Patents by Inventor William J. Curatolo

William J. Curatolo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical compositions providing enhanced drug concentrations
    Patent number: 9457095
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: October 4, 2016
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
  • PHARMACEUTICAL COMPOSITIONS PROVIDING ENHANCED DRUG CONCENTRATIONS
    Publication number: 20150190518
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Application
    Filed: March 16, 2015
    Publication date: July 9, 2015
    Applicant: Bend Research, Inc.
    Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
  • Hydrogel-driven drug dosage form
    Patent number: 9028870
    Abstract: A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific drug release profiles are disclosed.
    Type: Grant
    Filed: December 27, 2010
    Date of Patent: May 12, 2015
    Assignee: Bend Research, Inc.
    Inventors: Leah E. Appel, Ronald A. Beyerinck, Mark B. Chidlaw, William J. Curatolo, Dwayne T. Friesen, Kelly L. Smith, Avinash G. Thombre
  • Pharmaceutical compositions providing enhanced drug concentrations
    Patent number: 8980321
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: March 17, 2015
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
  • SOLID PHARMACEUTICAL DISPERSIONS WITH ENHANCED BIOAVAILABILITY
    Publication number: 20150024054
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or bioavailability in a use environment.
    Type: Application
    Filed: August 6, 2014
    Publication date: January 22, 2015
    Applicant: BEND RESEARCH, INC.
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • PHARMACEUTICAL COMPOSITIONS PROVIDING ENHANCED DRUG CONCENTRATIONS
    Publication number: 20140322325
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Application
    Filed: July 14, 2014
    Publication date: October 30, 2014
    Applicant: Bend Research, Inc.
    Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
  • Pharmaceutical compositions providing enhanced drug concentrations
    Patent number: 8796341
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: August 5, 2014
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
  • Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers
    Patent number: 8703196
    Abstract: A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: April 22, 2014
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, William J. Curatolo, Dwayne T. Friesen, Rodney J. Ketner, Julian B. Lo, James A. S. Nightingale, Ravi M. Shanker, James B. West
  • PHARMACEUTICAL COMPOSITIONS PROVIDING ENHANCED DRUG CONCENTRATIONS
    Publication number: 20130345236
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Application
    Filed: June 11, 2013
    Publication date: December 26, 2013
    Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
  • Pharmaceutical compositions providing enhanced drug concentrations
    Patent number: 8501231
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Grant
    Filed: June 19, 2012
    Date of Patent: August 6, 2013
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
  • Solid pharmaceutical dispersions with enhanced bioavailability
    Patent number: 8431159
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or bioavailability in a use environment.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: April 30, 2013
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
    Patent number: 8389011
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Grant
    Filed: June 12, 2012
    Date of Patent: March 5, 2013
    Assignee: Bend Research, Inc.
    Inventors: Marshall D. Crew, William J. Curatolo, Dwayne T. Friesen, Michael Jon Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
  • Solid pharmaceutical dispersions with enhanced bioavailability
    Patent number: 8367118
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: February 5, 2013
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • SOLID PHARMACEUTICAL DISPERSIONS WITH ENHANCED BIOAVAILABILITY
    Publication number: 20120328679
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or bioavailability in a use environment.
    Type: Application
    Filed: September 7, 2012
    Publication date: December 27, 2012
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • Solid pharmaceutical dispersions with enhanced bioavailability
    Patent number: 8337899
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: December 25, 2012
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • SOLID PHARMACEUTICAL DISPERSIONS WITH ENHANCED BIOAVAILABILITY
    Publication number: 20120292797
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
    Type: Application
    Filed: July 27, 2012
    Publication date: November 22, 2012
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • Pharmaceutical Compositions of Dispersions of Amorphous Drugs Mixed with Polymers
    Publication number: 20120295988
    Abstract: A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
    Type: Application
    Filed: July 31, 2012
    Publication date: November 22, 2012
    Inventors: Walter C. Babcock, William J. Curatolo, Dwayne T. Friesen, Rodney J. Ketner, Julian B. Lo, James A. S. Nightingale, Ravi M. Shanker, James B. West
  • SOLID PHARMACEUTICAL DISPERSIONS WITH ENHANCED BIOAVAILABILITY
    Publication number: 20120288542
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
    Type: Application
    Filed: July 20, 2012
    Publication date: November 15, 2012
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • PHARMACEUTICAL COMPOSITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS
    Publication number: 20120277315
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Application
    Filed: June 12, 2012
    Publication date: November 1, 2012
    Inventors: Marshall D. Crew, William J. Curatolo, Dwayne T. Friesen, Michael Jon Gumkowski, Dougles A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
  • PHARMACEUTICAL COMPOSITIONS PROVIDING ENHANCED DRUG CONCENTRATIONS
    Publication number: 20120259022
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Application
    Filed: June 19, 2012
    Publication date: October 11, 2012
    Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz