Patents by Inventor William Pugh

William Pugh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160097077
    Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the IIIF hydroxylase with a substrate. Modulators of IIIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
    Type: Application
    Filed: November 18, 2015
    Publication date: April 7, 2016
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
  • Publication number: 20160097078
    Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
    Type: Application
    Filed: November 18, 2015
    Publication date: April 7, 2016
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
  • Publication number: 20160097076
    Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
    Type: Application
    Filed: November 18, 2015
    Publication date: April 7, 2016
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
  • Patent number: 9285783
    Abstract: Power utilized in a local power network may be managed. The local power network may include a power management system. The power management system may communicate with one or more of a circuit controller, a switch controller, and/or an outlet controller in order to manage power utilization.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: March 15, 2016
    Assignee: InScope Energy, LLC
    Inventors: Jason Craig, Richard Daniel Albarran, William Pugh, Kevin Cassidy
  • Patent number: 9275143
    Abstract: Improved duplicate and near-duplicate detection techniques may assign a number of fingerprints to a given document by (i) extracting parts from the document, (ii) assigning the extracted parts to one or more of a predetermined number of lists, and (iii) generating a fingerprint from each of the populated lists. Two documents may be considered to be near-duplicates if any one of their fingerprints match.
    Type: Grant
    Filed: March 15, 2008
    Date of Patent: March 1, 2016
    Assignee: Google Inc.
    Inventors: William Pugh, Monika H. Henzinger
  • Publication number: 20150353646
    Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
    Type: Application
    Filed: May 15, 2015
    Publication date: December 10, 2015
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
  • Publication number: 20150195285
    Abstract: Application-manager software authenticates a user of a client device over a channel. The authentication operation is performed using a directory service. The application-manager software presents a plurality of applications in a GUI displayed by the client device. The plurality of applications depends on the authentication, the client device, and the channel. And the plurality of applications includes a thin application and a software-as-a-service (SaaS) application. The application-manager software receives a selection as to an application from the user. If the selection is for the SaaS application, the application-manager software provisions the SaaS application. The provision includes automatically logging the user onto an account with a provider of the SaaS application using a single sign-on and connecting the user to the account so that the user can interact with the SaaS application. If the selection is for the thin application, the application manager software launches the thin application.
    Type: Application
    Filed: March 23, 2015
    Publication date: July 9, 2015
    Inventors: William Pugh, Michael Eakes, Ojvind Bernander, Pradyumna Gundavaram
  • Publication number: 20150156139
    Abstract: Methods, systems, and techniques for managing groups of entities, such as individuals, employees, or systems, and providing entitlement and access to computer resources based on group membership are provided. Example embodiments provide a Group Management System having a Group Management Engine “GME,” an Entitlement Engine, and a Provisioning Engine, which work together to allow simplified grouping of entities and providing entitlement and access to the entities based upon the group membership. In one embodiment, the GME leverages dynamic programming techniques to enable accurate, scalable systems that can manage near real time updates and changes to the group's status or to the entities' status. These components cooperate to enable provisioning of applications based upon current entitlement.
    Type: Application
    Filed: February 9, 2015
    Publication date: June 4, 2015
    Inventor: William Pugh
  • Patent number: 8990699
    Abstract: Application-manager software authenticates a user of a client device over a channel. The authentication operation is performed using a directory service. The application-manager software presents a plurality of applications in a GUI displayed by the client device. The plurality of applications depends on the authentication, the client device, and the channel. And the plurality of applications includes a thin application and a software-as-a-service (SaaS) application. The application-manager software receives a selection as to an application from the user. If the selection is for the SaaS application, the application-manager software provisions the SaaS application. The provision includes automatically logging the user onto an account with a provider of the SaaS application using a single sign-on and connecting the user to the account so that the user can interact with the SaaS application. If the selection is for the thin application, the application manager software launches the thin application.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: March 24, 2015
    Assignee: VMware, Inc.
    Inventors: William Pugh, Michael Eakes, Ojvind Bernander, Pradyumna Gundavaram
  • Patent number: 8955151
    Abstract: Methods, systems, and techniques for managing groups of entities, such as individuals, employees, or systems, and providing entitlement and access to computer resources based on group membership are provided. Example embodiments provide a Group Management System having a Group Management Engine “GME,” an Entitlement Engine, and a Provisioning Engine, which work together to allow simplified grouping of entities and providing entitlement and access to the entities based upon the group membership. In one embodiment, the GME leverages dynamic programming techniques to enable accurate, scalable systems that can manage near real time updates and changes to the group's status or to the entities' status. These components cooperate to enable provisioning of applications based upon current entitlement.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: February 10, 2015
    Assignee: VMware, Inc.
