Abstract: A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemical entity, wherein said structural model of FIH is derived from structural factors or structural coordinates determined by subjecting to X-ray diffraction measurements a crystal comprising FIH. Such chemical entities may be used in the treatment of a condition associated with increased or decreased HIF levels or activity.

Abstract: The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor ? subunits, by targeting HIF ? for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF ? subunit sequences which may modulate this interaction.

Abstract: The invention provides a compound of one of the formulae (A), (B), (C), (D), (E), (F) as herein defined, or a salt thereof, for use in the treatment of a condition associated with increased or decreased HIF levels or activity, or a condition in which an increase or decrease in HIF levels or activity may be beneficial.

Abstract: A software debugging environment uses multiple abstract views to provide the flexibility required to perform effective debugging on an executing software program using data structures. Developers can select between one or more views to see different aspects of the software being examined. Each view can have a filter with specific properties determining which quantities are displayed, the format they are displayed in and any editing capability. In some embodiments, the selection of views, filters defining the views, and the editing properties for the contents shown in the views may be set interactively. In some cases, this interaction occurs through the interface of an Integrated Development Environment (IDE) containing the debugger. In other cases, the properties of views in the debugging environment are determined by definitions supplied in configuration files. Special facilities are provided for the debugging of JSP programs.

Abstract: The present invention is directed to methods of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprising contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate.

Abstract: A method of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprises contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate. Preferably the substrate is a HIF polypeptide comprising HIF-1?, a fragment thereof comprising Asn 803 of HIF-1? or a peptide analogue of HIF-1? or fragment thereof comprising an asparagine equivalent to Asn 803 of HIF-1? and wherein hydroxylation of Asn 803 or of a said equivalent asparagine is determined.

Abstract: The present invention provides a vortex generator that may be used in systems for separating oil from air oil mixtures. The vortex generator comprises a rotating disk having a rim having a plurality of passages extending through it and a cavity formed by the rotating disk and a cavity wall wherein a vortex is created when there is a flow through the plurality of passages into the cavity.

Abstract: Improved duplicate and near-duplicate detection techniques may assign a number of fingerprints to a given document by (i) extracting parts from the document, (ii) assigning the extracted parts to one or more of a predetermined number of lists, and (iii) generating a fingerprint from each of the populated lists. Two documents may be considered to be near-duplicates if any one of their fingerprints match.

Abstract: One embodiment is a microprobe. An example of the microprobe comprises a housing having an aperture. This example of the microprobe also comprises an ISFET attached to the housing. The ISFET may have a gate located proximate the aperture. This example of the microprobe further comprises a reference electrode attached to the housing proximate the aperture. Another embodiment is a microsensor system. Another embodiment is a method for measuring a characteristic of tissue. Yet another condition embodiment is a method for monitoring tissue pH.

Abstract: Improved methods of software diagnostics are provided. Searches of data sources are conducted using search terms from internal computer information to obtain searched data. The searched data is processed by extracting technical features. The technical features are indexed to create indexes that can be searched via machine state. Filtering is conducted over the gathered data to create feeds that are available to customers. Stack traces are extracted for the purpose of matching and researching using machine state rather than key words.

Abstract: Improved duplicate and near-duplicate detection techniques may assign a number of fingerprints to a given document by (i) extracting parts from the document, (ii) assigning the extracted parts to one or more of a predetermined number of lists, and (iii) generating a fingerprint from each of the populated lists. Two documents may be considered to be near-duplicates if any one of their fingerprints match.

Abstract: Software developers working on multi-language systems can utilize a multi-language debugging environment. The debugging environment can be uniform across languages, and can seamlessly perform debugging between one or more languages in a multi-language environment. Such a system can have a number of attributes intended to help developers facing debugging problems in multi-language environments. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.

