Abstract: A modified adenovirus, in particular Enadenotucirev (EnAd), armed with at least two bispecific T cell engagers each comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on an immune cell of interest, such as a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.

Abstract: A trailer for towing a power vehicle with a towable frame forming an undercarriage chassis and a tandem wheel assembly positioned under the undercarriage chassis. The tandem wheel assembly having a first wheel assembly, a second wheel assembly and an extension assembly moving the second wheel assembly along a longitudinal axis of the chassis between trailing position and self-propelled position, with the first wheel assembly and the second wheel assembly are positioned to support the undercarriage chassis.

Abstract: A Doherty amplifier die according to some embodiments includes a substrate having a bandgap of above about 2 eV, a main amplifier, at least one peak amplifier, an input network connected to a first input of the main amplifier and to a second input of the at least one peak amplifier, an output combiner connected to a first output of the main amplifier and to a second output of the at least one peak amplifier; and an isolation structure arranged on the substrate between the input network and the output combiner. The isolation structure is configured to isolate the input network and the output combiner.

Abstract: Tamper-respondent assemblies are provided which include individualized fluid chemical mixtures for tamper detection. The tamper-respondent assemblies include, for instance, a circuit board and an enclosure. The circuit board includes an electronic component, and the enclosure is mounted to the circuit board to enclose the electronic component within a secure volume, where the secure volume is a sealed space. A fluid is disposed within the secure volume that includes a chemical mixture of multiple chemical substances, and the multiple chemical substances have randomly generated concentrations within the chemical mixture. One or more sensors are provided to facilitate detecting a change in the chemical mixture of the fluid within the secure volume indicative of a tamper event.

Abstract: Arc fault detection modules for vehicles intended to supervise circuits and detect arc fault conditions in both alternating current and direct current circuits. A number of these arc fault detection modules may be integrated into a vehicle's electrical system in strategic locations. Each arc fault module contains sensing capabilities for monitoring the circuit, and may also include signal conditioning capabilities, processing capabilities for determining the occurrence of an arc fault, contactors for disabling the supervised circuit, and communications capabilities to interact with other vehicle components and telematics systems. As a result arc fault detection odules can be customized to leverage existing features of a vehicle's electrical system or to provide fully redundant arc fault protection.

Abstract: Dynamic trip planning via a vehicle interface is provided. A system identifies a drive route for a vehicle. The drive route includes a first charger at a first location along the drive route configured to charge a battery of the vehicle. The system receives, via a communication session established with a mobile device, a command. The command is to add a stop to the drive route at a second location. The system determines, responsive to the command to add the stop at the second location, that the second location is within a threshold distance of a second charger configured to charge the battery of the vehicle. The system updates, based on a comparison of the first location with the second location, the drive route to add the second charger at the second location and remove the first charger at the first location.

Abstract: A trailer for towing a power vehicle is provided and generally includes a frame and a self propelled tandem wheel assembly. The frame includes an undercarriage chassis, and the self propelled tandem wheel assembly is positioned under the undercarriage chassis. The self propelled tandem wheel assembly includes a rear wheel assembly and a front wheel assembly, and the rear wheel assembly and the front wheel assembly are equally positioned to support the undercarriage chassis.

Abstract: A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell activator comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.

Abstract: A hull for deployment as an underwater habitable vessel is described. The hull has at least two hull wall modules connected in series to enclose an interior volume of the underwater habitable vessel. The interior volume is bounded by the hull wall modules. There is also provided a kit of parts for a hull of an underwater habitable vessel. The kit comprises at least two hull wall modules configured to be connected in series to enclose an interior volume of the underwater habitable vessel. The interior volume is bounded by the hull wall modules when connected.

Abstract: The invention relates to a pressure hull for human occupancy, which is manufactured using an additive manufacturing process. This results in increased structural integrity and safety for the occupants of the pressure hull.

Abstract: A system includes a vehicle including a motive electrical power path; a power distribution unit including: a current protection circuit disposed in the motive electrical power path, the current protection circuit including a fuse and a contactor in a series arrangement with the fuse; a high voltage power input coupling including a first electrical interface for a high voltage power source; and a high voltage power output coupling including a second electrical interface for a motive power load, where the current protection circuit electrically couples the high voltage power input coupling to the high voltage power output coupling.

Abstract: Certain configurations of mass spectrometer components are described herein that comprise one or more mass spectrometer programmable elements. In some instances, the mass spectrometer programmable element can be configured as an electrode that can function independently of any underlying substrate or component. Ion guides, lenses, ion switches, mass analyzers and other components of a mass spectrometer are described which comprise one or more mass spectrometer programmable elements.

