Patents by Inventor William H. Andrews

William H. Andrews has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
    Publication number: 20020173476
    Abstract: The present invention provides TRT antisense oligonucleotides, methods of detecting TRT, methods of diagnosing telomerase-related conditions, methods of diagnosing and providing a prognosis for cancer, and methods of treating telomerase-related conditions, including cancer.
    Type: Application
    Filed: September 14, 2001
    Publication date: November 21, 2002
    Inventors: Thomas R. Cech, Joachim Lingner, Toru Nakamura, Karen B. Chapman, Gregg B. Morin, Calvin B. Harley, William H. Andrews
  • Novel telomerase
    Publication number: 20020164786
    Abstract: The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subunits of Euplotes aediculatus, and related sequences from Schizosaccharomyces, Saccharomyces sequences, and human telomerase. The present invention is also directed to polypeptides comprising these telomerase protein subunits, as well as functional polypeptides and ribonucleoproteins that contain these subunits.
    Type: Application
    Filed: April 26, 2001
    Publication date: November 7, 2002
    Inventors: Thomas R. Cech, Joachim Lingner, Toru Nakamura, Karen B. Chapman, Gregg B. Morin, Calvin B. Harley, William H. Andrews
  • Human telomerase catalytic subunit: diagnostic and therapeutic methods
    Patent number: 6475789
    Abstract: The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis, and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of diseases such as cancers.
    Type: Grant
    Filed: August 14, 1997
    Date of Patent: November 5, 2002
    Assignees: University Technology Corporation, Geron Corporation
    Inventors: Thomas R. Cech, Joachim Lingner, Toru Nakamura, Karen B. Chapman, Gregg B. Morin, Calvin B. Harley, William H. Andrews
  • Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
    Patent number: 6444650
    Abstract: The present invention provides TRT antisense oligonucleotides, methods of detecting TRT, methods of diagnosing telomerase-related conditions, methods of diagnosing and providing a prognosis for cancer, and methods of treating telomerase-related conditions, including cancer.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: September 3, 2002
    Assignees: Geron Corporation, University Technology Corporation
    Inventors: Thomas R. Cech, Joachim Lingner, Toru Nakamura, Karen B. Chapman, Gregg B. Morin, Calvin B. Harley, William H. Andrews
  • Mammalian telomerase
    Patent number: 6320039
    Abstract: Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
    Type: Grant
    Filed: May 25, 2000
    Date of Patent: November 20, 2001
    Assignee: Geron Corporation
    Inventors: Bryant Villeponteau, Junli Feng, Walter Funk, William H. Andrews
  • MAMMALIAN TELOMERASE
    Publication number: 20010034439
    Abstract: Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
    Type: Application
    Filed: April 8, 1998
    Publication date: October 25, 2001
    Inventors: BRYANT VILLEPONTEAU, JUNLI FENG, WALTER FUNK, WILLIAM H. ANDREWS
  • Peptides related to TPC2 and TPC3, two proteins that are coexpressed with telomerase activity
    Patent number: 6300110
    Abstract: Purified and recombinant proteins TPC2 and TPC3 and recombinant or synthetic oligonucleotides corresponding to those proteins or fragments thereof can be used to detect regulators of telomere length and telomerase activity in mammalian cells and for a variety of related diagnostic and therapeutic purposes.
    Type: Grant
    Filed: December 23, 1998
    Date of Patent: October 9, 2001
    Assignee: Geron Corporation
    Inventors: Bryant Villeponteau, Junli Feng, William H. Andrews, Robert R. Adams
  • Telomerase
    Patent number: 6261836
    Abstract: The present invention is directed to telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa telomerase protein subunits of Euplotes aediculatus, and related sequences from Schizosaccharomyces, Saccharomyces sequences, and human telomerase. The present invention is also directed to polypeptides comprising these telomerase protein subunits, as well as functional polypeptides and ribonucleoproteins that contain these subunits.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: July 17, 2001
    Assignees: Geron Corporation, University Technology Corporation
    Inventors: Thomas R. Cech, Joachim Lingner, Toru Nakamura, Karen B. Chapman, Gregg B. Morin, Calvin B. Harley, William H. Andrews
  • Mammalian telomerase
    Patent number: 6258535
    Abstract: This invention is directed to compositions enriched for telomerase and methods of preparing the same.
    Type: Grant
    Filed: April 14, 1998
    Date of Patent: July 10, 2001
    Assignee: Geron Corporation
    Inventors: Bryant Villeponteau, Junli Feng, Walter Funk, William H. Andrews
  • Phosphor thermometry system
    Patent number: 6123455
    Abstract: An apparatus for measuring the temperature of a moving substrate includes an air gun with a powder inlet port in communication with the outlet port of a powder reservoir, an air inlet port in communication with a pressurized air source, and an outlet nozzle spaced from and directed toward the moving substrate. The air gun is activated by the air pulses to spray controlled amounts of the powdered phosphor onto the moving substrate, where the phosphor assumes the temperature of the moving substrate. A laser produces light pulses, and optics direct the light pulses onto the phosphor on the moving substrate, in response to which the phosphor emits a luminescence with a decay rate indicative of the temperature of the phosphor. A collection lens is disposed to focus the luminescence, and a photodetector detects the luminescence focused by the collection lens and produces an electrical signal that is characteristic of the brightness of the luminescence.
