Abstract: Certain configurations of mass spectrometer components are described herein that comprise one or more mass spectrometer programmable elements. In some instances, the mass spectrometer programmable element can be configured as an electrode that can function independently of any underlying substrate or component. Ion guides, lenses, ion switches, mass analyzers and other components of a mass spectrometer are described which comprise one or more mass spectrometer programmable elements.

Abstract: A crankshaft for an internal combustion engine is provided and may include crank pins, crank journals, and webs extending between the crank pins and the crank journals. Each web further may include a web surface on each side of the web. On the web surface, a repair region is provided with an undercut formed in the web. Included in the crankshaft is a cladding deposit that is fused to the web surface in the repair region of the crankshaft.

Abstract: Ureteral or bladder catheters and systems are provided, including (a) a proximal portion; and (b) a distal portion, the distal portion including a retention portion including an outer periphery or protective surface area which prevents mucosal tissue from occluding one or more protected drainage holes, ports, or perforations disposed within the outer periphery or protective surface area upon application of negative pressure through the catheter.

Abstract: An instrument panel includes a frame defining an opening, a plurality of cards, and an HMI. The cards have a front face, a rear face, one or more circuits, and a data interface on the rear face in communication with the circuits. The cards include one or more first cards and one or more second cards. The first cards front face have a vertical dimension approximately equal to a vertical dimension of the opening. The second cards have a body, a nose projecting from the body defining the second cards front face, and a recess between the nose and body. The HMI includes a front face received within the opening. The first cards are positioned with the front face visible within the opening. The second cards are positioned with the nose visible within the opening and a depth of the HMI received within the recess.

Abstract: A crankshaft for an internal combustion engine is provided and may include crank pins, crank journals, and webs extending between the crank pins and the crank journals. Each web further may include a web surface on each side of the web. On the web surface, a repair region is provided with an undercut formed in the web. Included in the crankshaft is a cladding deposit that is fused to the web surface in the repair region of the crankshaft.

Abstract: Certain embodiments of ion interfaces are described that can provide higher sensitivities improved ion transmission and multiple operating modes. In some configurations, the ion interface may comprise a first element and a second element each of which can receive a non-zero voltage. In one configuration, the first element can be a hyperskimmer cone and the second element can be a cylindrical lens. Systems and methods using the interface are also described.

Abstract: A modified adenovirus, in particular Enadenotucirev (EnAd), armed with a bispecific T cell activator comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus.

Abstract: A forklift assembly is provided and generally includes a frame, a movement system assembly having, an extension assembly coupled to the rear support assembly, and a carriage assembly. The frame includes a front support assembly and a rear support assembly. The movement system assembly includes having a plurality of sensors. The extension assembly is coupled to the rear support assembly and includes a boom support, a sliding support positioned within the boom support, a sliding mechanism positioned within the sliding support, and a raising mechanism coupled to an outer edge of the boom support. The carriage assembly includes a knuckle rotation assembly, a carriage movement assembly, a back rest assembly coupled to the knuckle rotation assembly and the carriage movement assembly; a prong assembly, and a locking assembly.

Abstract: A vascular occlusion catheter for at least partial occlusion of a target vessel includes proximal and distal shafts, with an occlusion balloon connected therebetween. The proximal shaft has a proximal internal lumen, in fluid communication with the occlusion balloon. The distal shaft has a distal internal lumen. A hypotube having an internal lumen extends through the proximal lumen and the occlusion balloon and into communication with the distal lumen. The catheter includes at least one of (i) a distal sensor positioned within the distal lumen and facing an opening formed in the distal shaft, or (ii) the proximal shaft further includes a sensor lumen, and a proximal sensor is positioned within the sensor lumen and facing an opening formed in the proximal shaft. A display hub is mounted to the proximal shaft, and is electrically connected with the at least one of the distal sensor or the proximal sensor.

Abstract: An instrument panel includes a frame defining an opening, a plurality of cards, and an HMI. The cards have a front face, a rear face, one or more circuits, and a data interface on the rear face in communication with the circuits. The cards include one or more first cards and one or more second cards. The first cards front face have a vertical dimension approximately equal to a vertical dimension of the opening. The second cards have a body, a nose projecting from the body defining the second cards front face, and a recess between the nose and body. The HMI includes a front face received within the opening. The first cards are positioned with the front face visible within the opening. The second cards are positioned with the nose visible within the opening and a depth of the HMI received within the recess.

Abstract: A trailer for towing by a power vehicle is provided and generally includes a frame, a tandem wheel assembly and an extension assembly. The frame forms an undercarriage chassis and the tandem wheel assembly is positioned under the undercarriage chassis. The tandem wheel assembly includes a front wheel assembly and a rear wheel assembly having a drive assembly. The extension assembly moves the front wheel assembly between trailing position and a self-propelled position.

