the different carrier frequencies, and an optical interleaver to combine the upper and lower sideband pairs into an optical super-channel of interleaved sub-bands. Optical signal receiver includes a demodulator for extracting the data signals. Optical modulators are configured to reuse each carrier signal to transmit different data in each of the upper sideband and the lower sideband and increase the capacity of the super-channel. Also a method.

Abstract: Degradation of the reflectivity of one or more reflective optical elements in a system for generating EUV radiation is reduced by the controlled introduction of a gas into a vacuum chamber containing the optical element. The gas may be added to the flow of another gas such as hydrogen or alternated with the introduction of hydrogen radicals.

Abstract: Devices and methods for withdrawing bodily fluid from a subject are disclosed herein. In some embodiments, a handheld device can include a housing having an opening, a skin-piercing assembly, and an actuator coupled to the skin-piercing assembly. The skin-piercing assembly can include a casing, a drive member pivotably mounted within the casing and carrying a blade, and a biasing member coupling the drive member to the casing. The actuator can be movable relative to the housing from a first position to a second position. In the first position, the drive member can engage the casing to maintain the biasing member in a biased configuration. Movement of the actuator from the first position to the second position can disengage the drive member from the casing to permit the biasing member to drive the blade at least partially through and/or across the opening in the base.

Abstract: A bottle assembly has a bottle and a removable cap. The cap includes a nozzle and a vent arrangement. The vent arrangement can include a vent conduit that extends into an air cavity present at the bottom of the bottle assembly when the bottle assembly is inverted. The vent arrangement allows for pressure equalization within the bottom assembly in response to liquid being dispensed from the bottle assembly to permit high flow rates of the dispensed liquid without squeezing of the bottle.

Abstract: A method of detecting a leak in an evaporative emissions system includes sealing an evaporative emissions system, achieving a first target pressure in the evaporative emissions system, achieving a second target pressure in the evaporative emissions system after achieving the first target pressure, and monitoring a system pressure subsequent to the second target pressure achieving step to determine a leak condition of the evaporative emissions system.

Abstract: Methods for enhancing the binding rate between at least two particulate binding partners are disclosed. Methods include flowing a first binding partner and a second binding partner, e.g., in a viscoelastic fluid, under conditions to chemically bind the first binding partner and the second binding partner to create a third binding partner. The flow conditions induce a particle size dependent, migration, e.g., radial, velocity differential between the first binding partner and the second binding partner and between the first binding partner and third binding partner, e.g., to increasing a collision frequency of the nanoparticles and the larger particles. Devices for enhancing the binding rate between at least two particulate binding partners are also disclosed.

Abstract: A leak detection module (LDM) includes a housing, a canister valve solenoid (CVS) that is arranged within the housing and in fluid communication along a first fluid passageway between first and second ports. The module also includes a pump that is arranged within the housing and is in fluid communication with the first and second ports, and a pressure sensor that is in fluid communication with at least one of the first and second ports. A first controller is arranged in the housing and is in communication with the pump, the CVS and the pressure sensor. The first controller runs a test procedure using the pump and operating the CVS between open and closed positions to monitor a pressure within the module. The first controller communicates a result based upon the monitored pressure to a second controller that is arranged outside the housing and remotely from the module.

Abstract: Methods are herein described which reduce the non-specific light scattering background from polymeric microspheres in aqueous suspension to a level where individual metal or metal-like plasmonic nanoparticles that have been chemically bound to the surface of individual polymeric microspheres can be imaged by high resolution optics and enumerated by image analysis software. The non-specific light scattering background is reduced by employing aqueous-miscible solvents to remove residual water at the microsphere surfaces and resuspending the microspheres in a fluid having a refractive index substantially similar to the refractive index of polymeric microspheres. Embodiments of the method disclosed herein enable sensitive quantitative assays for ligand receptor binding, antigen antibody binding and nucleic acid hybridization binding. The embodiments disclosed herein further may employ polystyrene microspheres and gold plasmonic nanoparticles.