    Inventor: William Pugh
  • Publication number: 20140294842
    Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID No. 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
    Type: Application
    Filed: September 16, 2013
    Publication date: October 2, 2014
    Applicant: Isis Innovation Limited
    Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
  • Publication number: 20140244192
    Abstract: A system and method for providing monitoring of industrial equipment is disclosed. In such a system and method, one or more sensor units may be configured to generate output signals conveying information regarding power conducted to the industrial equipment. One or more power parameters may be determined based on the sensor output signals. Abnormal operations of the industrial equipment may be determined based on the power parameters and alerts responsive to the abnormal operations may be generated. In some embodiments, information regarding a present operation of the industrial equipment may be received from a control system and/or monitoring system. In those embodiments, a fault or a likelihood of fault of the control system and/or the monitoring system may be determined.
    Type: Application
    Filed: February 25, 2013
    Publication date: August 28, 2014
    Applicant: InScope Energy, LLC
    Inventors: Jason Craig, William Pugh, Richard Daniel Albarran
  • Publication number: 20140126346
    Abstract: In an embodiment, triplets of network-enabled FCIs operate to monitor the three phases of a power distribution system. In being network-enabled, the FCIs also operate as nodes of an RF mesh network. In an embodiment, upon the detection of a power failure, the triplet of network FCIs is serially operated so as to extend their networking capabilities by approximately three times.
    Type: Application
    Filed: November 5, 2012
    Publication date: May 8, 2014
    Applicant: SILVER SPRING NETWORKS, INC.
    Inventors: Jana VAN GREUNEN, William PUGH, Sterling HUGHES
  • Publication number: 20130336608
    Abstract: Bearing assemblies, such as for use with a turbine engine, are disclosed. An example the bearing assembly may include an outer ring comprising an oil drainage aperture defined therein; an inner ring disposed coaxially within the outer ring, the inner ring including an oil supply aperture defined therein; and a plurality of rolling elements engaged between the outer ring and the inner ring, wherein the plurality of rolling elements are constructed of a ceramic material.
    Type: Application
    Filed: March 6, 2013
    Publication date: December 19, 2013
    Applicant: General Electric Company
    Inventors: Jacob Patrick Miller, Bruce Alan Carter, Michael Gilbert Johnson, Gary Paul Moscarino, David William Pugh, Jonothan Allen Scheetz, Thomas DeWitt Woodrow
  • Patent number: 8535899
    Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: September 17, 2013
    Assignee: Isis Innovation Limited
    Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
  • Publication number: 20130166089
    Abstract: Power utilized in a local power network may be managed. The local power network may include a power management system. The power management system may communicate with one or more of a circuit controller, a switch controller, and/or an outlet controller in order to manage power utilization.
    Type: Application
    Filed: February 15, 2013
    Publication date: June 27, 2013
    Inventors: Jason Craig, Richard Daniel Albarran, William Pugh, Kevin Cassidy
  • Patent number: 8437882
    Abstract: Power utilized in a local power network may be managed. The local power network may include a power management system. The power management system may communicate with one or more of a circuit controller, a switch controller, and/or an outlet controller in order to manage power utilization.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: May 7, 2013
    Assignee: InScope Energy, LLC
    Inventors: Jason Craig, Richard Daniel Albarran, William Pugh, Kevin Cassidy
  • Publication number: 20120278903
    Abstract: Methods, systems, and techniques for managing groups of entities, such as individuals, employees, or systems, and providing entitlement and access to computer resources based on group membership are provided. Example embodiments provide a Group Management System having a Group Management Engine “GME,” an Entitlement Engine, and a Provisioning Engine, which work together to allow simplified grouping of entities and providing entitlement and access to the entities based upon the group membership. In one embodiment, the GME leverages dynamic programming techniques to enable accurate, scalable systems that can manage near real time updates and changes to the group's status or to the entities' status. These components cooperate to enable provisioning of applications based upon current entitlement.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 1, 2012
    Applicant: VMware, Inc.
    Inventor: William Pugh
  • Publication number: 20120078871
    Abstract: Improved duplicate and near-duplicate detection techniques may assign a number of fingerprints to a given document by (i) extracting parts from the document, (ii) assigning the extracted parts to one or more of a predetermined number of lists, and (iii) generating a fingerprint from each of the populated lists. Two documents may be considered to be near-duplicates if any one of their fingerprints match.
    Type: Application
    Filed: December 7, 2011
    Publication date: March 29, 2012
    Inventors: William Pugh, Monika H. Henzinger
  • Publication number: 20120054625
    Abstract: Application-manager software authenticates a user of a client device over a channel. The authentication operation is performed using a directory service. The application-manager software presents a plurality of applications in a GUI displayed by the client device. The plurality of applications depends on the authentication, the client device, and the channel. And the plurality of applications includes a thin application and a software-as-a-service (SaaS) application. The application-manager software receives a selection as to an application from the user. If the selection is for the SaaS application, the application-manager software provisions the SaaS application. The provision includes automatically logging the user onto an account with a provider of the SaaS application using a single sign-on and connecting the user to the account so that the user can interact with the SaaS application. If the selection is for the thin application, the application manager software launches the thin application.
    Type: Application
    Filed: August 26, 2011
    Publication date: March 1, 2012
    Applicant: VMWARE, INC.
    Inventors: William PUGH, Michael EAKES, Ojvind BERNANDER, Pradyumna GUNDAVARAM