Abstract: The present application relates to a method of producing an anti-C5 antibody (ravulizumab), wherein the method comprises: —culturing mammalian cells comprising a nucleic acid encoding the anti-C5 antibody in a cell culture production medium—Performing two or more steps selected from the group consisting of: a recovery step; purification by Protein A affinity chromatography, a low pH viral inactivation step; Purification by cation exchange chromatography; Purification by anion exchange chromatography; a virus reduction filtration step; and a concentration and diafiltration step.

Abstract: Systems and methods for removing organic compounds byproducts from a product stream from a pyrolysis reactor and associated systems and methods are disclosed herein. In some embodiments, the system includes a first condenser that is fluidly couplable to the product stream, a coalescer that is fluidly couplable to the product stream downstream from the first condenser along a first flow path, and a second condenser that is fluidly couplable to the product stream downstream from the first condenser along a second flow path. The system also includes a first valve positioned to regulate the flow of the product stream along the first flow path including a second valve positioned to regulate the flow of the product stream along the second flow path.

Abstract: An injector comprising: (a) a housing; (b) a control releasably secured to the housing; and (c) a syringe movably positioned within the housing, wherein when released, the control drives the syringe to expose a portion of the syringe outside of the housing.

Abstract: In the disclosed systems and methods for categorizing medical data, a computer system obtains, in electronic form, a plurality of medical records. Each medical record includes corresponding medical data from a respective medical evaluation and corresponding metadata comprising a plurality of attributes about the respective medical evaluation. Each respective attribute comprises a corresponding string of text. The computer system determines, for each respective pair of medical records consisting of a first medical record and a second medical record, a corresponding pairwise similarity between, for each respective attribute in a set of attributes, the corresponding string of text for the first medical record and the corresponding string of text for the second medical record. The computer system identifies a first subset of the plurality of medical records. Each respective medical record in the first subset is connected to each other through pairwise similarities that each satisfies a similarity threshold.

Abstract: An injector comprising a housing, a control releasably secured to the housing, and a syringe movably positioned within the housing. When released, the control drives the syringe to expose a portion of the syringe outside of the housing.

Abstract: The disclosure features compositions and methods for increasing the half-life of a therapeutic agent (e.g., a C5 antagonist) in the serum of a subject (e.g., a human). Also featured are compositions and methods for: (i) decreasing the frequency by which a therapeutically effective amount of a therapeutic agent must be administered to a human having, suspected of having, or at risk for developing, a medical condition for which the therapeutic agent is effective and (ii) decreasing the dosage of the therapeutic agent required for therapeutic efficacy in a human having, suspected of having, or at risk for developing, a medical condition for which the therapeutic agent is effective. The methods include reducing the serum concentration of the antigen to which the therapeutic agent binds.

Abstract: Described herein are fusion proteins which include factor H catalytic domains and may include VHH domains, factor H-related protein 5 domains, or integrin binding domains, and the use of such fusion proteins in methods of treatment of diseases mediated by complement alternative pathway activation or dysregulation, for example, kidney diseases.

Abstract: A heat exchanger can comprise: a housing; a heat transfer region disposed within the housing; and an inlet manifold or an inlet conduit defined at least partially by an interior surface extending axially from a first end of the heat exchanger to an inlet defined by the heat transfer region, the inlet manifold or the inlet conduit comprising a dimple configuration disposed in the interior surface. The heat exchanger can further comprise an outlet manifold or an outlet conduit including a dimple configuration disposed on an interior surface of the outlet manifold or outlet conduit.

Abstract: Systems and methods for monitoring a supply of gas cylinders in a gas cylinder storage cage, such as identifying a number of full gas cylinders and a number of empty gas cylinders, and/or a total number of gas cylinders present in the gas cylinder storage cage, and displaying the determined numbers to a user. In one embodiment, a method includes: transmitting distance measurement data from a sensor within a gas cylinder storage cage to a control system of a cage monitoring system; determining, with the control system, whether a gas cylinder is present at a sensing location within the gas cylinder storage cage proximate the sensor; and when the control system determines that a gas cylinder is present at the sensing location, determining, with the control system, whether the gas cylinder is full or empty.

