Abstract: Disclosed herein are compositions and methods for treating lung disorders including lung tumors by pulmonary administration of compositions comprising taxane particles such as docetaxel or paclitaxel particles.

Abstract: A subsea pump system includes a subsea pump, a fluid conditioner tank arranged upstream of the subsea pump, a liquid conservation tank arranged downstream of the subsea pump, a line arranged to recirculate a liquid from the liquid conservation tank to upstream of the subsea pump, an umbilical which provides power, a monitoring and a control, a first buoyancy element suspended in the fluid conditioner tank, a second buoyancy element suspended in the liquid conservation tank, optical fiber sensors which are arranged at least to a suspension of the first buoyancy element in the fluid conditioner tank and to a suspension of the second buoyancy element in the liquid conservation tank, and electronics.

Abstract: An apparatus for sensing acoustic waves below a surface of the earth includes an optical fiber disposed below the surface of the earth and having a series of sensing units along the optical fiber with each sensing unit having three or more reflectors and an optical interrogator in optical communication with the optical fiber. The reflectors in each sensing unit are positioned to provide a linearized response that approximates a sawtooth wave better than a sinusoidal wave to sense the acoustic waves in a desired dynamic range. The optical interrogator is configured to transmit an input light signal into the optical fiber and receive a reflected light signal from the optical fiber due to the input light signal in order to measure a strain on each sensing unit due to interaction with the acoustic waves and to determine a location of the sensing unit corresponding to the sensed strain.

Abstract: A distributed temperature sensor, a method of determining temperature, and a processing system to compute temperature are described. The sensor includes an optical fiber disposed in an area where temperature is to be measured, a primary light source to inject light into the optical fiber, and a secondary light source to inject light into the optical fiber. The sensor additionally includes a photodetector to detect backscatter light energy from the optical fiber the backscatter light energy including Stokes Raman scatter or anti-Stokes Raman scatter and primary Rayleigh scatter resulting from the primary light source and secondary Rayleigh scatter resulting from the secondary light source, and a processor to determine temperature based on a ratio of the Stokes Raman scatter or the anti-Stokes Raman scatter and a combination of the primary Rayleigh scatter and the secondary Rayleigh scatter.

Abstract: An apparatus for sensing acoustic waves below a surface of the earth includes an optical fiber disposed below the surface of the earth and having a series of sensing units along the optical fiber with each sensing unit having three or more reflectors and an optical interrogator in optical communication with the optical fiber. The reflectors in each sensing unit are positioned to provide a linearized response that approximates a sawtooth wave better than a sinusoidal wave to sense the acoustic waves in a desired dynamic range. The optical interrogator is configured to transmit an input light signal into the optical fiber and receive a reflected light signal from the optical fiber due to the input light signal in order to measure a strain on each sensing unit due to interaction with the acoustic waves and to determine a location of the sensing unit corresponding to the sensed strain.

Abstract: The present device is designed to enhance the efficiency of endoscopic surgeries by allowing for in situ cleaning of the lens via a combination of fluid flow and wiping mechanisms. By removing the need for intermittent halts in surgery, this device may provide a more seamless and fluid operation process, enhancing surgeon convenience and contributing to patient safety by providing a more consistent and clearer field of view for surgeons to operate in.

Abstract: The present application is directed to methods and systems for identifying small molecule compounds in mixtures using a library comprising calculated structures and corresponding calculated mass spectral fragmentation patterns of known and/or hypothetical small molecule compounds that may be in the mixture and screening of a mass spectrum of the mixture using the library to identify matching fragmentation patterns. If a mass spectral fragmentation pattern present in the mass spectrum of the mixture matches a calculated fragmentation pattern of one of the known or hypothetical compounds this confirms the identity of a compound in the mixture as the known or hypothetical compound. The method represents a platform method that can be used for a multitude of purposes related to the screening and identification of compounds in mixtures.

Abstract: The present invention relates to alkoxy-substituted 2,3-dihydroimidazo[1,2-c]quinazoline compounds of general formula (I) in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to substituted phenoxypyridine compounds of general formula (I); in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.

Abstract: A method of monitoring fluid flow in a borehole includes measuring acoustics at a plurality of locations along a downhole assembly in a borehole and calculating a fluid flow rate at the plurality of locations along the downhole assembly based on measuring the acoustics at the plurality of locations.

Abstract: A distributed acoustic sensing system and a method of obtaining acoustic levels using the distributed acoustic sensing system are described. The distributed acoustic sensing system includes an optical fiber, a light source to inject light into the optical fiber, and a photodetector to sample a DAS signal in each section of one or more sections of the optical fiber resulting from two or more points within the section on the optical fiber over a period of time. The system also includes a processor to process only a low frequency portion of the DAS signal to obtain the acoustic levels at each of the one or more sections on the optical fiber over the period of time, the low frequency portion of the DAS signal being less than 10 Hz.

Abstract: Various embodiments of methods and systems for apparatus monitoring are disclosed wherein the apparatus is associated with fitness equipment for humans.

Abstract: An apparatus for performing a measurement of a downhole property includes an optical fiber having a first section that has a first set of fiber Bragg gratings with a first resonant wavelength inscribed therein and a second section that has a second set of fiber Bragg gratings with a second resonant wavelength different from the first resonant wavelength inscribed therein. The second section is in series with the first section. An optical interrogator emits a swept-wavelength frequency domain light signal having varying wavelength amplitude modulation into the optical fiber, receives a frequency domain return light signal, and transforms the frequency domain return signal into a time domain to determine a resonant wavelength shift of each fiber Bragg grating and the corresponding location of each interrogated fiber Bragg grating. A processor converts the resonant wavelength shift of each interrogated fiber Bragg grating into the downhole property measurement.

Abstract: An apparatus for performing a measurement of a downhole property includes an optical fiber having a first section that has a first set of fiber Bragg gratings with a first resonant wavelength inscribed therein and a second section that has a second set of fiber Bragg gratings with a second resonant wavelength different from the first resonant wavelength inscribed therein. The second section is in series with the first section. An optical interrogator emits a swept-wavelength frequency domain light signal having varying wavelength amplitude modulation into the optical fiber, receives a frequency domain return light signal, and transforms the frequency domain return signal into a time domain to determine a resonant wavelength shift of each fiber Bragg grating and the corresponding location of each interrogated fiber Bragg grating. A processor converts the resonant wavelength shift of each interrogated fiber Bragg grating into the downhole property measurement.

Abstract: The present invention relates to substituted N-biphenyl-3-acetylamino-benzamides and N-[3-(acetylamino)phenyl]-biphenyl-carboxamides of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disorder, as a sole agent or in combination with other active ingredients.