Patents by Inventor William M. Grosse

William M. Grosse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7109000
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: September 19, 2006
    Assignee: CuraGen Corporation
    Inventors: Shlomit R. Edinger, John R. MacDougall, Isabelle Millet, Karen Ellerman, David J. Stone, Valerie Gerlach, William M. Grosse, John P. Alsobrook, II, Denise M. Lepley, Daniel K. Rieger, Catherine E. Burgess, Stacie J. Casman, Kimberly A. Spytek, Ferenc L. Boldog, Li Li, Muralidhara Padigaru, Vishnu Mishra, Meera Patturajan, Suresh G. Shenoy, Luca Rastelli, Velizar T. Tchernev, Corine A. M. Vernet, Bryan D. Zerhusen, Uriel M. Malyankar, Xiaojia Guo, Charles E. Miller, Esha A. Gangolli
  • Patent number: 6989232
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: January 24, 2006
    Assignees: Millennium Pharmaceuticals, Inc., Curagen Corporation
    Inventors: Catherine E. Burgess, Pamela B. Conley, William M. Grosse, Matthew Hart, Ramesh Kekuda, Richard A. Shimkets, Kimberly A. Spytek, Edward Szekeres, Jr., James E. Tomlinson, James N. Topper, Ruey-Bin Yang
  • Patent number: 6875570
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: April 5, 2005
    Assignee: CuraGen Corporation
    Inventors: Valerie L. Gerlach, John R. MacDougall, Glennda Smithson, Isabelle Millet, David Stone, Erik Gunther, Karen Ellerman, William M. Grosse, John P. Alsobrook, II, Denise M. Lepley, Catherine E. Burgess, Muralidhara Padigaru, Ramesh Kekuda, Kimberly A. Spytek, Martin D. Leach, Richard A. Shimkets
  • Publication number: 20040214759
    Abstract: In methods of using a fibroblast growth factor, such as for treating, preventing or delaying a proliferation-associated disorder, steps are provided to administer to a subject a therapeutically effective amount of a particular fibroblast growth factor polypeptide, or variant or fragment thereof.
    Type: Application
    Filed: May 9, 2003
    Publication date: October 28, 2004
    Inventors: John P. Alsobrook, Enrique Alvarez, David W. Anderson, Joel S. Bader, Ferenc L. Boldog, Catherine E. Burgess, Rajeev A. Chillakuru, Lisa Deegler, Shlomit R. Edinger, Elma R. Fernandes, Linda Gorman, William M. Grosse, John L. Herrmann, Michael E. Jeffers, William J. LaRochelle, Denise M. Lepley, Henri S. Lichenstein, Kumar Namdev, Muralidhara Padigaru, Carol E. A. Pena, Sudhirdas K. Prayaga, Daniel K. Rieger, Richard A. Shimkets, Pascal Valax, Meijia Yang, Zachary Yim, Mei Zhong
  • Publication number: 20040096877
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: July 21, 2003
    Publication date: May 20, 2004
    Inventors: Raymond J. Taupier, Muralidhara Padigaru, Luca Rastelli, Steven Kurt Spaderna, Richard A. Shimkets, Bryan D. Zerhusen, Kimberly Ann Spytek, Suresh G. Shenoy, Li Li, Vladimir Y. Gusev, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Catherine E. Burgess, Valerie L. Gerlach, Karen Ellerman, John R. MacDougall, David J. Stone, Glennda Smithson
  • Publication number: 20040072997
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: January 3, 2003
    Publication date: April 15, 2004
    Inventors: John P. Alsobrook, David W. Anderson, Catherine E. Burgess, Shlomit R. Edinger, Karen Ellerman, Katarzyna Furtak, Esha A. Gangolli, Valerie Gerlach, Jennifer A. Gilbert, Erik Gunther, Linda Gorman, Xiaojia (Sasha) Guo, Weizhen Ji, Li Li, Charles E. Miller, Muralidhara Padigaru, Meera Patturajan, Luca Rastelli, John R. MacDougall, Vishnu Mishra, Glennda Smithson, Kimberly A. Spytek, David J. Stone, Suresh G. Shenoy, Raymond J. Taupier, Corine A.M. Vernet, Mei Zhong, Uriel M. Malyankar, Isabelle Millet, Ramesh Kekuda, William M. Grosse
  • Publication number: 20040067882
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: November 5, 2002
    Publication date: April 8, 2004
