Abstract: Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.

Abstract: A simplified and improved pistonless cylinder based on an Aramid fiber reinforced elastomer tubular which is highly stiff in radial direction against radial expansion and elastic in axial extension, so as to form a completely sealed and extendable pressure chamber and to be able to perform as well as, or better than, most of the conventional hydraulic cylinders in terms of load bearing capacities, maximum stroke distances and service durability. This simplified cylinder employs no piston, piston rod, sealing seals or oil based hydraulic fluid, and utilizes non-metal materials to construct the majority of the parts for its extendable pressure chamber; therefore, this new cylinder can achieve significant weight and fabrication cost reduction. In addition, this new pistonless cylinder uses ordinary liquids, e.g., fresh water or seawater, as its hydraulic fluid, and can work directly as a hydraulic or pneumatic cylinder interchangeably without a need for much, if any, modification.

Abstract: A simplified and improved pistonless cylinder based on an Aramid fiber reinforced elastomer tubular which is highly stiff in radial direction against radial expansion and elastic in axial extension, so as to form a completely sealed and extendable pressure chamber and to be able to perform as well as, or better than, most of the conventional hydraulic cylinders in terms of load bearing capacities, maximum stroke distances and service durability. This simplified cylinder employs no piston, piston rod, sealing seals or oil based hydraulic fluid, and utilizes non-metal materials to construct the majority of the parts for its extendable pressure chamber; therefore, this new cylinder can achieve significant weight and fabrication cost reduction. In addition, this new pistonless cylinder uses ordinary liquids, e.g., fresh water or seawater, as its hydraulic fluid, and can work directly as a hydraulic or pneumatic cylinder interchangeably without a need for much, if any, modification.

Abstract: This invention discloses a new type of force bearing cylinder which does not use any piston and its related parts for pushing/pulling its stroke. The pistonless cylinder uses ordinary liquids, e.g., fresh water or seawater, as its hydraulic fluid. The pistonless cylinder can work as a hydraulic or pneumatic cylinder interchangeably without a need for any modification, and is basically maintenance free during its service life. As one example of its applications, the disclosed pistonless cylinder can be used for deepwater pile grippers in offshore platform installation.

Abstract: The Smart Generator of the present invention allows the designer/developer/user to model the EJB components in a natural way without being concerned with implementation-specific details. The developer models the business objects using a UML drawing tool and the Smart Generator creates a set of classes that implements these objects with reference to the Enterprise JavaBeans specification. That is, the Smart Generator automatically create access methods and handling containment of references from the UML diagram.

Abstract: The present invention provides novel calcium phosphate nanoparticles suitable for efficient encapsulation of biologically active molecules. The invention further provides pharmaceutical compositions comprising these nanoparticles, as well as methods of making such nanoparticles and using them as carriers for therapeutic delivery of biologically active macromolecules.

Abstract: The invention provides a pharmaceutical composition for oral drug delivery comprising a solid dosage form containing an effective amount of a therapeutic agent, a permeation enhancer and a pharmaceutically acceptable excipient and a bioadhesive layer containing a bioadhesive polymer, and optionally comprising an impermeable or semi-permeable layer having an opening capable of directing a unidirectional release of the therapeutic agent and the permeation enhancer from the solid dosage form. Methods of making and using the present pharmaceutical composition are also provided.

Abstract: The present invention provides calcium phosphate nano-particles encapsulated with biologically active macromolecules. The particles may be used as carriers of biologically active macromolecule for delivery of the macromolecules. The invention also provides methods of making and using the particles.

Abstract: The Smart Generator of the present invention allows the designer/developer/user to model the EJB components in a natural way without being concerned with implementation-specific details. The developer models the business objects using a UML drawing tool and the Smart Generator creates a set of classes that implements these objects with reference to the Enterprise JavaBeans specification. That is, the Smart Generator automatically create access methods and handling containment of references from the UML diagram.

Abstract: The Smart Generator of the present invention allows the designer/developer/user to model the EJB components in a natural way without being concerned with implementation-specific details. The developer models the business objects using a UML drawing tool and the Smart Generator creates a set of classes that implements these objects with reference to the Enterprise JavaBeans specification. That is, the Smart Generator automatically create access methods and handling containment of references from the UML diagram.

Abstract: A SmartHandle and method is provided which can extend capabilities of the EJB Handle. The SmartHandle can be mapped to a multi-column relational database. Additionally, the SmartHandle enables two EJB Handles to be compared without instantiating the actual EJB objects.

Abstract: A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.

Abstract: The Smart Generator of the present invention allows the designer/developer/user to model the EJB components in a natural way without being concerned with implementation-specific details. The developer models the business objects using a UML drawing tool and the Smart Generator creates a set of classes that implements these objects with reference to the Enterprise JavaBeans specification. That is, the Smart Generator automatically create access methods and handling containment of references from the UML diagram.

Abstract: A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.

Abstract: A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitive hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.

Abstract: A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.

Abstract: A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosentitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4- benzotriazine oxides is also disclosed.

Abstract: A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed no be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.

Abstract: A method for radiosensitizing hypoxic tumor cells in a warm-blooded animal is provided. The method involves administration of a nicotinamide compound having the structural formula ##STR1## wherein X is O or S, and Z is H, OR, SR or NHR where R is as defined herein. Exemplary compounds for use in conjunction with the disclosed method include: 5-hydroxynicotinamide; 5-hydroxynicotinamide, sodium salt; 5-(2,3-dihydroxypropoxy)nicotinamide; 5-aminonicotinamide; 5-(2-methoxyethylamino)nicotinamide; and 5-acetamidonicotinamide.

Abstract: A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.