Abstract: Devices and methods for withdrawing bodily fluid from a subject are disclosed herein. In some embodiments, a handheld device can include a housing having an opening, a skin-piercing assembly, and an actuator coupled to the skin-piercing assembly. The skin-piercing assembly can include a casing, a drive member pivotably mounted within the casing and carrying a blade, and a biasing member coupling the drive member to the casing. The actuator can be movable relative to the housing from a first position to a second position. In the first position, the drive member can engage the casing to maintain the biasing member in a biased configuration. Movement of the actuator from the first position to the second position can disengage the drive member from the casing to permit the biasing member to drive the blade at least partially through and/or across the opening in the base.

Abstract: An extractor system includes a negative pressure gas stream source, a negative pressure conduit, a positive pressure gas stream source, a plurality of positive pressure gas stream manifolds, and an operator interface. The negative pressure conduit is conveys the negative pressure gas stream from a work area. A first end of the negative pressure conduit is coupled to the negative pressure gas stream source, such that the negative pressure gas stream flows from the work area through a second end of the negative pressure conduit and toward the first end of the negative pressure conduit. The positive pressure gas stream manifolds are disposed about the negative pressure conduit at the second end of the negative pressure conduit, and fluidly coupled to the positive pressure gas stream source. The positive pressure gas stream is directed through the plurality of positive pressure gas stream manifolds.

Abstract: An apparatus comprises at least one processing device, the at least one processing device being configured to receive an encapsulation of two or more types of content associated with a camera system, the two or more types of content comprising one or more video signals and one or more data signals. The at least one processing device is also configured to separate the encapsulation into the two or more types of content to obtain the one or more video signals and the one or more data signals, to output at least a given one of the one or more video signals to a first display unit, and to provide at least a given one of the one or more data signals to at least one of (i) a controller associated with the first display unit and (ii) a second display unit.

Abstract: A leak detection module (LDM) includes a housing, a canister valve solenoid (CVS) that is arranged within the housing and in fluid communication along a first fluid passageway between first and second ports. The module also includes a pump that is arranged within the housing and is in fluid communication with the first and second ports, and a pressure sensor that is in fluid communication with at least one of the first and second ports. A first controller is arranged in the housing and is in communication with the pump, the CVS and the pressure sensor. The first controller runs a test procedure using the pump and operating the CVS between open and closed positions to monitor a pressure within the module. The first controller communicates a result based upon the monitored pressure to a second controller that is arranged outside the housing and remotely from the module.

Abstract: A contamination trap for use in a debris mitigation system of a radiation source, the contamination trap comprising a plurality of vanes configured to trap fuel debris emitted from a plasma formation region of the radiation source; wherein at least one vane or each vane of the plurality of vanes comprises a material comprising a thermal conductivity above 30 W m?1 K?1.

Abstract: A contamination trap for use in a debris mitigation system of a radiation source, the contamination trap comprising a plurality of vanes configured to trap fuel debris emitted from a plasma formation region of the radiation source; wherein at least one vane or each vane of the plurality of vanes comprises a material comprising a thermal conductivity above 30 W m?1K?1.

Abstract: An extractor system includes a negative pressure gas stream source, a negative pressure conduit, a positive pressure gas stream source, a plurality of positive pressure gas stream manifolds, and an operator interface. The negative pressure conduit is conveys the negative pressure gas stream from a work area. A first end of the negative pressure conduit is coupled to the negative pressure gas stream source, such that the negative pressure gas stream flows from the work area through a second end of the negative pressure conduit and toward the first end of the negative pressure conduit. The positive pressure gas stream manifolds are disposed about the negative pressure conduit at the second end of the negative pressure conduit, and fluidly coupled to the positive pressure gas stream source. The positive pressure gas stream is directed through the plurality of positive pressure gas stream manifolds.