    Inventors: John P. Alsobrook, Enrique Alvarez, David W. Anderson, Melanie Baron, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Andrei Chapoval, Mohanraj Dhanabal, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Seth Ettenberg, Esha A. Gangolli, Valerie Gerlach, Linda Gorman, William M. Grosse, Xiaojia (Sasha) Guo, Craig Hackett, Weizhen Ji, Ramesh Kekuda, Nikolai V. Khramtsov, Denise M. Lepley, Li Li, John R. MacDougall, Uriel M. Malyankar, Ann Mazur, Kelly McQueeney, Peter S. Mezes, Charles E. Miller, Isabelle Millet, Vishnu Mishra, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, John A. Peyman, Luca Rastelli, Daniel K. Rieger, Mark E. Rothenberg, Suresh G. Shenoy, Richard A. Shimkets, Glennda Smithson, Steven K. Spaderna, Gary Starling, Kimberly A. Spytek, David J. Stone, Velizar T. Tchernev, Nancy Twomlow, Corine A.M. Vernet, Bryan D. Zerhusen, Edward Z. Voss, Mei Zhong
  • Publication number: 20040068095
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: March 13, 2002
    Publication date: April 8, 2004
    Inventors: Richard A. Shimkets, Raymond J. Taupier, Catherine E. Burgess, Bryan D. Zerhusen, Peter S. Mezes, Luca Rastelli, Uriel M. Malyankar, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Kimberly Ann Spytek, Li Li, Shlomit Edinger, Valerie Gerlach, Karen Ellerman, John R. MacDougall, Erik Gunther, Isabelle Millet, David J. Stone, Glennda Smithson, Edward S. Szekeres, Weizhen Ji
  • Publication number: 20040067490
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: September 6, 2002
    Publication date: April 8, 2004
    Inventors: Mei Zhong, Li Li, Linda Gorman, Kimberly A. Spytek, Ramesh Kekuda, Raymond J. Taupier, David W. Anderson, Corine A.M. Vernet, Elina Catterton, Charles E. Miller, Suresh G. Shenoy, Meera Patturajan, Carol E. A. Pena, Velizar T. Tchernev, Muralidhara Padigaru, Vladimir Y. Gusev, Uriel M. Malyankar, Catherine E. Burgess, Valerie Gerlach, Stacie J. Casman, Daniel K. Rieger, William M. Grosse, Glennda Smithson, John A. Peyman, Gary Starling, Mark E. Rothenberg, William J. LaRochelle, Richard A. Shimkets, Julie Crabtree, Luca Rastelli, Edward Z. Voss, Ferenc L. Boldog, Shlomit R. Edinger, Isabelle Millet, John R. MacDougall, Karen Ellerman, Andrei Chapoval
  • Publication number: 20040052806
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: January 4, 2002
    Publication date: March 18, 2004
    Inventors: Ramesh Kekuda, John P. Alsobrook, Velizar T. Tchernev, Xiaohong Liu, Kimberly A. Spytek, Meera Patturajan, William M. Grosse, Denise M. Lepley, Catherine E. Burgess, Corine A.M. Vernet, Li Li, Linda Gorman, Shlomit R. Edinger, Paul Sciore, Karen Ellerman, Uriel M. Malyankar, Mark E. Rothenberg, David J. Stone, Ferenc L. Boldog, Xiaojia (Sasha) Guo, Suresh G. Shenoy, David W. Anderson, Muralidhara Padigaru, Raymond J. Taupier, Charles E. Miller, Andrew Eisen
  • Publication number: 20040048245
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: October 5, 2001
    Publication date: March 11, 2004
    Inventors: Richard A. Shimkets, Raymond J. Taupier, Catherine E. Burgess, Bryan D. Zerhusen, Peter S. Mezes, Luca Rastelli, Uriel M. Malyankar, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Kimberly Ann Spytek, Li Li, Shlomit Edinger, Valerie Gerlach, Karen Ellerman, John R. MacDougall, Erik Gunther, Isabelle Millet, David J. Stone, Glennda Smithson, Edward S. Szekeres
  • Publication number: 20040043926
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: September 26, 2001
    Publication date: March 4, 2004
    Inventors: Valerie L. Gerlach, John R. MacDougall, Glennda Smithson, Isabelle Millet, David Stone, Erik Gunther, Karen Ellerman, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Catherine E. Burgess, Muralidhara Padigaru, Ramesh Kekuda, Kimberly A. Spytek, Martin D. Leach, Richard A. Shimkets
  • Publication number: 20040039163
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: August 27, 2001
    Publication date: February 26, 2004
    Inventors: Catherine E. Burgess, Pamela B. Conley, William M. Grosse, Matthew Hart, Ramesh Kekuda, Richard A. Shimkets, Kimberly A. Spytek, Edward S. Szekeres, James E. Tomlinson, James N. Topper, Ruey-Bin Yang
  • Publication number: 20040033493
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: January 31, 2002
    Publication date: February 19, 2004