    Type: Grant
    Filed: May 2, 1997
    Date of Patent: September 26, 2000
    Assignee: American Iron and Steel Institute
    Inventors: David L. Beshears, David N. Sitter, Jr., William H. Andrews, Marc L. Simpson, Ruth A. Abston, Michael R. Cates, Steve W. Allison
  • Protease-resistant thrombomodulin analogs
    Patent number: 6063763
    Abstract: The present invention relates to the single-chain thrombomodulin ("TM") and analogs thereof that are not susceptible to cleavage by proteases and retain the biological activity of thrombomodulin, as well as methods of use in, for example, antithrombotic therapy. Novel proteins, nucleic acid gene sequences, pharmaceuticals and methods of inhibiting thrombotic activity are disclosed.
    Type: Grant
    Filed: February 16, 1994
    Date of Patent: May 16, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: David Richard Light, William H. Andrews, Jeffrey Homer Clarke, Robert Michael Wydro, Patricia Ann Young
  • Mammalian telomerase RNA gene promoter
    Patent number: 6054575
    Abstract: Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
    Type: Grant
    Filed: December 24, 1997
    Date of Patent: April 25, 2000
    Assignee: Geron Corporation
    Inventors: Bryant Villeponteau, Junli Feng, Walter Funk, William H. Andrews
  • RNA component of telomerase
    Patent number: 6013468
    Abstract: Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
    Type: Grant
    Filed: August 29, 1995
    Date of Patent: January 11, 2000
    Assignee: Cold Spring Harbor Laboratory
    Inventors: William H. Andrews, Ariel Athena Avilion, Junli Feng, Walter Funk, Carol Greider, Maria Antonia Blasco Marhuenda, Bryant Villeponteau
  • Mammalian telomerase
    Patent number: 5958680
    Abstract: Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 28, 1999
    Assignee: Geron Corporation
    Inventors: Bryant Villeponteau, Junli Feng, Walter Funk, William H. Andrews
  • RNA component of mouse, rat, Chinese hamster and bovine telomerase
    Patent number: 5876979
    Abstract: Nucleic acids comprising the RNA component of a mouse, rat, Chinese hamster and bovine telomerase are disclosed, as are recombinant expression plasmids comprising said nucleic acids and host cells transformed with said recombinant expression plasmids.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 2, 1999
    Assignee: Cold Spring Harbor Laboratory
    Inventors: William H. Andrews, Ariel Athena Avilion, Junli Feng, Walter Funk, Carol Greider, Maria Antonia Blasco Marhuenda, Bryant Villeponteau
  • Protease-resistant thrombomodulin analogs
    Patent number: 5863760
    Abstract: The present invention relates to the single-chain thrombomodulin ("TM") and analogs thereof that are not susceptible to cleavage by proteases and retain the biological activity of thrombomodulin, as well as methods of use in, for example, antithrombotic therapy. Novel proteins, nucleic acid gene sequences, pharmaceuticals and methods of inhibiting thrombotic activity are disclosed.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 26, 1999
    Assignee: Schering Altiengesellschaft
    Inventors: David Richard Light, William H. Andrews, Jeffrey Homer Clarke, Robert Michael Wydro, Patricia Ann Young
  • Methods and reagents for regulating telomere length and telomerase activity
    Patent number: 5858777
    Abstract: Purified and recombinant proteins TPC2 and TPC3 and recombinant or synthetic oligonucleotides corresponding to those proteins or fragments thereof can be used to detect regulators of telomere length and telomerase activity in mammalian cells and for a variety of related diagnostic and therapeutic purposes.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: January 12, 1999
    Assignee: Geron Corporation
    Inventors: Bryant Villeponteau, Junli Feng, William H. Andrews, Robert R. Adams
  • Mammalian telomerase
    Patent number: 5837857
    Abstract: Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
    Type: Grant
    Filed: June 5, 1996
    Date of Patent: November 17, 1998
    Assignee: Geron Corporation
    Inventors: Bryant Villeponteau, Junli Feng, Walter Funk, William H. Andrews
  • Protease-resistant thrombomodulin analogs
    Patent number: 5827824
    Abstract: The present invention relates to the single-chain thrombomodulin ("TM") and analogs thereof that are not susceptible to cleavage by proteases and retain the biological activity of thrombomodulin, as well as methods of use in, for example, antithrombotic therapy. Novel proteins, nucleic acid gene sequences, pharmaceuticals and methods of inhibiting thrombotic activity are disclosed.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: October 27, 1998
    Assignee: Schering Aktiengesellschaft
    Inventors: David Richard Light, William H. Andrews, Jeffrey Homer Clarke, Robert Michael Wydro, Patricia Ann Young
  • Assays for the DNA component of human telomerase
    Patent number: 5776679
    Abstract: Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 7, 1998
    Assignee: Geron Corporation
    Inventors: Bryant Villeponteau, Junli Feng, Walter Funk, William H. Andrews