Abstract: An instrument panel includes a frame defining an opening, a plurality of cards, and an HMI. The cards have a front face, a rear face, one or more circuits, and a data interface on the rear face in communication with the circuits. The cards include one or more first cards and one or more second cards. The first cards front face have a vertical dimension approximately equal to a vertical dimension of the opening. The second cards have a body, a nose projecting from the body defining the second cards front face, and a recess between the nose and body. The HMI includes a front face received within the opening. The first cards are positioned with the front face visible within the opening. The second cards are positioned with the nose visible within the opening and a depth of the HMI received within the recess.

Abstract: Certain embodiments of ion interfaces are described that can provide higher sensitivities improved ion transmission and multiple operating modes. In some configurations, the ion interface may comprise a first element and a second element each of which can receive a non-zero voltage. In one configuration, the first element can be a hyperskimmer cone and the second element can be a cylindrical lens. Systems and methods using the interface are also described.

Abstract: A forklift assembly is provided and generally includes a frame, a movement system assembly having, an extension assembly coupled to the rear support assembly, and a carriage assembly. The frame includes a front support assembly and a rear support assembly. The movement system assembly includes having a plurality of sensors. The extension assembly is coupled to the rear support assembly and includes a boom support, a sliding support positioned within the boom support, a sliding mechanism positioned within the sliding support, and a raising mechanism coupled to an outer edge of the boom support. The carriage assembly includes a knuckle rotation assembly, a carriage movement assembly, a back rest assembly coupled to the knuckle rotation assembly and the carriage movement assembly; a prong assembly, and a locking assembly.

Abstract: A vascular occlusion catheter for at least partial occlusion of a target vessel includes proximal and distal shafts, with an occlusion balloon connected therebetween. The proximal shaft has a proximal internal lumen, in fluid communication with the occlusion balloon. The distal shaft has a distal internal lumen. A hypotube having an internal lumen extends through the proximal lumen and the occlusion balloon and into communication with the distal lumen. The catheter includes at least one of (i) a distal sensor positioned within the distal lumen and facing an opening formed in the distal shaft, or (ii) the proximal shaft further includes a sensor lumen, and a proximal sensor is positioned within the sensor lumen and facing an opening formed in the proximal shaft. A display hub is mounted to the proximal shaft, and is electrically connected with the at least one of the distal sensor or the proximal sensor.

Abstract: An instrument panel includes a frame defining an opening, a plurality of cards, and an HMI. The cards have a front face, a rear face, one or more circuits, and a data interface on the rear face in communication with the circuits. The cards include one or more first cards and one or more second cards. The first cards front face have a vertical dimension approximately equal to a vertical dimension of the opening. The second cards have a body, a nose projecting from the body defining the second cards front face, and a recess between the nose and body. The HMI includes a front face received within the opening. The first cards are positioned with the front face visible within the opening. The second cards are positioned with the nose visible within the opening and a depth of the HMI received within the recess.

Abstract: A trailer for towing by a power vehicle is provided and generally includes a frame, a tandem wheel assembly and an extension assembly. The frame forms an undercarriage chassis and the tandem wheel assembly is positioned under the undercarriage chassis. The tandem wheel assembly includes a front wheel assembly and a rear wheel assembly having a drive assembly. The extension assembly moves the front wheel assembly between trailing position and a self-propelled position.

Abstract: A vehicle jacking assembly for selectively raising a wheel of a vehicle for changing a tire includes a plurality of cylinders and an actuator. Each cylinder is configured to be coupled to a frame of a vehicle proximate to a respective wheel of the vehicle. The cylinder comprises a plurality of nested sections so that the cylinder is selectively extensible. The actuator is configured to be coupled to the vehicle and to be operationally coupled to an electrical circuit of the vehicle. The actuator is operationally coupled to the plurality of cylinders so that the actuator is positioned to selectively actuate a respective cylinder to extend the respective cylinder from the frame of the vehicle so that the respective cylinder contacts a surface. The respective cylinder thus is configured to raise an associated wheel of the vehicle from the surface, allowing a tire of the wheel to be changed.

Abstract: A system for cooling an inductively coupled plasma (ICP) instrument includes: the ICP instrument; a pump in fluid communication with the instrument via a first conduit; and a micro-channel heat exchanger in fluid communication with the instrument via a second conduit, and in fluid communication with the pump via a third conduit. The pump is configured to generate a pump outlet pressure of coolant that exceeds a back pressure of the instrument such that a pressure of the coolant traveling through the second conduit and into the heat exchanger is less than or equal to 5 pounds per square inch (psi) above atmospheric pressure, as measured at an inlet to the heat exchanger.