Abstract: The invention provides combination therapies for treating cancer comprising compositions and methods for ?? T cell immunotherapy in combination DDR inhibitors, including but not limited to PARP inhibitors. Preferably, the combination of ?? T cell immunotherapy and PARP inhibitors for the treatment of cancer further includes combinations with other immunotherapies such as immune checkpoint (ICP) blockade therapy and/or DNA damaging agents such as cytotoxic chemotherapeutic agents. Preferably, when the combination of ?? T cell immunotherapy and DDR inhibitor therapy further include chemotherapeutic agents, the ?? T cells are genetically modified to impart resistance to that chemotherapeutic agent.

Abstract: The present invention provides compositions and methods for combination therapy comprising administering to a patient in need thereof, drug-resistant immunotherapy, immune checkpoint inhibitors, and chemotherapy for the treatment of cancer.

Abstract: A lipid nanoparticle including: an ionizable cationic lipid compound including a reaction product of an amino alcohol and one or more lipid acids having from 4 to 26 carbons; one or more lipid components selected from a helper neutral lipid, a PEG-modified lipid, a phospholipid, and cholesterol; and a nucleic acid agent, the nucleic acid agent encoding an N-terminal domain of gasdermin. A lipid nanoparticle including: an ionizable cationic lipid compound having a structure of Formula (I); one or more lipid components selected from a helper neutral lipid, a PEG-modified lipid, a phospholipid, and cholesterol; and a single-agent mRNA, the single-agent mRNA encoding an N-terminal domain of gasdermin and including a polynucleotide sequence having at least 90% sequence identity to SEQ ID NO. 1. A method of treating a tumor, the method comprising administering a pharmaceutical composition to a subject in need thereof, the pharmaceutical composition comprising the lipid nanoparticle.

Abstract: The example embodiments are directed toward leveraging the power of large language models (LLMs) in a messaging application. In a first embodiment, LLMs are utilized to generate message content (both original and reply). In a second embodiment, LLMs are utilized to provide enhanced semantic search functionality. In a third embodiment, LLMs are utilized to provide intelligent actions to take based on message content.

Abstract: The present technology pertains to a link service that can create, maintain, and service links to objects on behalf of a content management system or other services. The link service can share administration of links with other services when desired or can even allow other services to issue the link and manage the object that is the subject of the link while providing other functions to support the link. Additionally, link service can interface with a file system that can support links as actors in the file system, whereby greater control and flexibility in supporting links is provided. Link service can also accommodate servicing and management of links issued by legacy services, where the legacy services have unique link logic that should still be utilized to maintain a consistent user experience.

Abstract: The present technology pertains to a link service that can create, maintain, and service links to objects on behalf of a content management system or other services. The link service can share administration of links with other services when desired or can even allow other services to issue the link and manage the object that is the subject of the link while providing other functions to support the link. Additionally, link service can interface with a file system that can support links as actors in the file system, whereby greater control and flexibility in supporting links is provided. Link service can also accommodate servicing and management of links issued by legacy services, where the legacy services have unique link logic that should still be utilized to maintain a consistent user experience.

Abstract: Ionizable cationic lipid compounds have an amine moiety from amino alcohols and a lipid moiety from a lipid synthesized via esterification. The ionizable cationic lipid compounds which comprise an amino alcohol mediated ionizable cationic lipid compound are useful for in vivo or in vitro delivery of one or more nucleic acid agents including DNA, siRNA, a microRNA, an mRNA, a RNAi, and a plasmid.

Abstract: A case for a portable electronic device that includes a rigid outer layer and a more flexible inner layer is disclosed herein. The case is a single piece case. The outer layer has openings that extend through the thickness of the outer layer. The openings are connected by a groove in the outer layer. The openings and the groove may be filled by a more flexible material. The inner layer has openings. The outer layer is translucent so that the inner layer may be visible through the outer layer.

Abstract: A case for a portable electronic device that includes a rigid outer layer and a more flexible inner layer is disclosed herein. The case is a single piece case. The outer layer has openings that extend through the thickness of the outer layer. The openings are connected by a groove in the outer layer. The openings and the groove may be filled by a more flexible material. The inner layer has openings. The outer layer is translucent so that the inner layer may be visible through the outer layer.

Abstract: The present technology pertains to a link service that can create, maintain, and service links to objects on behalf of a content management system or other services. The link service can share administration of links with other services when desired or can even allow other services to issue the link and manage the object that is the subject of the link while providing other functions to support the link. Additionally, link service can interface with a file system that can support links as actors in the file system, whereby greater control and flexibility in supporting links is provided. Link service can also accommodate servicing and management of links issued by legacy services, where the legacy services have unique link logic that should still be utilized to maintain a consistent user experience.

