Abstract: A light, durable, and user friendly cover for a laptop computer that integrates the protective qualities of hard shell cases with the aesthetics of soft cut-and-sew covers is disclosed. The cover includes top and bottom panels configured to cover the display and keyboard portions, respectively. Each panel is independent and separate from the other and each is formed as a unitary component of a molded resilient polymer material, such as polycarbonate, that is configured to reversibly and retentively snap-fit over the outer surface of the laptop computer. Each panel includes a raised lip along its perimeter edge region that defines an internally extending recessed region on the panel's outer surface. Fabric and/or leather overlays are positioned, sized and adhesively coupled atop the recessed regions and are protected from delaminating, fraying, and/or peeling by the raised perimeter lip.

Abstract: Multi-mode auxiliary wheel system adapted for rolling a folded bike, comprising: an upper frame member, at least one supporting side frame member attached to the upper frame member and adapted for attachment to the foldable bike so that the upper frame member is positioned adjacent an upper portion of the rear wheel during an unfolded, ridable, condition of the bike, but adjacent a lower portion of the rear wheel and the ground during a folded, non-ridable, condition of the bike. Lateral and transverse attachment, detachment, and displacement, of the axle, whether horizontal pivotable displacement or not, are provided for with an axle member with auxiliary wheels thereon such that, together with a swivel caster auxiliary wheel, the system enables a user to wheel the bike when in a folded condition, in either a luggage cart type auxiliary wheeling mode or a shopping cart type wheeling mode.

Abstract: A light, durable, and user friendly cover for a laptop computer that integrates the protective qualities of hard shell cases with the aesthetics of soft cut-and-sew covers is disclosed. The cover includes top and bottom panels configured to cover the display and keyboard portions, respectively. Each panel is independent and separate from the other and each is formed as a unitary component of a molded resilient polymer material, such as polycarbonate, that is configured to reversibly and retentively snap-fit over the outer surface of the laptop computer. Each panel includes a raised lip along its perimeter edge region that defines an internally extending recessed region on the panel's outer surface. Fabric and/or leather overlays are positioned, sized and adhesively coupled atop the recessed regions and are protected from delaminating, fraying, and/or peeling by the raised perimeter lip.

Abstract: A case for a portable electronic device that includes a rigid outer layer and a more flexible inner layer is disclosed herein. The case is a single piece case. The outer layer has openings that extend through the thickness of the outer layer. The openings are connected by a groove in the outer layer. The openings and the groove may be filled by a more flexible material. The inner layer has openings. The outer layer is translucent so that the inner layer may be visible through the outer layer.

Abstract: Internet based digital content services, and mobile devices accessing the Internet based digital content services, are herein disclosed and enabled. The digital content services provide encrypted digital content to the mobile devices for ensuring security of the digital content. The encrypted digital content is device dependent to render at a specific device. In an example, a user of the mobile device may access the digital content at a digital content service by providing appropriate authentication or subscription information to the digital content service. Based on successful authentication, the user may select digital content from one or more digital content provided by the service. The service then generates encrypted output data that is based on the selected digital content and transmits the output data to the mobile device. The generated output data is device dependent and is rendered at specific devices, including the mobile device and output devices.

Abstract: A method for capturing and outputting digital content is herein disclosed and enabled, the output system includes an information apparatus, a server, and a client device. The information apparatus includes at least a digital camera and a wireless communication module (e.g., IEEE 802.11 or Bluetooth). The server is accessible by the client device over a network. The information apparatus, using the digital camera, captures digital content and transmits, over the Internet and using the wireless communication module, the digital content to the server for storage. The server generates output data from at least part of the digital content stored at the server, and provides the generated output data from the server to the client device that has security or authentication information for accessing the server. The client device outputs or plays at least part of the digital content at an output device associated with the client device.

