Abstract: An M2M Service Layer is expanded to access the services of third parties and exchange data with these third parties. The M2M Service Layer is then able to act as a proxy between M2M Devices and the third party services. The M2M Service Layer is able to present a single/consistent interface, or API, to the M2M Device and hide the details of the third party service provider from the M2M Device.

Abstract: Disclosed herein are medical systems, devices, and methods for performing vascular treatments and diagnoses. A vascular device include an optical fiber including a single fiber core disposed offset from a central axis of the optical fiber. The single fiber enables logic of the system to perform determine multiple conditions of the device and the patient. The conditions may include one or more of blood flow parameters, infusate delivery parameters, location of the device within the patient, pH of the blood, oxygen level of the blood, damage to the optical fiber, or core temperature of the patient. The elongate medical device may be a catheter, a stylet, a guidewire, or a probe.

Abstract: An antenna includes a folding mechanism for configuring the antenna into at least one of a first configuration and a second configuration. When in the first configuration, the antenna is configured for operational use. When in the second configuration, the antenna is configured for shipping in a package. A locking apparatus secures the antenna in either configuration. The folding mechanism and the locking mechanism configure the antenna into the first configuration. A method for preparing for shipment an antenna having a reflector with a width, a height, and depth, a backing structure coupled to the reflector, a first swivel plate, coupled to the backing structure, a feed arm bracket coupled to the first swivel plate, and a feed arm coupled to the feed arm bracket. The first swivel plate facilitates yaw rotations of the feed arm bracket, relative to the backing structure.

Abstract: Disclosed is an ultrasound probe including an array of ultrasonic transducers and an orientation system, wherein the orientation system obtains orientation information of the ultrasound probe.

Abstract: Disclosed are systems and methods for automatically determining needle guides for establishing vascular access. For example, a system can include an ultrasound probe, a console operably coupled to the ultrasound probe, and a display screen integrated into the console. The console can include one or more processors and memory including instructions configured to instantiate one or more processes when executed by the one-or-more processors for automatic determination of a needle guide in accordance with ultrasound-imaging data, historical data, or a combination thereof. The automatic determination of such a needle guide can use logic, algorithms, machine learning, artificial intelligence, or a combination thereof. The display screen can be configured to display an ultrasound image including one or more blood vessels below a skin surface of a patient as well as the needle guide resulting from the automatic determination for establishing vascular access to the one-or-more blood vessels in the ultrasound image.

Abstract: Provided are antibodies that target the cellular efflux pump ABCC4. Also provided are pharmaceutical compositions, nucleic acids, recombinant expression vectors, cells, and kits that include or encode such antibodies. Methods of using the antibodies for detecting presence or absence of ABCC4 expression in cells, e.g., tumor cells, level of ABCC4 expression, and/or inhibiting ABCC4 function are also disclosed. Also provided are methods for treating a subject for a cancer that include administering to the subject an anti-ABCC4 antibody disclosed herein.

Abstract: Methods, systems, and apparatuses that enable a Service Layer (SL) to support analysis of internet of things (IoT) data and enable shared access to information generated by the analysis. An analytics management service may allow SL entities to configure analytics functions for many different IoT sources of data and organize the results in a customizable manner. The SL may support coordinating the analysis of IoT data from multiple independent sources and organizing the results of the analysis.

Abstract: An illustrative application executing on a first device establishes a first network connection between the first device and a collaboration platform server managing a set of components for a collaboration platform providing voice communication services with respect to a virtual space. Using the first network connection, the application: 1) sets a first location within the virtual space at which a first voice component is positioned, and 2) determines a second location within the virtual space at which a second voice component is positioned. The application receives, by way of a second network connection between the first and second devices, audio data representing voice communication originating at the second device. Based on the first and second locations, the application generates a spatialized rendering of the audio data for presentation to a user. Corresponding methods and systems are also disclosed.

Abstract: Methods, systems, apparatuses, devices, and computer program products are described. A communication process flow management service that manages a communication process flow may receive an indication of a segment of entities from a second service that manages a data model for multiple entities. Based on an action of the communication process flow, the communication process flow management service may request schema of the data model or additional attribute data associated with the segment from the second service. The communication process flow management service may receive the schema or the additional attribute data and use it to determine a set of communications to be transmitted to one or more entities of the segment. The communication process flow management service may transmit the set of communications in accordance with the communication process flow.

Abstract: Methods, systems, apparatuses, devices, and computer program products are described. A communication platform may receive a first request indicating a first data object comprising metadata associated with an update to an action of a communication process flow. The metadata may indicate that a user with particular permissions is to approve the update. The communication platform may post an entry displaying the metadata and configured to receive an indication of approval of the update from the user. The communication platform may receive an indication of the approval from the user, for example via a user interface component. The communication platform may generate a second data object indicating the action and the user, ensuring that the update was successfully approved, and transmit a second request to a communication process flow management service supporting the communication process flow, the second request including the second object and configured to activate the update.

