Patents by Inventor William J. Dower

William J. Dower has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SEQUENCING OF SURFACE IMMOBILIZED POLYMERS UTILIZING MICROFLUORESCENCE DETECTION
    Publication number: 20010036629
    Abstract: Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine terminal manomers on solid phase immobilized polymers. Reagents which specifically recognize terminal manomers are used to label polymers at defined positions on a solid substrate.
    Type: Application
    Filed: April 2, 1997
    Publication date: November 1, 2001
    Inventors: WILLIAM J DOWER, STEPHEN P.A. FODOR
  • Use of modified tethers in screening compound libraries
    Patent number: 6309842
    Abstract: The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis of the compound, and a tether susceptible to modification by a reporter molecule. Modification of the tether is used to signify that a complex contains a compound having a desired property. The tag can be decoded to reveal at least one step in the synthesis of such a compound.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: October 30, 2001
    Assignee: Glaxo Wellcome Inc.
    Inventors: William J. Dower, Christian M. Gates, Gregory L. Heinkel, Guy Lalonde, Larry C. Mattheakis, Christopher J. Paddon, Peter J. Schatz
  • Method for comparing copy number of nucleic acid sequences
    Patent number: 6309822
    Abstract: The present invention provides methods for comparing and identifying differences in nucleic acid sequences using a plurality of sequence specific recognition reagents (i.e., probes comprising a nucleic acid complementary to a nucleic acid sequence in collections to be compared) bound to a solid surface.
    Type: Grant
    Filed: December 23, 1996
    Date of Patent: October 30, 2001
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, Dennis W. Solas, William J. Dower
  • Self-encoded combinatorial synthesis of compound multiplets
    Publication number: 20010031475
    Abstract: The present invention provides a variety of methods for synthesizing, encoding and decoding compounds in a combinatorial library. One step or cycle in the synthetic methods of the invention is a self-encoding step in which different pairs of components, each pair with a known and different molecular weight difference, are reacted with supports, whereby two compounds differing in molecular weight are formed on each support. The molecular weight difference between the two compounds on the support encodes for a particular component pair. Libraries of compounds formed according to the methods of the invention are also provided.
    Type: Application
    Filed: February 22, 2001
    Publication date: October 18, 2001
    Inventors: Mark A. Gallop, William J. Dower, Ron W. Barrett
  • Peptides and compounds that bind to a receptor
    Patent number: 6251864
    Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: June 26, 2001
    Assignee: Glaxo Group Limited
    Inventors: William J. Dower, Ronald W. Barrett, Steven E. Cwirla, Christian M. Gates, Peter J. Schatz, Palaniappan Balasubramanian, Christopher R. Wagstrom, Richard Wayne Hendren, Randolph B. Deprince, Surekha Podduturi, Qun Yin
  • Method of detecting nucleic acids
    Patent number: 6197506
    Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
    Type: Grant
    Filed: April 8, 1998
    Date of Patent: March 6, 2001
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, Dennis W. Solas, William J. Dower
  • Method of synthesizing diverse collections of oligomers
    Patent number: 6165717
    Abstract: A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate identification of the sequence of the monomers in the oligomer.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: December 26, 2000
    Assignee: Affymax Technologies N.V.
    Inventors: William J. Dower, Ronald W. Barrett, Mark A. Gallop
  • Method of synthesizing diverse collections of oligomers
    Patent number: 6143497
    Abstract: A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate identification of the sequence of the monomers in the oligomer.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: November 7, 2000
    Assignee: Affymax Technologies N.V.
    Inventors: William J. Dower, Ronald W. Barrett, Mark A. Gallop
  • Method of synthesizing diverse collections of oligomers
    Patent number: 6140493
    Abstract: A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates identification of oligomers with desired properties.
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: October 31, 2000
    Assignee: Affymax Technologies N.V.
    Inventors: William J. Dower, Ronald W. Barrett, Mark A. Gallop, Michael C. Needels
  • Peptides and compounds that bind to a receptor
    Patent number: 6121238
    Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
    Type: Grant
    Filed: February 3, 1999
    Date of Patent: September 19, 2000
    Assignee: Glaxo Wellcome Inc.
    Inventors: William J. Dower, Ronald W. Barrett, Steven E. Cwirla, Christian M. Gates, Peter J. Schatz, Palaniappan Balasubramanian, Christopher R. Wagstrom, Richard Wayne Hendren, Randolph B. Deprince, Surekha Podduturi, Qun Yin
  • Peptides and compounds that bind to a thrombopoietin receptor
    Patent number: 6083913
    Abstract: Receptors are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
    Type: Grant
    Filed: December 4, 1997
    Date of Patent: July 4, 2000
    Assignee: Glaxo Wellcome Inc.