Abstract: One aspect of the disclosure describes a lipid conjugated cationic molecule. Other aspects of the disclosure describes nanoparticle delivery systems and methods of making the systems are disclosed. An embodiment of the nanoparticle delivery system has sustained gene delivery properties, the nanoparticle delivery system can be synthesized using biodegradable and biocompatible polymers via self-assembly. The nanoparticle delivery system comprises a plurality of nanoparticle depots, each of which has a particle-in-particle structure, and is composed of a polymeric nanoparticle, which encapsulates cationic molecule/nucleic acid complexes, facilitating enhanced retention and prolonged release of the gene payload. The polymeric nanoparticle comprises a shell, and a nanocomplex of the cationic molecule and a polynucleotide, the nanocomplexes are distributed within the shell and/or embedded in the shell. Another embodiment of the nanoparticle delivery system has one or more nanocomplexes.

Abstract: The invention provides combination therapies for treating cancer comprising compositions and methods for ?? T cell immunotherapy in combination DDR inhibitors, including but not limited to PARP inhibitors. Preferably, the combination of ?? T cell immunotherapy and PARP inhibitors for the treatment of cancer further includes combinations with other immunotherapies such as immune checkpoint (ICP) blockade therapy and/or DNA damaging agents such as cytotoxic chemotherapeutic agents. Preferably, when the combination of ?? T cell immunotherapy and DDR inhibitor therapy further include chemotherapeutic agents, the ?? T cells are genetically modified to impart resistance to that chemotherapeutic agent.

Abstract: An integrated circuit device that includes a secure or protected memory component is herein disclosed and enabled. The integrated circuit device may be a wireless communication device, a smart phone, or a smart card. Additionally, the integrated circuit device may be part of, or included in, a computing device or a mobile device. The integrated circuit device includes a protected memory section for storing protected data that is not accessible by a user at the protected memory section, but is accessible by a memory controller included in the integrated circuit device. The access and transfer of the protected data is protected using combination security operations that may include encryption, cryptography, and user authentication. The integrated circuit device may further include a wireless component for establishing a wireless connection with wireless computing devices or readers for wirelessly transmitting the protected data accessed by the memory controller.

Abstract: Output devices or systems, such as televisions, speakers, projectors, or output controllers, are herein disclosed and enabled for wirelessly receiving digital content from a digital content service or from an information apparatus. The disclosed output device includes wireless communication circuitry and an interface. To set up the output device for receiving and playing the digital content, the output device first receives, via the interface, security information, and then establishes a wireless local area network connection. Subsequent to having established the wireless local area network connection, the output device connects to a server over a network, using the wireless communication circuitry, for downloading and installing software applications or components for upgrading or modifying capabilities of the output device.

Abstract: A light, durable, and user friendly cover for a laptop computer that integrates the protective qualities of hard shell cases with the aesthetics of soft cut-and-sew covers is disclosed. The cover includes top and bottom panels configured to cover the display and keyboard portions, respectively. Each panel is independent and separate from the other and each is formed as a unitary component of a molded resilient polymer material, such as polycarbonate, that is configured to reversibly and retentively snap-fit over the outer surface of the laptop computer, Each panel includes a raised lip along its perimeter edge region that defines an internally extending recessed region on the panel's outer surface. Fabric and/or leather overlays are positioned, sized and adhesively coupled atop the recessed regions and are protected from delaminating, fraying, and/or peeling by the raised perimeter lip.

Abstract: The present invention provides compositions and methods for combination therapy comprising administering to a patient in need thereof, drug-resistant immunotherapy, immune checkpoint inhibitors, and chemotherapy for the treatment of cancer.

Abstract: Output systems (e.g., television controllers, audio output devices, display devices) for accessing digital content from a service provided by one or more servers over the Internet are herein disclosed and enabled. To receive and play the digital content, the output system may obtain authentication information for accessing the service, receive a list of digital content that are available from the service for selection at the output system, receive output data from the service related to the selected digital content, and then play either audio data or video data, which is related to the received output data, at an output device coupled to the output system. The output system may further implement a discovery operation for a client device (e.g., smart phone or information pad), which is in the same network as the output system, to wirelessly discover the output system for providing output service to the client device.

