Patents by Inventor William D. Voorhees, III

William D. Voorhees, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150150696
    Abstract: Bioactive-coated medical devices are provided, including coated vascular stents. The medical device coating can include a coating layer posited over at least a portion of the medical device surface, and can include a butyl methacrylate polymer or an ethylene-vinyl acetate copolymer in combination with a bioactive material that can function as both an immunosuppressive agent and an antiproliferative agent. Optionally, multilayer coatings can further include an adhesion promoting layer comprising parylene positioned between the coating layer and the medical device surface, a porous layer comprising butyl methacrylate positioned over at least a portion of the coating layer, or both. The coating layer preferably comprises between about 0.5 and 2.0 ?g/mm2 of the bioactive material on the outer surface of the medical device. The bioactive material can be absorbed into the coating layer, which can have a thickness of between about 0.5 ?m to about 5 ?m.
    Type: Application
    Filed: February 13, 2015
    Publication date: June 4, 2015
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
  • Patent number: 8945206
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: February 3, 2015
    Assignee: Cook Medical Technologies LLC
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
  • Patent number: 8758428
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: June 24, 2014
    Assignee: Cook Medical Technologies LLC
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, William D. Voorhees, III, Thomas G. Kozma
  • Patent number: 8556962
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.
    Type: Grant
    Filed: May 25, 2005
    Date of Patent: October 15, 2013
    Assignee: Cook Medical Technologies LLC
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
  • Patent number: 8469943
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: June 25, 2013
    Assignee: Cook Medical Technologies LLC
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
  • Patent number: 8313521
    Abstract: Methods of delivering a bioactive material to a body vessel are disclosed. The method steps can include providing an expandable medical device with a coating having a bioactive layer, and providing a second layer of a biodegradable polymer positioned over the bioactive layer. The second layer provides for controlled release of the bioactive material from the bioactive layer. The medical device is inserted into a body vessel using a catheter such that the medical device contacts the body vessel.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: November 20, 2012
    Assignee: Cook Medical Technologies LLC
    Inventors: Patrick H. Ruane, Waleska Perez-Segarra, Anthony O. Ragheb, Neal E. Fearnot, William D. Voorhees, III, Brian L. Bates, Thomas A. Osborne
  • Patent number: 8257433
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of an immunosuppressive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of immunosuppressive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of immunosuppessive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a coronary stent. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: September 4, 2012
    Assignee: Cook Medical Technologies LLC
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
  • Patent number: 8216268
    Abstract: An apparatus and method comprising at least one intragastric member made of a digestive-resistant or substantially indigestible material that is introduced into a bag located in the gastric lumen of a mammal for the treatment of obesity. One or more intragastric members are loaded into a delivery tube in a partially compacted first configuration and delivered to an overtube. The overtube includes a proximal end, a distal end and a lumen configured to receive the intragastric members in the first configuration for delivery to the bag located in the gastric lumen wherein the intragastric member is expanded to a second configuration. The apparatus further comprises a constraining element engaged with the bag to secure the intragastric member upon delivery into the gastric lumen.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: July 10, 2012
    Assignee: Cook Medical Technologies LLC
    Inventors: Frederick B. Haller, John A. Karpiel, Donagh O'Sullivan, Brian K. Rucker, Maximiliano Soetermans, William D. Voorhees, III
  • Publication number: 20110196479
    Abstract: A coated implantable medical device includes a structure adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer posited on one surface of the structure; and at least one layer of a bioactive material posited on at least a portion of the coating layer. Preferably the structure is a stent graft.
    Type: Application
    Filed: April 18, 2011
    Publication date: August 11, 2011
    Applicants: Cook Incorporated, MED Institute, Inc.
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Feamot, Thomas G. Kozma, William D. Voorhees, III
  • Patent number: 7901453
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of an immunosuppressive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of immunosuppressive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of immunosuppressive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a coronary stent. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: March 8, 2011
    Assignees: Cook Incorporated, MED Institute, Inc.
    Inventors: Anthony O. Ragheb, Neal E. Fearnot, William D. Voorhees, III, Thomas G. Kozma, Brian L. Bates, Thomas A. Osborne
  • Patent number: 7896914
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: March 1, 2011
    Assignees: Cook Incorporated, MED Institute, Inc.
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
  • Publication number: 20110046723
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.
    Type: Application
    Filed: October 12, 2010
    Publication date: February 24, 2011
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
  • Patent number: 7867275
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: January 11, 2011
    Assignees: Cook Incorporated, MED Institute, Inc.
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, William D. Voorhees, III, Thomas G. Kozma
  • Patent number: 7862605
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of a bioactive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of bioactive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of bioactive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a stent graft. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition.
    Type: Grant
    Filed: November 27, 2006
    Date of Patent: January 4, 2011
    Assignees: MED Institute, Inc., Cook Incorporated
    Inventors: Anthony O. Ragheb, Brian L. Bates, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
  • Patent number: 7846202
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, where the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 may be posited over the bioactive material layer 18, where the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: December 7, 2010
    Assignees: Cook Incorporated, Med Institute, Inc.
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, William D. Voorhees, III, Thomas G. Kozma
  • Patent number: 7811622
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: October 12, 2010
    Assignees: Cook Incorporated, MED Institute, Inc.
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
  • Patent number: 7799070
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: September 21, 2010
    Assignees: Cook Incorporated, MED Institute
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, William D. Voorhees, III, Thomas G. Kozma
  • Publication number: 20090285975
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.
    Type: Application
    Filed: June 23, 2009
    Publication date: November 19, 2009
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
  • Patent number: 7611532
    Abstract: Disclosed in one embodiment is a medical device including an expandable metal vascular stent including at least one surface. A coating layer including parylene or a parylene derivative is positioned on the at least one surface. At least one layer comprising a bioactive agent is positioned on the coating layer, wherein the bioactive agent is selected from the group consisting of an immunosuppressive agent, anti-inflammatory agent and an anti-proliferative agent. A porous layer is positioned on the at least one layer including a bioactive agent, wherein upon implantation into a patient, the porous layer controls release of the bioactive agent from the at least one layer including the bioactive agent.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: November 3, 2009
    Assignee: Cook Incorporated
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
  • Patent number: 7611533
    Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of an immunosuppressive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of immunosuppressive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of immunosuppessive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a coronary stent. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition.
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: November 3, 2009
    Assignee: Cook Incorporated
    Inventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III, Thomas A. Osborne