Abstract: A superconducting distributed bidirectional current driver system includes multiple bidirectional current drivers, a bidirectional current load being operatively coupled between two adjacent bidirectional current drivers. Each of the bidirectional current drivers includes first and second superconducting latch circuits. The first superconducting latch circuit in a first one of the bidirectional current drivers and the second superconducting latch circuit in a second one of the bidirectional current drivers coupled to the current load are selectively activated by first and second activation signals, respectively, to establish a first current path through the current load in a first direction.

Abstract: One or more examples relate to a method. The method may include: comparing a first value and a second value, the first value representing a duty cycle of a reference clock and the second value representing a duty cycle of an output clock generated by a clock tracking circuit to track the reference clock; setting a duty cycle of a changed clock to reduce duty cycle mismatch between the reference clock and the output clock indicated by the comparing; and providing the changed clock having set duty cycle in lieu of the one of the reference clock or the output clock.

Abstract: A memory output circuit for selectively propagating proximate memory output data in a memory array of superconducting memory cells includes multiple datum inputs adapted to operably receive corresponding memory state signals from physically adjacent bit lines in the memory array, and at least one logic gate configured to implement logical OR functionality. The logic gate includes multiple inputs, for receiving at least a subset of the datum inputs operatively coupled thereto, and an output for propagating at least one datum output signal. The memory output circuit further includes at least one delay element operatively coupled to a corresponding one of the datum inputs. The delay element is configured to generate an output signal operably connected to a corresponding one of the inputs of the logic gate, the output signal generated by the delay element being a temporal sequence of at least a subset of the memory state signals supplied thereto delayed by a prescribed delay value.

Abstract: Disclosed herein is a system, apparatus and method directed to obtaining first data indicative of a first location within the patient vasculature, obtaining second data that is indicative of a second location within the patient vasculature, performing a confirmation process that includes determining whether the second location corresponds to the first location within a predetermined threshold, and when the second location is determined to correspond to the first location within the predetermined threshold, determining the first location accurately indicates the current location of the distal tip of the medical device. The first modality may be any of a fiber optic modality, a magnetically-based tip location system modality, or an electrocardiogram monitoring system modality and the second data may represent fluctuations of the distal tip of the medical device. The medical device may be an introducer wire, a guidewire, a stylet, a stylet within a needle, a needle, or a catheter.

Abstract: One or more examples relate to a method. The method includes: receiving up/down error signals indicative of duty cycle mismatch between a reference clock signal and a changed feedback clock signal that represents an output clock signal generated by a clock tracking circuit to track the reference clock signal; setting a duty cycle of a changed feedback clock signal to reduce duty cycle mismatch indicated by the up/down error signals; and providing the changed feedback clock having set duty cycle.

Abstract: One or more examples relate to triggering a single error detector on rising and falling edges of clock signals, and generating an error signal therefrom. A method may include receiving a first clock signal and a second clock signal. The method may include generating, via a single error detector being triggered at least partially responsive to like respective edges of the first clock signal and the second clock signal, an error signal that represents a phase difference between the first clock signal and the second clock signal.

Abstract: A composition dispenser with dynamically adjustable protrusions/bristles for delivery of a cosmetic composition to a substrate, particularly hair coloring agents. The composition dispenser comprises a protrusion unit including one or more protrusion elements and at least one dispensing orifices appointed for fluidic communication with a formulation reservoir. The protrusion unit is operably coupled to a length-adjustment element configured to adjust an exposed protrusion length of the protrusion elements along a direction perpendicular to a rotation plane of the length-adjust element.

Abstract: Disclosed herein is a method for communicating between platforms, comprising the steps of initializing a first platform and a second platform; optically tracking a movement of the second platform by the first platform; and optically communicating bi-directionally between the first platform and the second platform. Disclosed herein is an optical communication device comprising various elements including but not limited to: a processor configured to provide at least a tracking mode and a communications mode; an input-output interface coupled to the processor; an electro-optic controller coupled to the input-output interface; an acquisition-tracking portion coupled to the electro-optic controller; and a communication portion coupled to the electro-optic controller.

Abstract: Disclosed are systems and methods for automatic determination of one or more medical devices for vascular access prior to direct patient assessment. For example, a system can include a console and a display screen optionally integrated into the console. The console can include one or more processors and memory. The memory can include instructions configured to instantiate one or more processes when executed by the one-or-more processors for the automatic determination of the one-or-more medical devices for vascular access in accordance with a plurality of data inputs, various operating parameters, historical data, or a combination thereof. The automatic determination of the one-or-more medical devices can use at least logic, algorithms, machine learning including a machine-learning model trained with the historical data, artificial intelligence, or a combination thereof. The display screen can be configured to display the one-or-more medical devices recommended for vascular access.

Abstract: Disclosed herein are medical systems, devices, and methods for identifying a blood vessel as a vein or as an artery. The system includes an optical fiber configured for insertion into a blood vessel coupled with a console having a light source, an optical receiver, processors, and logic stored in memory. The optical fiber includes sensors disposed along its length configured to determine a state or condition of the optical fiber, where the state or condition includes a strain, movement, pressure, or temperature. The logic analyzes reflected optical signals emanating from the sensors to determine that the optical fiber is inserted within an artery or within a vein. Logic may also determine a red-blue shift of a projected light to determine a blood flow direction with respect to the optical fiber.