Abstract: A rotating seal for a gas turbine engine includes: (a) an annular seal body; (b) a sealing component carried by the seal body which is adapted to form one-half of a rotating seal interface; and (c) an impeller carried by the seal body which comprises a plurality of radially-inwardly-extending impeller blades.

Abstract: A microsensor array system, comprising a pad, a plurality of actuators attached to the pad, and a plurality of microprobes, wherein substantially each microprobe in the plurality of microprobes is attached to a respective actuator in the plurality of actuators.

Abstract: Software developers working on multi-language systems can utilize a multi-language debugging environment. The debugging environment can be uniform across languages, and can seamlessly perform debugging between one or more languages in a multi-language environment. Such a system can have a number of attributes intended to help developers facing debugging problems in multi-language environments. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.

Abstract: Power utilized in a local power network may be managed. The local power network may include a power management system. The power management system may communicate with one or more of a circuit controller, a switch controller, and/or an outlet controller in order to manage power utilization.

Abstract: A magnetic filter device and method for using same, for removing ferromagnetic particles from a liquid, which device comprises a vessel having an inlet for liquid to flow into the vessel and an outlet for the liquid to flow out of the vessel, and the vessel having one or more magnets suspended therein for removing ferromagnetic particles from liquid flowing between the inlet and outlet, characterised in that: the vessel is a horizontal pipe with the inlet at one end and the outlet at the other end, the magnets are suspended transverse to the longitudinal axis of the pipe in one or more sets, and the vessel has one or more helical flow generators which in use, generate helical flow of the liquid as it flows between the inlet and outlet, and/or one or more turbulent flow generators which in use, generate turbulent flow of the liquid as it flows between the inlet and outlet.

Abstract: The present invention provides a vortex generator that may be used in systems for separating oil from air oil mixtures. The vortex generator comprises a rotating disk having a rim having a plurality of passages extending through it and a cavity formed by the rotating disk and a cavity wall wherein a vortex is created when there is a flow through the plurality of passages into the cavity.

Abstract: The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor ? subunits, by targeting HIF ? for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF ? subunit sequences which may modulate this interaction.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemical entity, wherein said structural model of FIH is derived from structural factors or structural coordinates determined by subjecting to X-ray diffraction measurements a crystal comprising FIH. Such chemical entities may be used in the treatment of a condition associated with increased or decreased HIF levels or activity.

Abstract: A web based application having non-file system structures is copied or archived by first initializing a file to store the web based application, including creation of a root directory within the file. Then, data directories are created under the root directory, and a number of storage data objects under the data directories are initialized for all non-file system structures of the web based application. Thereafter, the non-file system structures are copied and stored into the storage data objects. In embodiments where the web based application further includes files that are part of a file system, the files are stored as additional storage data objects under the root directory. Accordingly, database and operating system independence is achieved.

Abstract: The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor ? subunits, by targeting HIF ? for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF ? subunit sequences which may modulate this interaction.

Abstract: The invention provides a compound of one of the formulae (A), (B), (C), (D), (E), (F) as herein defined, or a salt thereof, for use in the treatment of a condition associated with increased or decreased HIF levels or activity, or a condition in which an increase or decrease in HIF levels or activity may be beneficial.

Abstract: A software debugging environment uses multiple abstract views to provide the flexibility required to perform effective debugging on an executing software program using data structures. Developers can select between one or more views to see different aspects of the software being examined. Each view can have a filter with specific properties determining which quantities are displayed, the format they are displayed in and any editing capability. In some embodiments, the selection of views, filters defining the views, and the editing properties for the contents shown in the views may be set interactively. In some cases, this interaction occurs through the interface of an Integrated Development Environment (IDE) containing the debugger. In other cases, the properties of views in the debugging environment are determined by definitions supplied in configuration files. Special facilities are provided for the debugging of JSP programs.

Abstract: The present invention is directed to methods of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprising contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate.

Abstract: A method of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprises contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate. Preferably the substrate is a HIF polypeptide comprising HIF-1?, a fragment thereof comprising Asn 803 of HIF-1? or a peptide analogue of HIF-1? or fragment thereof comprising an asparagine equivalent to Asn 803 of HIF-1? and wherein hydroxylation of Asn 803 or of a said equivalent asparagine is determined.

Abstract: The present invention provides a vortex generator that may be used in systems for separating oil from air oil mixtures. The vortex generator comprises a rotating disk having a rim having a plurality of passages extending through it and a cavity formed by the rotating disk and a cavity wall wherein a vortex is created when there is a flow through the plurality of passages into the cavity.

Abstract: A debugging proxy can be used to manage communication between a client and a debugger or debugging component. A debugging protocol can be used by the debugging proxy to facilitate communication management. A debugging protocol can provide for asynchronous messaging, and can allow for the communication of large grain messages. A debugging protocol can also implement a priority scheme that can be used to process messages between a client and a debugger based upon a priority assigned to each message.

Abstract: Improved duplicate and near-duplicate detection techniques may assign a number of fingerprints to a given document by (i) extracting parts from the document, (ii) assigning the extracted parts to one or more of a predetermined number of lists, and (iii) generating a fingerprint from each of the populated lists. Two documents may be considered to be near-duplicates if any one of their fingerprints match.

Abstract: One embodiment is a microprobe. An example of the microprobe comprises a housing having an aperture. This example of the microprobe also comprises an ISFET attached to the housing. The ISFET may have a gate located proximate the aperture. This example of the microprobe further comprises a reference electrode attached to the housing proximate the aperture. Another embodiment is a microsensor system. Another embodiment is a method for measuring a characteristic of tissue. Yet another condition embodiment is a method for monitoring tissue pH.

Abstract: Improved methods of software diagnostics are provided. Searches of data sources are conducted using search terms from internal computer information to obtain searched data. The searched data is processed by extracting technical features. The technical features are indexed to create indexes that can be searched via machine state. Filtering is conducted over the gathered data to create feeds that are available to customers. Stack traces are extracted for the purpose of matching and researching using machine state rather than key words.