Abstract: The present invention relates to macrocyclic compounds of Formula (I) wherein Ar1, Ar2, R1, R2, R3, R4, and X are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as modulators of CFTR.

Abstract: Various examples described herein are directed to systems and methods for managing an interface between a user and a user computing device. The user computing device may determine that an audio sensor in communication with the user computing device indicates a first command in a user voice of the user, where the first command instructs the user computing device to perform a first task. The user computing device may determine that the audio sensor also indicates a first ambient voice different than the user voice and match the first ambient voice to a first known voice. The user computing device may determine that a second computing device associated with the first known voice is within a threshold distance of the user computing device and select a first privacy level for the first task based at least in part on the first known voice.

Abstract: A method of driving a plurality of LED-based light sources to provide accurate white points and saturated color points. The method includes receiving or setting a selectable target chromaticity: determining that the selectable target chromaticity is between two vertices of the global common gamut: defining an inner region within the global common gamut: calculating a first directed distance between the selectable target chromaticity and the transition boundary of the inner region and a second directed distance between the selectable target chromaticity and a straight side of the global common gamut: and modifying the selectable target chromaticity to a modified target chromaticity within a light fixture gamut based at least in part on the calculated first and second directed distances: or generating an activation signal for driving the plurality of light sources based on the selectable target chromaticity based at least in part on the calculated first and second directed distances.

Abstract: A carrier phase, a neutral surfactant or a reaction product thereof, and a reaction product of a saccharide polymer and a fatty acid or a fatty ester may be formulated as consumer or industrial products of various types. The reaction product of the saccharide polymer may be obtained in the presence of water and a hydroxide base (optionally in the presence of the neutral surfactant). The saccharide polymer comprises a dextran, a dextrin compound, or any combination thereof, and the fatty acid comprises about 50 wt. % or above of one or more straight-chain fatty acids. Illustrative products may include adjuvants, foaming agents, hard surface cleaners, skin creams and lotions, body washes, shampoos, liquid soaps, sunscreens, hair sprays and gels, cosmetics, deodorants, and antiperspirants.

Abstract: Systems and methods for providing situational awareness to pilots of an aircraft. One example system includes an electronic processor configured to receive a raw sensor value for an operational characteristic of the aircraft and generate a processed sensor value based on the raw sensor value. The electronic processor is configured to provide the processed sensor value to a flight control system. The electronic processor is configured to generate a first digital gauge object that includes a graphical representation of the raw sensor value. The electronic processor is configured to generate a second digital gauge object that includes a graphical representation of the processed sensor value and a graphical representation indicating that the processed sensor value is being displayed. The electronic processor is configured to present the first digital gauge object on a first display of the aircraft and the second digital gauge object on a second display of the aircraft.

Abstract: A system and method for providing real-time, sensory information associated with a remote location using a remote capture device and a head-mounted display. In some embodiments, the system comprises a fiber-optic cable to transmit a signal comprising sensory information collected by the remote capture device to the head-mounted display. Further, the remote capture device may be secured onto a boom of an aerial device.

Abstract: An avail comparator and method validates scheduled avail tones. The method includes receiving an automation playlist indicating at least one scheduled avail tone configured to be included in a broadcast. The method includes receiving a feed corresponding to the broadcast. The method includes receiving a signaling for each of the at least one scheduled avail tone based upon the automation playlist. The method includes determining whether the at least one scheduled avail tone was triggered in the broadcast based upon the corresponding signaling.

Abstract: A control apparatus for controlling a thickness of a substrate, such as a glass ribbon. The control apparatus comprises a laser assembly and a shielding assembly. The laser assembly generates an elongated laser beam traveling in a propagation direction along an optical path. The shielding assembly comprises at least one shield selectively disposed in the optical path. The shield is configured to decrease an optical intensity of a region of the elongated laser beam. The shielding assembly is configured to change an intensity profile of the elongated laser beam from an initial intensity profile to a targeted intensity profile. A desired targeted intensity profile can be dictated by an arrangement of the shield(s) relative to the optical path, and can be selected to affect a temperature change at portions of the substrate determined to benefit from a reduction in thickness.

Abstract: This invention relates generally to neurodegenerative diseases and conditions (e.g., Alzheimer's disease) characterized with aberrant CD44 and FERM protein interaction. This invention further relates to methods and compositions for treating such neurodegenerative diseases and conditions with pharmaceutical compositions comprising agents capable of inhibiting CD44 and FERM protein interaction.

Abstract: A system for ultrasound interrogation of a lung includes a memory, an electromagnetic (EM) board, an extended working channel (EWC), an EM sensor, a US transducer, and a processor. The memory stores a three dimensional (3D) model, a pathway plan for navigating a luminal network. An EM board generates an EM field. The EWC is configured to navigate the luminal network of a patient toward a target following the pathway plan and the EM sensor extends distally from the EWC and senses the EM field. The US transducer extends distally from a distal end of the EWC and generates US waves and receives US waves reflected from the luminal network and the processor processes the sensed EM field to synchronize a location of the EM sensor in the 3D model, to process the reflected US waves to generate images, or to integrate the generated images with the 3D model.