    Inventors: Velizar T. Tchernev, Kimberly A. Spytek, Bryan D. Zerhusen, Meera Patturajan, Richard A. Shimkets, Li Li, Esha A. Gangolli, Muralidhara Padigaru, David W. Anderson, Luca Rastelli, Charles E. Miller, Valerie Gerlach, Raymond J. Taupier, Vladimir Y. Gusev, Steven D. Colman, Adam Ryan Wolenc, Carol E. A. Pena, Katarzyna Furtak, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Daniel K. Rieger, Catherine E. Burgess
  • Publication number: 20040033491
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: December 10, 2001
    Publication date: February 19, 2004
    Inventors: John P. Alsobrook, David W. Anderson, Catherine E. Burgess, Ferenc L. Boldog, Stacie J. Casman, Steven D. Colman, Shlomit R. Edinger, Karen Ellerman, Valerie Gerlach, Linda Gorman, William M. Grosse, Xiaojia Sasha Guo, John L. Herrmann, Ramesh Kekuda, Denise M. Lepley, Li Li, John R. MacDougall, Isabelle Millet, Carol E. A. Pena, John A. Peyman, Luca Rastelli, Daniel K. Rieger, Richard A. Shimkets, Glennda Smithson, Kimberly A. Spytek, David J. Stone, Velizar T. Tchernev, Corine A.M. Vernet, Edward Z. Voss, Bryan D. Zerhusen, Haihong Zhong, Mei Zhong
  • Publication number: 20040029220
    Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: June 18, 2002
    Publication date: February 12, 2004
    Inventors: Corine A.M. Vernet, Elma R. Fernandes, Valerie Gerlach, Richard A. Shimkets, Uriel M. Malyankar, Ferenc L. Boldog, Bryan D. Zerhusen, Kimberly A. Spytek, Kumud Majumder, Velizar T. Tchernev, Muralidhara Padigaru, Meera Patturajan, Catherine E. Burgess, Esha A. Gangolli, Glennda Smithson, Luca Rastelli, John R. MacDougall, Raymond J. Taupier, William M. Grosse, Edward S. Szekeres, John P. Alsobrook, David W. Anderson, Xiaojia (Sasha) Guo, Li Li, Mei Zhong
  • Publication number: 20040029116
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: March 1, 2002
    Publication date: February 12, 2004
    Inventors: Shlomit R. Edinger, John R. MacDougall, Isabelle Millet, Karen Ellerman, David J. Stone, Valerie Gerlach, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Daniel K. Rieger, Catherine E. Burgess, Stacie J. Casman, Kimberly A. Spytek, Ferenc L. Boldog, Li Li, Muralidhara Padigaru, Vishnu Mishra, Meera Patturajan, Suresh G. Shenoy, Luca Rastelli, Velizar T. Tchernev, Corine A.M. Vernet, Bryan D. Zerhusen, Uriel M. Malyankar, Xiaojia Guo, Charles E. Miller, Esha A. Gangolli
  • Publication number: 20040029216
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: January 9, 2002
    Publication date: February 12, 2004
    Inventors: Muralidhara Padigaru, Li Li, Bryan D. Zerhusen, Stacie J. Casman, Suresh G. Shenoy, Kimberly Spytek, Mei Zhong, Esha A. Gangolli, Catherine E. Burgess, Meera Patturajan, Corine A.M. Vernet, Sarah Taylor, Velizar T. Tchernev, Charles E. Miller, Xiaojia Guo, Ferenc L. Boldog, William M. Grosse, John P. Alsobrook, Valerie L. Gerlach, Shlomit R. Edinger, Mark E. Rothenberg, Karen Ellerman, John MacDougall, Uriel M. Malyankar, Isabelle Millet, John Peyman, Glennda Smithson, Erik Gunther, David Stone
  • Publication number: 20040029222
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: August 14, 2002
    Publication date: February 12, 2004
    Inventors: Shlomit R. Edinger, John R. MacDougall, Isabelle Millet, Karen Ellerman, David J. Stone, Valerie Gerlach, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Danier K. Rieger, Catherine E. Burgess, Stacie J. Casman, Kimberly A. Spytek, Ference L. Boldog, Li Li, Muralidhara Padigaru, Vishnu Mishra, Meera Patturajan, Suresh G. Shenoy, Luca Rastelli, Velizar T. Tchernev, Corine A.M. Vernet, Bryan D. Zerhusen, Uriel M. Malyankar, Xiaojia (Sasha) Guo, Charles E. Miller, Esha A. Gangolli, Michael Grosse
  • Publication number: 20040018196
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: January 11, 2002
    Publication date: January 29, 2004
    Inventors: Peter D. Mezes, Luca Rastelli, John L. Herrmann, John R. MacDougall, Haihong Zhong, Stacie J. Casman, Ferenc L. Boldog, Richard A. Shimkets, Linda Gorman, Andrew J. Eisen, Steven K. Spaderna, Corine A.M. Vernet, Constance Berghs, Kimberly A. Spytek, Vincent A. DiPippo, Bryan D. Zerhusen, John A. Peyman, Karen Ellerman, David J. Stone, William M. Grosse, John P. Alsobrook, Denise M. Lepley, Daniel K. Rieger, Catherine E. Burgess, Shlomit R. Edinger