Patents by Inventor William G. Weisburg

William G. Weisburg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090048439
    Abstract: Provided are solid supports that contain at least one hydrophilic ligand; and at least one hydrophobic ligand, where amount of the at least one hydrophobic ligand on the solid support relative to the amount of the at least one hydrophilic ligand on the solid support is adjusted for binding target nucleic acid(s) from a sample onto the solid support and/or for eluting the bound target nucleic acid(s) from the solid support, so that the amount of target nucleic acid(s) bound to the solid support and/or recovered after elution from the solid support is about 5% to about 500% greater than the amount of target nucleic acid(s) bound to the solid support and/or recovered from the solid support in the absence of either the at least one hydrophobic ligand or the at least one hydrophilic ligand or both. The solid supports with ligands are used for isolation of nucleic acid molecules from samples.
    Type: Application
    Filed: August 5, 2008
    Publication date: February 19, 2009
    Inventors: William G. Weisburg, Elizabeth L. Mather, Marjan Haghnia
  • Publication number: 20080241893
    Abstract: Oligonucleotides useful for determining the presence of Trichomonas vaginalis in a test sample. The oligonucleotides may be incorporated into detection probes, helper probes, capture probes and amplification oligonucleotides, and used in various combinations thereof.
    Type: Application
    Filed: May 15, 2008
    Publication date: October 2, 2008
    Applicant: GEN-PROBE INCORPORATED
    Inventors: William G. WEISBURG, Jennifer J. BUNGO
  • Publication number: 20080234473
    Abstract: Oligonucleotides useful for determining the presence of Trichomonas vaginalis in a test sample. The oligonucleotides may be incorporated into detection probes, helper probes, capture probes and amplification oligonucleotides, and used in various combinations thereof.
    Type: Application
    Filed: May 15, 2008
    Publication date: September 25, 2008
    Applicant: GEN-PROBE INCORPORATED
    Inventors: William G. WEISBURG, Jennifer J. BUNGO
  • Publication number: 20080176221
    Abstract: The invention includes compositions and methods of detection of Bacillus anthracis that use oligonucleotide probes specific for genetic material contained in the pXO1 and pXO2 plasmids in nucleic acid hybridization reactions. Embodiments of the method may include additional probes specific for other gene sequences to distinguish B. anthracis from other bacterial species present in a sample or to provide an indication that the assay was performed properly even when no Bacillus sequence is detected.
    Type: Application
    Filed: November 12, 2003
    Publication date: July 24, 2008
    Applicant: Gen-Probe Incorporated
    Inventors: Sylvia A. Norman, Jennifer J. Bungo, James J. Hogan, William G. Weisburg
  • Patent number: 7381811
    Abstract: The present invention relates to oligonucleotides useful for determining the presence of Trichomonas vaginalis in a test sample. The oligonucleotides of the present invention may be incorporated into detection probes, helper probes, capture probes and amplification oligonucleotides, and used in various combinations thereof.
    Type: Grant
    Filed: May 18, 2004
    Date of Patent: June 3, 2008
    Assignee: Gen-Probe Incorporated
    Inventors: William G. Weisburg, Jennifer J. Bungo
  • Patent number: 7081527
    Abstract: The present invention describes novel oligonucleotides targeted to nucleic acid sequences derived from Cryptosporidium organisms, and Cryptosporidium parvum organisms in particular, which are useful for determining the presence of Cryptosporidium organisms in a test sample. The oligonucleotides of the present invention include hybridization assay probes, helper probes and amplification primers. The present invention further describes a novel method for obtaining purified ribonucleic acid from viable oocysts.
    Type: Grant
    Filed: September 11, 2001
    Date of Patent: July 25, 2006
    Assignee: Gen-Probe Incorporated
    Inventors: Melissa M. Cunningham, Paul D. Stull, William G. Weisburg
  • Publication number: 20040235138
    Abstract: The present invention relates to oligonucleotides useful for determining the presence of Trichomonas vaginalis in a test sample. The oligonucleotides of the present invention may be incorporated into detection probes, helper probes, capture probes and amplification oligonucleotides, and used in various combinations thereof.