Abstract: A vehicle jacking assembly for selectively raising a wheel of a vehicle for changing a tire includes a plurality of cylinders and an actuator. Each cylinder is configured to be coupled to a frame of a vehicle proximate to a respective wheel of the vehicle. The cylinder comprises a plurality of nested sections so that the cylinder is selectively extensible. The actuator is configured to be coupled to the vehicle and to be operationally coupled to an electrical circuit of the vehicle. The actuator is operationally coupled to the plurality of cylinders so that the actuator is positioned to selectively actuate a respective cylinder to extend the respective cylinder from the frame of the vehicle so that the respective cylinder contacts a surface. The respective cylinder thus is configured to raise an associated wheel of the vehicle from the surface, allowing a tire of the wheel to be changed.

Abstract: A system for cooling an inductively coupled plasma (ICP) instrument includes: the ICP instrument; a pump in fluid communication with the instrument via a first conduit; and a micro-channel heat exchanger in fluid communication with the instrument via a second conduit, and in fluid communication with the pump via a third conduit. The pump is configured to generate a pump outlet pressure of coolant that exceeds a back pressure of the instrument such that a pressure of the coolant traveling through the second conduit and into the heat exchanger is less than or equal to 5 pounds per square inch (psi) above atmospheric pressure, as measured at an inlet to the heat exchanger.

Abstract: A method includes interpreting a contactor open event and a contactor load value for a contactor positioned on a motive power circuit for a mobile application, determining that a contactor opening event under load has occurred in response to the contactor open event and the contactor load value, and updating a contactor wear condition in response to the contactor opening event under load, wherein updating the contactor wear condition comprises accumulating a number of the contactor opening events under load.

Abstract: A trailer for towing by a power vehicle is provided and generally includes a frame and a tandem wheel assembly. The frame forms an undercarriage chassis and the tandem wheel assembly positioned under the undercarriage chassis. The tandem wheel assembly includes a rear wheel assembly and a front wheel assembly. An extension assembly is provided and moves the front wheel assembly between trailing position and a self-propelled position where the rear wheel assembly and the front wheel assembly are positioned to equally support the undercarriage chassis.

Abstract: A trailer for towing by a power vehicle is provided and generally includes a frame and a tandem wheel assembly. The trailer is provided with a drive assembly having a locking mechanism to selectively engage the drive from the motor to the wheels of the trailer. The locking mechanism having a reciprocating pushing member that may push an urging member to act upon a flanged driveshaft to selectively engage a clutch of the drive assembly.

Abstract: A trailer for towing by a power vehicle is provided and generally includes a frame and a tandem wheel assembly. The frame forms an undercarriage chassis which the tandem wheel assembly is positioned there under. The undercarriage chassis includes a rear wheel assembly, a front wheel assembly, and an extension assembly moving the front wheel assembly between trailing position and a self-propelled position. At least one of the wheel assemblies is powered by a selectively engageable drive assembly including a motor, transmission, driveshaft, selectively engageable clutch and hub, to drive the rotation of at least one of the wheels.

Abstract: A mobile application includes a breaker/relay that includes a plurality of fixed contacts electrically coupled to a power bus, a plurality of corresponding moveable contacts that are selectively electrically coupled to the plurality of fixed contacts, allowing power flow through the power bus when electrically coupled to the fixed contacts and preventing power flow when not electrically coupled, an armature operationally coupled to at least one of the moveable contacts, such that the armature prevents electrical coupling between the at least one of the moveable contacts and the corresponding one of the fixed contacts when in a first position and allows electrical coupling when in a second position, a first biasing member biasing the armature into the first position or the second position; and an arc suppression assembly structured to guide and disperse an opening arc between each of the plurality of moveable contacts and the corresponding fixed contacts.

Abstract: Provided herein are various improvements to optical-inertial stabilization systems, such as those employed on electro-optical systems that receive or emit optical energy. In one example, a system includes an optical reference element rigidly coupled to a primary mirror. The optical reference element propagates a reference signal through optic elements that form at least a portion of an optical path corresponding to the primary mirror. A measurement of the reference signal is made after propagation through the optic elements to determine errors associated with the optical path. The system can also include inertial sensors rigidly coupled to the primary mirror and optical reference element to form an assembly. The inertial sensors are configured to measure inertial rotation of the assembly. Rotational adjustments about two axes can be produced for the assembly based at least on the inertial rotation properties to correct for disturbance or drift.

Abstract: A method includes interpreting a contactor open event and a contactor load value for a contactor positioned on a motive power circuit for a mobile application, determining that a contactor opening event under load has occurred in response to the contactor open event and the contactor load value, and updating a contactor wear condition in response to the contactor opening event under load, wherein updating the contactor wear condition comprises accumulating a number of the contactor opening events under load.