Abstract: An asset monitoring and security system includes at least one asset and at least one user identification device assigned a unique identifier and operable to transmit an identification signal embodying the identifier over a wireless communications link. A data store maintains lists of the assets, users authorized to use the assets, and privileges associated with the assets for each of the authorized users. A control unit is adapted to receive identification signals from the assets and user identification devices and monitor positions of the assets and user identification devices within a defined area based on the identification signals. The control unit communicates with the data store and is further operable to initiate an alarm event when privileges associated with a given authorized user for a given asset are exceeded. Each of the assets includes a lock-out mechanism that impedes use of the asset when the lock-out mechanism is activated.

Abstract: Improved methods of software diagnostics are provided. Searches of data sources are conducted using search terms from internal computer information to obtain searched data. The searched data is processed by extracting technical features. The technical features are indexed to create indexes that can be searched via machine state. Filtering is conducted over the gathered data to create feeds that are available to customers.

Abstract: An asset monitoring and security system includes at least one asset assigned a unique identifier and operable wirelessly transmit an identification signal embodying the identifier. A data store maintains a list of the assets and privileges associated with the assets for authorized users of the assets. A control unit is adapted to receive identification signals from the assets and monitor positions of the assets within a defined area. The control unit communicates with the data store and is further operable to initiate an alarm event when privileges associated with a given asset for authorized users of the asset are exceeded. Each of the assets includes a lock-out mechanism that impedes use of the asset when the lock-out mechanism is activated. The control unit activates the lock-out mechanism of a given asset when the privileges associated with the asset for authorized users of the asset are exceeded.

Abstract: One embodiment is a microprobe. An example of the microprobe comprises a housing having an aperture. This example of the microprobe also comprises an ISFET attached to the housing. The ISFET may have a gate located proximate the aperture. This example of the microprobe further comprises a reference electrode attached to the housing proximate the aperture. Another embodiment is a microsensor system. Another embodiment is a method for measuring a characteristic of tissue. Yet another embodiment is a method for monitoring tissue pH.

Abstract: An intrusion sensing device includes an intrusion detection sensor enclosed within a housing and operable to detect an intrusion into a container. A mounting detection mechanism contacts the surface of the container when the housing is mounted thereto and is operable to detect when the housing is not in contact with the surface of the container. An access detection mechanism is operably connected to an access panel of the housing and operable to detect removal of the access panel from the housing. A control module is operable in a setup mode and an active mode. The control module is adapted to receive an alarm message from the intrusion detection sensor and operable to initiate an alarm event during the setup mode which varies from an alarm event initiated during the active mode. A wireless transmitter is operable to transmit an alarm indication signal to a remote monitoring system.

Abstract: An asset monitoring and security system includes at least one asset assigned a unique identifier and operable wirelessly transmit an identification signal embodying the identifier. A data store maintains a list of the assets and privileges associated with the assets for authorized users of the assets. A control unit is adapted to receive identification signals from the assets and monitor positions of the assets within a defined area. The control unit communicates with the data store and is further operable to initiate an alarm event when privileges associated with a given asset for authorized users of the asset are exceeded. Each of the assets includes a lock-out mechanism that impedes use of the asset when the lock-out mechanism is activated. The control unit activates the lock-out mechanism of a given asset when the privileges associated with the asset for authorized users of the asset are exceeded.

Abstract: An asset monitoring and security system includes at least one asset and at least one user identification device assigned a unique identifier and operable to transmit an identification signal embodying the identifier over a wireless communications link. A data store maintains lists of the assets, users authorized to use the assets, and privileges associated with the assets for each of the authorized users. A control unit is adapted to receive identification signals from the assets and user identification devices and monitor positions of the assets and user identification devices within a defined area based on the identification signals. The control unit communicates with the data store and is further operable to initiate an alarm event when privileges associated with a given authorized user for a given asset are exceeded. Each of the assets includes a lock-out mechanism that impedes use of the asset when the lock-out mechanism is activated.

Abstract: Software developers working on multi-language systems can utilize a multi-language debugging environment. The debugging environment can be uniform across languages, and can seamlessly perform debugging between one or more languages in a multi-language environment. Such a system can have a number of attributes intended to help developers facing debugging problems in multi-language environments. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.