Patents by Inventor William B. Lacefield

William B. Lacefield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents
    Patent number: 4021553
    Abstract: A method of treating inflammation which utilizes topically-active 5,6-diaryl-1,2,4-triazines having the formula, ##STR1## wherein R is hydrogen or --(X).sub.n R.sub.1, in which X is either O or S, n is an integer which is either 0 or 1, and R.sub.1 is C.sub.1 -C.sub.8 alkyl, C.sub.7 -C.sub.8 aralkyl, C.sub.3 -C.sub.8 cycloalkyl, or C.sub.4 -C.sub.8 (cycloalkyl)alkyl; and R.sub.2 and R.sub.3 independently are C.sub.1 -C.sub.3 alkoxy or di(C.sub.1 -C.sub.3 alkyl)amino; and the pharmaceutically-acceptable acid addition salts of basic members thereof.
    Type: Grant
    Filed: March 10, 1976
    Date of Patent: May 3, 1977
    Assignee: Eli Lilly and Company
    Inventors: William B. Lacefield, Peter P. K. Ho
  • 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents
    Patent number: 4018923
    Abstract: A method of treating inflammation which utilizes topically-active 5,6-diaryl-1,2,4-triazines having the formula, ##STR1## wherein R is hydrogen or --(X).sub.n R.sub.1, in which X is either O or S, n is an integer which is either 0 or 1, and R.sub.1 is C.sub.1 -C.sub.8 alkyl, C.sub.7 -C.sub.8 aralkyl, C.sub.3 -C.sub.8 cycloalkyl, or C.sub.4 -C.sub.8 (cycloalkyl)alkyl; and R.sub.2 and R.sub.3 independently are halo, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, or di(C.sub.1 -C.sub.3 alkyl)amino, with the proviso that at least one of R.sub.2 and R.sub.3 is halo or C.sub.1 -C.sub.3 alkyl; and the pharmaceutically-acceptable acid addition salts of basic members thereof.
    Type: Grant
    Filed: March 10, 1976
    Date of Patent: April 19, 1977
    Assignee: Eli Lilly and Company
    Inventors: William B. Lacefield, Peter P. K. Ho
  • 5,6-DIARYL-1,2,4-TRIAZINES
    Patent number: 4013654
    Abstract: 5,6-Diaryl-1,2,4-triazines, topically-active anti-inflammatory agents, having the formula, ##STR1## wherein R is hydrogen or --(X).sub.n R.sub.1, in which X is either O or S, n is an integer which is either 0 or 1, and R.sub.1 is C.sub.1 -C.sub.8 alkyl, C.sub.7 -C.sub.8 aralkyl, C.sub.3 -C.sub.8 cycloalkyl, or C.sub.4 -C.sub.8 (cycloalkyl)alkyl; and R.sub.2 and R.sub.3 independently are halo, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, or di(C.sub.1 -C.sub.3 alkyl)amino, with the proviso that at least one of R.sub.2 and R.sub.3 is halo or C.sub.1 -C.sub.3 alkyl; and the pharmaceutically-acceptable acid addition salts of basic members thereof.
    Type: Grant
    Filed: March 10, 1976
    Date of Patent: March 22, 1977
    Assignee: Eli Lilly and Company
    Inventor: William B. Lacefield
  • 3-Amino-5,6-diaryl-1,2,4-triazines
    Patent number: 4008232
    Abstract: This invention relates to certain 3-amino-5,6-diaryl-1,2,4-triazines useful as anti-inflammatory agents and a method of treating inflammation.
    Type: Grant
    Filed: April 12, 1976
    Date of Patent: February 15, 1977
    Assignee: Eli Lilly and Company
    Inventor: William B. Lacefield
  • Topically-active anti-inflammatory 3-chloro-5,6-diaryl-1,2,4-triazines
    Patent number: 3989831
    Abstract: 3-Chloro-5,6-diaryl-1,2,4-triazines, topically active anti-inflammatory agents, having the formula ##SPC1##Wherein R.sub.2 and R.sub.3 independently are halo, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, or di(C.sub.1 -C.sub.3 alkyl)amino; and the pharmaceutically-acceptable acid addition salts of basic members thereof.
    Type: Grant
    Filed: March 10, 1976
    Date of Patent: November 2, 1976
    Assignee: Eli Lilly and Company
    Inventor: William B. Lacefield
  • Anti-inflammatory 3-amino-5,6-diaryl-1,2,4-triazines
    Patent number: 3979516
    Abstract: This invention relates to certain 3-amino-5,6-diaryl-1,2,4-triazines useful as anti-inflammatory agents and a method of treating inflammation.
    Type: Grant
    Filed: June 23, 1975
    Date of Patent: September 7, 1976
    Assignee: Eli Lilly and Company
    Inventor: William B. Lacefield
  • Arylacetylene compounds as antithrombotic agents
    Patent number: 3968251
    Abstract: A method of treating vascular thrombosis in Warm-blooded animals, employing an arylacetylene as the active antithrombotic agent.
    Type: Grant
    Filed: August 25, 1975
    Date of Patent: July 6, 1976
    Assignee: Eli Lilly and Company
    Inventors: William B. Lacefield, Winston S. Marshall
  • 2,4-Diaminoquinazolines as antithrombotic agents
    Patent number: 3956495
    Abstract: 2,4-diaminoquinazolines are employed as antithrombotic agents and have the following general formula: ##SPC1##Wherein R.sub.1 and R.sub.2 are monovalent groups independently selected from the group consisting of ##EQU1## wherein R.sub.4 and R.sub.5 independently are selected from the group consisting of hydrogen, alkyl, and cycloalkyl, with the proviso that both R.sub.4 and R.sub.5 cannot be cycloalkyl, ##EQU2## wherein R.sub.6, R.sub.7, and R.sub.8 independently are selected from the group consisting of hydrogen and alkyl, and A is a divalent organic group having from two to about six carbon atoms such that the two nitrogen atoms are separated by at least two carbon atoms, andC. heterocyclic-amino, andR.sub.3 is a monovalent group selected from the group consisting of hydrogen, halogen, and alkyl.
    Type: Grant
    Filed: October 30, 1973
    Date of Patent: May 11, 1976
    Assignee: Eli Lilly and Company
    Inventor: William B. Lacefield
  • 3-Amino-5,6-diaryl-1,2,4-triazines
    Patent number: 3948894
    Abstract: This invention relates to certain 3-amino-5,6-diaryl-1,2,4-triazines useful as anti-inflammatory agents and a method of treating inflammation.
    Type: Grant
    Filed: January 31, 1974
    Date of Patent: April 6, 1976
    Assignee: Eli Lilly and Company
    Inventor: William B. Lacefield
  • Phenoxyphenyl-acetylenes and thio analogues thereof as antithrombotic agents
    Patent number: 3939278
    Abstract: A method of treating vascular thrombosis in warm-blooded animals, employing a phenoxyphenylacetylene or thio analogue thereof as the active antithrombotic agent.
    Type: Grant
    Filed: July 5, 1974
    Date of Patent: February 17, 1976
    Assignee: Eli Lilly and Company
    Inventors: William B. Lacefield, Winston S. Marshall