Patents by Inventor William J. Hoekstra

William J. Hoekstra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isonipecotamides for the treatment of integrin-mediated disorders
    Publication number: 20030181440
    Abstract: The invention is directed to novel isonipecotamide derivatives of Formula (I): 1
    Type: Application
    Filed: January 16, 2003
    Publication date: September 25, 2003
    Inventors: Michael J. Costanzo, William J. Hoekstra, Bruce E. Maryanoff
  • Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
    Publication number: 20030139398
    Abstract: The invention is directed to novel quinazoline and quinazoline-like derivatives of Formula (I): 1
    Type: Application
    Filed: April 5, 2002
    Publication date: July 24, 2003
    Inventors: William J. Hoekstra, Edward C. Lawson, Michael J. Costanzo
  • Bridged bicyclic amino acid-derived [1,4]benzodiazepine vasopressin receptor antagonists
    Publication number: 20030119822
    Abstract: The invention is directed to bridged bicyclic amino acid-derived [1,4]benzodiazepine compounds, intermediates and pharmaceutical compositions thereof useful as vasopressin receptor antagonists and methods for treating vasopressin mediated disorders.
    Type: Application
    Filed: October 11, 2002
    Publication date: June 26, 2003
    Inventors: Alexey B. Dyatkin, William J. Hoekstra, Bruce E. Maryanoff
  • Tricyclic benzodiazepines as vasopressin receptor antagonists
    Publication number: 20020103373
    Abstract: The invention is directed to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the present invention and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.
    Type: Application
    Filed: July 24, 2001
    Publication date: August 1, 2002
    Inventors: William J. Hoekstra, Alexey B. Dyatkin, Bruce E. Maryanoff, Jay M. Matthews
  • Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists
    Publication number: 20020091115
    Abstract: The invention is directed to aza-bridged-bicyclic compounds having Formula (I): 1
    Type: Application
    Filed: June 26, 2001
    Publication date: July 11, 2002
    Inventors: Alexey B. Dyatkin, Bruce E. Maryanoff, William J. Hoekstra, Wei He, William A. Kinney
  • Indole and indazole urea-peptoids as thrombin receptor antagonists
    Patent number: 6365617
    Abstract: The invention is directed to novel indole and indazole urea-peptoid compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted indole and indazole urea-peptoid compounds of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Grant
    Filed: June 26, 2000
    Date of Patent: April 2, 2002
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: David F. McComsey, William J. Hoekstra, Bruce E. Maryanoff, Han-Cheng Zhang
  • Triazolopyridines for the treatment of thrombosis disorders
    Patent number: 6303625
    Abstract: The invention is directed to novel triazolopyridine derivatives which are useful as antagonists of GPIIb/IIIa. Pharmaceutical compositions comprising the triazolopyridine derivatives of the present invention, methods of treating conditions mediated by GPIIb/IIIa (e.g., methods for treating platelet-mediated thrombotic disorders) along with processes for making the compounds and novel intermediates are also disclosed.
    Type: Grant
    Filed: July 15, 1999
    Date of Patent: October 16, 2001
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: William J. Hoekstra, Edward C. Lawson, Bruce E. Maryanoff
  • Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders
    Patent number: 6191145
    Abstract: Orally-active nipecotamide glycolamide ester derivatives of formula (I): are disclosed as useful in treating platelet-mediated thrombotic disorders.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: February 20, 2001
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventor: William J. Hoekstra
  • Carboxamide derivatives of piperidine for the treatment of thrombosis disorders
    Patent number: 6069254
    Abstract: Carboxamide derivatives of pyrrolidine, piperidine, and hexahydroazepine of formula (I): ##STR1## are disclosed as useful in treating platelet-mediated thrombotic disorders.
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: May 30, 2000
    Assignee: Ortho Pharmaceutical Corp.
    Inventors: Michael J. Costanzo, William J. Hoekstra, Bruce E. Maryanoff
  • Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders
    Patent number: 6066651
    Abstract: Orally-active nipecotamide glycolamide ester derivatives of formula (I): ##STR1## are disclosed as useful in treating platelet-mediated thrombotic disorders.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: May 23, 2000
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventor: William J. Hoekstra
  • Nipecotic acid derivatives as antithrombotic compounds
    Patent number: 5770575
    Abstract: Nipecotic acid-derived compounds of formula (I): ##STR1## are disclosed as useful in treating platelet-mediated thrombotic disorders.
    Type: Grant
    Filed: March 6, 1995
    Date of Patent: June 23, 1998
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Mary Pat Beavers, Patricia Andrade-Gordon, William J. Hoekstra