Abstract: Compounds of the formula (I) and pharmaceutically acceptable salts thereof: (I) wherein the substituents are defined in the specification. The compounds are hyperpolarisation activated cyclic-nucleotide modulated ion channel 2 (HCN2) inhibitors. Also disclosed are pharmaceutical compositions comprising the compounds, and the use of the compounds for the treatment or prevention of medical conditions mediated by HCN2, including neuropathic pain.

Abstract: A three-dimensional nanolithography system includes forming a photocurable resin including one or more organic monomers, a photoinitiator, and an inhibitor, defining a lithographical patterning region, directing a light beam toward the lithographical patterning region to initiate polymerization, and controlling an initiator depletion technique to reduce an undesired portion of the polymerization.

Abstract: A method for locating a mobile device which is not in possession of the owner using an owner verification server. A mobile network operator server sends a message to the owner verification server requesting verification of ownership. The owner verification server retrieves ownership status and transmits a request to the mobile network operator server to transmit location tracking data when the ownership status indicates that the device is not in the owner's possession. The owner verification server forwards the location tracking data to the device owner.

Abstract: Provided is an amination method for a polystyrene-type resin, and a method for immobilizing an enzyme using an aminated polystyrene-type resin. The amination method includes: in a solvent, a catalyst is used to catalyze a polystyrene-type resin and an enamine salt to perform a Friedel-Crafts alkylation reaction, to obtain an aminated polystyrene-type resin, herein the catalyst is a Lewis acid catalyst. By means of the Friedel-Crafts alkylation reaction, the enamine salt is grafted onto the polystyrene-type resin, and the polystyrene-type resin is aminated. The conditions of the Friedel-Crafts alkylation reaction are easy to control, the post-treatment process is simple, and it is only necessary to remove the catalyst and the unreacted enamine salt by washing. Therefore, the above amination method in the present application has few steps and is simple and easy to implement. Meanwhile, the amination method further avoids the use of a noble metal catalyst, thereby reducing production cost.

Abstract: In one embodiment, a method includes capturing, by a machine vision device, an image of an object in a railway environment. The machine vision device is attached to a first train car that is moving in a first direction along a first railroad track of the railway environment. The method also includes analyzing, by the machine vision device, the image of the object using one or more machine vision algorithms to determine a value associated with the object. The method further includes determining, by the machine vision device, that the value associated with the object indicates a potential deficiency of the object and communicating, by the machine vision device, an alert to a component external to the first train car. The alert comprises an indication of the potential deficiency of the object.

Abstract: An aircraft capable of carrying at least 400 pounds of payload, has four rotors systems, each of the rotor systems being independently driven by an electric motor or other torque-producing source. Each of the rotor systems provide sufficient thrust such that the aircraft is capable of controlled vertical takeoff and landing, even if one of the variable pitch rotor is inoperable. An electronic control system is configured to control the rotational speed and pitch of at least one of the rotor systems in each of the first and second rotor pairs. The rotors may be arranged in coaxial stacks or may be otherwise configured.

Abstract: Systems and methods are presented herein for providing an integrated disconnect. The integrated disconnect may be used within a drive unit. The integrated disconnect comprises an output gear having a cavity. A torque transfer adapter is arranged within the cavity. A clutch body is also arranged within the cavity. The clutch is actuatable through the output gear by an actuator to engage and disengage the clutch with the torque transfer adaptor. The actuator is located external to the cavity.

Abstract: A waste heat gathering and transfer system and method that, in certain embodiments, includes a collector for collecting at least a portion of waste heat dissipating from one or more waste heat sources, such as equipment surfaces and flames, a heat-to-electricity converter; and an electricity-to-grid transfer interface. In some instances, the system and method also include an electric-to-grid optimizer. In some embodiments, the heat-to-electricity converter is a semiconductor-based converter. In other embodiments, the heat-to-electricity converter is an organic rankine cycle. In some instances, the heat collector includes an external collector layer with an inner and outer surface, an internal collector layer with an internal and external surface, an interior gap area between the external collector layer inner surface and the internal collector layer internal surface, an insulating material, a heat collecting component, and a heat transfer component.

Abstract: A force sensor includes: a substrate that forms a three-dimensional, 3D, body disposed about a central z-axis of an r, ?, z-cylindrical coordinate system, the 3D body having a first surface, an second surface, and a sidewall disposed between the first and second surfaces, wherein the sidewall at least partially encloses a void in the 3D body that extends from and through the first surface to and through the second surface; an electrical circuit disposed on either one of the first surface or the second surface, the electrical circuit having at least one strain gauge, and a plurality of electrical terminals electrically connected to the at least one strain gauge; wherein the sidewall includes at least one strain focusing feature; wherein the at least one strain gauge is disposed proximate to the at least one strain focusing feature.

Abstract: Drone-based offroad vehicle routing systems and corresponding methods are proposed. In one aspect, a vehicle and uniquely assigned an aerial drone embedded with sensors, radar, lidar, etc. may establish a data link. The driver or occupant may input information into the user interface in the vehicle about a region or destination of interest. The vehicle's processor may instruct the drone to scout a target region and receive data about the topographic features of the terrain. The drone may scout the region, receive the data, and forward the data to the vehicle. The processor may compute optimal routes based on data from both the drone and the vehicle sensors. In some aspects, the drone performs calculations of the route and may communicate in or near real time with the vehicle. The system may take into account vehicle data, the skill level of the driver, or both.