Abstract: Wireless output controller for wirelessly receiving, over a wireless local area network connection, digital content from a mobile information apparatus that is within the same wireless local area network as the wireless output controller is herein disclosed and enabled. To set up the wireless output controller, the wireless output controller receives first information from a portable electronic device and then provides, in response, second information to the portable electronic device over a short range wireless connection.

Abstract: A light, durable, and user friendly cover for a laptop computer that integrates the protective qualities of hard shell cases with the aesthetics of soft cut-and-sew covers is disclosed. The cover includes top and bottom panels configured to cover the display and keyboard portions, respectively. Each panel is independent and separate from the other and each is formed as a unitary component of a molded resilient polymer material, such as polycarbonate, that is configured to reversibly and retentively snap-fit over the outer surface of the laptop computer. Each panel includes a raised lip along its perimeter edge region that defines an internally extending recessed region on the panel's outer surface. Fabric and/or leather overlays are positioned, sized and adhesively coupled atop the recessed regions and are protected from delaminating, fraying, and/or peeling by the raised perimeter lip.

Abstract: An integrated circuit device that includes a secure or protected memory component is herein disclosed and enabled. The integrated circuit device may be a wireless communication device or a smart card or a USB device. Additionally, the integrated circuit device may be part of, or included in, a computing device or a mobile device. The integrated circuit device includes a protected memory section for storing protected data that is not accessible by a user at the protected memory section, but is accessible by a memory controller included in the integrated circuit device. The memory controller accesses the protected data with a combination of security operations that may include cryptography. The integrated circuit device may further include a wireless component for establishing a wireless connection with wireless computing devices or readers for wirelessly transmitting the protected data accessed by the memory controller to the wireless computing devices or the readers.

Abstract: A wireless output device for connecting to a wireless local area network and receiving digital content from servers over a network that includes the Internet is herein disclosed and enabled. The wireless output device may include, among others, a television, a speaker, a projector, or an output controller. The wireless output device includes an interface and wireless communication units. The wireless communication units of the wireless output device may receive information from a portable electronic device. The wireless output device may further receive the digital content from one or more application servers or content servers operated over the Internet by a digital content service. The digital content may include audio digital content or video digital content. The output device may process the received digital content and render the processed digital content onto a display medium.

Abstract: An information apparatus that supports a touch sensitive screen for managing e-mails is disclosed and enabled. The information apparatus may include a graphical user interface, an e-mail application, an Internet browsing application, and applications for playing audio/video content. The information apparatus includes an operating system software and support for installation of new applications. In one example, a user of the information apparatus may reply to an e-mail by selecting an item over the touch sensitive screen. The user may scroll down or up an email using the touch sensitive screen. In other examples, the user may further select an item or functional control via the touch sensitive screen to output, synchronize, stream, transmit, play, print, display, or mirror at least part of digital content from the information apparatus to one or more output devices over air.

Abstract: Printing devices (or output controllers) supporting printing over air or wireless network printing or Internet printing, are herein disclosed and enabled. The printing device may include wireless communication chips or chipsets supporting part of IEEE 802.11 standards for (1) connecting to a wireless local area network (LAN) to establish communication with a client that is in the wireless LAN; (2) transmitting device information related to the printing device from the printing device to the client; and (3) receiving print data from the client over the wireless LAN for printing at the printing device. The print data is based on the device information transmitted to the client. A printer driver specific to the printing device may or may not be necessary for printing to the printing device. The printing device may require registration with a service over a network prior to providing printing services to the client.

Abstract: An information apparatus (e.g., Internet appliance, information pad, digital camera, video camera, etc.), or software applications of the information apparatus, supporting voice commands for receiving and playing digital content from a service provided over a network (e.g., Internet) are herein disclosed and enabled. The information apparatus may establish a wireless local area network connection to access a service over the Internet. The service may be a subscribed service. While connected to the service, the information apparatus may capture, using a digital capturing device included in the information apparatus, digital content that includes image or video content; send the captured digital content to the service; and, in response to having sent the digital content to the service, the information apparatus may receive, from the service, output data that includes audio content or video content for outputting or playing at a display device associated with the information apparatus.