Abstract: Liquid chromatography column coupling assembly having a column enclosed in a housing member to form a column cartridge and including coupling assemblies at respective ends of the cartridge, each comprising a coupler member and a collar member. The coupler member and collar member are tubular in configuration and disposed in coaxial telescoping relation with one end of the coupler member abutting the respective end of the column with an annular seal interposed therebetween. The collar member has one end threaded onto the end of the column housing and at its opposite end an inwardly extending radial flange coacting with an outwardly extending radial flange on said one end of the coupling member. Rotation of the collar member when threading it onto the column housing causes relative axial displacement of the members to compress the seal between the abutting ends of the column and coupler member.

Abstract: A liquid chromatography column assembly includes a separation column having stationary phase retaining frits is positioned within a housing adapted to accept conventional column termination fittings. The assembly includes a sealed cylindrical cavity to ensure radial distribution of the incoming fluid across the cross-section of the column.