Patents by Inventor William D. Arnold

William D. Arnold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR ASSIGNING LIKELIHOOD OF ACUTE KIDNEY INJURY PROGRESSION
    Publication number: 20140315734
    Abstract: The invention encompasses diagnosis and prognosis in the context of heart or renal failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The invention also relates to methods of assigning an increased likelihood that a subject having AKI is susceptible to AKI progression. The invention relates in part to assigning a diagnosis of heart and/or renal failure, and/or an outcome risk (e.g., worsening cardiac and/or renal function or a mortality risk) to a subject based, at least in part, on the result(s) obtained from an assay that detects WAP four-disulfide core domain protein 2 performed on a body fluid sample obtained from a subject.
    Type: Application
    Filed: July 3, 2012
    Publication date: October 23, 2014
    Applicant: ALERE SAN DIEGO INC.
    Inventors: William D. Arnold, Christelle Jost, Brian Noland, Jonathan Gary, Joseph Buechler, Vance Wong, Scott Harold Rongey, Uday Kumar Veeramallu, Kelline Marie Rodems
  • Methods and compositions for diagnosis and risk prediction in heart failure
    Patent number: 8795975
    Abstract: The present invention relates in part to diagnosing the occurrence of heart failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The present invention further relates in part to assigning an outcome risk (e.g., worsening cardiac function or a mortality risk, a risk of rehospitalization) to a subject. The methods comprise performing one or more assays that detect one or more biomarkers selected from the group consisting of WAP4C, ESAM, LTBR, Mesothelin, and Syndecan-1 performed on a body fluid sample obtained from a subject, and assigning diagnosis or risk based, at least in part, on the result(s) obtained thereby.
    Type: Grant
    Filed: November 25, 2011
    Date of Patent: August 5, 2014
    Assignee: Alere San Diego, Inc.
    Inventors: William D. Arnold, Christelle Jost, Brian Noland, Jonathan Gary, Joseph Buechler, Vance Wong, Scott Harold Rongey, Uday Kumar Veeramallu, Kelline Marie Rodems
  • METHODS AND COMPOSITIONS FOR DIAGNOSIS AND RISK PREDICTION IN HEART FAILURE
    Publication number: 20140147867
    Abstract: The present invention relates in part to diagnosing the occurrence of heart failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The present invention further relates in part to assigning an outcome risk (e.g., worsening cardiac function or a mortality risk, a risk of rehospitalization) to a subject. The methods comprise performing one or more assays that detect one or more biomarkers selected from the group consisting of WAP4C, ESAM, LTBR, Mesothelin, and Syndecan-1 performed on a body fluid sample obtained from a subject, and assigning diagnosis or risk based, at least in part, on the result(s) obtained thereby.
    Type: Application
    Filed: November 25, 2011
    Publication date: May 29, 2014
    Applicant: ALERE SAN DIEGO, INC.
    Inventors: William D. Arnold, Christelle Jost, Brian Noland, Jonathan Gary, Joseph Buechler, Vance Wong, Scott Harold Rongey, Uday Kumar Veeramallu, Kelline Marie Rodems
  • Fused ring heterocycle kinase modulators
    Patent number: 8268994
    Abstract: The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: September 18, 2012
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Pierre Bounaud, Chixu Chen, Brian Eastman, Andreas Gosberg, Stefan N. Gradl, Stephanie Hopkins, Zhe Li, Ian McDonald, Paul A. Sprengeler, Ruo W. Steensma, Mark E. Wilson
  • Pyrimidinyl-thiophene kinase modulators
    Patent number: 7977481
    Abstract: The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: July 12, 2011
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Chixu Chen, Stefan N. Gradl, Stephanie Hopkins, Ruo W. Steensma, Masaki Tomimoto, Mark E. Wilson
  • Pyrrolo-pyridine kinase modulators
    Patent number: 7906648
    Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: March 15, 2011
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Pierre Bounaud, Andreas Gosberg, Zhe Li, Ian McDonald, Ruo W. Steensma, Mark E. Wilson
  • Pyrimidinyl-Thiophene Kinase Modulators
    Publication number: 20100305128
    Abstract: The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity.
