Abstract: This invention provides compounds of the formula: useful in the inhibition or modulation of serine palmitoyl transferase and their use in methods of treatment or amelioration of type 2 diabetes, type 1 diabetes, insulin resistance, the effects of obesity, metabolic syndrome (sometimes referred to as Syndrome X), impaired glucose tolerance, Cushing's disease, cardiovascular disease, prothrombotic conditions, myocardial infarction, hypertension, congestive heart failure, cardiomyopathy, atherosclerosis, dyslipidemia, sepsis, liver damage, retinal degenerative disorders, cachexia, emphysema, hepatitis C infections, HIV infections and inflammatory disorders and useful in methods for raising HDL plasma levels in a mammal. The compounds of this invention can also be used to prevent damage or loss of pancreatic islet beta cells (such as in the case of pancreatic beta cell apoptosis, including those related to insulin-dependent diabetes mellitus).

Abstract: The system includes a bin hopper which temporarily stores a plurality of small elements, such as medications. The elements are moved out of the bin and singulated into a one-by-one sequence by a series of singulating conveyors. The resulting sequence of elements is moved onto a main system conveyor where the element is identified and then moved to a loading mechanism which arranges the item so it is ready to be gripped and stored. The system includes a mass storage apparatus comprising a series of four upstanding cylindrical drums, each having a plurality of individually accessible and addressable cell storage locations for the elements. A gripping apparatus removes the elements from the loading mechanism and transfers them to a selected location in a cylindrical drum. When an article is to be dispensed, the drum is rotated so that an ejection arm comes adjacent the desired location in the drum.

Abstract: Novel imidazole compounds and pharmaceutical compositions are described, as are methods of using such compounds, alone or in combination with another pharmaceutically active agent, to treat subjects, including humans, suffering from hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and atherosclerosis.

Abstract: Logical partitions in an information processing apparatus share an IP address and are assigned different MAC addresses. A representative logical partition communicates with an external entity on behalf of the other logical partitions. A driver is provided with a virtual interface and a physical interface. Internal communication between the logical partitions is done via the virtual interface and communication with an external entity is done via the physical interface. If a packet received from an external destination is destined to one of the other logical partitions, the protocol stack of the representative logical partition replaces the destination MAC address by the MAC address of the destination logical partition. The protocol stack provides the packet in which the destination MAC address has been replaced to the virtual interface. The virtual interface transfers the packet provided by the protocol stack to the destination logical partition.

Abstract: The medication apparatus includes a mobile housing assembly and a plurality of tray members supported therein for rotation on a central mounting assembly. A lockable access door is present in the housing assembly for controlled access to the trays. A tray locking assembly locks and unlocks the trays individually in a plurality of angular positions so that each of the compartments on a particular tray member can be presented before the door. A drive assembly selectively engages and rotates each tray individually when the tray is unlocked. A control system, including a stored program, identifies a compartment associated with a particular patient or associated with particular medications, unlocks the tray associated with the desired compartment, and rotates the tray to present the compartment before the access door, which is then unlocked and openable.

Abstract: The system includes a bin hopper which temporarily stores a plurality of small elements, such as medications. The elements are moved out of the bin and singulated into a one-by-one sequence by a series of singulating conveyors. The resulting sequence of elements is moved onto a main system conveyor where the element is identified and then moved to a loading mechanism which arranges the item so it is ready to be gripped and stored. The system includes a mass storage apparatus comprising a series of four upstanding cylindrical drums, each having a plurality of individually accessible and addressable cell storage locations for the elements. A gripping apparatus removes the elements from the loading mechanism and transfers them to a selected location in a cylindrical drum. When an article is to be dispensed, the drum is rotated so that an ejection arm comes adjacent the desired location in the drum.

Abstract: Novel imidazoles and novel pyrroles are provided. Also provided are pharmaceutical compositions, methods of making and methods of using the compounds.

Abstract: Methods and systems are provided for cooling an ultrasound transducer using a refrigeration system located within the imaging system. A closed loop of recirculating coolant located in the transducer assembly transports waste heat from the remotely located heat producing acoustic components or active electronics components to a thermally conductive shoe, located within the transducer connector. Thermally conductive materials in each connector, the ultrasound system connector and the transducer assembly connector, are positioned in contact to thermally conduct heat from the transducer assembly to a refrigeration system, located in the imaging system, free of fluid transfer.

