Patents by Inventor William J. Hoekstra

William J. Hoekstra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antifungal compounds and processes for making
    Patent number: 9840492
    Abstract: The present invention relates to polymorphic forms of compound 1 or 1a and processes for preparing compound 1 and 1a polymorphs, which are useful as antifungal agents. In particular, the invention seeks to provide a new methodology for preparing polymorphs of compound 1 and substituted derivatives thereof.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: December 12, 2017
    Assignee: Viamet Pharmaceuticals, Inc.
    Inventors: William J. Hoekstra, David Dale Wirth, Tracy Ehiwe, Thierry Bonnaud
  • Antifungal compound process
    Patent number: 9802914
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 or 1a and substituted derivatives thereof.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: October 31, 2017
    Assignee: Viamet Pharmaceuticals, Inc.
    Inventors: William J. Hoekstra, Christopher M. Yates
  • METALLOENZYME INHIBITOR COMPOUNDS AS FUNGICIDES
    Publication number: 20170233369
    Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Application
    Filed: May 4, 2017
    Publication date: August 17, 2017
    Inventors: Michael R. Loso, Gary D. Gustafson, Asako Kubota, Maurice C. Yap, Zachary A. Buchan, Kimberly M. Steward, Michael T. Sullenberger, William J. Hoekstra, Christopher M. Yates
  • Metalloenzyme inhibitor compounds
    Patent number: 9688671
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: June 27, 2017
    Assignee: Viamet Pharmaceuticals, Inc.
    Inventors: William J. Hoekstra, Christopher M. Yates
  • 2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-1-(5-SUBSTITUTED-PYRIDIN-2-YL)-3-(1H-TETRAZOL-1-YL)PROPAN-2-OLS AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20170158667
    Abstract: Provided herein are 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and 1-(2,4-difluorophenyl)-2,2-difluoro-2-(5-substituted-pyridin-2-yl)ethanones and processes for their preparation.
    Type: Application
    Filed: March 19, 2015
    Publication date: June 8, 2017
    Inventors: William J. Hoekstra, Nakyen Choy, Carl DeAmicis, Daniel Knueppel, Jim Renga, Michael T. Sullenberger, Gregory Whiteker, Yuanming Zhu, Gary D. Gustafson
  • Metalloenzyme inhibitor compounds as fungicides
    Patent number: 9663491
    Abstract: The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: May 30, 2017
    Assignee: Dow AgroSciences LLC
    Inventors: Michael R. Loso, Gary D. Gustafson, Asako Kubota, Maurice C. Yap, Zachary A. Buchan, Kimberly M. Steward, Michael T. Sullenberger, William J. Hoekstra, Christopher M. Yates
  • Metalloenzyme inhibitor compounds
    Patent number: 9663488
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: May 30, 2017
    Assignee: Viamet Pharmaceuticals, Inc.
    Inventors: William J. Hoekstra, Christopher M. Yates, Stephen W. Rafferty
  • ANTIFUNGAL COMPOUND PROCESS
    Publication number: 20170144991
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: March 19, 2015
    Publication date: May 25, 2017
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
  • ANTIFUNGAL COMPOUND PROCESS
    Publication number: 20170144990
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: March 19, 2015
    Publication date: May 25, 2017
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
  • METALLOENZYME INHIBITOR COMPOUNDS
    Publication number: 20170143694
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Application
    Filed: February 2, 2017
    Publication date: May 25, 2017
    Inventors: William J. Hoekstra, Robert J. Schotzinger, Stephen W. Rafferty
  • ANTIFUNGAL COMPOUNDS AND PROCESSES FOR MAKING
    Publication number: 20170121307
    Abstract: The present invention relates to polymorphic forms of compound 1 or 1a and processes for preparing compound 1 and 1a polymorphs, which are useful as antifungal agents. In particular, the invention seeks to provide a new methodology for preparing polymorphs of compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: March 17, 2016
    Publication date: May 4, 2017
    Inventors: William J. Hoekstra, David Dale Wirth, Tracy Ehiwe, Thierry Bonnaud
  • ANTIFUNGAL COMPOUND PROCESS
    Publication number: 20170096410
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: March 19, 2015
    Publication date: April 6, 2017
    Inventors: William J. HOEKSTRA, Christopher M. YATES, Mark BEHNKE, Asaf ALIMARDANOV, Scott A. DAVID, Douglas Franklin FRY
  • ANTIFUNGAL COMPOUND PROCESS
    Publication number: 20170088539
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: March 19, 2015
    Publication date: March 30, 2017
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asat Alimardanov, Scott A. David, Douglas Franklin Fry
  • ANTIFUNGAL COMPOUND PROCESS
    Publication number: 20170088540
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: March 19, 2015
    Publication date: March 30, 2017
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
  • ANTIFUNGAL COMPOUND PROCESS
    Publication number: 20170081309
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 or 1a and substituted derivatives thereof.
    Type: Application
    Filed: March 19, 2015
    Publication date: March 23, 2017
    Inventors: William J. Hoekstra, Christopher M. Yates
  • ANTIFUNGAL COMPOUND PROCESS
    Publication number: 20170081310
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: March 19, 2015
    Publication date: March 23, 2017
    Inventors: William J. Hoekstra, Christopher M. Yates
  • ANTIFUNGAL COMPOUND PROCESS
    Publication number: 20170081285
    Abstract: The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof.
    Type: Application
    Filed: March 19, 2015
    Publication date: March 23, 2017
    Inventors: William J. Hoekstra, Christopher M. Yates, Mark Behnke, Asaf Alimardanov, Scott A. David, Douglas Franklin Fry
  • 2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-1-(5-SUBSTITUTED-PYRIDIN-2-YL)-3-(1H-TETRAZOL-1-YL)PROPAN-2-OLS AND PROCESSES FOR THEIR PREPARATION
    Publication number: 20170081316
    Abstract: Provided herein are 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation.
    Type: Application
    Filed: March 19, 2015
    Publication date: March 23, 2017
    Inventors: William J. Hoekstra, Daniel Knueppel, Jim Renga, Gregory Whiteker, Michael T. Sullenberger
  • Metalloenzyme inhibitor compounds
    Patent number: 9556143
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: December 1, 2014
    Date of Patent: January 31, 2017
    Assignee: Viamet Pharmaceuticals, Inc.
    Inventors: William J. Hoekstra, Stephen W. Rafferty, Christopher M. Yates, Robert J. Schotzinger, Michael R. Loso, Michael T. Sullenberger
  • Fungicidal compositions
    Patent number: 9447073
    Abstract: The instant invention describes tetrazole compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: September 20, 2016
    Assignee: Viamet Pharmaceuticals, Inc.
    Inventors: William J. Hoekstra, Michael R. Loso, Gary D. Gustafson, Daniel Knueppel, Zachary A. Buchan, Michael T. Sullenberger