Patents by Inventor William Brondyk

William Brondyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-NGF ANTIBODIES AND USES THEREOF
    Publication number: 20240010717
    Abstract: The invention provides novel anti-NGF proteins, antibodies, and NGF-binding fragments thereof which inhibit association of NGF with TrkA and/or p75 and are suitable for administration to a canine or feline subject. The invention also provides novel compositions and methods of treating pain or eliciting an analgesic effect in a canine or feline subject, comprising administering an effective amount of an anti-NGF protein, antibody or fragment thereof. The methods and compositions are used to treat or prevent NGF-related disorders.
    Type: Application
    Filed: July 6, 2023
    Publication date: January 11, 2024
    Inventors: William BRONDYK, Jordan WILLIS, Leila SEVIGNY
  • FGFR3 ANTIBODIES AND METHODS OF USE
    Publication number: 20230303704
    Abstract: Anti-FGFR3 antigen-binding proteins and antigen-binding binding fragments thereof are provided. Methods of inhibiting FGFR3 activity and methods of treating FGFR3-mediated diseases and disorders are also provided.
    Type: Application
    Filed: October 12, 2022
    Publication date: September 28, 2023
    Inventors: Yves SABBAGH, Yangde CHEN, William BRONDYK, Huawei QIU, Sunghae PARK, Ronnie WEI, Yu QIU, Yanfeng ZHOU, Cendrine LEMOINE, HyunSuk CHO
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN CANINES AND METHODS OF USE
    Publication number: 20230279118
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.
    Type: Application
    Filed: December 5, 2022
    Publication date: September 7, 2023
    Inventors: William BRONDYK, Brett CHEVALIER, Juergen HORN, Madhusudan NATARAJAN
  • Compositions for increasing half-life of a therapeutic agent in felines and methods of use
    Patent number: 11739135
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a feline and methods of their use. The compositions involve variant feline IgG Fc regions.
    Type: Grant
    Filed: April 29, 2022
    Date of Patent: August 29, 2023
    Assignee: Invetx, Inc.
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN CANINES AND METHODS OF USE
    Publication number: 20230127241
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.
    Type: Application
    Filed: July 28, 2022
    Publication date: April 27, 2023
    Inventors: William BRONDYK, Brett CHEVALIER, Juergen HORN, Madhusudan NATARAJAN
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN FELINES AND METHODS OF USE
    Publication number: 20230090405
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a feline and methods of their use. The compositions involve variant feline IgG Fc regions.
    Type: Application
    Filed: October 12, 2022
    Publication date: March 23, 2023
    Inventors: William BRONDYK, Brett CHEVALIER, Juergen HORN, Madhusudan NATARAJAN
  • Compositions for increasing half-life of a therapeutic agent in canines and methods of use
    Patent number: 11548949
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.
    Type: Grant
    Filed: April 28, 2020
    Date of Patent: January 10, 2023
    Assignee: Invetx, Inc.
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • Compositions for increasing half-life of a therapeutic agent in canines and methods of use
    Patent number: 11542333
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: January 3, 2023
    Assignee: Invetx, Inc.
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • FGFR3 antibodies and methods of use
    Patent number: 11505611
    Abstract: Anti-FGFR3 antigen-binding proteins and antigen-binding binding fragments thereof are provided. Methods of inhibiting FGFR3 activity and methods of treating FGFR3-mediated diseases and disorders are also provided.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: November 22, 2022
    Assignee: GENZYME CORPORATION
    Inventors: Yves Sabbagh, Yangde Chen, William Brondyk, Huawei Qiu, Sunghae Park, Ronnie Wei, Yu Qiu, Yanfeng Zhou, Cendrine Lemoine, HyunSuk Cho
  • Compositions for increasing half-life of a therapeutic agent in felines and methods of use
    Patent number: 11498953
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a feline and methods of their use. The compositions involve variant feline IgG Fc regions.
    Type: Grant
    Filed: June 23, 2021
    Date of Patent: November 15, 2022
    Assignee: Invetx, Inc.