Abstract: Novel compounds and pharmaceutical compositions useful as hypocholesterolemic and hypolipidemic agents are described. More specifically, potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (“HMG CoA reductase”) are described. Methods of using such compounds and compositions to treat subjects, including humans, suffering from hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, Alzheimer's Disease, benign prostatic hypertrophy (BPH), diabetes and osteoporosis are also described.

Abstract: Novel optical disc storage units comprising transparent polypropylene are provided. Such storage units exhibit sufficient impact resistance to protect the target disc and sufficient clarity that any informational literature may be placed entirely within the storage unit and easily viewed and read through the walls thereof without impediment. Furthermore, the target storage unit must also include a spine section of sufficient width to permit a section of the informational literature to be placed internally thereon and viewed and easily read (such as, for example, the title and accompanying language describing the target disc placed therein) substantially without impediment as well. Specific novel storage units, in addition to these necessarily transparent walls and spine portions, are also possible to maximize the benefits of the transparent properties thereof.

Abstract: An adjustable bias folder includes a fabric path through which a fabric strip passes, and an adjusting device. The fabric path includes a first end and a second end. The fabric strip enters the fabric path at the first end, and the fabric strip is folded to have one or more folded portions at the second end as the fabric strip exits the fabric path. The adjusting device adjusts the dimension of the folded portions. The adjusting device includes a first adjuster that adjusts the dimension of one of the folded portions of the fabric strip, and a second adjuster that adjusts the dimension of another one of the folded portions.

Abstract: Novel imidazoles are provided. The compounds are useful as HMGCo-A Reductase Inhibitor. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided.

Abstract: An apparatus for releasing a single road cone at a timed interval comprising a mechanism comprising at least one reciprocating shoe which support a plurality of road cones in a first position, and which lock a single cone on a second position which is then released at a timed interval, a chute proximate to the door to permit said released cone to slide downward toward the road surface, and a vertical angle slide plate affixed to said chute to permit said cone to be released smoothly onto a road surface as the vehicle moves forward.

Abstract: An ultrasound transducer assembly is disclosed having a housing, a transducer array mounted in the housing and an electronics assembly mounted in the housing, the electronics assembly including one or more sub-assemblies having heat generating components disposed thereon. The electronics sub-assemblies further include thermal conducting features which conduct heat generated by the heat generating components out of the electronics assembly where it can be further removed by other thermal management techniques. These other thermal management techniques may include techniques utilized to cool the transducer array.

Abstract: A remote temperature monitoring apparatus includes a base-located energizing wave transmission/communication wave reception unit (e.g. located on a cooking stove) and a remotely-located, energizing-wave-powered, temperature-dependent communication wave emission unit (e. g. located on a cooking vessel). The base-located energizing wave transmission/communication wave reception unit transmits a series of probing energizing waves and receives temperature-dependent resonant communication wave emissions.

Abstract: 50 HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided.

Abstract: A tube squeezing device comprises a rectangular housing having a longitudinal slot formed in its front wall. The housing is pivoted to a backing plate which includes a tube retaining base for receiving and clamping the neck of the tube. A slide is arranged to slide within the housing, with the first and second rollers being mounted to the carriage. Each roller is provided with a slide advancing face and a tube squeezing face which are substantially perpendicular to each other, with a serrated and curved tube gripping face extending therebetween. The slide advancing faces define a nip which is slightly wider than a squeezed portion of the tube, thereby allowing the slide to move to a position in which the gripping faces or each roller abut the tube shoulders at the commencement of the unsqueezed portion of tube. Upon downward actuation of a lever, the rollers counter-rotate towards one another so that material from an adjacent unsqueezed portion of the tube may be squeezed.

Abstract: A seat for, for example, an aircraft that has an open outer shell which embraces a seat portion, a seat back, a head rest and a foot rest when the seat is in an upright position. Also embraced by the shell are a pair of arm rests. The seat is reclinable into a bed configuration such that the seat portion is moved forwardly out of the open end of the shell. Simultaneously, the arm rests are movable between the raised position and the position substantially flush with the seat portion. In the bed configuration, the removal of the arm rests from the raised position significantly increases the width of the bed, thus enhancing the comfort of the user.

Abstract: A seat for, for example, an aircraft that has an open outer shell which embraces a seat portion, a seat back, a head rest and a foot rest when the seat is in an upright position. Also embraced by the shell are a pair of arm rests. The seat is reclinable into a bed configuration such that the seat portion is moved forwardly out of the open end of the shell. Simultaneously, the arm rests are movable between the raised position and the position substantially flush with the seat portion. In the bed configuration, the removal of the arm rests from the raised position significantly increases the width of the bed, thus enhancing the comfort of the user.