Patents by Inventor William H. Parsons

William H. Parsons has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Triterpene derivatives with immunosuppressant activity
    Patent number: 5696156
    Abstract: The compounds of Formula I ##STR1## are useful as immunosuppressive agents.
    Type: Grant
    Filed: October 16, 1996
    Date of Patent: December 9, 1997
    Assignee: Merck & Co. Inc.
    Inventors: Robert K. Baker, Frank Kayser, Jianming Bao, William H. Parsons, Kathleen M. Rupprecht
  • O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
    Patent number: 5693648
    Abstract: Substituted compounds of the FK-506 Type. These compounds are useful for the same or essentially the same purposes as FK-506 and are applied in the same or a similar manner. These compounds are immunosuppressants and useful for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. Still other uses are described in the disclosure.
    Type: Grant
    Filed: March 27, 1996
    Date of Patent: December 2, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Mark Goulet, Helen M. Organ, William H. Parsons, Peter J. Sinclair, Frederick Wong, Matthew J. Wyvratt
  • Triterpene derivatives with immunosuppressant activity
    Patent number: 5679705
    Abstract: The compounds of Formula I ##STR1## are useful as immunosuppressive agents.
    Type: Grant
    Filed: October 16, 1996
    Date of Patent: October 21, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Robert K. Baker, Frank Kayser, Jianming Bao, William H. Parsons, Kathleen M. Rupprecht
  • 2,6-diaryl pyridazinones with immunosuppressant activity
    Patent number: 5670504
    Abstract: A class of 2,6-diarylpyridazinones of general structural formula I have been identified that exhibit exhibit immunosuppressant activity with human T-lymphocytes, and are useful as an immunosuppressants.
    Type: Grant
    Filed: February 23, 1995
    Date of Patent: September 23, 1997
    Assignee: Merck & Co. Inc.
    Inventors: Richard J. Bochis, Andrew Kotliar, William H. Parsons, Kathleen Rupprecht
  • O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
    Patent number: 5565560
    Abstract: O-Aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
    Type: Grant
    Filed: October 4, 1993
    Date of Patent: October 15, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Mark Goulet, Helen M. Organ, William H. Parsons, Peter J. Sinclair, Frederick Wong, Matthew J. Wyvratt
  • Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
    Patent number: 5550233
    Abstract: Aryl, alkyl, alkenyl and alkynyl macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by oxidation and alkylation at C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
    Type: Grant
    Filed: June 21, 1994
    Date of Patent: August 27, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Kathleen M. Rupprecht, Robert K. Baker, Hyun O. Ok, William H. Parsons
  • Aryl and heteroaryl macrolides having immunosuppressive activity
    Patent number: 5545734
    Abstract: Aryl and heteroaryl macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by olefination at C-27. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases, the prevention of rejection of foreign organ transplants and/or related afflictions, diseases, and illnesses.
    Type: Grant
    Filed: October 25, 1994
    Date of Patent: August 13, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Robert K. Baker, Gerard R. Kieczykowski, Hyun O. Ok, William H. Parsons, Kathleen M. Rupprecht
  • O-aryl,O-alkyl, and O-alkenyl-macrolides having immunosuppressive activity
    Patent number: 5532248
    Abstract: O-Aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: July 2, 1996
    Assignee: Merck Co., Inc.
    Inventors: Mark Goulet, William H. Parsons, Helen M. Organ, Peter J. Sinclair, Frederick Wong, Matthew J. Wyvratt
  • Cholesterol lowering compounds
    Patent number: 5506262
    Abstract: Disclosed herein are compounds of structural formula (I) ##STR1## which are useful as cholesterol lowering agents. These compounds are also useful as inhibitors of squalene synthetase, inhibitors of fungal growth, inhibitors of farnesyl-protein transferase and farnesylation of the oncogene protein Ras. These compounds are also useful in the treatment of cancer.
    Type: Grant
    Filed: November 10, 1993
    Date of Patent: April 9, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Robert M. Burk, William H. Parsons, John J. Acton, III, Gregory D. Berger, Tesfaye Biftu, Robert L. Bugianesi, Yuan-Ching P. Chiang, Claude Dufresne, Narindar N. Girotra, Robert W. Marquis, Jr., Chan-Hwa Kuo, Sandra P. Plevyak, Mitree M. Ponpipom, Lori L. Whiting, James D. Bergstrom, Conrad Santini
  • Cholesterol-lowering agents
    Patent number: 5369125
    Abstract: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer.