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • Polypeptides with altered binding to neonatal Fc receptor (FcRn) and methods of use
    Patent number: 11434276
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: September 6, 2022
    Assignee: Invetx, Inc.
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN FELINES AND METHODS OF USE
    Publication number: 20220259282
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a feline and methods of their use. The compositions involve variant feline IgG Fc regions.
    Type: Application
    Filed: April 29, 2022
    Publication date: August 18, 2022
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN LIVESTOCK ANIMALS AND METHODS OF USE
    Publication number: 20220177549
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a livestock animal and methods of their use. The compositions involve variant IgG Fc regions.
    Type: Application
    Filed: December 1, 2021
    Publication date: June 9, 2022
    Inventors: William Brondyk, Juergen Horn
  • FGFR3 ANTIBODIES AND METHODS OF USE
    Publication number: 20220056142
    Abstract: Anti-FGFR3 antigen-binding proteins and antigen-binding binding fragments thereof are provided. Methods of inhibiting FGFR3 activity and methods of treating FGFR3-mediated diseases and disorders are also provided.
    Type: Application
    Filed: August 20, 2021
    Publication date: February 24, 2022
    Inventors: Yves SABBAGH, Yangde CHEN, William BRONDYK, Huawei QIU, Sunghae PARK, Ronnie WEI, Yu QIU, Yanfeng ZHOU, Cendrine LEMOINE, HyunSuk CHO
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN FELINES AND METHODS OF USE
    Publication number: 20220009994
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a feline and methods of their use. The compositions involve variant feline IgG Fc regions.
    Type: Application
    Filed: June 23, 2021
    Publication date: January 13, 2022
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN CANINES AND METHODS OF USE
    Publication number: 20210347854
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.
    Type: Application
    Filed: May 11, 2021
    Publication date: November 11, 2021
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN CANINES AND METHODS OF USE
    Publication number: 20200362035
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.
    Type: Application
    Filed: April 28, 2020
    Publication date: November 19, 2020
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN CANINES AND METHODS OF USE
    Publication number: 20200216536
    Abstract: Provided are compositions for increasing the half-life of a polypeptide or polypeptides in a canine and methods of their use. The compositions involve variant canine IgG Fc regions.
    Type: Application
    Filed: January 2, 2020
    Publication date: July 9, 2020
    Inventors: William Brondyk, Brett Chevalier, Juergen Horn, Madhusudan Natarajan
  • METHODS OF INCREASING PROTEIN EXPRESSION LEVELS
    Publication number: 20080014635
    Abstract: The present invention relates to methods of increasing protein expression levels whereby at least one amino acid in a protein amino acid sequence is substituted for the amino acid, proline. Preferably, the substitution occurs within 15 amino acids, more preferably within 10 amino acids and most preferably within 5 amino acids of a cysteine amino acid residue. The present invention not only includes methods for polypeptides with proline substitutions, but also polynucleotides with codon substitutions for which a codon for any amino acid, except proline, is substituted for a codon encoding for proline.
    Type: Application
    Filed: July 16, 2007
    Publication date: January 17, 2008
    Inventors: William Brondyk, Xuliang Jiang, Rene Schweickhardt
  • Methods of increasing protein expression levels
    Patent number: 7258997
    Abstract: The present invention relates to methods of increasing protein expression levels whereby at least one amino acid in a protein amino acid sequence is substituted for the amino acid, proline. Preferably, the substitution occurs within 15 amino acids, more preferably within 10 amino acids and most preferably within 5 amino acids of a cysteine amino acid residue. The present invention not only includes methods for polypeptides with proline substitutions, but also polynucleotides with codon substitutions for which a codon for any amino acid, except proline, is substituted for a codon encoding for proline.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: August 21, 2007
    Assignee: Applied Research Systems Ars Holding N.V.
    Inventors: William Brondyk, Xuliang Jiang, Rene Lynn Schweickhardt