Abstract: The present disclosure provides compositions comprising at least two messenger RNAs (mRNAs) consisting of a human respiratory syncytial virus (hRSV or RSV) F protein antigen, a human metapneumovirus (hMPV) F protein antigen, and/or a human parainfluenza virus 3 (hPIV3 or PIV3) F protein antigen, and methods of eliciting an immune response by administering said compositions.

Abstract: Disclosed herein are hybrid multivalent vaccine or immunogenic compositions comprising (i) one or more influenza virus proteins selected from one or more influenza virus hemagglutinin (HA) proteins, one or more influenza virus neuraminidase (NA) proteins, or a combination thereof; and (ii) one or more ribonucleic acid molecules encoding one or more influenza virus proteins selected from one or more influenza virus HA proteins, one or more influenza virus NA proteins, or a combination thereof. Also disclosed are methods of using the vaccine or immunogenic compositions.

Abstract: Disclosed herein are multivalent vaccine or immunogenic compositions comprising one or more recombinant influenza virus hemagglutinin (HA), one or more recombinant influenza virus neuraminidase (NA), and an optional adjuvant. Also disclosed are methods of using the vaccine or immunogenic composition.

Abstract: Disclosed are multivalent vaccine or immunogenic compositions comprising influenza virus hemagglutinin (HA) from standard of care influenza virus strains, or ribonucleic acid molecules encoding the same; and one or more influenza virus HA identified or designed by machine learning, or one or more ribonucleic acid molecules that encode the influenza virus HA identified or designed by machine learning. Also disclosed are methods of using the vaccine or immunogenic compositions.

Abstract: This present disclosure provides reliable methods and apparatus for delivering a pharmaceutical active ingredient to an edible substrate. In some examples, the pharmaceutical active ingredient is delivered to voids that are formed in the edible substrate. The voids can then be closed as desired. The edible substrate can be configured as a food product or a dosage form as desired.

Abstract: Aspects and embodiments of the present invention include an apparatus, including a body suit, for providing improved interactions with media content, particularly interactive digital content. The body suit is rotatable around a base and includes one or more of knee, hip and elbow joints that can be driven by motors, or manually. Furthermore, one or more of the knee, hip and elbow can apply resistance to motion by way of braking means. The motors and braking means of aspects and embodiments of the invention, as well as force feedback attachments, provide a sense of realism through improved interaction with interactive digital content. In addition, real world movements of the body suit can be interpreted into digital interactions within an interactive digital content environment.

Abstract: A mobile device having a position determination device and a mobile application configured, in response to the location of the mobile device determined by the position determination device, to: predict a transaction based at least in part on the location of the mobile device; select, based at least in part on the location of the mobile device, a first account for the transaction from a plurality of accounts identified by the identification information; and provide, via the user interface, an alert identifying the first account, before a user of the mobile device begins to make the transaction. The prediction can be made based on a location pattern relative to the location of a transaction terminal and/or the detection of short-range wireless signals of the transaction terminal.

Abstract: A layered edible product includes a core and at least one active layer that is supported by the core. The at least one active layer can include a respective API. The edible product is configured to be placed against a mucosal surface of the oral cavity, which causes the respective API of the at least one active layer to enter the bloodstream through the mucosal surface. The core can be ingested gastrointestinally or can be dissolvable against the mucosal surface or both. The core can include a core API, or optionally the core can be API-free.

Abstract: A method for providing an asset over a network comprises receiving, by a first computing system from a client device, request to provide a digital asset over a network, the request including a network identifier and configuration information associated with the client device; determining, by the first computing system, one or more chatbots available to the client device based on the network identifier and the configuration information associated with the client device; generating, by the first computing system, the digital asset including an invocation scheme for deploying a chatbot of the one or more chatbots on the client device, the invocation scheme configured to connect the chatbot hosted on a second computing system to the client device through the first computing system; and providing, by the first computing system, the digital asset to the client device.