Abstract: Systems and methods for monitoring a supply of gas cylinders in a gas cylinder storage cage, such as identifying a number of full gas cylinders and a number of empty gas cylinders, and/or a total number of gas cylinders present in the gas cylinder storage cage, and displaying the determined numbers to a user. In one embodiment, a method includes: transmitting distance measurement data from a sensor within a gas cylinder storage cage to a control system of a cage monitoring system; determining, with the control system, whether a gas cylinder is present at a sensing location within the gas cylinder storage cage proximate the sensor; and when the control system determines that a gas cylinder is present at the sensing location, determining, with the control system, whether the gas cylinder is full or empty.

Abstract: A case for a mobile device including a back section and a first front section and a second front section, the first front section being adapted for connection to and separation from the second front section and the back section including an opening for receiving a mobile device; a receiving space located within the first front section and second front section for receiving an injection device, wherein the injection device is at least partially visible when the second section is detached from the first section; a release latch located on one or more of the first front section and second front section for facilitating separation of the second front section from the first front section; and a connector portion for connecting the back section to the first and second front sections.

Abstract: A case for a mobile device including a back section and a first front section and a second front section, the first front section being adapted for connection to and separation from the second front section and the back section including an opening for receiving a mobile device; a receiving space located within the first front section and second front section for receiving an injection device, wherein the injection device is at least partially visible when the second section is detached from the first section; a release latch located on one or more of the first front section and second front section for facilitating separation of the second front section from the first front section; and a connector portion for connecting the back section to the first and second front sections.

Abstract: Present embodiments provide a console refrigerator for use in a vehicle. More specifically, but without limitation, present embodiments provide a console refrigerator which may be easily integrated into a vehicle compartment or console for cooling of various items including, but not limited to, food, drink, or medicine.

Abstract: The electric machine comprises at least one winding (30) having at least one conductor (20) and electrical insulation for insulating one or more of the windings (30) and/or conductors (20), wherein the insulation is formed by a metal oxide. The method for producing such an electric machine having at least one winding (30) having at least one conductor (20) comprises the steps of metallizing the at least one winding (30) and/or conductor (20) with metal and oxidizing the metal. The aircraft is in particular an electric or hybrid-electric aircraft and has such an electric machine (10).

Abstract: A shield system for an electric power transmission tower includes a plurality of panels configured to be secured to a cross-arm structure of the tower in adjacent, end-to-end arrangement so as to overlie insulators supported by the tower and prevent excrement from birds nesting and/or congregating on the tower from contacting and accumulating on the insulators. Each panel has opposite ends and opposite lateral edges extending between the opposite ends. A plurality of spaced-apart apertures are formed in each panel adjacent each of the lateral edges and at least one of the ends, and each aperture is configured to receive a respective fastener therethrough for securing the panel to the cross-arm structure. Each panel has a shape that generally conforms to a shape of a portion of the cross-arm structure to which the panel is secured.

Abstract: The present disclosure relates to, inter alia, a recombinant eculizumab protein or a recombinant eculizumab variant protein having specific glycosylation patterns. The present disclosure relates to, inter alia, a recombinant eculizumab protein or a recombinant eculizumab variant protein made from CHO cells. The present disclosure also relates to methods for the use of these proteins.

Abstract: Systems and methods to maintain constant pressure within a chamber within a tool via a sliding seal, wherein the seal moves to increase or decrease the size of the chamber.

Abstract: Utilizing a fluid flow rate within a tool to close and open a vent extending through a circumference of the tool. The vent may be positioned above a packer pair that is configured to extend across an annulus. The tool may include a vent, sliding sleeve, adjustable member, and plunger.