Patents by Inventor William J. Curatolo

William J. Curatolo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid pharmaceutical dispersions with enhanced bioavailability
    Patent number: 8263128
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: September 11, 2012
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • Solid pharmaceutical dispersions with enhanced bioavailability
    Patent number: 8257741
    Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: September 4, 2012
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Scott M. Herbig, James A. S. Nightingale
  • Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers
    Patent number: 8236328
    Abstract: A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
    Type: Grant
    Filed: July 8, 2008
    Date of Patent: August 7, 2012
    Assignee: Bend Research, Inc.
    Inventors: Walter C. Babcock, William J. Curatolo, Dwayne T. Friesen, Rodney J. Ketner, Julian B. Lo, James A. S. Nightingale, Ravi M. Shanker, James B. West
  • Pharmaceutical compositions providing enhanced drug concentrations
    Patent number: 8202912
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: June 19, 2012
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
  • Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
    Patent number: 8197848
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Grant
    Filed: April 30, 2007
    Date of Patent: June 12, 2012
    Assignee: Bend Research, Inc.
    Inventors: Marshall D. Crew, William J. Curatolo, Dwayne T. Friesen, Michael J. Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
  • PHARMACEUTICAL COMPOSITIONS PROVIDING ENHANCED DRUG CONCENTRATIONS
    Publication number: 20110294902
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Application
    Filed: August 11, 2011
    Publication date: December 1, 2011
    Inventors: William J. CURATOLO, Ravi M. Shanker, Walter C. Babccck, Dwayne T. Friesen, James A.S. Nightingale, Douglas A. Lorenz
  • Pharmaceutical compositions of cholesteryl ester transfer protein inhibitor
    Patent number: 8048452
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: November 1, 2011
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Dwayne T. Friesen, Michael J. Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
  • Pharmaceutical compositions providing enhanced drug concentrations
    Patent number: 8026286
    Abstract: A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: September 27, 2011
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
  • HYDROGEL-DRIVEN DRUG DOSAGE FORM
    Publication number: 20110182947
    Abstract: A controlled release dosage form has a coated core with the core comprising a drug-containing composition and a water-swellable composition, each occupying separate regions within the core. The drug-containing composition comprises a low-solubility drug and a drug-entraining agent. The coating around the core is water-permeable, water-insoluble and has at least one delivery port therethrough. A variety of formulations having specific drug release profiles are disclosed.
    Type: Application
    Filed: December 27, 2010
    Publication date: July 28, 2011
    Inventors: Leah E. Appel, Ronald A. Beyerinck, Mark B. Chidlaw, William J. Curatolo, Dwayne T. Friesen, Kelly L. Smith, Avinash G. Thombre
  • Pharmaceutical compositions comprising drug and concentration-enhancing polymers
    Patent number: 7887840
    Abstract: A solubility-improved drug form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same drug form without the concentration-enhancing polymer.
    Type: Grant
    Filed: June 20, 2002
    Date of Patent: February 15, 2011
    Assignee: Bend Research, Inc.
    Inventors: William J. Curatolo, Dwayne T. Friesen
  • Controlled release by extrusion of solid amorphous dispersions of drugs
    Patent number: 7550158
    Abstract: Controlled release dosage forms for low solubility drugs are disclosed wherein an amorphous solid dispersion of the drug is coated with a non-dissolving and non-eroding coating that controls the influx of water to the core so as to cause extrusion of a portion of the core, as well as a method of treating a disease or disorder comprising administering such dosage form to a person.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: June 23, 2009
    Assignee: Bend Research, Inc.
    Inventors: Leah E. Appel, William J. Curatolo, Scott M. Herbig, James A. S. Nightingale, Avinash G. Thombre
  • Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers
    Publication number: 20090011024
    Abstract: A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
    Type: Application
    Filed: July 8, 2008
    Publication date: January 8, 2009
    Inventors: Walter C. Babcock, William J. Curatolo, Dwayne T. Friesen, Rodney J. Ketner, Julian B. Lo, James A.S. Nightingale, Ravi M. Shanker, James B. West
  • Enteric Coated Azithromycin Multiparticulates
    Publication number: 20080199527
    Abstract: A pharmaceutical composition is disclosed which comprises multiparticulates wherein said multiparticulates further comprise an azithromycin core and an enteric coating disposed upon said azithromycin core.
