Abstract: Disclosed are integrated devices capable of performing a polymerase chain reaction within a single vessel. Also disclosed are related methods of sample analysis.

Abstract: Disclosed are integrated devices capable of performing a polymerase chain reaction within a single vessel. Also disclosed are related methods of sample analysis.

Abstract: Disclosed are methods, devices and systems for biological and chemical sample processing using microfluidic chips. The disclosed microfluidic chips contain at least two detection zones for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens to determine their presence in the sample. Systems are also described comprising a cassette having at least one port and a sample inlet in fluid communication with a detection zone for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens, or mixtures thereof, if present, in a sample. Methods for concurrent testing of at least two of RNA, DNA, antibody, and antigen in a sample are also described, as are methods for testing for pre-selected pathogens and microfluidic methods.

Abstract: The invention is directed to compositions comprising polyvalent complexes containing a biocompatible polymer backbone to which is attached a plurality of monomeric anti-microbial peptides and to methods for using such complexes to stabilize anti-microbial peptides for treating or preventing a disease or condition resulting from infection with a microbe. Multivalent derivatives of existing antimicrobial peptides in which several peptides are covalently linked have been investigated. The resulting construct may contain up to 30 or more units, and exhibits a significant enhancement of anti-microbial effect relative to the free peptides: on the order of a ten fold improvement in effectiveness, suggesting that higher multimerization can indeed lead to more effective agents.

Abstract: A system for managing and organizing content includes a source capable of operating at least one application (i.e., content manager, taxonomy manager, etc.). The application(s) are capable of providing a plurality of pieces of content and a plurality of master taxonomies, each master taxonomy including at least one piece of content placed at one or more locations. After providing the pieces of content and the master taxonomies, the application(s) can identify a subset of the pieces of content and at least one master taxonomy, where the subset includes at least one piece of content. The application(s) can then generate at least one client taxonomy based upon the identified subset and the master taxonom(ies) such that the subset of the pieces of content can thereafter be organized in the client taxonom(ies). The system can also include a client capable of organizing the subset in the client taxonom(ies).

Abstract: A system for providing digial rights management of protected content includes a client and a DRM manager. The client is capable of receiving at least one piece of content, the piece(s) of content being encrypted with at least one encryption key regardless of client user(s) authorized to access the piece(s) of encrypted content. To facilitate the client accessing one or more of the piece(s) of content, the DRM manager is capable of transferring the encryption key(s) to the client, the encryption key(s) being encrypted with a private key of a public key/private key pair unique to a client user associated with the client. The client can thereafter decrypt the encryption key(s) using the public key of the public key/private key pair unique to the client user. Then, the client can decrypt the piece(s) of content using the decrypted encryption key(s), and access the decrypted piece(s) of content.

Abstract: A system for providing content includes a source and a client. The source is capable of generating a representation of the content, the content being hierarchically-structured and including at least one item having an associated type. The source is capable of generating a representation including an identity table and at least one type table, each item of content being included in the identity table, and included in a type table based upon the type of the item. Thereafter, the source can be capable of providing the representation of the content. The client is capable of receiving the representation of the content, and accessing at least a portion of the content based upon the representation. The client can also be capable of receiving a query for at least one item of content, searching the representation for the item(s), and accessing at least a portion of the content including the item(s).

Abstract: A golf ball and package assembly, comprising: at least one golf ball; a package separable from said golf ball defining a cavity within which said golf ball is positioned, said package comprising: (a) a moisture proof, resealable container and an integrally attached cap, wherein the package has a base, an internal cavity, an outer surface, an upper portion and lower portion, a rim at the upper portion, the cap has a base and a skirt extending perpendicularly around the outer periphery of the base, the cap is provided with a thumb tab for facilitating the opening and closing of the container, and is attached to the package by a hinge; (b) the cap and container are non-circular in shape having curved sides and flat sides, joined by rounded corners; (c) an outer wall of the ridge and wall surfaces of the cap rim define a gap into which rim is fitted to form a moisture proof seal when the cap is in the closed position; and (d) a desiccant insert.

Abstract: The invention includes compositions comprising substantially purified salivary glycoproteins and carbohydrate ligands thereof which are useful in methods for the treatment and prevention of HIV-1 infection. The invention also includes methods for the treatment and prevention of HIV-1 infection comprising contacting a composition of the invention with a human patient. Additionally, the invention includes antibodies and kits useful in the treatment and prevention of HIV-1 infection.