    Inventors: William J. Dower, Ronald W. Barrett, Steven E. Cwirla, David J. Duffin, Christian M. Gates, Sherril S. Haselden, Larry C. Mattheakis, Peter J. Schatz, Christopher R. Wagstrom, Nicholas C. Wrighton
  • Peptides that bind to the erythropoietin receptor
    Patent number: 5986047
    Abstract: Peptides of 10 to 40 or more amino acid residues in length and having the sequence X3X4X5GPX6TWX7X8 (SEQ ID NO:252) where each amino acid is indicated by standard one letter abbreviation; X3 is C; X4 is R, H, L, or W; X.sub.5 is M, F, or I; X6 is independently selected from any one of the 20 genetically coded L-amino acids; X7 is D, E, I, L, or V; and X8 is C, which bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist, and methods for their use.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: November 16, 1999
    Assignee: Affymax Technologies N.V.
    Inventors: Nicholas C. Wrighton, William J. Dower, Ray S. Chang, Arun K. Kashyap
  • Use of modified tethers in screening compound libraries
    Patent number: 5958703
    Abstract: The invention provides methods for screening libraries of complexes for compounds having a desired property, especially, the capacity to agonize, bind to, or antagonize a cellular receptor. The complexes in such libraries comprise a compound under test, a tag recording at least one step in synthesis of the compound, and a tether susceptible to modification by a reporter molecule. Modification of the tether is used to signify that a complex contains a compound having a desired property. The tag can be decoded to reveal at least one step in the synthesis of such a compound.
    Type: Grant
    Filed: December 3, 1996
    Date of Patent: September 28, 1999
    Assignee: Glaxo Group Limited
    Inventors: William J. Dower, Gregory L. Heinkel, Larry Mattheakis, Peter J. Schatz
  • Peptides and compounds that bind to the thrombopoietin receptor
    Patent number: 5932546
    Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
    Type: Grant
    Filed: October 4, 1996
    Date of Patent: August 3, 1999
    Assignee: Glaxo Wellcome Inc.
    Inventors: Ronald W. Barrett, William J. Dower, Steven E. Cwirla, Sherril S. Johnson, Nicholas C. Wrighton, David J. Duffin, Christopher R. Wagstrom
  • Method of identifying nucleotide differences
    Patent number: 5925525
    Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
    Type: Grant
    Filed: April 3, 1998
    Date of Patent: July 20, 1999
    Assignee: Affymetrix, Inc.
    Inventors: Stephen P. A. Fodor, Dennis W. Solas, William J. Dower
  • In vitro peptide and antibody display libraries
    Patent number: 5922545
    Abstract: Improved methods and novel compositions for identifying peptides and single-chain antibodies that bind to predetermined receptors or epitopes. Such peptides and antibodies are identified by improved and novel methods for affinity screening of polysomes displaying nascent peptides.
    Type: Grant
    Filed: July 29, 1997
    Date of Patent: July 13, 1999
    Assignee: Affymax Technologies N.V.
    Inventors: Larry C. Mattheakis, William J. Dower
  • Analysis of surface immobilized polymers utilizing microfluorescence detection
    Patent number: 5902723
    Abstract: Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine terminal monomers on solid phase immobilized polymers. Reagents which specifically recognize terminal manomers are used to label polymers at defined positions on a solid substrate.
    Type: Grant
    Filed: July 12, 1996
    Date of Patent: May 11, 1999
    Inventors: William J. Dower, Stephen P. A. Fodor
  • Methods for nucleic acid analysis
    Patent number: 5871928
    Abstract: The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
    Type: Grant
    Filed: June 11, 1997
    Date of Patent: February 16, 1999
    Inventors: Stephen P. A. Fodor, Dennis W. Solas, William J. Dower
  • Peptides and compounds that bind to a receptor
    Patent number: 5869451
    Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: February 9, 1999
    Assignee: Glaxo Group Limited
    Inventors: William J. Dower, Ronald W. Barrett, Steven E. Cwirla, Christian M. Gates, Peter J. Schatz, Palaniappan Balasubramanian, Christopher R. Wagstrom, Richard Wayne Hendren, Randoph B. DePrince, Surekha Podduturi, Qun Yin
  • Methods of administering peptides that bind to the erythropoietin receptor
    Patent number: 5830851
    Abstract: Peptides of 10 to 40 or more amino acid residues in length and having the sequence X.sub.3 X.sub.4 X.sub.5 GPX.sub.6 TWX.sub.7 X.sub.8 (SEQ ID NO:252) where each amino acid is indicated by standard one letter abbreviation; X.sub.3 is C; X.sub.4 is R, H, L, or W; X.sub.5 is M, F, or I; X.sub.6 is independently selected from any one of the 20 genetically coded L-amino acids; X.sub.7 is D, E, I, L, or V; and X.sub.8 is C, which bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist, and methods for their use.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 3, 1998
    Assignee: Affymax Technologies N.V.
    Inventors: Nicholas C. Wrighton, William J. Dower, Ray S. Chang, Arun K. Kashyap