Patents by Inventor William Brondyk

William Brondyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF INCREASING PROTEIN EXPRESSION LEVELS
    Publication number: 20080014635
    Abstract: The present invention relates to methods of increasing protein expression levels whereby at least one amino acid in a protein amino acid sequence is substituted for the amino acid, proline. Preferably, the substitution occurs within 15 amino acids, more preferably within 10 amino acids and most preferably within 5 amino acids of a cysteine amino acid residue. The present invention not only includes methods for polypeptides with proline substitutions, but also polynucleotides with codon substitutions for which a codon for any amino acid, except proline, is substituted for a codon encoding for proline.
    Type: Application
    Filed: July 16, 2007
    Publication date: January 17, 2008
    Inventors: William Brondyk, Xuliang Jiang, Rene Schweickhardt
  • Methods of increasing protein expression levels
    Patent number: 7258997
    Abstract: The present invention relates to methods of increasing protein expression levels whereby at least one amino acid in a protein amino acid sequence is substituted for the amino acid, proline. Preferably, the substitution occurs within 15 amino acids, more preferably within 10 amino acids and most preferably within 5 amino acids of a cysteine amino acid residue. The present invention not only includes methods for polypeptides with proline substitutions, but also polynucleotides with codon substitutions for which a codon for any amino acid, except proline, is substituted for a codon encoding for proline.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: August 21, 2007
    Assignee: Applied Research Systems Ars Holding N.V.
    Inventors: William Brondyk, Xuliang Jiang, Rene Lynn Schweickhardt
  • Mutant glycoproteins
    Publication number: 20050119465
    Abstract: The inventors have designed novel FSH mutants with increased glycosylation and longer half-lives for use in inducing folliculogenesis in human patients. The use of a FSH mutant preparation of the invention permits the use of lower cumulative doses of FSH to achieve the same or better clinical result.
    Type: Application
    Filed: October 22, 2002
    Publication date: June 2, 2005
    Inventors: William Brondyk, Xuliang Jiang, Robert Campbell
  • FSH glycosylation mutant
    Publication number: 20050100989
    Abstract: A novel FSH mutant with increased glycosylation and longer half-lifes for use in inducing folliculogenesis in human patients is described. The FSH mutant permits the use of lower cumulative doses of FSH to achieve the same or better clinical result.
    Type: Application
    Filed: September 2, 2004
    Publication date: May 12, 2005
    Inventors: Louise Garone, Stephen Arkinstall, William Brondyk, Robert Campbell, Xuliang Jiang, Sean McKenna, Mark Tepper
  • METHODS OF INCERASING PROTEIN EXPESSION LEVELS
    Publication number: 20050074840
    Abstract: Abstract of the Disclosure The present invention relates to methods of increasing protein expression levels whereby at least one amino acid in a protein amino acid sequence is substituted for the amino acid, proline. Preferably, the substitution occurs within 15 amino acids, more preferably within 10 amino acids and most preferably within 5 amino acids of a cysteine amino acid residue. The present invention not only includes methods for polypeptides with proline substitutions, but also polynucleotides with codon substitutions for which a codon for any amino acid, except proline, is substituted for a codon encoding for proline.
    Type: Application
    Filed: September 13, 2004
    Publication date: April 7, 2005
    Applicant: Applied Research Systems ARS Holding N.V.
    Inventors: William Brondyk, Xuliang Jiang, Rene Schweickhardt