    Type: Application
    Filed: May 18, 2004
    Publication date: November 25, 2004
    Inventors: William G. Weisburg, Jennifer J. Bungo
  • Patent number: 6534273
    Abstract: A method for capturing a target polynucleotide in a sample onto a solid support with an attached immobilized probe by using a capture probe and two different hybridization conditions that control the order of hybridization, where the first hybridization condition allows hybridization of the capture probe to the target polynucleotide, and the second hybridization condition allows hybridization of the capture probe to the immobilized probe. The method further includes amplifying the captured target polynucleotide by hybridizing at least one primer oligonucleotide to the target polynucleotide and using nucleic acid amplification that initiates from the primer oligonucleotide.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: March 18, 2003
    Assignee: Gen-Probe Incorporated
    Inventors: William G. Weisburg, Jay H. Shaw, Michael M. Becker, Mehrdad R. Majlessi, Steven T. Brentano, Kiyotada Nunomura
  • Patent number: 6482589
    Abstract: Nucleic acids having approximately 10 to 250 nucleotides which are capable of hybridizing to rRNA and RDNA of mycoplasma etiological agents of nongonococcal urethritis, pelvic inflammatory disease, salpingiuis, and other infections due to mycoplasmas from the genital areas, Mycoplasma hominis, Mycoplasma genitalium, and Ureaplasma urealyticum.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: November 19, 2002
    Assignee: Vysis, Inc.
    Inventors: William G. Weisburg, Dale A. Pelletier
  • Publication number: 20020146717
    Abstract: The present invention describes novel oligonucleotides targeted to nucleic acid sequences derived from Cryptosporidium organisms, and Cryptosporidium parvum organisms in particular, which are useful for determining the presence of Cryptosporidium organisms in a test sample. The oligonucleotides of the present invention include hybridization assay probes, helper probes and amplification primers. The present invention further describes a novel method for obtaining purified ribonucleic acid from viable oocysts.
    Type: Application
    Filed: September 11, 2001
    Publication date: October 10, 2002
    Inventors: Melissa M. Cunningham, Paul D. Stull, William G. Weisburg
  • Publication number: 20020127569
    Abstract: A method for capturing a target polynucleotide in a sample onto a solid support with an attached immobilized probe by using a capture probe and two different hybridization conditions that control the order of hybridization, where the first hybridization condition allows hybridization of the capture probe to the target polynucleotide, and the second hybridization condition allows hybridization of the capture probe to the immobilized probe. The method further includes amplifying the captured target polynucleotide by hybridizing at least one primer oligonucleotide to the target polynucleotide and using nucleic acid amplification that initiates from the primer oligonucleotide.
    Type: Application
    Filed: September 18, 2001
    Publication date: September 12, 2002
    Inventors: William G. Weisburg, Jay H. Shaw, Michael M. Becker, Mehrdad R. Majlessi, Steven T. Brentano, Kiyotada Nunomura
  • Publication number: 20020055116
    Abstract: The present invention describes novel oligonucleotides targeted to nucleic acid sequences derived from Cryptosporidium organisms, and Cryptosporidium parvumorganisms in particular, which are useful for determining the presence of Cryptosporidium organisms in a test sample. The oligonucleotides of the present invention include hybridization assay probes, helper probes and amplification primers. The present invention further describes a novel method for obtaining purified ribonucleic acid from viable oocysts.
    Type: Application
    Filed: September 11, 2001
    Publication date: May 9, 2002
    Inventors: Melissa M. Cunningham, Paul D. Stull, William G. Weisburg
  • Publication number: 20020028459
    Abstract: A method for capturing a target polynucleotide in a sample onto a solid support with an attached immobilized probe by using a capture probe and two different hybridization conditions, which preferably differ in temperature only, is disclosed. The two hybridization conditions control the order of hybridization, where the first hybridization conditions allow hybridization of the capture probe to the target polynucleotide, and the second hybridization conditions allow hybridization of the capture probe to the immobilized probe. The method may be used to detect the presence of a target polynucleotide in a sample by detecting the captured target polynucleotide or amplified target polynucleotide.
