Abstract: The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

Abstract: A document review system is configured to quickly provide search results for large amounts of documents. Ontology templates are used to generate objects and links based on the documents. Users can view documents, and linked objects and object properties can be displayed. An index assisted search can be performed to determine the linked objects and object properties. A supplemental search can be performed on a second database that tracks modifications to the documents or objects. The modifications in the second database can be periodically written to the first database, and the index can be rebuilt. The user experience can be free of slow searches and slow index rebuilds.

Abstract: A computer-implemented method is provided to provide analysis of claim information. The system may receive claim data from a plurality of entities and, for one or more claim items in the received claim data, determine a format of the claim item. The system may convert the claim item from the determined format into a standard format. The system may receive a selection of one or more providers, and determine one or more claim items associated with the provider in the selection. The system may generate a user interface, the user interface comprising a visual representation of one or more attributes of the one or more claim items.

Abstract: A document review system is configured to quickly provide search results for large amounts of documents. Ontology templates are used to generate objects and links based on the documents. Users can view documents, and linked objects and object properties can be displayed. An index assisted search can be performed to determine the linked objects and object properties. A supplemental search can be performed on a second database that tracks modifications to the documents or objects. The modifications in the second database can be periodically written to the first database, and the index can be rebuilt. The user experience can be free of slow searches and slow index rebuilds.

Abstract: Disclosed herein are multi-specific binding polypeptide molecules (e.g., multi-specific antibodies) that can interact with a tumor cell and an immunosuppressive cell. In some embodiments, also described herein are methods for treating one or more diseases or conditions (e.g., cancers) using the multi-specific binding polypeptides (e.g., multi-specific antibodies).

Abstract: A computer-implemented method is provided to provide analysis of claim information. The system may receive claim data from a plurality of entities and, for one or more claim items in the received claim data, determine a format of the claim item. The system may convert the claim item from the determined format into a standard format. The system may receive a selection of one or more providers, and determine one or more claim items associated with the provider in the selection. The system may generate a user interface, the user interface comprising a visual representation of one or more attributes of the one or more claim items.

Abstract: A document review system is configured to quickly provide search results for large amounts of documents. Ontology templates are used to generate objects and links based on the documents. Users can view documents, and linked objects and object properties can be displayed. An index assisted search can be performed to determine the linked objects and object properties. A supplemental search can be performed on a second database that tracks modifications to the documents or objects. The modifications in the second database can be periodically written to the first database, and the index can be rebuilt. The user experience can be free of slow searches and slow index rebuilds.

Abstract: The invention relates to prostate specific membrane antigen humanized antibodies (anti-PSMA) and anti-PSMA antibody drug conjugates. The invention also relates to methods and compositions for using anti-PSMA antibody drug conjugates in inhibiting, preventing or treating PSMA related diseases or cancers.

Abstract: Multivalent binding peptides, including bi-specific binding peptides, having immunoglobulin effector function are provided, along with encoding nucleic acids, vectors and host cells as well as methods for making such peptides and methods for using such peptides to treat or prevent a variety of diseases, disorders or conditions, as well as to ameliorate at least one symptom associated with such a disease, disorder or condition.

Abstract: An optical system and method that utilize multiple low-etendue lasers to illuminate multiple spots one or more spatial light modulators. Stereoscopic systems may be formed by using different wavelengths or different polarizations for each spot. Light from each spot is guided to each eye of the viewer by wearing 3D glasses.

Abstract: A removably attachable insulator having a jacket adapted to slide over a container for keeping the contents of the container at or near a predetermined temperature is provided. The jacket may include heating elements attached thereto for heating the container. A control circuitry is also integrated with the jacket, the control circuitry providing a thermostat adapted to set and control the temperature through operatively associating with the heating elements. The jacket and container may become removably attached through the use of detachable fasteners integrated with the container and or the jacket.

Abstract: The present disclosure generally relates systems, apparatus, and methods for security devices, in particular, low-power, security devices and other devices. The devices typically connect to the Internet or other networks only on an intermittent, event-based basis, typically by cellular modem. The invention meets a need for security devices, as well as other devices, that can connect to the Internet and other networks but that are low-power and/or intermittently connected to networks such as the Internet on an intermittent and/or on demand basis. This renders them more secure, less susceptible to hacking and other attacks, less prone to continuously gathering data that a user might consider to be superfluous and/or invasive in terms of data collected, and can make them low-power, thus allowing them to run on battery for long periods of time.

Abstract: The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition; the invention provides humanized CD37-specific binding molecules.

Abstract: A removably attachable insulator having a jacket adapted to slide over a container for keeping the contents of the container at or near a predetermined temperature is provided. The jacket may include heating elements attached thereto for heating the container. A control circuitry is also integrated with the jacket, the control circuitry providing a thermostat adapted to set and control the temperature through operatively associating with the heating elements. The jacket and container may become removably attached through the use of detachable fasteners integrated with the container and or the jacket.

Abstract: The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules.

Abstract: There is provided inter alia a process for stabilizing a eukaryotic cell line which expresses PylRS and tRNAPyl and which is suitable for incorporation of a gene encoding a target protein containing one or more non-natural amino acids encoded by a nonsense codon which comprises culturing said cell line under conditions in which the adverse effect of tRNAPyl expression on cell viability and/or cell growth is reduced or eliminated.

Abstract: The invention relates inter alia to a bivalent, bispecific construct comprising an anti-IL-6 antibody, or derivative thereof, and an anti-IL-23 antibody, or derivative thereof and its use in therapy. The invention also relates to useful anti-IL-6 antibodies and anti-IL-23 antibodies.

Abstract: The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules.

Abstract: A dc rechargeable, battery powered, food preparation device uses rapid angular displacement action thereby enabling a human operator to use barely more than the weight of the instrument's spinning cutter against a wide variety of fruit and vegetable peels ranging from dense eggplant to delicate peach, while also providing for operator safety through the use of safe-start interlock technology along with a catch-and-release safety cover over the cutting head itself. As a result the user friendly appliance scales the entire surface of common produce items while rapidly and efficiently removing the outer layer of skin in bitwise fashion as opposed to generating continuous long strings of discard material.