    Type: Grant
    Filed: March 19, 1993
    Date of Patent: November 29, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Gregory D. Berger, James D. Bergstrom, Tesfaye Biftu, Robert L. Bugianesi, Robert M. Burk, Narindar N. Girotra, C. H. Kuo, William H. Parsons, Mitree M. Ponpipom, Lori L. Whiting
  • Slide switch on-off indicator and lock apparatus
    Patent number: 5357070
    Abstract: The present invention provides a means for locking "off" or locking "on" an electrical slide switch. The shape definition of the invention further serves as a position indicator, whereby even a casual glance confirms the position of the switch, even from some distance.
    Type: Grant
    Filed: July 26, 1993
    Date of Patent: October 18, 1994
    Inventor: William H. Parsons, Jr.
  • O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
    Patent number: 5349061
    Abstract: O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroaryl-macrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases, the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
    Type: Grant
    Filed: October 12, 1993
    Date of Patent: September 20, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Peter J. Sinclair, Joung Goulet, Frederick Wong, Mark Goulet, William H. Parsons, Matthew J. Wyvratt
  • Imidazolidyl rapamycin derivatives
    Patent number: 5310903
    Abstract: Imidazolidyl rapamycin derivatives of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-42 and/or C-31. These compounds are useful in a mammalian host for the treatment of autoimmune diseases and diseases of inflammation, infectious diseases, the prevention of rejection of foreign organ transplants and the treatment of solid tumors.
    Type: Grant
    Filed: March 5, 1993
    Date of Patent: May 10, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Mark Goulet, William H. Parsons, Matthew J. Wyvratt
  • O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynlheteroarylrapamycin derivatives
    Patent number: 5310901
    Abstract: O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylrapamycin derivatives of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-42 and/or C-31. These compounds are useful in a mammalian host for the treatment of autoimmune diseases and diseases of inflammation, infectious diseases, the prevention of rejection of foreign organ transplants and the treatment of solid tumors.
    Type: Grant
    Filed: March 5, 1993
    Date of Patent: May 10, 1994
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, Peter J. Sinclair, Frederick Wong, Matthew J. Wyvratt
  • O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
    Patent number: 5258389
    Abstract: O-Aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-42 and/or C-31. These compounds are useful in a mammalian host for the treatment of autoimmune diseases and diseases of inflammation, infectious diseases, the prevention of rejection of foreign organ transplants and the treatment of solid tumors.
    Type: Grant
    Filed: November 9, 1992
    Date of Patent: November 2, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Mark Goulet, William H. Parsons, Peter J. Sinclair, Frederick Wong, Matthew J. Wyvratt
  • Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)-hydroxy-butanoic acid or 4-cyclo-hexyl-(2R, 3S)-dihydroxybutanoic acid or related analogs
    Patent number: 5254682
    Abstract: Compounds of the formula: ##STR1## are disclosed. These compounds inhibit the angiotensinogen-cleaving action of the natural proteolytic enzyme, renin, and are useful in treating, preventing or managing renin-associated hypertension, hyperaldosteronism, congestive heart failure, and glaucoma.
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: October 19, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Daljit S. Dhanoa, Arthur A. Patchett, William J. Greenlee, William H. Parsons, Thomas A. Halgren, Ann E. Weber, Lihu Yang
  • D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
    Patent number: 5252732
    Abstract: O-Heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides of the general structural Formula I: ##STR1## have been prepared from suitable precursors by alkylation and/or arylation at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases, the prevention of rejection of foreign organ transplants and/or related afflictions, diseases and illnesses.
    Type: Grant
    Filed: August 5, 1992
    Date of Patent: October 12, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Peter J. Sinclair, Joung Goulet, Frederick Wong, Mark Goulet, William H. Parsons, Matthew J. Wyvratt
  • Specific intensity distribution light reflector
    Patent number: 5251115
    Abstract: A reflector for modifying the light intensity distribution patterns of a cylindrical light source has a first reflecting surface formed to provide a desired light intensity distribution pattern in the vertical plane and at least one other reflecting surface extending from one end of the first reflecting surface and which is oriented and formed to provide a second desired light intensity distribution pattern in the horizontal plane.
    Type: Grant
    Filed: May 15, 1992
    Date of Patent: October 5, 1993
    Assignee: William H. Parsons
    Inventors: Lloyd W. Hillman, William H. Parsons
  • Phosphorus containing enzyme inhibitors
    Patent number: 5147867
    Abstract: Dipeptide mimics which contain phosphorus and their pharmaceutical use and preparation are disclosed. The compounds have dehydropeptidase (DHP) enzyme inhibitor activity.
    Type: Grant
    Filed: January 21, 1992
    Date of Patent: September 15, 1992
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, William R. Schoen, Arthur A. Patchett
  • Reflector
    Patent number: D346562
    Type: Grant
    Filed: April 23, 1992
    Date of Patent: May 3, 1994
    Inventors: William H. Parsons, Lloyd W. Hillman