Abstract: The COVID-19 pandemic has exacerbated society's tremendous health equity gap. Disadvantaged populations have been disproportionally affected by COVID-19, lacking access to affordable testing, a known effective tool for preventing viral spread, hospitalizations, and deaths. Here, we describe COvid-19 Low-cost Optodiagnostic for Rapid testing (COLOR), a colorimetric biosensor fabricated on cotton swabs using gold nanoparticles modified with human angiotensin-converting enzyme 2 (ACE2), which costs 15 ¢ to produce and detects SARS-COV-2 within 5 minutes. COLOR detected very low viral particle loads (limit of detection: 0.154 pg mL?1 of SARS-COV-2 spike protein) and its color intensity correlated with the cycle threshold (Ct) values obtained using RT-PCR. The performance of COLOR was assessed using 100 nasopharyngeal/oropharyngeal (NP/OP) clinical samples, yielding sensitivity, specificity, and accuracy values of 96%, 84%, and 90%, respectively.

Abstract: In various examples, detected object data representative of locations of detected objects in a field of view may be determined. One or more clusters of the detected objects may be generated based at least in part on the locations and features of the cluster may be determined for use as inputs to a machine learning model(s). A confidence score, computed by the machine learning model(s) based at least in part on the inputs, may be received, where the confidence score may be representative of a probability that the cluster corresponds to an object depicted at least partially in the field of view. Further examples provide approaches for determining ground truth data for training object detectors, such as for determining coverage values for ground truth objects using associated shapes, and for determining soft coverage values for ground truth objects.

Abstract: A harmonic drive assembly and fluid-powered linear motors with both axial pistons are rotary piston arrangements incorporating the harmonic drive assembly are disclosed. The motors may be used in downhole drilling applications, but the drive assembly and/or motors may be used in other applications. The assembly, motors and methods use advanced harmonic drives, advanced helical drives, and combinations thereof with 1) motors with axial pistons and reciprocating linear rings to convert reciprocative axial motion to continuous rotary motion, and 2) motors with rotary pistons and reciprocating linear rings to rectify reciprocative rotary motion to continual rotary motion to improve performance over prior configurations. Axial pistons provide a robust simple solution for generating rotation; Rotational pistons provide increased torque generation as the torque generated is proportional to motor length. Since downhole drills are long, a high-torque motor can be produced using this method.

Abstract: A display article is described herein that includes: a substrate comprising a thickness and a primary surface; and the primary surface having defined thereon a diffractive surface region. The diffractive surface region comprises a plurality of structural features that comprises a plurality of different heights in a multimodal distribution. Further, the substrate exhibits a sparkle of less than 4%, as measured by pixel power deviation (PPD140) at an incident angle of 0° from normal, a distinctness of image (DOI) of less than 80% at an incident angle of 20° from normal, and a transmittance haze of less than 20% from an incident angle of 0° from normal.

Abstract: An exemplary pipeline pig tracking and locator system includes a low frequency electromagnetic receiver in communication with a control circuit to communicate a received low frequency electromagnetic signal to the control circuit, where the control circuit is configured to transform the received low frequency electromagnetic signal to an audible frequency signal; and a speaker in communication with the control circuit to output the audible frequency signal. Additional embodiments of the present disclosure pertain to a method for locating a pipeline pig in a pipeline by utilizing the systems of the present disclosure.

Abstract: Aspects of the disclosure relate to enhancing redundancy of computer systems. The disclosure provides a system architecture for maintaining operation of computer systems despite technical and infrastructure failures, such as a server going offline or losing network connections. The described architecture may include a digital twin that models the computer system. The digital twin may simulate evolution of data records and use the simulated data records to process computing tasks submitted to the unavailable computer system despite no access to the computer system.

Abstract: The invention describes methods to produce high molecular weight silicones via ring opening polymerization of cyclic siloxanes in the presence of a Lewis acid catalyst.

Abstract: Implementations described and claimed herein provide systems and methods for an optical domain controller for managing and maintaining a record of network component configuration and interconnections. The optical domain controller detects changes in a configuration of optical network elements in response to a requested service from the network, coordinates additional changes in configurations to optical network elements that may be affected by the detected change, communicates with the optical network elements to incorporate the changes to the configurations of the network element, and stores the configurations and states of the network elements. The use of the optical domain controller may thus replace or supplement a database storing network configuration information by automatically managing changes to the network as new services are instantiated directly on the optical network elements.

Abstract: The disclosure provides rotary machines that include, in one embodiment, a rotatable shaft defining a central axis A, the shaft having a first end and a second end. The shaft can have a first hub disposed thereon with a plurality of cavities. At least one contour is slidably received into an arcuate cavity in an exterior surface of the hub. The contour has a convex outer surface that cooperates with an inwardly facing curved surface of a housing to form a working volume.

Abstract: Embodiments of the present disclosure include techniques for branch prediction. A branch predictor may be included in a processor. The branch predictor may use heuristics to control lookups against multiple different memory caches in a branch target buffer. In one embodiment, a branch predictor monitors successful lookups and a lookup is performed against one cache before another cache based on a number of successful lookups. In another embodiment, lookups are performed against different caches based on a current available capacity of a fetch target queue.