Abstract: A method of treating a coronavirus infection involves administering an inhibitor of the Neu1 sialidase-G protein-coupled receptor-Matrix metalloproteinase 9 (Neu1-GPCR-MMP9) signaling platform, in particular administering intravenously or by inhalation to a patient infected with COVID-19 and its variants a therapeutically effective amount of oseltamivir phosphate, preferably in conjunction with the oral administration of aspirin, in order to reduce the symptoms of respiratory compromise and/or prevent Acute Respiratory Distress Syndrome (ARDS).

Abstract: Methods and apparatus are described for delivering API to a smokable structures and tea bags that contain a fill material. The fill material can include cannabis plant matter, such as cannabis flowers. In one example, an injection tube can be inserted into a smokable structure, and the API can be emitted as a spray. Other methods examples of delivering API to smokable structures are disclosed.

Abstract: This present disclosure provides reliable methods and apparatus for delivering microdroplets containing an active pharmaceutical ingredient (API) to underlying substrates. A control system is provided to ensure that the API dosage is both accurate and repeatable.

Abstract: This present disclosure provides reliable methods and apparatus for delivering a pharmaceutical active ingredient to a food product that is produced in a batch process. In one example, the active pharmaceutical ingredient is added after the batch food product has been cooked and cooled. The food product can be a candy, a baked good, or any alternative food product that is mixed as a batch and subsequently cooked and cooled.

Abstract: A mobile device having a position determination device and a mobile application configured, in response to the location of the mobile device determined by the position determination device, to: predict a transaction based at least in part on the location of the mobile device; select, based at least in part on the location of the mobile device, a first account for the transaction from a plurality of accounts identified by the identification information; and provide, via the user interface, an alert identifying the first account, before a user of the mobile device begins to make the transaction. The prediction can be made based on a location pattern relative to the location of a transaction terminal and/or the detection of short-range wireless signals of the transaction terminal.

Abstract: A mobile device having a position determination device and a mobile application configured, in response to the location of the mobile device determined by the position determination device, to: predict a transaction based at least in part on the location of the mobile device; select, based at least in part on the location of the mobile device, a first account for the transaction from a plurality of accounts identified by the identification information; and provide, via the user interface, an alert identifying the first account, before a user of the mobile device begins to make the transaction. The prediction can be made based on a location pattern relative to the location of a transaction terminal and/or the detection of short-range wireless signals of the transaction terminal.

Abstract: A method for augmenting message streams may comprise receiving a request for augmentation of a message, the request including a parameter associated with the message. The method may further include determining a rule associated with the message. The method may further include applying the determined rule to the message parameters to select an augmentation component. The method may further include transmitting an augmented message to the requestor, the augmented message including the augmentation component.

Abstract: A method for augmenting message streams may comprise receiving a request for augmentation of a message, the request including a parameter associated with the message. The method may further include determining a rule associated with the message. The method may further include applying the determined rule to the message parameters to select an augmentation component. The method may further include transmitting an augmented message to the requestor, the augmented message including the augmentation component.

Abstract: In vitro biomimetic models of the neonatal immune system are provided along with methods of using the models in pre-clinical assessment of infant immune cell-mediated and humoral responses to immunogenic stimulation, such as vaccination. The models include one comprising cord blood-derived T follicular helper cells and B cells, and one comprising cord blood-derived dendritic cells and CD4+ T cells. The models can be used, for example, to assess candidate vaccines via analysis of cellular responses to antigen and vaccine exposure.

Abstract: A method for augmenting message streams may comprise receiving a request for augmentation of a message, the request including a parameter associated with the message. The method may further include determining a rule associated with the message. The method may further include applying the determined rule to the message parameters to select an augmentation component. The method may further include transmitting an augmented message to the requestor, the augmented message including the augmentation component.

Abstract: Systems and methods can apply machine learning techniques to predict biological responses. One of the methods is performed by at least one processor executing executable logic including at least one machine learning model trained to predict biological responses. The method includes receiving first sequence data of a first molecular sequence, receiving second sequence data of a second molecular sequence, and predicting a biological response for the second molecular sequence based at least partly on the received first and second sequence data.