    Type: Application
    Filed: December 9, 2005
    Publication date: August 21, 2008
    Applicant: Pfizer Inc.
    Inventors: William J. Curatolo, Scott M. Herbig, Steven R. LeMott, Julian B. Lo, Leah E. Appel, Dwayne T. Friesen, David K. Lyon, Scott B. McCray, James B. West
  • Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
    Patent number: 7235259
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: June 26, 2007
    Assignee: Pfizer Inc
    Inventors: Marshall D. Crew, William J. Curatolo, Dwayne T. Friesen, Michael Jon Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
  • Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
    Patent number: 7115279
    Abstract: A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: October 3, 2006
    Inventors: William J. Curatolo, Dwayne T. Friesen, Michael J. Gumkowski, Douglas A. Lorenz, James A. S. Nightingale, Roger B. Ruggeri, Ravi M. Shanker
  • Controlled-release dosage forms of azithromycin
    Patent number: 7108865
    Abstract: A controlled-release dosage form of azithromycin having an improved side effect profile; a process for preparing the dosage form; and a method of treating a microbial infection, comprising administering azithromycin in such a controlled-release dosage form to a mammal, including a human patient, in need of such treatment.
    Type: Grant
    Filed: March 9, 2001
    Date of Patent: September 19, 2006
    Assignee: Pfizer Inc
    Inventors: William J. Curatolo, Hylar L. Friedman, Richard W. Korsmeyer, Steven R. LeMott
  • Hydrogel-driven layered drug dosage form
    Patent number: 6899896
    Abstract: A controlled release dosage form for sertraline has a core comprising a sertraline-containing composition and a water-swellable composition wherein the water-swellable composition is in a separate region within the core. A coating around the core is water-permeable, water-insoluble, and has at least one delivery port therethrough. In one embodiment, the dosage form releases sertraline to the use environment at an average rate of 6 to 10 wt % per hour from the second to the twenth hour after introduction to a use environment and less than about 25 wt % for the first two hours and at least 70 wt % by the twelfth hour, where the percentages correspond to the mass of drug released from the tablet divided by the total mass of drug originally present in the tablet.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: May 31, 2005
    Assignee: Pfizer Inc
    Inventors: William J. Curatolo, Kenneth C. Waterman, Avinash G. Thombre, Michael B. Fergione, Michael C. Roy, Leah A. Appel, Danni Supplee, Dwayne T. Friesen, Mark B. Chidlaw, Ronald A. Beyerinck
  • Controlled release by extrusion of solid amorphous dispersions of drugs
    Publication number: 20040175428
    Abstract: Controlled release dosage forms for low solubility drugs are disclosed wherein an amorphous solid dispersion of the drug is coated with a non-dissolving and non-eroding coating that controls the influx of water to the core so as to cause extrusion of a portion of the core, as well as a method of treating a disease or disorder comprising administering such dosage form to a person.
    Type: Application
    Filed: March 11, 2004
    Publication date: September 9, 2004
    Applicant: Pfizer Inc.
    Inventors: Leah E. Appel, William J. Curatolo, Scott M. Herbig, James A.S. Nightingale, Avinash G. Thombre
  • Sustained release formulations for growth hormone secretagogues
    Publication number: 20040091530
    Abstract: The present invention relates to formulations for administering a growth hormone secretagogue. More specifically, the present invention relates to sustained release formulations for administering a growth hormone secretagogue and formulations for administering a growth hormone secretagogue that provide for a part of the dose of the growth hormone secretagogue to be administered using an immediate release formulation and part of the dose of the growth hormone secretagogue to be administered using a sustained release formulation.
    Type: Application
    Filed: June 30, 2003
    Publication date: May 13, 2004
    Inventors: Mary T. Am Ende, William J. Curatolo, Scott M. Herbig
  • Method of administering azithromycin
    Patent number: RE39149
    Abstract: An oral dosage form of azithromycin which does not exhibit an adverse food effect; Specific azithromycin oral dosage forms including tablets, powders for oral suspensions and unit dose packets; Methods of treating microbial infections with the dosage forms; And therapeutic packages containing the dosage forms.
    Type: Grant
    Filed: January 20, 2005
    Date of Patent: June 27, 2006
    Assignee: Pfizer Inc.
    Inventors: William J. Curatolo, George H. Foulds, Hylar L. Friedman