Abstract: The present technology pertains to a link service that can create, maintain, and service links to objects on behalf of a content management system or other services. The link service can share administration of links with other services when desired or can even allow other services to issue the link and manage the object that is the subject of the link while providing other functions to support the link. Additionally, link service can interface with a file system that can support links as actors in the file system, whereby greater control and flexibility in supporting links is provided. Link service can also accommodate servicing and management of links issued by legacy services, where the legacy services have unique link logic that should still be utilized to maintain a consistent user experience.

Abstract: The present technology pertains to a link service that can create, maintain, and service links to objects on behalf of a content management system or other services. The link service can share administration of links with other services when desired or can even allow other services to issue the link and manage the object that is the subject of the link while providing other functions to support the link. Additionally, link service can interface with a file system that can support links as actors in the file system, whereby greater control and flexibility in supporting links is provided. Link service can also accommodate servicing and management of links issued by legacy services, where the legacy services have unique link logic that should still be utilized to maintain a consistent user experience.

Abstract: The present technology pertains to a link service that can create, maintain, and service links to objects on behalf of a content management system or other services. The link service can share administration of links with other services when desired or can even allow other services to issue the link and manage the object that is the subject of the link while providing other functions to support the link. Additionally, link service can interface with a file system that can support links as actors in the file system, whereby greater control and flexibility in supporting links is provided. Link service can also accommodate servicing and management of links issued by legacy services, where the legacy services have unique link logic that should still be utilized to maintain a consistent user experience.

Abstract: The present technology pertains to a link service that can create, maintain, and service links to objects on behalf of a content management system or other services. The link service can share administration of links with other services when desired or can even allow other services to issue the link and manage the object that is the subject of the link while providing other functions to support the link. Additionally, link service can interface with a file system that can support links as actors in the file system, whereby greater control and flexibility in supporting links is provided. Link service can also accommodate servicing and management of links issued by legacy services, where the legacy services have unique link logic that should still be utilized to maintain a consistent user experience.

Abstract: The present technology pertains to a link service that can create, maintain, and service links to objects on behalf of a content management system or other services. The link service can share administration of links with other services when desired or can even allow other services to issue the link and manage the object that is the subject of the link while providing other functions to support the link. Additionally, link service can interface with a file system that can support links as actors in the file system, whereby greater control and flexibility in supporting links is provided. Link service can also accommodate servicing and management of links issued by legacy services, where the legacy services have unique link logic that should still be utilized to maintain a consistent user experience.

Abstract: A light, durable, and user friendly cover for a laptop computer that integrates the protective qualities of hard shell cases with the aesthetics of soft cut-and-sew covers is disclosed herein. The cover includes top and bottom panels configured to cover the display and keyboard portions, respectively. Each panel is independent and separate from the other and each is formed as a unitary component of a molded resilient polymer material, such as polycarbonate, that is configured to reversibly and retentively snap-fit over the outer surface of the laptop computer. Each panel includes a raised lip along its perimeter edge region that defines an internally extending recessed region on the panel's outer surface. Fabric and/or leather overlays are positioned, sized, and adhesively coupled atop the recessed regions and are protected from delaminating, fraying, and/or peeling by the raised perimeter lip.

Abstract: A light, durable, and user friendly cover for a laptop computer that integrates the protective qualities of hard shell cases with the aesthetics of soft cut-and-sew covers is disclosed. The cover includes top and bottom panels configured to cover the display and keyboard portions, respectively. Each panel is independent and separate from the other and each is formed as a unitary component of a molded resilient polymer material, such as polycarbonate, that is configured to reversibly and retentively snap-fit over the outer surface of the laptop computer. Each panel includes a raised lip along its perimeter edge region that defines an internally extending recessed region on the panel's outer surface. Fabric and/or leather overlays are positioned, sized and adhesively coupled atop the recessed regions and are protected from delaminating, fraying, and/or peeling by the raised perimeter lip.

Abstract: Multi-mode auxiliary wheel system adapted for rolling a folded bike, comprising: an upper frame member, at least one supporting side frame member attached to the upper frame member and adapted for attachment to the foldable bike so that the upper frame member is positioned adjacent an upper portion of the rear wheel during an unfolded, ridable, condition of the bike, but adjacent a lower portion of the rear wheel and the ground during a folded, non-ridable, condition of the bike. Lateral and transverse attachment, detachment, and displacement, of the axle, whether horizontal pivotable displacement or not, are provided for with an axle member with auxiliary wheels thereon such that, together with a swivel caster auxiliary wheel, the system enables a user to wheel the bike when in a folded condition, in either a luggage cart type auxiliary wheeling mode or a shopping cart type wheeling mode.