Abstract: At a display of a computer system, a user interface is displayed that includes a placement location configured to spatially accommodate a respective user interface object of a plurality of user interface objects corresponding to different applications. In response to detecting the input that is directed to the placement location and in accordance with a determination that the input meets first criteria, including a duration criterion, one or more selectable options associated with the first user interface object corresponding to the first application are displayed. In response to detecting the input and in accordance with a determination that the input meets second criteria, wherein the second criteria requires that the input includes movement in a first direction, display of the first user interface object is replaced with display of the second user interface object from the plurality of user interface objects associated with the placement location.

Abstract: A demonstration unit for demonstrating at least one photochromic characteristic of an optical article having at least one photochromic material includes a housing defining an interior, at least two activating light sources configured to radiate ultraviolet light into the interior, at least one visible light source configured to illuminate at least a portion of the interior of the housing. and a control device operatively connected to the at least two activating light sources and the at least one visible light source. The control device is configured to control operation of the activating light sources and the visible light source to activate at least one photochromic compound of the photochromic material based on at least one predetermined spectral profile corresponding to a simulated outdoor lighting condition. A method of demonstrating at least one photochromic characteristic of an optical article having a photochromic material using the demonstration unit is also disclosed.

Abstract: A method for forming an electroactive material includes sourcing a current or voltage to an electrochemical reactor that includes a cation source, an electrolyte mixture, and an electroactive material precursor in contact with one another, where the current or voltage serves to ionize and form cations at the cation source that react with the electroactive material precursor in the electrolyte mixture to form the electroactive material. The method may include one or more filtering steps, one or more rinsing steps, or a combination of one or more filtering steps and one or more rinsing steps to collect the electroactive material from the electrolyte.

Abstract: The present invention displays an in-the-ear Electroencephalography (EEG) electrode system designed to monitor brain activity in clinical environments, using eartips composed of n-doped silicon or alternative conductive rubber-based materials positioned in the ear canal to accurately detect neurological signals. This electrode system offers wireless and wired configurations, ensuring adaptability to various platforms. This invention addresses the limitations of traditional EEG methodologies by providing a solution for continuous and reliable brain activity monitoring, particularly during intricate surgical procedures. The electrode system displays patient vitals and EEG data in real time, providing medical professionals in diverse clinical settings with comprehensive insights into brain states across a spectrum of frequencies. This system captures Event-Related Potentials (ERPs) and activities in the temporal lobes.

Abstract: A user interface of a terminal is enhanced to provide a screen depicting suggested items for purchasing by a customer before completing a transaction at the terminal. The suggested items can include items likely to have been forgotten by the customer based on the current basket of items in the transaction and/or items that are otherwise related to the current basket of items. Any suggested item selected by the customer for adding to the transaction is communicated to a server. The server maintains a data structure for transactions that require items to be picked up and current statuses for item picking transactions. Store-operated devices allow in-store pickers to select items that need to be picked from the store for the transactions identified in the data structure. When a picker acquires the items from store shelves, the items are delivered to a designated area of the store and the customer retrieves the items from that area.

Abstract: A write circuit for an MJJ-based memory circuit includes first and second current sources configured to generate first and second currents, respectively. The first current imparting an easy axis magnetic field component on an MJJ in a selected memory cell during a write operation. The second current inducing a third current in the selected memory cell that passes through the MJJ, the third current being a seed current for setting a ?-state current of the MJJ in a superconducting loop of the selected memory cell. The first current source is configured such that, during the write operation, the MJJ cell transitions: (i) from a ?-state, in which a clockwise or counter-clockwise current circulates in the superconducting loop, to a zero-state, in which no current circulates in the superconducting loop, back to the ?-state; or (ii) from the zero-state to the ?-state; or (iii) from the ?-state to the zero-state.

Abstract: Tissue-integrating biosensors, systems comprising these sensors and methods of using these sensors and systems for the detection of one or more analytes are provided.

Abstract: Methods for recovering viable microorganisms from a sample comprising an antimicrobial agent comprise incubating the sample with coated particles to form particle-microorganism complexes and then separating the particle-microorganism complexes from the antimicrobial agent. These methods are used to detect the absence or presence of a microorganism in a sample that also contains an antimicrobial agent. Corresponding compositions and kits are also provided.

Abstract: A turbofan engine is provided. The turbofan engine includes a fan comprising a plurality of fan blades; a turbomachine operably coupled to the fan for driving the fan, the turbomachine comprising a compressor section, a combustion section, and a turbine section in serial flow order and together defining a core air flowpath; a nacelle surrounding and at least partially enclosing the fan; an inlet pre-swirl feature located upstream of the plurality of fan blades, the inlet pre-swirl feature attached to or integrated into the nacelle; and a means for directing incoming objects towards an outer portion of the turbofan engine in communication with the inlet pre-swirl feature.

Abstract: Methods, devices and systems are disclosed for improved depth perception in stereoscopic night vision devices. Among these are embodiments for aligning information overlays in the stereo view with associated objects, and for generating stereo information from single lenses or intensifiers. In some illustrative embodiments, a camera and position sensor are provided for at least two viewers, e.g., a pilot and a copilot, such that when a scene overlaps between viewers, the system produces a stereoptic scene, in which the users can more accurately determine a difference in depth between two or more distant objects. An illustrative binocular night vision system uses a high-resolution depth map to present binocular images to a user. In some embodiments, supplementary content can be overlaid, with an appropriate binocular disparity that is based on the depth map.