    Type: Application
    Filed: July 20, 2001
    Publication date: March 7, 2002
    Inventors: William G. Weisburg, Jay H. Shaw, Michael M. Becker, Mehrdad Majlessi
  • Patent number: 6280952
    Abstract: A method for capturing a target polynucleotide in a sample onto a solid support with an attached immobilized probe by using a capture probe and two different hybridization conditions, which preferably differ in temperature only, is disclosed. The two hybridization conditions control the order of hybridization, where the first hybridization conditions allow hybridization of the capture probe to the target polynucleotide, and the second hybridization conditions allow hybridization of the capture probe to the immobilized probe. The method may be used to detect the presence of a target polynucleotide in a sample by detecting the captured target polynucleotide or amplified target polynucleotide.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: August 28, 2001
    Assignee: Gen-Probe Incorporated
    Inventors: William G. Weisburg, Jay H. Shaw, Michael M. Becker, Mehrdad Majlessi
  • Patent number: 6110678
    Abstract: A method for capturing a target polynucleotide in a sample onto a solid support with an attached immobilized probe by using a capture probe and two different hybridization conditions, which preferably differ in temperature only, is disclosed. The two hybridization conditions control the order of hybridization, where the first hybridization conditions allow hybridization of the capture probe to the target polynucleotide, and the second hybridization conditions allow hybridization of the capture probe to the immobilized probe. The method may be used to detect the presence of a target polynucleotide in a sample by detecting the captured target polynucleotide or amplified target polynucleotide.
    Type: Grant
    Filed: May 1, 1998
    Date of Patent: August 29, 2000
    Assignee: Gen-Probe Incorporated
    Inventors: William G. Weisburg, Jay H. Shaw, Michael M. Becker, Mehrdad Majlessi
  • Patent number: 5843667
    Abstract: Nucleic acids having approximately 10 to 250 nucleotides which are capable of hybridizing to rRNA and rDNA of mycoplasma etiological agents of nongonococcal urethritis, pelvic inflammatory disease, salpingitis, and other infections due to mycoplasmas from the genital areas, Mycoplasma hominis, Mycoplasma genitalium, and Ureaplasma urealyticum.
    Type: Grant
    Filed: March 22, 1991
    Date of Patent: December 1, 1998
    Assignee: Amoco Corporation
    Inventors: William G. Weisburg, Dale A. Pelletier
  • Patent number: 5705339
    Abstract: Nucleic acid sequences which preferentially bind to the rRNA or rDNA of microorganisms which cause the spoilage of beer are disclosed. The beer spoilage microorganisms are predominantly of the genera Lactobacillus and Pediococcus. The nucleic acids may be used as probes in assays to detect the presence of these microorganisms. Kits containing two or more probes are also described.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: January 6, 1998
    Assignee: Amoco Corporation
    Inventors: Raymond M. Nietupski, Benjamin B. Stone, William G. Weisburg
  • Patent number: 5569586
    Abstract: Nucleic acid sequences which hybridize preferentially to the 16S or 23S rRNA or rDNA of Legionella sp., L. pneumophila, L. micdadei, a L. pneumophila, or a Legionella subset are taught. These organisms are the etiological agents of Legionnaires' disease, Pontiac fever, Pittsburgh pneumonia and other infections. The nucleic acids are useful in the detection of these pathogenic microorganisms. Probes based on these sequences and kits containing the probes are also disclosed.
    Type: Grant
    Filed: September 20, 1994
    Date of Patent: October 29, 1996
    Assignee: Amoco Corporation
    Inventors: Dale A. Pelletier, William G. Weisburg
  • Patent number: 5552279
    Abstract: Nucleic acid probes are described for detecting the principle etiological agent of primary atypical pneumonia, Mycoplasma pneumoniae, or, optionally, Mycoplasma pneumoniae and Mycoplasma genitalium. Said probes are complementary to ribonucleic acid sequences found in these mycoplasmas and absent from other mycoplasma, other bacterial, animal, or plant genomes. As such, these probes can detect the rRNA, rDNA, or polymerase chain reaction amplification products from these mycoplasma species. This set of probes, plus the described amplification primers, circumscribe a method for detecting the etiological agents of atypical pneumonia, and for making a clinical diagnosis of this disease. This set of probes also circumscribes a method for identification of these infectious agents in culture media enrichments inoculated from clinical samples.
    Type: Grant
    Filed: July 29, 1994
    Date of Patent: September 3, 1996
    Assignee: Amoco Corporation
    Inventors: William G. Weisburg, Dale A. Pelletier
  • Patent number: 5484909
    Abstract: Nucleic acid sequences which preferentially bind to the rRNA or rDNA of microorganisms which cause the spoilage of beer are disclosed. The beer spoilage microorganisms are predominantly of the genera Lactobacillus and Pediococcus. The nucleic acids may be used as probes in assays to detect the presence of these microorganisms. Kits containing two or more probes are also described.
    Type: Grant
    Filed: September 10, 1993
    Date of Patent: January 16, 1996
    Assignee: Amoco Corporation
    Inventors: Raymond M. Nietupski, Benjamin B. Stone, William G. Weisburg