Abstract: Technologies as described herein are directed towards generating optimized stent designs for treatment of tubular anatomical structures. In an exemplary computing system, the system obtains imaging data comprising images representative of anatomical structures. The system then generates a plurality of models based upon the imaging data. The models are then clustered based upon similar characteristics of the models. Certain fit parameters are applied to the models in each cluster and an optimized stent shape is generated for each cluster, wherein each optimized stent shape is representative of the models within the cluster.

Abstract: A method for configuring a stent provides a patient anatomical lumen model and provides a target anatomical lumen model. The method determines a stent strength profile for the stent based on the patient anatomical lumen model and the target anatomical lumen model. The method determines a stent model including an elastomeric body model and a scaffold model based on the stent strength profile. The method then transmits instructions effective to construct the stent using the stent model. The stent has an elastomeric body corresponding to the elastomeric body model and a scaffold, having metallic material, corresponding to the scaffold model.

Abstract: Technologies as described herein are directed towards generating optimized stent designs for treatment of tubular anatomical structures. In an exemplary computing system, the system obtains imaging data comprising images representative of anatomical structures. The system then generates a plurality of models based upon the imaging data. The models are then clustered based upon similar characteristics of the models. Certain fit parameters are applied to the models in each cluster and an optimized stent shape is generated for each cluster, wherein each optimized stent shape is representative of the models within the cluster.

Abstract: A method of operating a remote medical navigation system using ultrasound, employs ultrasound imaging from a medical device to supplement or to replace conventional x-ray imaging of the operating region during navigation.

Abstract: A medical device guide having an inner member having a proximal end, a distal end, and at least one lumen therein. An outer member surrounds the proximal portion of the inner member such that the distal end of the inner member projects beyond the distal end of the outer member, the portion of the inner member being sufficient flexible to flex with a guide wire extending through the lumen. The outer member is sufficiently stiff that the proximal end of the medical device guide can be engaged by a driven by a medical device advancer.

Abstract: A method of operating a remote medical navigation system using ultrasound, employs ultrasound imaging from a medical device to supplement or to replace conventional x-ray imaging of the operating region during navigation.

Abstract: A medical device guide having an inner member having a proximal end, a distal end, and at least one lumen therein. An outer member surrounds the proximal portion of the inner member such that the distal end of the inner member projects beyond the distal end of the outer member, the portion of the inner member being sufficient flexible to flex with a guide wire extending through the lumen. The outer member is sufficiently stiff that the proximal end of the medical device guide can be engaged by a driven by a medical device advancer.

Abstract: An implantable medical device and method are provided for determining if a patient is in a substantially horizontal position and delaying a programmed cardioversion/defibrillation shock therapy in response to determining the patient is in a substantially horizontal position. In various embodiments, the shock therapy may be delayed by adjusting tachycardia detection criteria or scheduling the shock therapy after a maximum tachycardia episode duration.

Abstract: A telescoping medical device system is provided that includes an outer sheath having a proximal end and a distal end, and a lumen extending through at least the distal end portion, and a slot extending along a portion of the outer sheath. The telescoping medical device also includes an inner member extending through the slot and through the lumen in the outer sheath. A first drive mechanically engages and drives the outer sheath, and a second drive mechanically engages and drives the inner member through the slot and into the lumen of the outer sheath.

Abstract: A system for identifying locations for pacing the heart, the system comprising a pacing electrode, a remote navigation system for positioning the pacing electrode at each of a plurality of locations; a system for determining Pressure-Volume loop data resulting from pacing at each location; an ECG system, a phrenic nerve stimulation detection system, and a means of identifying at least one preferred location based upon at least the Pressure-Volume loop, ECG, and phrenic nerve stimulation data at each location. A method of identifying locations for pacing the heart, the method comprising: navigating a pacing electrode to each of a plurality of locations in the heart; pacing the heart at each of the plurality of locations; and assessing the effectiveness of the pacing at each location by measuring cardiac blood flow and cardiac wall strain.

Abstract: A method of operating a remote medical navigation system using ultrasound, employs ultrasound imaging from a medical device to supplement or to replace conventional x-ray imaging of the operating region during navigation.

Abstract: A connector system for an implantable lead, which includes a header having a lumen for receiving the implantable lead. The lumen defines a mating surface and has an internal diameter larger than the lead to be connected therein. A collar is slidably engageable with the lead. Part of the collar is slidable into the header lumen, and part of the collar is releasably securable to the header such that the lead is retained in the lumen. The part of the collar that is slidable into the header lumen may be tapered. The tapered part of the collar and/or the mating surface may be formed of a compressible material.

Abstract: An improved system and method for detecting dislodgement of an implantable medical device (IMD) such as a catheter or lead is disclosed. The system includes means for generating multiple, orthogonally-related signals within a body. For example, three current signals having a current path substantially oriented in the X, Y, and Z directions may be generated within the body. The invention further includes an IMD having an affixation device such as a helix at a distal tip for attachment to body tissue, and at least two sensing devices to sense the signals generated within the body. The difference in signal levels between two of the sensing devices may be measured. For example, a voltage potential difference created by the currents within the body may be measured between two electrodes. This measured signal level has components in the X, Y, and Z directions, and may therefore be used to define a directional vector in three-dimensional space. This vector is indicative of the orientation of the IMD.