    Type: Application
    Filed: August 6, 2010
    Publication date: December 2, 2010
    Inventors: William D. Arnold, Chixu Chen, Stefan N. Gradl, Stephanie A. Hopkins, Ruo W. Steensma, Masaki Tomimoto, Mark E. Wilson
  • Fused ring heterocycle kinase modulators
    Patent number: 7829558
    Abstract: The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: September 22, 2008
    Date of Patent: November 9, 2010
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Andreas Gosberg, Zhe Li, Ruo W. Steensma, Mark E. Wilson
  • Pyrimidinyl-thiophene kinase modulators
    Patent number: 7803806
    Abstract: The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: November 2, 2006
    Date of Patent: September 28, 2010
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Chixu Chen, Stefan N. Gradl, Stephanie A. Hopkins, Ruo W. Steensma, Masaki Tomimoto, Mark E. Wilson
  • Pyrrolo-pyridine kinase modulators
    Patent number: 7709645
    Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: May 4, 2010
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: William D Arnold, Pierre Bounaud, Chixu Chen, Brian Eastman, Andreas Gosberg, Stefan N. Gradl, Stephanie Hopkins, Zhe Li, Ian McDonald, Paul A. Sprengeler, Ruo W. Steensma, Mark E. Wilson
  • Fused Ring Heterocycle Kinase Modulators
    Publication number: 20100036118
    Abstract: The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
    Type: Application
    Filed: August 11, 2009
    Publication date: February 11, 2010
    Inventors: William D. Arnold, Pierre Bounaud, Chixu Chen, Brian Eastman, Andreas Gosberg, Stefan N. Gradl, Stephanie Hopkins, Zhe Li, Ian McDonald, Paul A. Sprengeler, Ruo W. Steensma, Mark E. Wilson
  • PYRROLO-PYRIDINE KINASE MODULATORS
    Publication number: 20090306056
    Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
    Type: Application
    Filed: July 10, 2009
    Publication date: December 10, 2009
    Inventors: WILLIAM D. ARNOLD, PIERRE BOUNAUD, ANDREAS GOSBERG, ZHE LI, IAN MCDONALD, RUO W. STEENSMA, MARK E. WILSON
  • Fused ring heterocycle kinase modulators
    Patent number: 7626021
    Abstract: The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: December 1, 2009
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Pierre Bounaud, Chixu Chen, Brian Eastman, Andreas Gosberg, Stefan N. Gradl, Stephanie Hopkins, Zhe Li, Ian McDonald, Paul A. Sprengeler, Ruo W. Steensma, Mark E. Wilson
  • Pyrrolo-pyridine kinase modulators
    Patent number: 7601839
    Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: October 13, 2009
    Assignee: SGX Pharmaceuticals Inc.
    Inventors: William D. Arnold, Pierre-Yves Bounaud, Andreas Gosberg, Zhe Li Bounaud, Ian McDonald, Ruo W. Steensma, Mark E. Wilson
  • Pyrrolo-pyridine kinase modulators
    Patent number: 7582637
    Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: September 1, 2009
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Pierre-Yves Bounaud, Andreas Gosberg, Zhe Li Bounaud, Ian McDonald, Ruo W. Steensma, Mark E. Wilson
  • FUSED RING HETEROCYCLE KINASE MODULATORS
    Publication number: 20090203687
    Abstract: The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
    Type: Application
    Filed: September 22, 2008
    Publication date: August 13, 2009
    Applicant: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Andreas Gosberg, Zhe Li, Ruo W. Steemsma, Mark E. Wilson
  • PYRROLO-PYRIDINE KINASE MODULATIORS
    Publication number: 20090143352
    Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
    Type: Application
    Filed: April 10, 2007
    Publication date: June 4, 2009
    Applicant: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Pierre Bounaud, Chixu Chen, Brian Eastman, Andreas Gosberg, Stefan N. Gradl, Stephanie Hopkins, Zhe Li, Ian McDonald, Paul A. Sprengeler, Ruo W. Steensma, Mark E. Wilson
  • PYRROLO-PYRIDINE KINASE MODULATORS
    Publication number: 20090005378
    Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
    Type: Application
    Filed: February 29, 2008
    Publication date: January 1, 2009
    Applicant: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Pierre-Yves Bounaud, Andreas Gosberg, Zhe Li Bounaud, Ian McDonald, Ruo W. Steensma, Mark E. Wilson
  • Fused ring heterocycle kinase modulators
    Patent number: 7452993
    Abstract: The present invention provides novel fused ring heterocycle kinase modulators and methods of using the novel fused ring heterocycle kinase modulators to treat diseases mediated by kinase activity.
    Type: Grant
    Filed: July 27, 2005
    Date of Patent: November 18, 2008
    Assignee: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Andreas Gosberg, Zhe Li, Ruo W. Steensma, Mark E. Wilson
  • PYRROLO-PYRIDINE KINASE MODULATORS
    Publication number: 20080221119
    Abstract: The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.
    Type: Application
    Filed: February 29, 2008
    Publication date: September 11, 2008
    Applicant: SGX Pharmaceuticals, Inc.
    Inventors: William D. Arnold, Pierre Bounaud, Andreas Gosberg, Zhe Li, Ian McDonald, Ruo W. Steensma, Mark E. Wilson