Patents by Inventor William D. Carlson

William D. Carlson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC COMBINATIONS OF TDFRPs AND ADDITIONAL AGENTS AND METHODS OF USE
    Publication number: 20220000978
    Abstract: The present disclosure relates generally to methods of treating or preventing a tissue differentiation factor-associated disorder or disease and methods of treating or preventing fibrosis in a subject using tissue differentiation factor related polypeptide (TDFRPs) in combination with an additional agent. The present disclosure also relates to compositions and pharmaceutical compositions comprising the TDFRPs and an additional agent.
    Type: Application
    Filed: April 20, 2021
    Publication date: January 6, 2022
    Inventor: William D. Carlson
  • TDF-RELATED COMPOUNDS AND ANALOGS THEREOF
    Publication number: 20160152674
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Application
    Filed: October 2, 2015
    Publication date: June 2, 2016
    Inventors: William D. Carlson, Peter C. Keck, Michael Sworin, Dattatreyamurty Bosukonda
  • SINGLE DOMAIN TDF-RELATED COMPOUNDS AND ANALOGS THEREOF
    Publication number: 20160152677
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Application
    Filed: October 2, 2015
    Publication date: June 2, 2016
    Inventors: William D. Carlson, Peter C. Keck
  • TDF-related compounds and analogs thereof
    Patent number: 9181301
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: November 10, 2015
    Assignee: Thrasos Innovation, Inc.
    Inventors: William D. Carlson, Peter C. Keck, Michael Sworin, Dattatreyamurty Bosukonda
  • TDF-RELATED COMPOUNDS AND ANALOGS THEREOF
    Publication number: 20150132355
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 14, 2015
    Inventors: William D. Carlson, Peter C. Keck, Michael Sworin, Dattatreyamurty Bosukonda
  • TDF-RELATED COMPOUNDS AND ANALOGS THEREOF, ANALOGS AND BIOACTIVE FRAGMENTS
    Publication number: 20150126451
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Application
    Filed: November 5, 2014
    Publication date: May 7, 2015
    Inventors: William D. Carlson, Peter C. Keck, Michael Sworin, Dattatreyamurty Bosukonda, Kellie Watson, Philippe Bey, Romesh Subramanian
  • TDF-related compounds and analogs thereof
    Patent number: 8916686
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: December 23, 2014
    Assignee: Thrasos Innovation, Inc.
    Inventors: William D. Carlson, Peter C. Keck, Michael Sworin, Dattatreyamurty Bosukonda
  • TDF-related compounds and analogs thereof, analogs and bioactive fragments
    Patent number: 8911953
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: December 16, 2014
    Assignee: Thrasos Innovation, Inc.
    Inventors: William D. Carlson, Peter C. Keck, Dattatreyamurty Bosukonda, Philippe Bey
  • SINGLE DOMAIN TDF-RELATED COMPOUNDS AND ANALOGS THEREOF
    Publication number: 20140328831
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Application
    Filed: March 24, 2014
    Publication date: November 6, 2014
    Inventors: William D. Carlson, Peter C. Keck
  • TDF-RELATED COMPOUNDS AND ANALOGS THEREOF
    Publication number: 20140044754
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Application
    Filed: February 26, 2013
    Publication date: February 13, 2014
    Inventors: William D. Carlson, Peter C. Keck, Michael Sworin, Dattatreyamurty Bosukonda
  • SINGLE DOMAIN TDF-RELATED COMPOUNDS AND ANALOGS THEREOF
    Publication number: 20130274172
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Application
    Filed: March 26, 2013
    Publication date: October 17, 2013
    Inventors: William D. Carlson, Peter C. Keck
  • TDF-RELATED COMPOUNDS AND ANALOGS THEREOF, ANALOGS AND BIOACTIVE FRAGMENTS
    Publication number: 20130231294
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Application
    Filed: September 20, 2012
    Publication date: September 5, 2013
    Inventors: William D Carlson, Peter C. Keck, Michael Sworin, Dattatreyamurty Bosukonda, Kellie Watson, Philippe Bey, Romesh Subramanian
  • Single domain TDF-related compounds and analogs thereof for use in treating a tissue differentiation factor related disorder
    Patent number: 8455446
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Grant
    Filed: January 16, 2009
    Date of Patent: June 4, 2013
    Assignee: Thrasos, Inc.
    Inventors: William D. Carlson, Peter C. Keck
  • TDF-related compounds and analogs thereof
    Patent number: 8410246
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: April 2, 2013
    Assignee: Thrasos, Inc.
    Inventors: William D. Carlson, Peter C. Keck, Michael Sworin, Dattatreymurty Bosukonda
  • TDF-related compounds and analogs thereof, analogs and bioactive fragments
    Patent number: 8299212
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: October 30, 2012
    Assignee: Thrasos Therapeutics, Inc.
    Inventors: William D. Carlson, Peter C. Keck, Dattatreymurty Bosukonda, Philippe Bey
  • Single domain TDF-related compounds and analogs thereof
    Publication number: 20110055942
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Application
    Filed: January 16, 2009
    Publication date: March 3, 2011
    Applicant: Thrasos, Inc.
    Inventors: William D. Carlson, Peter C. Keck
  • TDF-RELATED COMPOUNDS AND ANALOGS THEREOF, ANALOGS AND BIOACTIVE FRAGMENTS
    Publication number: 20100209467
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Application
    Filed: September 20, 2006
    Publication date: August 19, 2010
    Applicant: Thrasos Therapeutics , Inc.
    Inventors: William D. Carlson, Peter C. Keck, Michael Sworin, Dattatreymurty Bosukonda, Kellie Watson, Philippe Bey, Romesh Subramanian
  • Tdf-related compounds and analogs thereof
    Publication number: 20100015150
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Application
    Filed: June 17, 2005
    Publication date: January 21, 2010
    Applicant: Thrasos Therapeutics, Inc.
    Inventors: William D. Carlson, Peter C. Keck, Michael Sworin, Dattatreymurty Bosukonda
  • Single domain TDF-related compounds and analogs thereof
    Patent number: 7482329
    Abstract: The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of TDF-like receptors. The invention further relates to methods of detecting, preventing, and treating TDF-associated disorders.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: January 27, 2009
    Assignee: Thrasos Therapeutics
    Inventors: William D. Carlson, Peter C. Keck
  • Computer system and methods for producing morphogen analogs of human TDF-1
    Publication number: 20040093164
    Abstract: The invention disclosed herein provides methods and compositions for the computer-assisted design of morphogen analogs. Practice of the invention is enabled by the use of at least a portion of the atomic co-ordinates defining the three-dimensional structure of human transformation and differentiation factor-1 (hTDF-1) as a starting point in the design of the morphogen analogs. In addition, the invention provides methods for producing morphogen analogs of interest, and methods for testing whether the resulting analogs mimic or agonize human TDF-1-like biological activity. The invention also provides a family of morphogen analogs produced by such methods.
    Type: Application
    Filed: November 8, 2002
    Publication date: May 13, 2004
    Inventors: William D. Carlson, Peter C. Keck