Abstract: The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules.

Abstract: The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.

Abstract: The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.

Abstract: The invention is embodied in a heavy duty drill bit for hard/soft rock drilling comprising a high fatigue-resistant, high alloy steel bit body having a PCD cutter member and an enlarged shank portion constructed to accommodate torsional forces at high thrust pressures, and reamer means for compensating the effect of bore hole rifling. The invention further involves the method of forming a roof bolting matrix in extremely hard rock formations having a compression strength up to about 50,000 psi using PCD wafers on a high tensile strength steel body coupled by a heavy duty shank through high fatigue-resistant reamer means to a high strength drive steel member.

Abstract: The invention is embodied in a heavy duty drill bit for hard/soft rock drilling comprising a high fatigue resistant, high alloy steel bit body having a PCD cutter element of super hard material and an enlarged shank portion constructed to accommodate torsional forces at high thrust pressures, and reamer means for compensating the effect of bore hole rifling. The invention further involves the method of forming a roof bolting matrix in extremely hard rock formations having a compression strength up to about 50,000 psi using PCD wafers on a high tensile strength steel body coupled by a heavy duty shank through high fatigue resistant reamer means to a high strength drive steel member.

Abstract: The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules.

Abstract: The invention is embodied in a diesel system for reducing particulate matter emissions in off-road vehicles, coal mining and metal/non-metal mining operations, comprising, in combination, a supply of highly paraffinic diesel fuel having a high Cetane rating and substantially no sulfur, aromatics and nitrogen content and being formulated to greatly reduce PM output levels from the engine relative to conventional diesel fuels, The invention is further embodied in the method of reducing diesel emission contaminants including providing a supply of highly paraffinic diesel fuel having a negligible sulfur, aromatics or nitrogen content, and a high Cetane number, and other apparatus useful for filtering engine emissions before discharge to ambient.

Abstract: The invention is embodied in a diesel system for reducing diesel particulate matter (DPM) emissions particularly in underground diesel engine operations, comprising, in combination, a supply of synthetic paraffinic diesel fuel having substantially no sulfur, aromatics and nitrogen content and formulated to greatly reduce DPM levels in the engine exhaust emissions relative to conventional diesel fuels, and other exhaust emissions processing apparatus preferably forming an aqueous filter constructed and arranged to form a water bath for all exhaust gas output from the engine and including in the water bath a preselected significant quantity of a low foaming wetting composition having a high affinity for hydrocarbons. The invention is further embodied in the method of reducing diesel emission contaminants including providing a supply of synthetic diesel fuel having a negligible sulfur, aromatics or nitrogen content, pre-filtering the diesel fuel, and removing DPM from exhaust gases by filtration.

Abstract: The present invention provides soluble CTLA4 mutant molecules which bind CD80 and/or CD86 antigen.

Abstract: The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. The invention further provides methods for using antibodies to B7, or fragments thereof, to regulate CD28 positive T cell response and immune responses mediated by T cells.

Abstract: The invention is embodied in an emission control system for reducing diesel particulate matter (DPM) from diesel engine exhaust gases comprising an aqueous filter apparatus constructed and arranged to form a water bath for all exhaust gas output from the engine and including in the water bath a preselected significant quantity of a low foaming wetting composition having a high affinity for hydrocarbons. The invention is further embodied in a diesel emissions filtering method including pre-filtering diesel fuel and removing DPM from exhaust gases by filtration through an aqueous solution having a low foaming wetting composition.

Abstract: The present invention relates to regulation of lymphocyte activation. In particular, it relates to compositions and methods for regulating lymphocyte activation by selectively binding multiple cell surface antigens expressed by the same lymphocyte.